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Zenodo. https:\/\/zenodo.org\/records\/20805884."}],"container-title":["Genome Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13073-026-01709-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13073-026-01709-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13073-026-01709-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:02:10Z","timestamp":1790560930000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13073-026-01709-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":97,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1709"],"URL":"https:\/\/doi.org\/10.1186\/s13073-026-01709-8","relation":{},"ISSN":["1756-994X"],"issn-type":[{"value":"1756-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"10 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Approval was obtained from the Institutional Review Board (IRB) of the Albert Einstein College of Medicine (IRB# 2022\u201314425), which serves as the overall IRB approval for this study. The study was reviewed and approved by IRBs at all participating institutions (approval for the multi-omics analysis, Albert Einstein College of Medicine, 2022\u201314425; Bronx site, Biomedical Research Alliance of New York, 21\u201302-210-01E; Pittsburgh site, University of Pittsburgh, STUDY21050072; Chicago site, Northwestern University, STU00022906; Baltimore site and DACC, Johns Hopkins Bloomberg School of Public Health, 16882 and 23015; Los Angeles site, University of California, Los Angeles, 20\u2013002292-AM-00001). All participants provided written informed consent. The research conformed to the principles of the Helsinki Declaration.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"T.T.B. has served as a consultant to ViiV Healthcare, Merck, EMD-Serono, and GSK. Other authors have nothing to disclose.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"140"}}