{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:51:55Z","timestamp":1785455515408,"version":"3.56.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Dutch Arthritis Association","award":["LLP-22"],"award-info":[{"award-number":["LLP-22"]}]},{"name":"Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, culture and Science","award":["TerM P2.02"],"award-info":[{"award-number":["TerM P2.02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0865-1","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T07:42:15Z","timestamp":1449214935000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Triamcinolone acetonide activates an anti-inflammatory and folate receptor\u2013positive macrophage that prevents osteophytosis in vivo"],"prefix":"10.1186","volume":"17","author":[{"given":"Michiel","family":"Siebelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline","family":"Korthagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Bastiaansen-Jenniskens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hendrik","family":"Waarsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrie","family":"Weinans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,5]]},"reference":[{"key":"865_CR1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bone.2011.10.010","volume":"51","author":"S Suri","year":"2012","unstructured":"Suri S, Walsh DA. Osteochondral alterations in osteoarthritis. Bone. 2012;51:204\u201311.","journal-title":"Bone"},{"key":"865_CR2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bone.2012.02.002","volume":"51","author":"H Weinans","year":"2012","unstructured":"Weinans H, Siebelt M, Agricola R, Botter SM, Piscaer TM, Waarsing JH. Pathophysiology of peri-articular bone changes in osteoarthritis. Bone. 2012;51:190\u20136.","journal-title":"Bone"},{"key":"865_CR3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","volume":"51","author":"CR Scanzello","year":"2012","unstructured":"Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51:249\u201357. doi: 10.1016\/j.bone.2012.02.012 .","journal-title":"Bone"},{"key":"865_CR4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/art.11422","volume":"50","author":"PL Lent van","year":"2004","unstructured":"van Lent PL, Blom AB, van der Kraan P, Holthuysen AE, Vitters E, van Rooijen N, et al. Crucial role of synovial lining macrophages in the promotion of transforming growth factor \u03b2\u2013mediated osteophyte formation. Arthritis Rheum. 2004;50:103\u201311.","journal-title":"Arthritis Rheum"},{"key":"865_CR5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.joca.2004.03.003","volume":"12","author":"AB Blom","year":"2004","unstructured":"Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, et al. Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage. 2004;12:627\u201335.","journal-title":"Osteoarthritis Cartilage"},{"key":"865_CR6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/art.27290","volume":"62","author":"J Bondeson","year":"2010","unstructured":"Bondeson J, Blom AB, Wainwright S, Hughes C, Caterson B, van den Berg WB. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum. 2010;62:647\u201357. doi: 10.1002\/art.27290 .","journal-title":"Arthritis Rheum"},{"key":"865_CR7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/art.38965","volume":"67","author":"BJ Lange-Brokaar de","year":"2015","unstructured":"de Lange-Brokaar BJ, Ioan-Facsinay A, Yusuf E, Visser AW, Kroon HM, van Osch GJ, et al. Association of pain in knee osteoarthritis with distinct patterns of synovitis. Arthritis Rheumatol. 2015;67:733\u201340. doi: 10.1002\/art.38965 .","journal-title":"Arthritis Rheumatol"},{"key":"865_CR8","first-page":"CD005328","volume":"2","author":"N Bellamy","year":"2006","unstructured":"Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;2:CD005328. doi: 10.1002\/14651858.CD005328.pub2 .","journal-title":"Cochrane Database Syst Rev."},{"key":"865_CR9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","volume":"22","author":"TE McAlindon","year":"2014","unstructured":"McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22:363\u201388. doi: 10.1016\/j.joca.2014.01.003 .","journal-title":"Osteoarthritis Cartilage"},{"key":"865_CR10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.5435\/00124635-200910000-00006","volume":"17","author":"CT Hepper","year":"2009","unstructured":"Hepper CT, Halvorson JJ, Duncan ST, Gregory AJ, Dunn WR, Spindler KP. The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies. J Am Acad Orthop Surg. 2009;17:638\u201346.","journal-title":"J Am Acad Orthop Surg"},{"key":"865_CR11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/art.1780281111","volume":"28","author":"JM Williams","year":"1985","unstructured":"Williams JM, Brandt KD. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985;28:1267\u201374.","journal-title":"Arthritis Rheum"},{"key":"865_CR12","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/jor.22568","volume":"32","author":"KD Huebner","year":"2014","unstructured":"Huebner KD, Shrive NG, Frank CB. Dexamethasone inhibits inflammation and cartilage damage in a new model of post-traumatic osteoarthritis. J Orthop Res. 2014;32:566\u201372. doi: 10.1002\/jor.22568 .","journal-title":"J Orthop Res"},{"key":"865_CR13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4615-8855-9_5","volume":"93","author":"GB Mackaness","year":"1977","unstructured":"Mackaness GB. Cellular immunity and the parasite. Adv Exp Med Biol. 1977;93:65\u201373.","journal-title":"Adv Exp Med Biol."},{"key":"865_CR14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.immuni.2008.03.002","volume":"28","author":"JJ O\u2019Shea","year":"2008","unstructured":"O\u2019Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity. 2008;28:477\u201387. doi: 10.1016\/j.immuni.2008.03.002 .","journal-title":"Immunity"},{"key":"865_CR15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrc970","volume":"3","author":"S Gordon","year":"2003","unstructured":"Gordon S. Alternative activation of macrophages. Nat Rev. 2003;3:23\u201335. doi: 10.1038\/nri978 .","journal-title":"Nat Rev"},{"key":"865_CR16","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.4049\/jimmunol.179.6.3926","volume":"179","author":"P Loke","year":"2007","unstructured":"Loke P, Gallagher I, Nair MG, Zang X, Brombacher F, Mohrs M, et al. Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol. 2007;179:3926\u201336.","journal-title":"J Immunol"},{"key":"865_CR17","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.4049\/jimmunol.1200662","volume":"189","author":"G Zizzo","year":"2012","unstructured":"Zizzo G, Hilliard BA, Monestier M, Cohen PL. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol. 2012;189:3508\u201320. doi: 10.4049\/jimmunol.1200662 .","journal-title":"J Immunol"},{"key":"865_CR18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2741\/2692","volume":"13","author":"FO Martinez","year":"2008","unstructured":"Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci. 2008;13:453\u201361.","journal-title":"Front Biosci."},{"key":"865_CR19","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/ar4461","volume":"16","author":"M Siebelt","year":"2014","unstructured":"Siebelt M, Groen HC, Koelewijn SJ, de Blois E, Sandker M, Waarsing JH, et al. Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulphate-glycosaminoglycan depleted cartilage. Arthritis Res Ther. 2014;16:R32. doi: 10.1186\/ar4461 .","journal-title":"Arthritis Res Ther"},{"key":"865_CR20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/ar7000815","volume":"41","author":"PS Low","year":"2008","unstructured":"Low PS, Henne WA, Doorneweerd DD. Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res. 2008;41:120\u20139. doi: 10.1021\/ar7000815 .","journal-title":"Acc Chem Res"},{"key":"865_CR21","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/art.10405","volume":"46","author":"MJ Turk","year":"2002","unstructured":"Turk MJ, Breur GJ, Widmer WR, Paulos CM, Xu LC, Grote LA, et al. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum. 2002;46:1947\u201355.","journal-title":"Arthritis Rheum"},{"key":"865_CR22","first-page":"233","volume":"41","author":"N Murat","year":"2007","unstructured":"Murat N, Karadam B, Ozkal S, Karatosun V, Gidener S. [Quantification of papain-induced rat osteoarthritis in relation to time with the Mankin score]. Acta Orthop Traumatol Turc. 2007;41:233\u20137. Turkish.","journal-title":"Acta Orthop Traumatol Turc"},{"key":"865_CR23","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/art.30363","volume":"63","author":"TM Piscaer","year":"2011","unstructured":"Piscaer TM, M\u00fcller C, Mindt TL, Lubberts E, Verhaar JA, Krenning EP, et al. Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon\u2013emission computed tomography\/computed tomography. Arthritis Rheum. 2011;63:1898\u2013907.","journal-title":"Arthritis Rheum"},{"key":"865_CR24","doi-asserted-by":"crossref","first-page":"19255","DOI":"10.1073\/pnas.0606406103","volume":"103","author":"AW Palmer","year":"2006","unstructured":"Palmer AW, Guldberg RE, Levenston ME. Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography. Proc Natl Acad Sci U S A. 2006;103:19255\u201360.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"865_CR25","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1359\/JBMR.040705","volume":"19","author":"JH Waarsing","year":"2004","unstructured":"Waarsing JH, Day JS, Weinans H. An improved segmentation method for in vivo \u03bcCT imaging. J Bone Miner Res. 2004;19:1640\u201350.","journal-title":"J Bone Miner Res"},{"key":"865_CR26","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/jor.20910","volume":"27","author":"OP Jagt van der","year":"2009","unstructured":"van der Jagt OP, van der Linden JC, Schaden W, van Schie HT, Piscaer TM, Verhaar JA, et al. Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis. J Orthop Res. 2009;27:1528\u201333.","journal-title":"J Orthop Res"},{"key":"865_CR27","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/art.30307","volume":"63","author":"SM Botter","year":"2011","unstructured":"Botter SM, van Osch GJ, Clockaerts S, Waarsing JH, Weinans H, van Leeuwen JP. Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study. Arthritis Rheum. 2011;63:2690\u20139.","journal-title":"Arthritis Rheum"},{"key":"865_CR28","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1182\/blood-2008-04-150789","volume":"113","author":"W Xia","year":"2009","unstructured":"Xia W, Hilgenbrink AR, Matteson EL, Lockwood MB, Cheng JX, Low PS. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood. 2009;113:438\u201346. doi: 10.1182\/blood-2008-04-150789 .","journal-title":"Blood"},{"key":"865_CR29","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1136\/ard.2004.025270","volume":"64","author":"MJ Benito","year":"2005","unstructured":"Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005;64:1263\u20137.","journal-title":"Ann Rheum Dis"},{"key":"865_CR30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.joca.2008.05.012","volume":"17","author":"TS Silvast","year":"2009","unstructured":"Silvast TS, Jurvelin JS, Lammi MJ, T\u00f6yr\u00e4s J. pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage \u2013 associations to matrix composition and integrity. Osteoarthritis Cartilage. 2009;17:26\u201332. doi: 10.1016\/j.joca.2008.05.012 .","journal-title":"Osteoarthritis Cartilage"},{"key":"865_CR31","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jim.2011.10.013","volume":"375","author":"CA Ambarus","year":"2012","unstructured":"Ambarus CA, Krausz S, van Eijk M, Hamann J, Radstake TR, Reedquist KA, et al. Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods. 2012;375:196\u2013206. doi: 10.1016\/j.jim.2011.10.013 .","journal-title":"J Immunol Methods"},{"key":"865_CR32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.0000109414.78907.F9","volume":"94","author":"P Philippidis","year":"2004","unstructured":"Philippidis P, Mason JC, Evans BJ, Nadra I, Taylor KM, Haskard DO, et al. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res. 2004;94:119\u201326. doi: 10.1161\/01.RES.0000109414.78907.F9 .","journal-title":"Circ Res"},{"key":"865_CR33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1189\/jlb.0105015","volume":"79","author":"FA Verreck","year":"2006","unstructured":"Verreck FA, de Boer T, Langenberg DM, van der Zanden L, Ottenhoff TH. Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-\u03b3- and CD40L-mediated costimulation. J Leukoc Biol. 2006;79:285\u201393. doi: 10.1189\/jlb.0105015 .","journal-title":"J Leukoc Biol"},{"key":"865_CR34","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L","volume":"42","author":"N Nakashima-Matsushita","year":"1999","unstructured":"Nakashima-Matsushita N, Homma T, Yu S, Matsuda T, Sunahara N, Nakamura T, et al. Selective expression of folate receptor \u03b2 and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum. 1999;42:1609\u201316. doi: 10.1002\/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L .","journal-title":"Arthritis Rheum"},{"key":"865_CR35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2005.06.029","volume":"122","author":"S Ogawa","year":"2005","unstructured":"Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, et al. Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors. Cell. 2005;122:707\u201321. doi: 10.1016\/j.cell.2005.06.029 .","journal-title":"Cell"},{"key":"865_CR36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","volume":"16","author":"S Ghosh","year":"1998","unstructured":"Ghosh S, May MJ, Kopp EB. NF-\u03baB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 1998;16:225\u201360. doi: 10.1146\/annurev.immunol.16.1.225 .","journal-title":"Annu Rev Immunol."},{"key":"865_CR37","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1128\/MCB.15.2.943","volume":"15","author":"RI Scheinman","year":"1995","unstructured":"Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin Jr AS. Characterization of mechanisms involved in transrepression of NF-\u03baB by activated glucocorticoid receptors. Mol Cell Biol. 1995;15:943\u201353.","journal-title":"Mol Cell Biol"},{"key":"865_CR38","first-page":"958","volume":"8","author":"DM Mosser","year":"2008","unstructured":"Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev. 2008;8:958\u201369.","journal-title":"Nat Rev"},{"key":"865_CR39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.orthres.2004.10.003","volume":"23","author":"C Celeste","year":"2005","unstructured":"Celeste C, Ionescu M, Robin Poole A, Laverty S. Repeated intraarticular injections of triamcinolone acetonide alter cartilage matrix metabolism measured by biomarkers in synovial fluid. J Orthop Res. 2005;23:602\u201310. doi: 10.1016\/j.orthres.2004.10.003 .","journal-title":"J Orthop Res"},{"key":"865_CR40","first-page":"773","volume":"20","author":"F Nakazawa","year":"2002","unstructured":"Nakazawa F, Matsuno H, Yudoh K, Watanabe Y, Katayama R, Kimura T. Corticosteroid treatment induces chondrocyte apoptosis in an experimental arthritis model and in chondrocyte cultures. Clin Exp Rheumatol. 2002;20:773\u201381.","journal-title":"Clin Exp Rheumatol"},{"key":"865_CR41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s11307-009-0211-6","volume":"11","author":"J Doorduin","year":"2009","unstructured":"Doorduin J, Klein HC, Dierckx RA, James M, Kassiou M, de Vries EF. [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Mol Imaging Biol. 2009;11:386\u201398.","journal-title":"Mol Imaging Biol"},{"key":"865_CR42","first-page":"269","volume":"58","author":"C Wiele Van De","year":"2014","unstructured":"Van De Wiele C, Sathekge M, Maes A. Targeting monocytes and macrophages by means of SPECT and PET. Q J Nucl Med Mol Imaging. 2014;58:269\u201375.","journal-title":"Q J Nucl Med Mol Imaging"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0865-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T21:02:09Z","timestamp":1498251729000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["865"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0865-1","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"352"}}