{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:19:50Z","timestamp":1789395590514,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0809-9","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T17:40:00Z","timestamp":1445535600000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma"],"prefix":"10.1186","volume":"17","author":[{"given":"Piet","family":"Geusens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"De Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Quaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Vanhoof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Vosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joop","family":"van den Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Somers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"key":"809_CR1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ejim.2011.06.006","volume":"22","author":"A Maghraoui El","year":"2011","unstructured":"El Maghraoui A. Extra-articular manifestations of ankylosing spondylitis: prevalence, characteristics and therapeutic implications. Eur J Intern Med. 2011;22:554\u201360. doi: 10.1016\/j.ejim.2011.06.006 .","journal-title":"Eur J Intern Med"},{"key":"809_CR2","doi-asserted-by":"crossref","unstructured":"Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A. Ankylosing spondylitis: an overview. Ann Rheum Dis. 2002;61 Suppl 3:iii8\u201318.","DOI":"10.1136\/ard.61.suppl_3.iii8"},{"key":"809_CR3","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.3899\/jrheum.100363","volume":"37","author":"RJ Weiss","year":"2010","unstructured":"Weiss RJ, Wick MC, Ackermann PW, Montgomery SM. Increased fracture risk in patients with rheumatic disorders and other inflammatory diseases\u2014a case\u2013control study with 53,108 patients with fracture. J Rheumatol. 2010;37:2247\u201350. doi: 10.3899\/jrheum.100363 .","journal-title":"J Rheumatol"},{"key":"809_CR4","doi-asserted-by":"crossref","first-page":"R16","DOI":"10.1186\/ar3240","volume":"13","author":"PG Pedreira","year":"2011","unstructured":"Pedreira PG, Pinheiro MM, Szejnfeld VL. Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis. Arthritis Res Ther. 2011;13:R16. doi: 10.1186\/ar3240 .","journal-title":"Arthritis Res Ther"},{"key":"809_CR5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00198-014-2939-3","volume":"26","author":"D Prieto-Alhambra","year":"2015","unstructured":"Prieto-Alhambra D, Munoz-Ortego J, De Vries F, Vosse D, Arden NK, Bowness P, et al. Ankylosing spondylitis confers substantially increased risk of clinical spine fractures: a nationwide case\u2013control study. Osteoporos Int. 2015;26:85\u201391. doi: 10.1007\/s00198-014-2939-3 .","journal-title":"Osteoporos Int"},{"key":"809_CR6","first-page":"1877","volume":"21","author":"C Cooper","year":"1994","unstructured":"Cooper C, Carbone L, Michet CJ, Atkinson EJ, O\u2019Fallon WM, Melton 3rd LJ. Fracture risk in patients with ankylosing spondylitis: a population based study. J Rheumatol. 1994;21:1877\u201382.","journal-title":"J Rheumatol"},{"key":"809_CR7","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1136\/ard.2008.100503","volume":"68","author":"D Vosse","year":"2009","unstructured":"Vosse D, Landew\u00e9 R, van der Heijde D, van der Linden S, van Staa TP, Geusens P. Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case\u2013control study. Ann Rheum Dis. 2009;68:1839\u201342. doi: 10.1136\/ard.2008.100503 .","journal-title":"Ann Rheum Dis"},{"key":"809_CR8","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/jbmr.2217","volume":"29","author":"J Mu\u00f1oz-Ortego","year":"2014","unstructured":"Mu\u00f1oz-Ortego J, Vestergaard P, Rubio JB, Wordsworth P, Judge A, Javaid MK, et al. Ankylosing spondylitis is associated with an increased risk of vertebral and nonvertebral clinical fractures: a population-based cohort study. J Bone Miner Res. 2014;29:1770\u20136. doi: 10.1002\/jbmr.2217 .","journal-title":"J Bone Miner Res"},{"key":"809_CR9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1754-9493-7-2","volume":"7","author":"Y Robinson","year":"2013","unstructured":"Robinson Y, Sanden B, Olerud C. Increased occurrence of spinal fractures related to ankylosing spondylitis: a prospective 22-year cohort study in 17,764 patients from a national registry in Sweden. Patient Saf Surg. 2013;7:2. doi: 10.1186\/1754-9493-7-2 .","journal-title":"Patient Saf Surg"},{"key":"809_CR10","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s10067-012-2018-0","volume":"31","author":"MA Weijden van der","year":"2012","unstructured":"van der Weijden MA, Claushuis TA, Nazari T, Lems WF, Dijkmans BA, van der Horst-Bruinsma IE. High prevalence of low bone mineral density in patients within 10 years of onset of ankylosing spondylitis: a systematic review. Clin Rheumatol. 2012;31:1529\u201335. doi: 10.1007\/s10067-012-2018-0 .","journal-title":"Clin Rheumatol"},{"key":"809_CR11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/BOR.0b013e328133f5b3","volume":"19","author":"P Geusens","year":"2007","unstructured":"Geusens P, Vosse D, van der Linden S. Osteoporosis and vertebral fractures in ankylosing spondylitis. Curr Opin Rheumatol. 2007;19:335\u20139. doi: 10.1097\/BOR.0b013e328133f5b3 .","journal-title":"Curr Opin Rheumatol"},{"key":"809_CR12","first-page":"1856","volume":"28","author":"P Geusens","year":"2001","unstructured":"Geusens P, Vosse D, van der Heijde D, Vanhoof J, van Tubergen A, Raus J, et al. High prevalence of thoracic vertebral deformities and discal wedging in ankylosing spondylitis patients with hyperkyphosis. J Rheumatol. 2001;28:1856\u201361.","journal-title":"J Rheumatol"},{"key":"809_CR13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/1759720X12441276","volume":"4","author":"PN Sambrook","year":"2012","unstructured":"Sambrook PN, Geusens P. The epidemiology of osteoporosis and fractures in ankylosing spondylitis. Ther Adv Musculoskelet Dis. 2012;4:287\u201392. doi: 10.1177\/1759720x12441276 .","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"809_CR14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bone.2008.12.028","volume":"44","author":"I Ghozlani","year":"2009","unstructured":"Ghozlani I, Ghazi M, Nouijai A, Mounach A, Rezqi A, Achemlal L, et al. Prevalence and risk factors of osteoporosis and vertebral fractures in patients with ankylosing spondylitis. Bone. 2009;44:772\u20136. doi: 10.1016\/j.bone.2008.12.028 .","journal-title":"Bone"},{"key":"809_CR15","doi-asserted-by":"crossref","unstructured":"Sieper J, Rudwaleit M, Baraliakos X, Brandt J, Braun J, Burgos-Vargas R, et al. The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis. 2009;68 Suppl 2:ii1\u201344. doi: 10.1136\/ard.2008.104018 .","DOI":"10.1136\/ard.2008.104018"},{"key":"809_CR16","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/ard.2011.151027","volume":"70","author":"J Braun","year":"2011","unstructured":"Braun J, van den Berg R, Baraliakos X, Boehm H, Burgos-Vargas R, Collantes-Estevez E, et al. 2010 update of the ASAS\/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis. 2011;70:896\u2013904. doi: 10.1136\/ard.2011.151027 .","journal-title":"Ann Rheum Dis"},{"key":"809_CR17","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00198-006-0121-2","volume":"17","author":"RD Chapurlat","year":"2006","unstructured":"Chapurlat RD, Duboeuf F, Marion-Audibert HO, Kalpakcioglu B, Mitlak BH, Delmas PD. Effectiveness of instant vertebral assessment to detect prevalent vertebral fracture. Osteoporos Int. 2006;17:1189\u201395. doi: 10.1007\/s00198-006-0121-2 .","journal-title":"Osteoporos Int"},{"key":"809_CR18","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/rheumatology\/kem135","volume":"46","author":"D Vosse","year":"2007","unstructured":"Vosse D, Heijckmann C, Landew\u00e9 R, van der Heijde D, van der Linden S, Geusens P. Comparing morphometric X-ray absorptiometry and radiography in defining vertebral wedge fractures in patients with ankylosing spondylitis. Rheumatology (Oxford). 2007;46:1667\u201371. doi: 10.1093\/rheumatology\/kem135 .","journal-title":"Rheumatology (Oxford)"},{"key":"809_CR19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/rheumatology\/ken133","volume":"47","author":"A Scott-Russell","year":"2008","unstructured":"Scott-Russell A, Dennison E, Taylor P, Cooper C. Comment on: Comparing morphometric X-ray absorptiometry and radiography in defining vertebral wedge fractures in patients with ankylosing spondylitis. Rheumatology (Oxford). 2008;47:1107\u20139. doi: 10.1093\/rheumatology\/ken133 .","journal-title":"Rheumatology (Oxford)"},{"key":"809_CR20","volume-title":"EULAR textbook on rheumatic diseases","author":"JWJ Bijlsma","year":"2012","unstructured":"Bijlsma JWJ. EULAR textbook on rheumatic diseases. London: BMJ\/EULAR; 2012."},{"key":"809_CR21","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/jbmr.5650110716","volume":"11","author":"HK Genant","year":"1996","unstructured":"Genant HK, Jergas M, Palermo L, Nevitt M, Valentin RS, Black D, et al. Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis. J Bone Miner Res. 1996;11:984\u201396. doi: 10.1002\/jbmr.5650110716 .","journal-title":"J Bone Miner Res"},{"key":"809_CR22","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res. 1993;8:1137\u201348. doi: 10.1002\/jbmr.5650080915 .","journal-title":"J Bone Miner Res"},{"key":"809_CR23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jocd.2012.03.005","volume":"15","author":"AM Bonnyman","year":"2012","unstructured":"Bonnyman AM, Webber CE, Stratford PW, MacIntyre NJ. Intrarater reliability of dual-energy X-ray absorptiometry-based measures of vertebral height in postmenopausal women. J Clin Densitom. 2012;15:405\u201312. doi: 10.1016\/j.jocd.2012.03.005 .","journal-title":"J Clin Densitom"},{"key":"809_CR24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/ar3375","volume":"13","author":"P Geusens","year":"2011","unstructured":"Geusens P, Lems WF. Osteoimmunology and osteoporosis. Arthritis Res Ther. 2011;13:242. doi: 10.1186\/ar3375 .","journal-title":"Arthritis Res Ther"},{"key":"809_CR25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00198-010-1319-x","volume":"22","author":"C Roux","year":"2011","unstructured":"Roux C. Osteoporosis in inflammatory joint diseases. Osteoporos Int. 2011;22:421\u201333. doi: 10.1007\/s00198-010-1319-x .","journal-title":"Osteoporos Int"},{"key":"809_CR26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s11926-013-0342-2","volume":"15","author":"SR Goldring","year":"2013","unstructured":"Goldring SR. Osteoimmunology and bone homeostasis: relevance to spondyloarthritis. Curr Rheumatol Rep. 2013;15:342. doi: 10.1007\/s11926-013-0342-2 .","journal-title":"Curr Rheumatol Rep"},{"key":"809_CR27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jbspin.2012.08.004","volume":"80","author":"G Coiffier","year":"2013","unstructured":"Coiffier G, Bouvard B, Chopin F, Biver E, Funck-Brentano T, Garnero P, et al. Common bone turnover markers in rheumatoid arthritis and ankylosing spondylitis: a literature review. Joint Bone Spine. 2013;80:250\u20137. doi: 10.1016\/j.jbspin.2012.08.004 .","journal-title":"Joint Bone Spine"},{"key":"809_CR28","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/rheumatology\/ken148","volume":"47","author":"D Vosse","year":"2008","unstructured":"Vosse D, Landew\u00e9 R, Garnero P, van der Heijde D, van der Linden S, Geusens P. Association of markers of bone- and cartilage-degradation with radiological changes at baseline and after 2 years follow-up in patients with ankylosing spondylitis. Rheumatology (Oxford). 2008;47:1219\u201322. doi: 10.1093\/rheumatology\/ken148 .","journal-title":"Rheumatology (Oxford)"},{"key":"809_CR29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0002-9343(97)00143-5","volume":"103","author":"YS Lee","year":"1997","unstructured":"Lee YS, Schlotzhauer T, Ott SM, van Vollenhoven RF, Hunter J, Shapiro J, et al. Skeletal status of men with early and late ankylosing spondylitis. Am J Med. 1997;103:233\u201341.","journal-title":"Am J Med"},{"key":"809_CR30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00296-004-0515-4","volume":"26","author":"U Lange","year":"2005","unstructured":"Lange U, Kluge A, Strunk J, Teichmann J, Bachmann G. Ankylosing spondylitis and bone mineral density\u2014what is the ideal tool for measurement? Rheumatol Int. 2005;26:115\u201320. doi: 10.1007\/s00296-004-0515-4 .","journal-title":"Rheumatol Int"},{"key":"809_CR31","doi-asserted-by":"crossref","first-page":"R179","DOI":"10.1186\/ar4368","volume":"15","author":"E Klingberg","year":"2013","unstructured":"Klingberg E, Lorentzon M, G\u00f6thlin J, Mellstr\u00f6m D, Geijer M, Ohlsson C, et al. Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes. Arthritis Res Ther. 2013;15:R179. doi: 10.1186\/ar4368 .","journal-title":"Arthritis Res Ther"},{"key":"809_CR32","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/annrheumdis-2014-206971","volume":"74","author":"P Mandl","year":"2015","unstructured":"Mandl P, Navarro-Compan V, Terslev L, Aegerter P, van der Heijde D. EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice. Ann Rheum Dis. 2015;74:1327\u201339. doi: 10.1136\/annrheumdis-2014-206971 .","journal-title":"Ann Rheum Dis"},{"key":"809_CR33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1359\/JBMR.041214","volume":"20","author":"PD Delmas","year":"2005","unstructured":"Delmas PD, van de Langerijt L, Watts NB, Eastell R, Genant H, Grauer A, et al. Underdiagnosis of vertebral fractures is a worldwide problem: the IMPACT study. J Bone Miner Res. 2005;20:557\u201363. doi: 10.1359\/jbmr.041214 .","journal-title":"J Bone Miner Res"},{"key":"809_CR34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01623271","volume":"3","author":"LJ Melton 3rd","year":"1993","unstructured":"Melton 3rd LJ, Lane AW, Cooper C, Eastell R, O\u2019Fallon WM, Riggs BL. Prevalence and incidence of vertebral deformities. Osteoporos Int. 1993;3:113\u20139.","journal-title":"Osteoporos Int"},{"key":"809_CR35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11914-010-0031-2","volume":"8","author":"BA Christiansen","year":"2010","unstructured":"Christiansen BA, Bouxsein ML. Biomechanics of vertebral fractures and the vertebral fracture cascade. Curr Osteoporos Rep. 2010;8:198\u2013204. doi: 10.1007\/s11914-010-0031-2 .","journal-title":"Curr Osteoporos Rep"},{"key":"809_CR36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.spinee.2014.11.019","volume":"15","author":"Y Okamoto","year":"2015","unstructured":"Okamoto Y, Murakami H, Demura S, Kato S, Yoshioka K, Hayashi H, et al. The effect of kyphotic deformity because of vertebral fracture: a finite element analysis of a 10\u00b0 and 20\u00b0 wedge-shaped vertebral fracture model. Spine J. 2015;15:713\u201320. doi: 10.1016\/j.spinee.2014.11.019 .","journal-title":"Spine J"},{"key":"809_CR37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00002281-200007000-00002","volume":"12","author":"E Feldtkeller","year":"2000","unstructured":"Feldtkeller E, Bruckel J, Khan MA. Scientific contributions of ankylosing spondylitis patient advocacy groups. Curr Opin Rheumatol. 2000;12:239\u201347.","journal-title":"Curr Opin Rheumatol"},{"key":"809_CR38","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/ard.2010.141598","volume":"70","author":"E Haglund","year":"2011","unstructured":"Haglund E, Bremander AB, Petersson IF, Strombeck B, Bergman S, Jacobsson LT, et al. Prevalence of spondyloarthritis and its subtypes in southern Sweden. Ann Rheum Dis. 2011;70:943\u20138. doi: 10.1136\/ard.2010.141598 .","journal-title":"Ann Rheum Dis"},{"key":"809_CR39","unstructured":"Assessment of SpondyloArthritis International Society. Mission statement. http:\/\/www.asas-group.org\/mission-statement.php . Accessed 14 Oct 2015."},{"key":"809_CR40","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/MEG.0000000000000026","volume":"26","author":"AJ Lucendo","year":"2014","unstructured":"Lucendo AJ, Hervias D, Roncero O, Lorente R, Bouhmidi A, Angueira T, et al. Epidemiology and temporal trends (2000\u20132012) of inflammatory bowel disease in adult patients in a central region of Spain. Eur J Gastroenterol Hepatol. 2014;26:1399\u2013407. doi: 10.1097\/meg.0000000000000226 .","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0809-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T21:49:09Z","timestamp":1498254549000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,22]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["809"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0809-9","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,22]]},"article-number":"294"}}