{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:52:35Z","timestamp":1792101155320,"version":"4.4.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0822-z","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T16:51:16Z","timestamp":1446137476000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is urate crystal precipitation a predictor of cardiovascular risk in hyperuricemic patients? A Danish cohort study"],"prefix":"10.1186","volume":"17","author":[{"given":"Kasper S\u00f8ltoft","family":"Larsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Lindegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,29]]},"reference":[{"key":"822_CR1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/acr.20065","volume":"62","author":"SY Kim","year":"2010","unstructured":"Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res. 2010;62:170\u201380.","journal-title":"Arthritis Care Res."},{"key":"822_CR2","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/art.24612","volume":"61","author":"SY Kim","year":"2009","unstructured":"Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Arthritis Rheum. 2009;61:885\u201392.","journal-title":"Arthritis Rheum."},{"key":"822_CR3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/joim.12120","volume":"274","author":"H Wang","year":"2013","unstructured":"Wang H, Jacobs Jr DR, Gaffo AL, Gross MD, Goff Jr DC, Carr JJ. Longitudinal association between serum urate and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Intern Med. 2013;274:594\u2013609.","journal-title":"J Intern Med."},{"key":"822_CR4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/rheumatology\/kep364","volume":"49","author":"CF Kuo","year":"2010","unstructured":"Kuo CF, See LC, Luo SF, Ko YS, Lin YS, Hwang JS, et al. Gout: an independent risk factor for all-cause and cardiovascular mortality. Rheumatology. 2010;49:141\u20136.","journal-title":"Rheumatology."},{"key":"822_CR5","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1002\/art.22014","volume":"54","author":"E Krishnan","year":"2006","unstructured":"Krishnan E, Baker JF, Furst DE, Schumacher HR. Gout and the risk of acute myocardial infarction. Arthritis Rheum. 2006;54:2688\u201396.","journal-title":"Arthritis Rheum."},{"key":"822_CR6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/annrheumdis-2014-205252","volume":"74","author":"LE Clarson","year":"2015","unstructured":"Clarson LE, Hider SL, Belcher J, Heneghan C, Roddy E, Mallen CD. Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink. Ann Rheum Dis. 2015;74:642\u20137.","journal-title":"Ann Rheum Dis"},{"key":"822_CR7","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1136\/ard.2006.055251","volume":"65","author":"W Zhang","year":"2006","unstructured":"Zhang W, Doherty M, Pascual E, Bardin T, Barskova V, Conaghan P, et al. EULAR evidence based recommendations for gout. Part I: diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2006;65:1301\u201311.","journal-title":"Ann Rheum Dis"},{"key":"822_CR8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-131-1-199907060-00003","volume":"131","author":"BF Culleton","year":"1999","unstructured":"Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131:7\u201313.","journal-title":"Ann Intern Med."},{"key":"822_CR9","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","volume":"359","author":"DIKD Feig","year":"2008","unstructured":"Feig DIKD, Johnson RJ. Uric acid and cardiovacular risk. N Engl J Med. 2008;359:1811\u201321.","journal-title":"N Engl J Med."},{"key":"822_CR10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/annrheumdis-2012-202421","volume":"73","author":"F Perez-Ruiz","year":"2014","unstructured":"Perez-Ruiz F, Mart\u00ednez-Indart L, Carmona L, Herrero-Beites AM, Pijoan JI, Krishnan E. Tophaceous gout and high level of hyperuricaemia are both associated with increased risk of mortality in patients with gout. Ann Rheum Dis. 2014;73:177\u201382.","journal-title":"Ann Rheum Dis."},{"key":"822_CR11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/art.33369","volume":"64","author":"T Neogi","year":"2012","unstructured":"Neogi T, George J, Rekhraj S, Struthers AD, Choi H, Terkeltaub RA. Are either or both hyperuricemia and xanthine oxidase directly toxic to the vasculature? A critical appraisal. Arthritis Rheum. 2012;64:327\u201338.","journal-title":"Arthritis Rheum."},{"key":"822_CR12","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1097\/HJH.0000000000000701","volume":"33","author":"C Borghi","year":"2015","unstructured":"Borghi C, Rosei EA, Bardin T, Dawson J, Dominiczak A, Kielstein JT, et al. Serum uric acid and the risk of cardiovascular and renal disease. J Hypertens. 2015;33:1729\u201341.","journal-title":"J Hypertens."},{"key":"822_CR13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.7326\/0003-4819-143-7-200510040-00009","volume":"143","author":"HK Choi","year":"2005","unstructured":"Choi HK, Mount DB, Reginato AM. Pathogenesis of gout. Ann Intern Med. 2005;143:499\u2013516.","journal-title":"Ann Intern Med."},{"key":"822_CR14","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa040967","volume":"351","author":"JK Pai","year":"2004","unstructured":"Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med. 2004;351:2599\u2013610.","journal-title":"N Engl J Med."},{"key":"822_CR15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ahj.2004.12.019","volume":"150","author":"AY Tiong","year":"2005","unstructured":"Tiong AY, Brieger D. Inflammation and coronary artery disease. Am Heart J. 2005;150:11\u20138.","journal-title":"Am Heart J."},{"key":"822_CR16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/annrheumdis-2012-202594","volume":"72","author":"E Pascual","year":"2013","unstructured":"Pascual E, Andr\u00e9s M, Vela P. Gout treatment: should we aim for rapid crystal dissolution? Ann Rheum Dis. 2013;72:635\u20137.","journal-title":"Ann Rheum Dis."},{"issue":"7 Suppl","key":"822_CR17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","volume":"39","author":"CB Pedersen","year":"2011","unstructured":"Pedersen CB. The Danish civil registration system. Scand J Public Health. 2011;39(7 Suppl):22\u20135.","journal-title":"Scand J Public Health"},{"issue":"7 Suppl","key":"822_CR18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/1403494811409654","volume":"39","author":"LC Thygesen","year":"2011","unstructured":"Thygesen LC, Ersboll AK. Danish population-based registers for public health and health-related welfare research: introduction to the supplement. Scand J Public Health. 2011;39(7 Suppl):8\u201310.","journal-title":"Scand J Public Health"},{"key":"822_CR19","first-page":"445","volume":"44","author":"D Gaist","year":"1997","unstructured":"Gaist D, Sorensen HT, Hallas J. The Danish prescription registries. Dan Med Bull. 1997;44:445\u20138.","journal-title":"Dan Med Bull."},{"key":"822_CR20","volume-title":"Guidelines for ATC classification and DDD assignment 2011","author":"WHO Collaborating Centre for Drug Statistics Methodology","year":"2010","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment 2011. Oslo: WHO Collaborating Centre for Drug Statistics Methodology; 2010."},{"issue":"7 Suppl","key":"822_CR21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/1403494811399958","volume":"39","author":"K Helweg-Larsen","year":"2011","unstructured":"Helweg-Larsen K. The Danish register of causes of death. Scand J Public Health. 2011;39(7 Suppl):26\u20139.","journal-title":"Scand J Public Health"},{"key":"822_CR22","first-page":"81","volume":"8","author":"AT Collaboration","year":"1994","unstructured":"Collaboration AT. Antiplatelet Trialists\u2019 Collaboration BMJ 1994. Br Med J. 1994;8:81\u2013106.","journal-title":"Br Med J."},{"key":"822_CR23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/pds.3263","volume":"21","author":"JA Rassen","year":"2012","unstructured":"Rassen JA, Shelat AA, Myers J, Glynn RJ, Rothman KJ, Schneeweiss S. One-to-many propensity score matching in cohort studies. Pharmacoepidemiol Drug Saf. 2012;21:69\u201380.","journal-title":"Pharmacoepidemiol Drug Saf."},{"issue":"2 Suppl 1","key":"822_CR24","first-page":"S1","volume":"39","author":"NK Foundation","year":"2002","unstructured":"National Kidney Foundation. KDOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1\u2013266.","journal-title":"Am J Kidney Dis"},{"key":"822_CR25","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0140-6736(10)60391-1","volume":"375","author":"A Noman","year":"2010","unstructured":"Noman A, Ang DS, Ogston S, Lang CC, Struthers AD. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet. 2010;375:2161\u20137.","journal-title":"Lancet."},{"key":"822_CR26","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/jama.300.8.924","volume":"300","author":"DI Feig","year":"2008","unstructured":"Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension. J Am Med Assoc. 2008;300:924\u201332.","journal-title":"J Am Med Assoc."},{"key":"822_CR27","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1365-2125.2010.03887.x","volume":"71","author":"L Wei","year":"2011","unstructured":"Wei L, Mackenzie IS, Chen Y, Struthers AD, MacDonald TM. Impact of allopurinol use on urate concentration and cardiovascular outcome. Br J Clin Pharmacol. 2011;71:600\u20137.","journal-title":"Br J Clin Pharmacol."},{"key":"822_CR28","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.2215\/CJN.01580210","volume":"5","author":"M Goicoechea","year":"2010","unstructured":"Goicoechea M, de Vinuesa SG, Verdalles U, Ruiz-Caro C, Ampuero J, Rincon A, et al. Effect of allopurinol in chronic kidney disease progression and cardiovascular risk. Clin J Am Soc Nephrol CJASN. 2010;5:1388\u201393.","journal-title":"Clin J Am Soc Nephrol CJASN."},{"key":"822_CR29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/eurheartj\/ehu403","volume":"36","author":"JC Mason","year":"2015","unstructured":"Mason JC, Libby P. Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions. Eur Heart J. 2015;36:482\u20139.","journal-title":"Eur Heart J."},{"key":"822_CR30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/jdv.12163","volume":"27","author":"C Horreau","year":"2013","unstructured":"Horreau C, Pouplard C, Brenaut E, Barnetche T, Misery L, Cribier B, et al. Cardiovascular morbidity and mortality in psoriasis and psoriatic arthritis: a systematic literature review. J Eur Acad Dermatol Venereol. 2013;27:12\u201329.","journal-title":"J Eur Acad Dermatol Venereol."},{"issue":"7 Suppl","key":"822_CR31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/1403494811399956","volume":"39","author":"LC Thygesen","year":"2011","unstructured":"Thygesen LC, Daasnes C, Thaulow I, Bronnum-Hansen H. Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving. Scand J Public Health. 2011;39(7 Suppl):12\u20136.","journal-title":"Scand J Public Health"},{"key":"822_CR32","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/archinte.168.10.1104","volume":"168","author":"ESK Krishnan","year":"2008","unstructured":"Krishnan ESK, Neaton JD, Grandits G, Kuller LH, MRFIT Research Group. Long-term cardiovascular mortality among middle-aged men with gout. Arch Internal Med. 2008;168:1104\u201310.","journal-title":"Arch Internal Med."},{"key":"822_CR33","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/annrheumdis-2013-203325","volume":"73","author":"F Sivera","year":"2014","unstructured":"Sivera F, Andres M, Carmona L, Kydd AS, Moi J, Seth R, et al. Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative. Ann Rheum Dis. 2014;73:328\u201335.","journal-title":"Ann Rheum Dis."},{"key":"822_CR34","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/01.CIR.93.3.450","volume":"93","author":"I Nj\u00f8lstad","year":"1996","unstructured":"Nj\u00f8lstad I, Arnesen E, Lund-Larsen PG. Smoking, serum lipids, blood pressure, and sex differences in myocardial infarction: a 12-year follow-up of the finnmark study. Circulation. 1996;93:450\u20136.","journal-title":"Circulation."},{"key":"822_CR35","unstructured":"Organisation is Statens Serum Institut. Medstat.dk. http:\/\/www.medstat.dk\/en\/viewDataTables\/medicineAndMedicalGroups\/{%22year%22:[%222010%22],%22region%22:[%225%22],%22gender%22:[%22A%22],%22ageGroup%22:[%22A%22],%22searchVariable%22:[%22people_count%22],%22errorMessages%22:[],%22atcCode%22:[%22M04A%22,%22M04AA01%22],%22sector%22:[%220%22]}. Accessed 3 Feb 2015."},{"key":"822_CR36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/CRD.0b013e318229a908","volume":"19","author":"A Kelkar","year":"2011","unstructured":"Kelkar A, Kuo A, Frishman WH. Allopurinol as a cardiovascular drug. Cardiol Rev. 2011;19:265\u201371.","journal-title":"Cardiol Rev."},{"key":"822_CR37","doi-asserted-by":"crossref","first-page":"e005308","DOI":"10.1136\/bmjopen-2014-005308","volume":"4","author":"JJ Park","year":"2014","unstructured":"Park JJ, Roudier MP, Soman D, Mokadam NA, Simkin PA. Prevalence of birefringent crystals in cardiac and prostatic tissues, an observational study. BMJ Open. 2014;4:e005308.","journal-title":"BMJ Open."},{"key":"822_CR38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/ard.61.6.493","volume":"61","author":"A Swan","year":"2002","unstructured":"Swan A, Amer H, Dieppe P. The value of synovial fluid assays in the diagnosis of joint disease: a literature survey. Ann Rheum Dis. 2002;61:493\u20138.","journal-title":"Ann Rheum Dis."},{"key":"822_CR39","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/ard.2004.027268","volume":"64","author":"B Lumbreras","year":"2005","unstructured":"Lumbreras B, Pascual E, Frasquet J, Gonzalez-Salinas J, Rodriguez E, Hernandez-Aguado I. Analysis for crystals in synovial fluid: training of the analysts results in high consistency. Ann Rheum Dis. 2005;64:612\u20135.","journal-title":"Ann Rheum Dis."},{"key":"822_CR40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s11926-008-0063-0","volume":"10","author":"MCM Wasko","year":"2008","unstructured":"Wasko MCM. Rheumatoid arthritis and cardiovascular disease. Curr Rheumatol Rep. 2008;10:390\u20137.","journal-title":"Curr Rheumatol Rep."}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0822-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T03:27:39Z","timestamp":1718162859000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,29]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["822"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0822-z","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,29]]},"article-number":"304"}}