{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:43:01Z","timestamp":1793911381425,"version":"4.8.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["12331017"],"award-info":[{"award-number":["12331017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82574188"],"award-info":[{"award-number":["82574188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2025A1515012707"],"award-info":[{"award-number":["2025A1515012707"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2024A1515013260"],"award-info":[{"award-number":["2024A1515013260"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Science and Technology Program","award":["ZDSYS20230626091203007"],"award-info":[{"award-number":["ZDSYS20230626091203007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genome Med"],"DOI":"10.1186\/s13073-026-01668-0","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:44:04Z","timestamp":1779108244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multi-omics profiling of the diabetic human heart reveals coupled dysregulation in lipid metabolism, mitophagy, and extracellular matrix remodeling"],"prefix":"10.1186","volume":"18","author":[{"given":"Qiuhan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mintong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengju","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"issue":"9","key":"1668_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41569-020-0339-2","volume":"17","author":"Y Tan","year":"2020","unstructured":"Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol. 2020;17(9):585\u2013607.","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"1668_CR2","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.2337\/dci22-0014","volume":"45","author":"R Pop-Busui","year":"2022","unstructured":"Pop-Busui R, Januzzi JL, Bruemmer D, Butalia S, Green JB, Horton WB, et al. Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association. Diabetes Care. 2022;45(7):1670\u201390.","journal-title":"Diabetes Care"},{"issue":"11","key":"1668_CR3","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.2337\/dc17-0697","volume":"40","author":"M Dauriz","year":"2017","unstructured":"Dauriz M, Mantovani A, Bonapace S, Verlato G, Zoppini G, Bonora E, et al. Prognostic Impact of Diabetes on Long-term Survival Outcomes in Patients With Heart Failure: A Meta-analysis. Diabetes Care. 2017;40(11):1597\u2013605.","journal-title":"Diabetes Care"},{"key":"1668_CR4","unstructured":"Dauriz M, Targher G, Temporelli PL, Lucci D, Gonzini L, Nicolosi GL et al. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial. J Am Heart Assoc. 2017;6(7):e005156."},{"issue":"11","key":"1668_CR5","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.120.315913","volume":"126","author":"RH Ritchie","year":"2020","unstructured":"Ritchie RH, Abel ED. Basic Mechanisms of Diabetic Heart Disease. Circ Res. 2020;126(11):1501\u201325.","journal-title":"Circ Res"},{"issue":"4","key":"1668_CR6","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","volume":"122","author":"G Jia","year":"2018","unstructured":"Jia G, Hill MA, Sowers JR. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circ Res. 2018;122(4):624\u201338.","journal-title":"Circ Res"},{"issue":"1","key":"1668_CR7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12933-017-0506-x","volume":"16","author":"A Lorenzo-Almoros","year":"2017","unstructured":"Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O. Diagnostic approaches for diabetic cardiomyopathy. Cardiovasc Diabetol. 2017;16(1):28.","journal-title":"Cardiovasc Diabetol"},{"issue":"16","key":"1668_CR8","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/j.jacc.2021.08.020","volume":"78","author":"MW Segar","year":"2021","unstructured":"Segar MW, Khan MS, Patel KV, Butler J, Tang WHW, Vaduganathan M, et al. Prevalence and Prognostic Implications of Diabetes With Cardiomyopathy in Community-Dwelling Adults. J Am Coll Cardiol. 2021;78(16):1587\u201398.","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"1668_CR9","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1002\/ejhf.3347","volume":"26","author":"PM Seferovi\u0107","year":"2024","unstructured":"Seferovi\u0107 PM, Paulus WJ, Rosano G, Polovina M, Petrie MC, Jhund PS, et al. Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases. Eur J Heart Fail. 2024;26(9):1893\u2013903.","journal-title":"Eur J Heart Fail"},{"key":"1668_CR10","doi-asserted-by":"crossref","unstructured":"Swiatkiewicz I, Patel NT, Villarreal-Gonzalez M, Taub PR. Prevalence of diabetic cardiomyopathy in patients with type 2 diabetes in a large academic medical center. BMC Med. 2024;22(1):195.","DOI":"10.1186\/s12916-024-03401-3"},{"issue":"14","key":"1668_CR11","doi-asserted-by":"publisher","first-page":"5276","DOI":"10.7150\/ijbs.75402","volume":"18","author":"C Cai","year":"2022","unstructured":"Cai C, Wu F, He J, Zhang Y, Shi N, Peng X, et al. Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies. Int J Biol Sci. 2022;18(14):5276\u201390.","journal-title":"Int J Biol Sci"},{"key":"1668_CR12","doi-asserted-by":"publisher","first-page":"1032268","DOI":"10.3389\/fendo.2022.1032268","volume":"13","author":"X Zhao","year":"2022","unstructured":"Zhao X, Liu S, Wang X, Chen Y, Pang P, Yang Q, et al. Diabetic cardiomyopathy: Clinical phenotype and practice. Front Endocrinol (Lausanne). 2022;13:1032268.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"40","key":"1668_CR13","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.1093\/eurheartj\/ehad541","volume":"44","author":"E Braunwald","year":"2023","unstructured":"Braunwald E. Diabetocardiology: a new subspecialty? Eur Heart J. 2023;44(40):4214\u20136.","journal-title":"Eur Heart J"},{"issue":"2","key":"1668_CR14","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1161\/CIRCULATIONAHA.120.050498","volume":"143","author":"VS Hahn","year":"2021","unstructured":"Hahn VS, Knutsdottir H, Luo X, Bedi K, Margulies KB, Haldar SM, et al. Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction. Circulation. 2021;143(2):120\u201334.","journal-title":"Circulation"},{"issue":"15","key":"1668_CR15","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1161\/CIRCULATIONAHA.122.061846","volume":"147","author":"VS Hahn","year":"2023","unstructured":"Hahn VS, Petucci C, Kim MS, Bedi KC Jr., Wang H, Mishra S, et al. Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. Circulation. 2023;147(15):1147\u201361.","journal-title":"Circulation"},{"key":"1668_CR16","doi-asserted-by":"publisher","first-page":"155977","DOI":"10.1016\/j.metabol.2024.155977","volume":"158","author":"S Shu","year":"2024","unstructured":"Shu S, Cui H, Liu Z, Zhang H, Yang Y, Chen X, et al. Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy. Metabolism. 2024;158:155977.","journal-title":"Metabolism"},{"key":"1668_CR17","doi-asserted-by":"crossref","unstructured":"Song M, Dai H, Zhou Q, Meng X. The immunology of diabetic cardiomyopathy. Front Endocrinol. 2025;16:1542208.","DOI":"10.3389\/fendo.2025.1542208"},{"key":"1668_CR18","doi-asserted-by":"crossref","unstructured":"Guan X, Zhou C, Zhuo X, Yang W, Wang H. The heart of diabetes: unraveling metabolic drivers of cardiomyopathy. Cardiovasc Diabetol \u2013 Endocrinol Rep. 2025;11(1):18.","DOI":"10.1186\/s40842-025-00231-x"},{"key":"1668_CR19","doi-asserted-by":"crossref","unstructured":"Benchea L-C, Anghel L, Dubei N, Zanfirescu R-L, B\u00eergoan G-S, Sasc\u0103u RA et al. Impaired Left Atrial Strain as an Early Marker of Cardiac Involvement in Type 2 Diabetes Mellitus: A Cross-Sectional Study. J Cardiovasc Dev Disease. 2025;12(9):369.","DOI":"10.3390\/jcdd12090369"},{"key":"1668_CR20","doi-asserted-by":"crossref","unstructured":"Jankauskas SS, Kansakar U, Varzideh F, Wilson S, Mone P, Lombardi A et al. Heart failure in diabetes. Metabolism. 2021;125:154910.","DOI":"10.1016\/j.metabol.2021.154910"},{"key":"1668_CR21","doi-asserted-by":"crossref","unstructured":"Cui M, Wu H, An Y, Liu Y, Wei L, Qi X. Identification of important modules and biomarkers in diabetic cardiomyopathy based on WGCNA and LASSO analysis. Front Endocrinol. 2024;15:1185062.","DOI":"10.3389\/fendo.2024.1185062"},{"key":"1668_CR22","doi-asserted-by":"crossref","unstructured":"Rostami A, Palomer X, Pizarro-Delgado J, Barroso E, Valenzuela-Alcaraz B, Crispi F et al. PPAR\u03b2\/\u03b4 prevents inflammation and fibrosis during diabetic cardiomyopathy. Pharmacol Res. 2024;210:107515.","DOI":"10.1016\/j.phrs.2024.107515"},{"issue":"21\u201324","key":"1668_CR23","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1080\/15384101.2025.2581629","volume":"24","author":"L Yu","year":"2025","unstructured":"Yu L, Chen S, Zhang W, Huang C, Hu L, Liu L, et al. HSP22 reduces diabetic cardiomyopathy by inhibition oxidative stress and inflammation. Cell Cycle. 2025;24(21\u201324):655\u201369.","journal-title":"Cell Cycle"},{"key":"1668_CR24","doi-asserted-by":"crossref","unstructured":"Fiordelisi A, Cerasuolo FA, Avvisato R, Buonaiuto A, Maisto M, Bianco A et al. L-Arginine supplementation as mitochondrial therapy in diabetic cardiomyopathy. Cardiovasc Diabetol. 2024;23(1):450.","DOI":"10.1186\/s12933-024-02490-x"},{"issue":"1","key":"1668_CR25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41467-024-55557-4","volume":"16","author":"P She","year":"2025","unstructured":"She P, Gao B, Li D, Wu C, Zhu X, He Y, et al. The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nat Commun. 2025;16(1):232.","journal-title":"Nat Commun"},{"key":"1668_CR26","unstructured":"Lu Q, Tang S, Fang S, Wu Y, Chen L, Liang M, et al. Multi-omics profiling of diabetic cardiomyopathy transcriptomic dataset (HRA012847). National Genomics Data Center (NGDC); 2026."},{"key":"1668_CR27","unstructured":"Lu Q, Tang S, Fang S, Wu Y, Chen L, Liang M, et al. Proteomic and metabolomic datasets for multi-omics profiling of the diabetic human heart (OMIX011502; OMIX011503). National Genomics Data Center (NGDC); 2026."},{"issue":"1","key":"1668_CR28","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1038\/s41467-020-16584-z","volume":"11","author":"M Li","year":"2020","unstructured":"Li M, Parker BL, Pearson E, Hunter B, Cao J, Koay YC, et al. Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. Nat Commun. 2020;11(1):2843.","journal-title":"Nat Commun"},{"issue":"5","key":"1668_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s44161-022-00057-1","volume":"1","author":"WM Wang","year":"2022","unstructured":"Wang WM, Wang JZ, Yao K, Wang SY, Nie M, Zhao YZ, et al. Metabolic characterization of hypertrophic cardiomyopathy in human heart. Nat Cardiovasc Res. 2022;1(5):445\u2013.","journal-title":"Nat Cardiovasc Res"},{"issue":"1","key":"1668_CR30","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s12859-018-2371-3","volume":"19","author":"SE Bouhaddani","year":"2018","unstructured":"Bouhaddani SE, Uh HW, Jongbloed G, Hayward C, Klaric L, Kielbasa SM, et al. Integrating omics datasets with the OmicsPLS package. BMC Bioinformatics. 2018;19(1):371.","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"1668_CR31","doi-asserted-by":"publisher","first-page":"e8124","DOI":"10.15252\/msb.20178124","volume":"14","author":"R Argelaguet","year":"2018","unstructured":"Argelaguet R, Velten B, Arnol D, Dietrich S, Zenz T, Marioni JC, et al. Multi-Omics Factor Analysis-a framework for unsupervised integration of multi-omics data sets. Mol Syst Biol. 2018;14(6):e8124.","journal-title":"Mol Syst Biol"},{"issue":"D1","key":"1668_CR32","doi-asserted-by":"publisher","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","volume":"49","author":"S Rath","year":"2021","unstructured":"Rath S, Sharma R, Gupta R, Ast T, Chan C, Durham TJ, et al. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 2021;49(D1):D1541\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1668_CR33","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.","journal-title":"Nat Commun"},{"issue":"W1","key":"1668_CR34","doi-asserted-by":"publisher","first-page":"W388","DOI":"10.1093\/nar\/gkab382","volume":"49","author":"Z Pang","year":"2021","unstructured":"Pang Z, Chong J, Zhou G, de Lima Morais DA, Chang L, Barrette M, et al. MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res. 2021;49(W1):W388\u201396.","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"1668_CR35","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","volume":"13","author":"S Tyanova","year":"2016","unstructured":"Tyanova S, Temu T, Sinitcyn P, Carlson A, Hein MY, Geiger T, et al. The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat Methods. 2016;13(9):731\u201340.","journal-title":"Nat Methods"},{"issue":"5","key":"1668_CR36","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453\u20137.","journal-title":"Nat Methods"},{"issue":"1","key":"1668_CR37","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18(1):220.","journal-title":"Genome Biol"},{"issue":"1","key":"1668_CR38","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","volume":"18","author":"P Charoentong","year":"2017","unstructured":"Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, et al. Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade. Cell Rep. 2017;18(1):248\u201362.","journal-title":"Cell Rep"},{"issue":"1 7","key":"1668_CR39","first-page":"1","volume":"56","author":"DR Shaw","year":"2016","unstructured":"Shaw DR. Searching the Mouse Genome Informatics (MGI) Resources for Information on Mouse Biology from Genotype to Phenotype. Curr Protoc Bioinf. 2016;56(1 7):1\u2013716.","journal-title":"Curr Protoc Bioinf"},{"issue":"6","key":"1668_CR40","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.2337\/db11-0952","volume":"61","author":"S Greco","year":"2012","unstructured":"Greco S, Fasanaro P, Castelvecchio S, D\u2019Alessandra Y, Arcelli D, Di Donato M, et al. MicroRNA dysregulation in diabetic ischemic heart failure patients. Diabetes. 2012;61(6):1633\u201341.","journal-title":"Diabetes"},{"key":"1668_CR41","unstructured":"Lu Q, Tang S, Fang S, Wu Y, Chen L, Liang M et al. Code for multi-omics study of diabetic cardiomyopathy in human heart (https:\/\/github.com\/JiangLab-spec\/Multi-omics-study-of-diabetic-cardiomyopathy-in-human-heart). GitHub; 2026."},{"issue":"1","key":"1668_CR42","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1152\/physrev.00015.2009","volume":"90","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol Rev. 2010;90(1):207\u201358.","journal-title":"Physiol Rev"},{"issue":"4","key":"1668_CR43","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/cvr\/cvx018","volume":"113","author":"CR Chong","year":"2017","unstructured":"Chong CR, Clarke K, Levelt E. Metabolic Remodeling in Diabetic Cardiomyopathy. Cardiovasc Res. 2017;113(4):422\u201330.","journal-title":"Cardiovasc Res"},{"issue":"9","key":"1668_CR44","first-page":"817","volume":"1","author":"E Flam","year":"2022","unstructured":"Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, et al. Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nat Cardiovasc Res. 2022;1(9):817\u201329.","journal-title":"Nat Cardiovasc Res"},{"key":"1668_CR45","doi-asserted-by":"publisher","first-page":"120371","DOI":"10.1016\/j.lfs.2022.120371","volume":"294","author":"Y Li","year":"2022","unstructured":"Li Y, Yang M, Tan J, Shen C, Deng S, Fu X, et al. Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration. Life Sci. 2022;294:120371.","journal-title":"Life Sci"},{"issue":"12","key":"1668_CR46","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1089\/ars.2019.8013","volume":"32","author":"L Liu","year":"2020","unstructured":"Liu L, Liao X, Wu H, Li Y, Zhu Y, Chen Q. Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders. Antioxid Redox Signal. 2020;32(12):906\u201327.","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"1668_CR47","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1080\/15548627.2021.1975914","volume":"18","author":"T Zhang","year":"2022","unstructured":"Zhang T, Liu Q, Gao W, Sehgal SA, Wu H. The multifaceted regulation of mitophagy by endogenous metabolites. Autophagy. 2022;18(6):1216\u201339.","journal-title":"Autophagy"},{"key":"1668_CR48","doi-asserted-by":"publisher","first-page":"155313","DOI":"10.1016\/j.metabol.2022.155313","volume":"137","author":"X Chang","year":"2022","unstructured":"Chang X, Li Y, Cai C, Wu F, He J, Zhang Y, et al. Mitochondrial quality control mechanisms as molecular targets in diabetic heart. Metabolism. 2022;137:155313.","journal-title":"Metabolism"},{"issue":"11","key":"1668_CR49","doi-asserted-by":"publisher","first-page":"e14054","DOI":"10.1111\/eci.14054","volume":"53","author":"T Svagusa","year":"2023","unstructured":"Svagusa T, Sikiric S, Milavic M, Sepac A, Seiwerth S, Milicic D, et al. Heart failure in patients is associated with downregulation of mitochondrial quality control genes. Eur J Clin Invest. 2023;53(11):e14054.","journal-title":"Eur J Clin Invest"},{"issue":"7","key":"1668_CR50","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1080\/15548627.2019.1580095","volume":"15","author":"MA Lampert","year":"2019","unstructured":"Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, et al. BNIP3L\/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation. Autophagy. 2019;15(7):1182\u201398.","journal-title":"Autophagy"},{"issue":"9","key":"1668_CR51","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1161\/CIRCRESAHA.118.314607","volume":"124","author":"M Tong","year":"2019","unstructured":"Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, et al. Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy. Circ Res. 2019;124(9):1360\u201371.","journal-title":"Circ Res"},{"issue":"1","key":"1668_CR52","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40659-018-0169-4","volume":"51","author":"C Huang","year":"2018","unstructured":"Huang C, Lu H, Xu J, Yu H, Wang X, Zhang X. Protective roles of autophagy in retinal pigment epithelium under high glucose condition via regulating PINK1\/Parkin pathway and BNIP3L. Biol Res. 2018;51(1):22.","journal-title":"Biol Res"},{"issue":"7","key":"1668_CR53","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1016\/j.celrep.2019.10.032","volume":"29","author":"SS Gupta","year":"2019","unstructured":"Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW 2nd, Wang J, et al. NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells. Cell Rep. 2019;29(7):1862\u201377 e7.","journal-title":"Cell Rep"},{"issue":"12","key":"1668_CR54","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1002\/jcp.25884","volume":"232","author":"S Riaz","year":"2017","unstructured":"Riaz S, Zeidan A, Mraiche F. Myocardial proteases and cardiac remodeling. J Cell Physiol. 2017;232(12):3244\u201350.","journal-title":"J Cell Physiol"},{"issue":"3","key":"1668_CR55","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cell.2020.06.030","volume":"182","author":"T Yokota","year":"2020","unstructured":"Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, et al. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020;182(3):545\u201362. e23.","journal-title":"Cell"},{"issue":"3","key":"1668_CR56","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/sj.ki.5000030","volume":"69","author":"M Porst","year":"2006","unstructured":"Porst M, Plank C, Bieritz B, Konik E, Fees H, Dotsch J, et al. Fibrillin-1 regulates mesangial cell attachment, spreading, migration and proliferation. Kidney Int. 2006;69(3):450\u20136.","journal-title":"Kidney Int"},{"issue":"2","key":"1668_CR57","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1042\/BJ20100414","volume":"432","author":"AB Gaikwad","year":"2010","unstructured":"Gaikwad AB, Gupta J, Tikoo K. Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. Biochem J. 2010;432(2):333\u201341.","journal-title":"Biochem J"},{"issue":"1","key":"1668_CR58","doi-asserted-by":"publisher","first-page":"e20526","DOI":"10.1096\/fj.201900076RRRRR","volume":"35","author":"B Li","year":"2021","unstructured":"Li B, Zhou Y, Chen J, Wang T, Li Z, Fu Y, et al. Long noncoding RNA H19 acts as a miR-29b sponge to promote wound healing in diabetic foot ulcer. FASEB J. 2021;35(1):e20526.","journal-title":"FASEB J"},{"issue":"11","key":"1668_CR59","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1016\/j.jid.2019.05.014","volume":"139","author":"HN Wilkinson","year":"2019","unstructured":"Wilkinson HN, Upson SE, Banyard KL, Knight R, Mace KA, Hardman MJ. Reduced Iron in Diabetic Wounds: An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling. J Invest Dermatol. 2019;139(11):2368\u201377. e7.","journal-title":"J Invest Dermatol"},{"issue":"4","key":"1668_CR60","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1161\/HYPERTENSIONAHA.120.14752","volume":"76","author":"PL Li","year":"2020","unstructured":"Li PL, Liu H, Chen GP, Li L, Shi HJ, Nie HY, et al. STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy. Hypertension. 2020;76(4):1219\u201330.","journal-title":"Hypertension"},{"issue":"5","key":"1668_CR61","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1172\/JCI87491","volume":"127","author":"NG Frangogiannis","year":"2017","unstructured":"Frangogiannis NG. The extracellular matrix in myocardial injury, repair, and remodeling. J Clin Invest. 2017;127(5):1600\u201312.","journal-title":"J Clin Invest"},{"issue":"11","key":"1668_CR62","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","volume":"75","author":"SP Murphy","year":"2020","unstructured":"Murphy SP, Kakkar R, McCarthy CP, Januzzi JL. Jr. Inflammation in Heart Failure: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75(11):1324\u201340.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"1668_CR63","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","volume":"17","author":"L Adamo","year":"2020","unstructured":"Adamo L, Rocha-Resende C, Prabhu SD, Mann DL. Reappraising the role of inflammation in heart failure. Nat Rev Cardiol. 2020;17(5):269\u201385.","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"1668_CR64","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1161\/CIRCRESAHA.116.308030","volume":"119","author":"SA Dick","year":"2016","unstructured":"Dick SA, Epelman S. Chronic Heart Failure and Inflammation: What Do We Really Know? Circ Res. 2016;119(1):159\u201376.","journal-title":"Circ Res"},{"issue":"15","key":"1668_CR65","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1093\/cvr\/cvae181","volume":"120","author":"MS Conning-Rowland","year":"2024","unstructured":"Conning-Rowland MS, Giannoudi M, Drozd M, Brown OI, Yuldasheva NY, Cheng CW, et al. The diabetic myocardial transcriptome reveals Erbb3 and Hspa2 as a novel biomarkers of incident heart failure. Cardiovasc Res. 2024;120(15):1898\u2013906.","journal-title":"Cardiovasc Res"}],"container-title":["Genome Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13073-026-01668-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13073-026-01668-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13073-026-01668-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:04:57Z","timestamp":1783641897000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13073-026-01668-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1668"],"URL":"https:\/\/doi.org\/10.1186\/s13073-026-01668-0","relation":{},"ISSN":["1756-994X"],"issn-type":[{"value":"1756-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"26 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study followed the Declaration of Helsinki and was approved by the Ethics Committee of Guangdong Provincial People\u2019s Hospital (GDREC2016255H). Written informed consent was obtained from all participants (Informed consent form No. 20160628).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"102"}}