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Their capacity to stimulate allogeneic CD4<jats:sup>+<\/jats:sup> T cells from unrelated healthy donor was tested. Transcriptomic study was performed with Affymetrix HuGene 1.0 ST microarrays. Gene expression levels were compared between patients and controls using a multivariate design under a linear model (LIMMA). Real-time quantitative PCR (qRT-PCR) was performed for validation of the most striking gene expression differences.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The stimulatory capacity of allogeneic CD4<jats:sup>+<\/jats:sup> T cells by MD-DCs from SpA patients was decreased. Transcriptomic analysis revealed 81 genes differentially expressed in MD-DCs between SpA patients and controls (<jats:italic>P<\/jats:italic> &lt;0.01 and fold-change &lt;0.66 or &gt;1.5). Four selected genes were validated by qRT-PCR: <jats:italic>ADAMTS15, CITED2, F13A1<\/jats:italic> and <jats:italic>SELL<\/jats:italic>. Expression levels of <jats:italic>ADAMTS15<\/jats:italic> and <jats:italic>CITED2,<\/jats:italic> encoding a metallopeptidase and a transcription factor, respectively, were inversely correlated with each other (R = 0.75, <jats:italic>P<\/jats:italic> = 0.0003). Furthermore, <jats:italic>in silico<\/jats:italic> analysis identified several genes of the Wnt signaling pathway having expression co-regulated with <jats:italic>CITED2<\/jats:italic>.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>This study revealed altered function and gene expression pattern in MD-DCs from HLA-B27<jats:sup>+<\/jats:sup> axial SpA. Co-expression study showed an inverse correlation between <jats:italic>ADAMTS15<\/jats:italic> and <jats:italic>CITED2<\/jats:italic>. Moreover, the Wnt signaling pathway appeared as deregulated in SpA MD-DCs, a finding which may be connected to Th17-driven inflammatory responses.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/s13075-014-0417-0","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T10:17:23Z","timestamp":1408529843000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Monocyte-derived dendritic cells from HLA-B27+ axial spondyloarthritis (SpA) patients display altered functional capacity and deregulated gene expression"],"prefix":"10.1186","volume":"16","author":[{"given":"Alice","family":"Talpin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9licie","family":"Costantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Leboime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Letourneur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Jacques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Amraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Antoine","family":"Dutertre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri-Jean","family":"Garchon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Breban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Chiocchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"417_CR1","doi-asserted-by":"crossref","unstructured":"Costantino F, Talpin A, Said-Nahal R, Goldberg M, Henny J, Chiocchia G, Garchon H-J, Zins M, Breban M: Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort.Ann Rheum Dis 2013,:. doi:10.1136\/annrheumdis-2013-204436.,","DOI":"10.1136\/annrheumdis-2013-204436"},{"key":"417_CR2","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1002\/art.23512","volume":"58","author":"JA Smith","year":"2008","unstructured":"Smith JA, Barnes MD, Hong D, DeLay ML, Inman RD, Colbert RA: Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation. 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