{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:18:05Z","timestamp":1793888285324,"version":"4.8.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0786-z","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T07:24:22Z","timestamp":1444029862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting"],"prefix":"10.1186","volume":"17","author":[{"given":"Jurgen","family":"van Heemst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leendert A.","family":"Trouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna W.","family":"van Steenbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette H. M.","family":"van der Helm-van Mil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia F.","family":"Allaart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Serre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikard","family":"Holmdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom W. J.","family":"Huizinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 E. M.","family":"Toes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"van der Woude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"786_CR1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","volume":"376","author":"DL Scott","year":"2010","unstructured":"Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094\u2013108.","journal-title":"Lancet"},{"key":"786_CR2","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","volume":"48","author":"S Rantap\u00e4\u00e4-Dahlqvist","year":"2003","unstructured":"Rantap\u00e4\u00e4-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741\u20139.","journal-title":"Arthritis Rheum"},{"key":"786_CR3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","volume":"50","author":"MM Nielen","year":"2004","unstructured":"Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50:380\u20136.","journal-title":"Arthritis Rheum"},{"key":"786_CR4","doi-asserted-by":"crossref","first-page":"R949","DOI":"10.1186\/ar1767","volume":"7","author":"AH Mil van der Helm-van","year":"2005","unstructured":"van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Toes RE, Huizinga TW, et al. Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis. Arthritis Res Ther. 2005;7:R949\u201358.","journal-title":"Arthritis Res Ther"},{"key":"786_CR5","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1002\/art.21385","volume":"52","author":"TW Huizinga","year":"2005","unstructured":"Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen FA, Jawaheer D, et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum. 2005;52:3433\u20138.","journal-title":"Arthritis Rheum"},{"key":"786_CR6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","volume":"54","author":"L Klareskog","year":"2006","unstructured":"Klareskog L, Stolt P, Lundberg K, K\u00e4llberg H, Bengtsson C, Grunewald J, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006;54:38\u201346.","journal-title":"Arthritis Rheum"},{"key":"786_CR7","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1002\/art.24716","volume":"60","author":"MP Linden van der","year":"2009","unstructured":"van der Linden MP, van der Woude D, Ioan-Facsinay A, Levarht EW, Stoeken-Rijsbergen G, Huizinga TW, et al. Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis. Arthritis Rheum. 2009;60:2232\u201341.","journal-title":"Arthritis Rheum"},{"key":"786_CR8","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/art.22817","volume":"56","author":"H Bang","year":"2007","unstructured":"Bang H, Egerer K, Gauliard A, L\u00fcthke K, Rudolph PE, Fredenhagen G, et al. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 2007;56:2503\u201311.","journal-title":"Arthritis Rheum"},{"key":"786_CR9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrrheum.2011.76","volume":"7","author":"WJ Venrooij van","year":"2011","unstructured":"van Venrooij WJ, van Beers JJ, Pruijn GJ. Anti-CCP antibodies: the past, the present and the future. Nat Rev Rheumatol. 2011;7:391\u20138.","journal-title":"Nat Rev Rheumatol"},{"key":"786_CR10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/annrheumdis-2013-203915","volume":"74","author":"CA Wagner","year":"2015","unstructured":"Wagner CA, Sokolove J, Lahey LJ, Bengtsson C, Saevarsdottir S, Alfredsson L, et al. Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 \u2018shared epitope\u2019 alleles. Ann Rheum Dis. 2015;74:579\u201386.","journal-title":"Ann Rheum Dis"},{"key":"786_CR11","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1186\/ar4039","volume":"14","author":"M Hansson","year":"2012","unstructured":"Hansson M, Mathsson L, Schlederer T, Israelsson L, Matsson P, Nogueira L, et al. Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides. Arthritis Res Ther. 2012;14:R201.","journal-title":"Arthritis Res Ther"},{"key":"786_CR12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/art.38273","volume":"66","author":"MJ Hair de","year":"2014","unstructured":"de Hair MJ, van de Sande MG, Ramwadhdoebe TH, Hansson M, Landew\u00e9 R, van der Leij C, et al. Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis. Arthritis Rheumatol. 2014;66:513\u201322.","journal-title":"Arthritis Rheumatol"},{"key":"786_CR13","doi-asserted-by":"crossref","unstructured":"Brink M, Hansson M, Mathsson L, Jakobsson PJ, Holmdahl R, Hallmans G, et al. Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum. 2013;65:899\u2013910.","DOI":"10.1002\/art.37835"},{"key":"786_CR14","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2014-eular.4530","volume":"73","author":"M Brink","year":"2014","unstructured":"Brink M, Hansson M, R\u00f6nnelid J, Klareskog L, Rantap\u00e4\u00e4 Dahlqvist S. The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides. Ann Rheum Dis. 2014;73, e46.","journal-title":"Ann Rheum Dis"},{"key":"786_CR15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/rheumatology\/keq230","volume":"50","author":"DP Rooy de","year":"2011","unstructured":"de Rooy DP, van der Linden MP, Knevel R, Huizinga TW, van der Helm-van Mil AH. Predicting arthritis outcomes--what can be learned from the Leiden Early Arthritis Clinic? Rheumatology (Oxford). 2011;50:93\u2013100.","journal-title":"Rheumatology (Oxford)"},{"key":"786_CR16","unstructured":"van Aken J, van Bilsen JH, Allaart CF, Huizinga TW, Breedveld FC, van Aken J, et al. The Leiden Early Arthritis Clinic. Clin Exp Rheumatol. 2003;21:S100\u20135."},{"key":"786_CR17","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/annrheumdis-2013-203243","volume":"73","author":"L Heimans","year":"2014","unstructured":"Heimans L, Wevers-de Boer KV, Visser K, Goekoop RJ, van Oosterhout M, Harbers JB, et al. A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: the IMPROVED study. Ann Rheum Dis. 2014;73:1356\u201361.","journal-title":"Ann Rheum Dis"},{"key":"786_CR18","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","volume":"30","author":"PK Gregersen","year":"1987","unstructured":"Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 1987;30:1205\u201313.","journal-title":"Arthritis Rheum"},{"key":"786_CR19","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1002\/art.24721","volume":"60","author":"MP Linden van der","year":"2009","unstructured":"van der Linden MP, Feitsma AL, le Cessie S, Kern M, Olsson LM, Raychaudhuri S, et al. Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis. Arthritis Rheum. 2009;60:2242\u20137.","journal-title":"Arthritis Rheum"},{"key":"786_CR20","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/eji.200526000","volume":"35","author":"H Burkhardt","year":"2005","unstructured":"Burkhardt H, Sehnert B, Bockermann R, Engstr\u00f6m A, Kalden JR, Holmdahl R. Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. Eur J Immunol. 2005;35:1643\u201352.","journal-title":"Eur J Immunol"},{"key":"786_CR21","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1002\/art.30611","volume":"63","author":"D Dobritzsch","year":"2011","unstructured":"Dobritzsch D, Lindh I, Uysal H, Nandakumar KS, Burkhardt H, Schneider G, et al. Crystal structure of an arthritogenic anticollagen immune complex. Arthritis Rheum. 2011;63:3740\u20138.","journal-title":"Arthritis Rheum"},{"key":"786_CR22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10654-005-7835-x","volume":"20","author":"T Andersson","year":"2005","unstructured":"Andersson T, Alfredsson L, K\u00e4llberg H, Zdravkovic S, Ahlbom A. Calculating measures of biological interaction. Eur J Epidemiol. 2005;20:575\u20139.","journal-title":"Eur J Epidemiol"},{"key":"786_CR23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/03009742.2012.728618","volume":"42","author":"R Knevel","year":"2013","unstructured":"Knevel R, Tsonaka R, le Cessie S, van der Linden MP, Huizinga TW, van der Heijde DM, et al. Comparison of methodologies for analysing the progression of joint destruction in rheumatoid arthritis. Scand J Rheumatol. 2013;42:182\u20139.","journal-title":"Scand J Rheumatol"},{"key":"786_CR24","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/ar4322","volume":"15","author":"JJ Beers van","year":"2013","unstructured":"van Beers JJ, Willemze A, Jansen JJ, Engbers GH, Salden M, Raats J, et al. ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression. Arthritis Res Ther. 2013;15:R140.","journal-title":"Arthritis Res Ther"},{"key":"786_CR25","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1002\/art.23127","volume":"56","author":"KN Verpoort","year":"2007","unstructured":"Verpoort KN, Cheung K, Ioan-Facsinay A, van der Helm-van Mil AH, de Vries-Bouwstra JK, Allaart CF, et al. Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles. Arthritis Rheum. 2007;56:3949\u201352.","journal-title":"Arthritis Rheum"},{"key":"786_CR26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.20081862","volume":"206","author":"H Uysal","year":"2009","unstructured":"Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engstr\u00f6m A, et al. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009;206:449\u201362.","journal-title":"J Exp Med"},{"key":"786_CR27","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/art.38383","volume":"66","author":"S Haag","year":"2014","unstructured":"Haag S, Schneider N, Mason DE, Tuncel J, Andersson IE, Peters EC, et al. Identification of new citrulline-specific autoantibodies, which bind to human arthritic cartilage, by mass spectrometric analysis of citrullinated type II collagen. Arthritis Rheumatol. 2014;66:1440\u20139.","journal-title":"Arthritis Rheumatol"},{"key":"786_CR28","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1136\/ard.2010.148197","volume":"70","author":"AG Pratt","year":"2011","unstructured":"Pratt AG, Charles PJ, Chowdhury M, Wilson G, Venables PJ, Isaacs JD. Serotyping for an extended anti-citrullinated peptide autoantibody panel does not add value to CCP2 testing for diagnosing RA in an early undifferentiated arthritis cohort. Ann Rheum Dis. 2011;70:2056\u20138.","journal-title":"Ann Rheum Dis"},{"key":"786_CR29","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1172\/JCI60975","volume":"122","author":"U Harre","year":"2012","unstructured":"Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012;122:1791\u2013802.","journal-title":"J Clin Invest"},{"key":"786_CR30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.autrev.2012.05.007","volume":"12","author":"LA Trouw","year":"2012","unstructured":"Trouw LA, Mahler M. Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis. Autoimmun Rev. 2012;12:318\u201322.","journal-title":"Autoimmun Rev"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0786-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T16:46:44Z","timestamp":1498236404000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,5]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["786"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0786-z","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,5]]},"article-number":"276"}}