{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:25:15Z","timestamp":1769693115082,"version":"3.49.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand (NZ)","doi-asserted-by":"publisher","award":["11\/1175"],"award-info":[{"award-number":["11\/1175"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0802-3","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T14:13:53Z","timestamp":1444745633000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout"],"prefix":"10.1186","volume":"17","author":[{"given":"Cushla","family":"McKinney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa K.","family":"Stamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth K.","family":"Topless","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O.","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diluk RW","family":"Kannangara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy L.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo A.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.","family":"Radstake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L.","family":"Riches","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Kathrin","family":"Tausche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Liot\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"So","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony R.","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"802_CR1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/rheumatology\/keh640","volume":"44","author":"N Dalbeth","year":"2005","unstructured":"Dalbeth N, Haskard D. Mechanisms of inflammation in gout. Rheumatol. 2005;44:1090\u20136.","journal-title":"Rheumatol."},{"key":"802_CR2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/ard.51.3.375","volume":"51","author":"BT Emmerson","year":"1992","unstructured":"Emmerson BT, Nagel SL, Duffy DL, Martin NG. Genetic control of the renal clearance of urate: a study of twins. Ann Rheum Dis. 1992;51:375\u20137.","journal-title":"Ann Rheum Dis."},{"key":"802_CR3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/rheumatology\/23.4.276","volume":"23","author":"T Gibson","year":"1984","unstructured":"Gibson T, Waterworth R, Hatfield P, Robinson G, Bremner K. Hyperuricaemia, gout and kidney function in New Zealand Maori men. Br J Rheumatol. 1984;23:276\u201382.","journal-title":"Br J Rheumatol."},{"key":"802_CR4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng.2500","volume":"45","author":"A Kottgen","year":"2013","unstructured":"Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013;45:145\u201354.","journal-title":"Nat Genet."},{"key":"802_CR5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.rdc.2014.01.009","volume":"40","author":"TR Merriman","year":"2014","unstructured":"Merriman TR, Choi HK, Dalbeth N. The genetic basis of gout. Rheum Dis Clin North Am. 2014;40:279\u201390.","journal-title":"Rheum Dis Clin North Am."},{"key":"802_CR6","doi-asserted-by":"crossref","unstructured":"Phipps-Green A, Merriman M, Topless R, Altaf S, Montgomery G, Franklin C, et al. Twenty-eight loci that influence serum urate levels: analysis of association with gout. Ann Rheum Dis. 2014. doi: 10.1136\/annrheumdis-2014-205877 .","DOI":"10.1136\/annrheumdis-2014-205877"},{"key":"802_CR7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0002-9343(87)90441-4","volume":"82","author":"EW Campion","year":"1987","unstructured":"Campion EW, Glynn RJ, DeLabry LO. Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am J Med. 1987;82:421\u20136.","journal-title":"Am J Med"},{"key":"802_CR8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.0105-2896.2009.00851.x","volume":"233","author":"Y Shi","year":"2010","unstructured":"Shi Y, Mucsi AD, Ng G. Monosodium urate crystals in inflammation and immunity. Immunological Rev. 2010;233:203\u201317.","journal-title":"Immunological Rev."},{"key":"802_CR9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/BOR.0b013e3282f1bf4b","volume":"20","author":"JG Ryan","year":"2008","unstructured":"Ryan JG, Goldbach-Mansky R. The spectrum of autoinflammatory diseases: recent bench to bedside observations. Curr Op Rheumatol. 2008;20:66\u201375.","journal-title":"Curr Op Rheumatol."},{"key":"802_CR10","first-page":"59","volume":"2011","author":"R Liu-Bryan","year":"2011","unstructured":"Liu-Bryan R, Terkeltaub R. Tophus biology and pathogenesis of monosodium urate crystal\u2013induced inflammation. Gout and Other Crystal Arthropathies. 2011;2011:59.","journal-title":"Gout and Other Crystal Arthropathies."},{"key":"802_CR11","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","volume":"464","author":"P Duewell","year":"2010","unstructured":"Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464:1357\u201361.","journal-title":"Nature."},{"key":"802_CR12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","volume":"27","author":"F Martinon","year":"2009","unstructured":"Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Ann Rev Immunol. 2009;27:229\u201365.","journal-title":"Ann Rev Immunol."},{"key":"802_CR13","doi-asserted-by":"crossref","first-page":"13952","DOI":"10.1074\/jbc.M107811200","volume":"277","author":"M Razmara","year":"2002","unstructured":"Razmara M, Srinivasula SM, Wang L, Poyet J-L, Geddes BJ, DiStefano PS, et al. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem. 2002;277:13952\u20138.","journal-title":"J Biol Chem."},{"key":"802_CR14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","volume":"20","author":"L Agostini","year":"2004","unstructured":"Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-1\u03b2-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319\u201325.","journal-title":"Immunity."},{"key":"802_CR15","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/ar4483","volume":"16","author":"S Ito","year":"2014","unstructured":"Ito S, Hara Y, Kubota T. CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction. Arthritis Res Ther. 2014;16:R52.","journal-title":"Arthritis Res Ther."},{"key":"802_CR16","doi-asserted-by":"crossref","first-page":"846782","DOI":"10.1155\/2015\/846782","volume":"2015","author":"G Paramel","year":"2015","unstructured":"Paramel G, Sirsj\u00f6 A, Frans\u00e9n K. Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease. Mediators Inflamm. 2015;2015:846782.","journal-title":"Mediators Inflamm."},{"key":"802_CR17","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1159\/000373960","volume":"35","author":"Y Chen","year":"2015","unstructured":"Chen Y, Ren X, Li C, Xing S, Fu Z, Yuan Y, et al. CARD8 rs2043211 polymorphism is associated with gout in a Chinese male population. Cell Physiol Biochem. 2015;35:1394\u2013400.","journal-title":"Cell Physiol Biochem."},{"key":"802_CR18","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1002\/art.21238","volume":"52","author":"R Liu-Bryan","year":"2005","unstructured":"Liu-Bryan R, Scott P, Sydlaske A, Rose DM, Terkeltaub R. Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum. 2005;52:2936\u201346.","journal-title":"Arthritis Rheum."},{"key":"802_CR19","doi-asserted-by":"crossref","first-page":"64845","DOI":"10.1371\/journal.pone.0064845","volume":"8","author":"Y-F Qing","year":"2013","unstructured":"Qing Y-F, Zhou J-G, Zhang Q-B, Wang D-S, Li M, Yang Q-B, et al. Association of TLR4 gene rs2149356 polymorphism with primary gouty arthritis in a case-control study. PLoS One. 2013;8:64845.","journal-title":"PLoS One."},{"key":"802_CR20","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.3892\/mmr.2013.1429","volume":"7","author":"D-M Meng","year":"2013","unstructured":"Meng D-M, Zhou Y-J, Wang L, Ren W, Cui L-L, Han L, et al. Polymorphisms in the NLRP3 gene and risk of primary gouty arthritis. Mol Med Rep. 2013;7:1761\u20136.","journal-title":"Mol Med Rep."},{"key":"802_CR21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/rheumatology\/ker361","volume":"51","author":"D Winnard","year":"2012","unstructured":"Winnard D, Wright C, Taylor WJ, Jackson G, Te Karu L, Gow PJ, et al. National prevalence of gout derived from administrative health data in Aotearoa New Zealand. Rheumatology (Oxford). 2012;51:901\u20139.","journal-title":"Rheumatology (Oxford)"},{"key":"802_CR22","unstructured":"Kuo C-F, Grainge MJ, Zhang W, Doherty M. Global epidemiology of gout: prevalence, incidence and risk factors. Nature Rev Rheumatol. 2015. doi: 10.1038\/nrrhuem.2015.91 ."},{"key":"802_CR23","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/ar4348","volume":"15","author":"F Liote","year":"2013","unstructured":"Liote F, Merriman T, Nasi S, So A. 4th European Crystal Netrowk meeting, Paris 8-9th March 2013. Arthritis Res Ther. 2013;15:304.","journal-title":"Arthritis Res Ther."},{"key":"802_CR24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.1780200320","volume":"20","author":"SL Wallace","year":"1977","unstructured":"Wallace SL, Robinson H, Masi AT, Decker JL, McCarty DJ, Yu TF. Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum. 1977;20:895\u2013900.","journal-title":"Arthritis Rheum."},{"key":"802_CR25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-2125.2012.04207.x","volume":"74","author":"SL Stocker","year":"2012","unstructured":"Stocker SL, McLachlan AJ, Savic RM, Kirkpatrick CM, Graham GG, Williams KM, et al. The pharmacokinetics of oxypurinol in people with gout. Br J Clin Pharmacol. 2012;74:477\u201389.","journal-title":"Br J Clin Pharmacol."},{"key":"802_CR26","unstructured":"www.ncbi.nim.nih\/gov\/dbgap .\u00a0The database of Genotypes and Phenotypes."},{"key":"802_CR27","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/ar3816","volume":"14","author":"JE Hollis-Moffatt","year":"2012","unstructured":"Hollis-Moffatt JE, Phipps-Green AJ, Chapman B, Jones GT, van Rij A, Gow PJ, et al. The renal urate transporter SLC17A1 locus: confirmation of association with gout. Arthritis Res Ther. 2012;14:R92.","journal-title":"Arthritis Res Ther."},{"key":"802_CR28","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26:2190\u20131.","journal-title":"Bioinformatics."},{"key":"802_CR29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrg2579","volume":"10","author":"HJ Cordell","year":"2009","unstructured":"Cordell HJ. Detecting gene-gene interactions that underlie human diseases. Nature Rev Genet. 2009;10:392\u2013404.","journal-title":"Nature Rev Genet."},{"key":"802_CR30","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1093\/hmg\/ddq412","volume":"19","author":"AJH-MJ Phipps-Green","year":"2010","unstructured":"Phipps-Green AJH-MJ, Dalbeth N, Merriman ME, Topless R, Gow PJ, Harrison AA, et al. A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Maori, case and control sample sets. Hum Mol Genet. 2010;19:4813\u20139.","journal-title":"Hum Mol Genet."},{"key":"802_CR31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/gene.2010.11","volume":"11","author":"R Roberts","year":"2010","unstructured":"Roberts R, Topless R, Phipps-Green A, Gearry R, Barclay M, Merriman T. Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease. Genes Immun. 2010;11:351\u20136.","journal-title":"Genes Immun."},{"key":"802_CR32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/ar2952","volume":"12","author":"N Busso","year":"2010","unstructured":"Busso N, So A. Mechanisms of inflammation in gout. Arthritis Res Ther. 2010;12:206.","journal-title":"Arthritis Res Ther."},{"key":"802_CR33","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/SNP\/snp_ref.cgi?rs=rs2043211 ."},{"key":"802_CR34","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/annrheumdis-2013-203276","volume":"73","author":"RJ Mathews","year":"2014","unstructured":"Mathews RJ, Robinson JI, Battellino M, Wong C, Taylor JC, Eyre S, et al. Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Ann Rheum Dis. 2014;73:1202\u201310.","journal-title":"Ann Rheum Dis."},{"key":"802_CR35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2011.04.043","volume":"218","author":"RL Roberts","year":"2011","unstructured":"Roberts RL, Van Rij AM, Phillips LV, Young S, McCormick S, Merriman TR, et al. Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. Atherosclerosis. 2011;218:123\u20136.","journal-title":"Atherosclerosis."},{"key":"802_CR36","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/art.27667","volume":"62","author":"LA Joosten","year":"2010","unstructured":"Joosten LA, Netea MG, Mylona E, Koenders MI, Malireddi RK, Oosting M, et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1\u03b2 production via the ASC\/caspase 1 pathway in monosodium urate crystal-induced gouty arthritis. Arthritis Rheum. 2010;62:3237\u201348.","journal-title":"Arthritis Rheum."},{"key":"802_CR37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00535-003-1315-4","volume":"39","author":"K-A Lee","year":"2004","unstructured":"Lee K-A, Ki C-S, Kim H-J, Sohn K-M, Kim J-W, Kang WK, et al. Novel interleukin 1\u03b2 polymorphism increased the risk of gastric cancer in a Korean population. J Gastoenterol. 2004;39:429\u201333.","journal-title":"J Gastoenterol."},{"key":"802_CR38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/hmg\/ddi469","volume":"15","author":"H Chen","year":"2006","unstructured":"Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet. 2006;15:519\u201329.","journal-title":"Hum Mol Genet."},{"key":"802_CR39","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/jhg.2012.106","volume":"57","author":"NE Landvik","year":"2012","unstructured":"Landvik NE, Hart K, Haugen A, Zienolddiny S. Functional analysis of a lung cancer risk haplotype in the IL1B gene regulatory region. J Hum Genet. 2012;57:747\u201352.","journal-title":"J Hum Genet."},{"key":"802_CR40","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/carcin\/bgp122","volume":"30","author":"NE Landvik","year":"2009","unstructured":"Landvik NE, Hart K, Skaug V, Stangeland LB, Haugen A, Zienolddiny S. A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer. Carcinogenesis. 2009;30:1186\u201392.","journal-title":"Carcinogenesis."},{"key":"802_CR41","doi-asserted-by":"crossref","first-page":"E816","DOI":"10.1210\/jc.2010-2455","volume":"96","author":"J Delgado-Lista","year":"2011","unstructured":"Delgado-Lista J, Garcia-Rios A, Perez-Martinez P, Solivera J, Yubero-Serrano EM, Fuentes F, et al. Interleukin 1B variant-1473G\/C (rs1143623) influences triglyceride and interleukin 6 metabolism. J Clin Endocrinol Metab. 2011;96:E816\u201320.","journal-title":"J Clin Endocrinol Metab."},{"key":"802_CR42","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.4049\/jimmunol.167.10.5838","volume":"167","author":"TD LeVan","year":"2001","unstructured":"LeVan TD, Bloom JW, Bailey TJ, Karp CL, Halonen M, Martinez FD, et al. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol. 2001;167:5838\u201344.","journal-title":"J Immunol."},{"key":"802_CR43","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00109-009-0479-7","volume":"87","author":"J Mertens","year":"2009","unstructured":"Mertens J, Bregadze R, Mansur A, Askar E, Bickeb\u00f6ller H, Ramadori G, et al. Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity. J Mol Med. 2009;87:815\u201324.","journal-title":"J Mol Med."},{"key":"802_CR44","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jaci.2007.08.050","volume":"121","author":"TD LeVan","year":"2008","unstructured":"LeVan TD, Michel O, Dentener M, Thorn J, Vertongen F, Beijer L, et al. Association between CD14 polymorphisms and serum soluble CD14 levels: Effect of atopy and endotoxin inhalation. J Allergy Clin Immunol. 2008;121:434\u201340.","journal-title":"J Allergy Clin Immunol."},{"key":"802_CR45","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1165\/ajrcmb.20.5.3494","volume":"20","author":"M Baldini","year":"1999","unstructured":"Baldini M, Carla Lohman I, Halonen M, Erickson RP, Holt PG, Martinez FD. A Polymorphism in the 5\u2019 flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Resp Cell Mol Biol. 1999;20:976\u201383.","journal-title":"Am J Resp Cell Mol Biol."},{"key":"802_CR46","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jaci.2009.07.044","volume":"124","author":"Y Hitomi","year":"2009","unstructured":"Hitomi Y, Ebisawa M, Tomikawa M, Imai T, Komata T, Hirota T, et al. Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol. 2009;124:779\u201385.","journal-title":"J Allergy Clin Immunol."},{"key":"802_CR47","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/art.23286","volume":"58","author":"D Verma","year":"2008","unstructured":"Verma D, Lerm M, Blomgran Julinder R, Eriksson P, S\u00f6derkvist P, S\u00e4rndahl E. Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? Arthritis Rheum. 2008;58:888\u201394.","journal-title":"Arthritis Rheum."},{"key":"802_CR48","doi-asserted-by":"crossref","first-page":"e34977","DOI":"10.1371\/journal.pone.0034977","volume":"7","author":"D Verma","year":"2012","unstructured":"Verma D, S\u00e4rndahl E, Andersson H, Eriksson P, Fredrikson M, J\u00f6nsson J-I, et al. The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1\u03b2 and IL-18 production. PLoS One. 2012;7:e34977.","journal-title":"PLoS One."},{"key":"802_CR49","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/ajg.2010.474","volume":"106","author":"A Pontillo","year":"2011","unstructured":"Pontillo A, Vendramin A, Catamo E, Fabris A, Crovella S. The missense variation Q705K in CIAS1\/NALP3\/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease. Am J Gastroenterol. 2011;106:539\u201344.","journal-title":"Am J Gastroenterol."},{"key":"802_CR50","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.4049\/jimmunol.179.7.4867","volume":"179","author":"AM-TV Fontalba","year":"2007","unstructured":"Fontalba AM-TV, Gutierrez O, Pipaon C, Benito N, Balsa A, Blanco R, et al. Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. J Immunol. 2007;179:4867\u201373.","journal-title":"J Immunol."},{"key":"802_CR51","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/sj.ejhg.5201996","volume":"16","author":"RD Bagnall","year":"2008","unstructured":"Bagnall RD, Roberts RG, Mirza MM, Torigoe T, Prescott NJ, Mathew CG. Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation. Eur J Hum Genet. 2008;16:619\u201325.","journal-title":"Eur J Hum Genet."},{"key":"802_CR52","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00228-012-1389-0","volume":"69","author":"D Lacruz-Guzm\u00e1n","year":"2013","unstructured":"Lacruz-Guzm\u00e1n D, Torres-Moreno D, Pedrero F, Romero-Cara P, Garc\u00eda-Tercero I, Trujillo-Santos J, et al. Influence of polymorphisms and TNF and IL1\u03b2 serum concentration on the infliximab response in Crohn\u2019s disease and ulcerative colitis. Eur J Clin Pharmacol. 2013;69:431\u20138.","journal-title":"Eur J Clin Pharmacol."},{"key":"802_CR53","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/rheumatology\/ken374","volume":"47","author":"P Harrison","year":"2008","unstructured":"Harrison P, Pointon J, Chapman K, Roddam A, Wordsworth B. Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A\/G variant reveals association with rheumatoid arthritis. Rheumatol. 2008;47:1768\u201370.","journal-title":"Rheumatol."},{"key":"802_CR54","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1468-3083.2010.03812.x","volume":"25","author":"D Potaczek","year":"2011","unstructured":"Potaczek D, Nastalek M, Okumura K, Wojas\u2010Pelc A, Undas A, Nishiyama C. An association of TLR2\u201316934A\u2009>\u2009T polymorphism and severity\/phenotype of atopic dermatitis. J Eur Acad Dermatol Venerol. 2011;25:715\u201321.","journal-title":"J Eur Acad Dermatol Venerol."},{"key":"802_CR55","doi-asserted-by":"crossref","first-page":"e45144","DOI":"10.1371\/journal.pone.0045144","volume":"7","author":"Z Wang","year":"2012","unstructured":"Wang Z, Hu J, Fan R, Zhou J, Zhong J. Association between CD14 gene C-260\u00a0T polymorphism and inflammatory bowel disease: a meta-analysis. PLoS One. 2012;7:e45144.","journal-title":"PLoS One."},{"key":"802_CR56","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2350-12-93","volume":"12","author":"L Zhao","year":"2011","unstructured":"Zhao L, Bracken MB. Association of CD14-260 (-159) C\u2009>\u2009T and asthma: a systematic review and meta-analysis. BMC Med genet. 2011;12:93.","journal-title":"BMC Med genet."},{"key":"802_CR57","doi-asserted-by":"crossref","unstructured":"Wang Y, Sun C, Li T, Xu H, Zhou Y, Dan H, et al. Integrative approach detected association between genetic variants of microRNA binding sites of TLRs pathway genes and OSCC susceptibility in Chinese Han population.\u00a0PLoS One. 2014;7:e101965.","DOI":"10.1371\/journal.pone.0101695"},{"key":"802_CR58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpsychires.2009.10.005","volume":"44","author":"S Roger","year":"2010","unstructured":"Roger S, Mei Z-Z, Baldwin JM, Dong L, Bradley H, Baldwin SA, et al. Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X 7 receptor functions. J Psychiatric Res. 2010;44:347\u201355.","journal-title":"J Psychiatric Res."},{"key":"802_CR59","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1093\/hmg\/ddl178","volume":"15","author":"Y Li","year":"2006","unstructured":"Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JS, Smemo S, et al. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet. 2006;15:2560\u20138.","journal-title":"Hum Mol Genet."},{"key":"802_CR60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.atherosclerosis.2011.12.009","volume":"221","author":"NE Ferreira","year":"2012","unstructured":"Ferreira NE, Omae S, Pereira A, Rodrigues MV, Miyakawa AA, Campos LC, et al. Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population. Atherosclerosis. 2012;221:131\u20136.","journal-title":"Atherosclerosis."},{"key":"802_CR61","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.3892\/mmr.2013.1747","volume":"8","author":"D-M Meng","year":"2013","unstructured":"Meng D-M, Zhou Y-J, Wang L, Ren W, Cui L-L, Han L, et al. Erratum: Polymorphisms in the NLRP3 gene and risk of primary gouty arthritis. Mol Med Rep. 2013;8:1888.","journal-title":"Mol Med Rep."}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0802-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T09:45:08Z","timestamp":1567244708000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["802"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0802-3","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]},"article-number":"288"}}