{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:27:04Z","timestamp":1792106824539,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0870-4","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T16:23:40Z","timestamp":1449159820000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation"],"prefix":"10.1186","volume":"17","author":[{"given":"Eun-Ju","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Ho","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Hyun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokchan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Keun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Ju","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"870_CR1","first-page":"593","volume":"58","author":"WW Ginsburg","year":"1983","unstructured":"Ginsburg WW, Cohen MD. Peripheral arthritis in ankylosing spondylitis. A review of 209 patients followed up for more than 20\u00a0years. Mayo Clin Proc. 1983;58:593\u20136.","journal-title":"Mayo Clin Proc"},{"key":"870_CR2","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1007\/s00018-010-0410-y","volume":"67","author":"SH Mun","year":"2010","unstructured":"Mun SH, Ko NY, Kim HS, Kim JW, Kim do K, Kim AR, et al. Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes. Cell Mol Life Sci. 2010;67:3883\u201392. doi: 10.1007\/s00018-010-0410-y .","journal-title":"Cell Mol Life Sci"},{"key":"870_CR3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00256-007-0376-5","volume":"36","author":"PS Helliwell","year":"2007","unstructured":"Helliwell PS, Porter G, group Cs. Sensitivity and specificity of plain radiographic features of peripheral enthesopathy at major sites in psoriatic arthritis. Skeletal Radiol. 2007;36:1061\u20136. doi: 10.1007\/s00256-007-0376-5 .","journal-title":"Skeletal Radiol"},{"key":"870_CR4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/art.23260","volume":"58","author":"J Sieper","year":"2008","unstructured":"Sieper J, Appel H, Braun J, Rudwaleit M. Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes. Arthritis Rheum. 2008;58:649\u201356. doi: 10.1002\/art.23260 .","journal-title":"Arthritis Rheum"},{"key":"870_CR5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.berh.2010.01.005","volume":"24","author":"G Schett","year":"2010","unstructured":"Schett G, Rudwaleit M. Can we stop progression of ankylosing spondylitis? Best Pract Res Clin Rheumatol. 2010;24:363\u201371. doi: 10.1016\/j.berh.2010.01.005 .","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"870_CR6","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1002\/art.24767","volume":"60","author":"G Schett","year":"2009","unstructured":"Schett G, Stolina M, Dwyer D, Zack D, Uderhardt S, Kronke G, et al. Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis. Arthritis Rheum. 2009;60:2644\u201354. doi: 10.1002\/art.24767 .","journal-title":"Arthritis Rheum"},{"key":"870_CR7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ceb.2008.01.009","volume":"20","author":"H Huang","year":"2008","unstructured":"Huang H, He X. Wnt\/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol. 2008;20:119\u201325. doi: 10.1016\/j.ceb.2008.01.009 .","journal-title":"Curr Opin Cell Biol"},{"key":"870_CR8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00774-009-0064-8","volume":"27","author":"T Kubota","year":"2009","unstructured":"Kubota T, Michigami T, Ozono K. Wnt signaling in bone metabolism. J Bone Miner Metab. 2009;27:265\u201371. doi: 10.1007\/s00774-009-0064-8 .","journal-title":"J Bone Miner Metab"},{"key":"870_CR9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bone.2006.03.017","volume":"39","author":"J Li","year":"2006","unstructured":"Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, Grisanti M, et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone. 2006;39:754\u201366. doi: 10.1016\/j.bone.2006.03.017 .","journal-title":"Bone"},{"key":"870_CR10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nm1538","volume":"13","author":"D Diarra","year":"2007","unstructured":"Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007;13:156\u201363. doi: 10.1038\/nm1538 .","journal-title":"Nat Med"},{"key":"870_CR11","first-page":"131","volume":"22","author":"SH Kim","year":"2005","unstructured":"Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity. 2005;22:131\u201342. doi: 10.1016\/j.immuni.2004.12.003 .","journal-title":"Immunity"},{"key":"870_CR12","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/art.24299","volume":"60","author":"SH Mun","year":"2009","unstructured":"Mun SH, Kim JW, Nah SS, Ko NY, Lee JH, Kim JD, et al. Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk\/protein kinase Cdelta\/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum. 2009;60:678\u201385. doi: 10.1002\/art.24299 .","journal-title":"Arthritis Rheum"},{"key":"870_CR13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s10875-009-9360-2","volume":"30","author":"YG Kim","year":"2010","unstructured":"Kim YG, Lee CK, Kim SH, Cho WS, Mun SH, Yoo B. Interleukin-32gamma enhances the production of IL-6 and IL-8 in fibroblast-like synoviocytes via Erk1\/2 activation. J Clin Immunol. 2010;30:260\u20137. doi: 10.1007\/s10875-009-9360-2 .","journal-title":"J Clin Immunol"},{"key":"870_CR14","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/art.27197","volume":"62","author":"YG Kim","year":"2010","unstructured":"Kim YG, Lee CK, Oh JS, Kim SH, Kim KA, Yoo B. Effect of interleukin-32gamma on differentiation of osteoclasts from CD14+ monocytes. Arthritis Rheum. 2010;62:515\u201323. doi: 10.1002\/art.27197 .","journal-title":"Arthritis Rheum"},{"key":"870_CR15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10875-011-9611-x","volume":"32","author":"YG Kim","year":"2012","unstructured":"Kim YG, So MW, Koo BS, Chang EJ, Song SJ, Lee CK, et al. The influence of interleukin-32gamma on osteoclastogenesis with a focus on fusion-related genes. J Clin Immunol. 2012;32:201\u20136. doi: 10.1007\/s10875-011-9611-x .","journal-title":"J Clin Immunol"},{"key":"870_CR16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S Linden van der","year":"1984","unstructured":"van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27:361\u20138.","journal-title":"Arthritis Rheum"},{"key":"870_CR17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315\u201324.","journal-title":"Arthritis Rheum"},{"key":"870_CR18","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","volume":"29","author":"R Altman","year":"1986","unstructured":"Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29:1039\u201349.","journal-title":"Arthritis Rheum"},{"key":"870_CR19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nm.1860","volume":"14","author":"EJ Chang","year":"2008","unstructured":"Chang EJ, Ha J, Oerlemans F, Lee YJ, Lee SW, Ryu J, et al. Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption. Nat Med. 2008;14:966\u201372. doi: 10.1038\/nm.1860 .","journal-title":"Nat Med"},{"key":"870_CR20","first-page":"2286","volume":"21","author":"S Garrett","year":"1994","unstructured":"Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994;21:2286\u201391.","journal-title":"J Rheumatol"},{"key":"870_CR21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/ard.2004.020503","volume":"64","author":"MC Creemers","year":"2005","unstructured":"Creemers MC, Franssen MJ, van't Hof MA, Gribnau FW, van de Putte LB, van Riel PL. Assessment of outcome in ankylosing spondylitis: an extended radiographic scoring system. Ann Rheum Dis. 2005;64:127\u20139. doi: 10.1136\/ard.2004.020503 .","journal-title":"Ann Rheum Dis"},{"key":"870_CR22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00167-010-1071-y","volume":"18","author":"H Madry","year":"2010","unstructured":"Madry H. The subchondral bone: a new frontier in articular cartilage repair. Knee Surg Sports Traumatol Arthrosc. 2010;18:417\u20138. doi: 10.1007\/s00167-010-1071-y .","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"870_CR23","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1073\/pnas.0511233103","volume":"103","author":"LA Joosten","year":"2006","unstructured":"Joosten LA, Netea MG, Kim SH, Yoon DY, Oppers-Walgreen B, Radstake TR, et al. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2006;103:3298\u2013303. doi: 10.1073\/pnas.0511233103 .","journal-title":"Proc Natl Acad Sci U S A"},{"key":"870_CR24","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1074\/jbc.M709909200","volume":"283","author":"LJ Raggatt","year":"2008","unstructured":"Raggatt LJ, Qin L, Tamasi J, Jefcoat Jr SC, Shimizu E, Selvamurugan N, et al. Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions. J Biol Chem. 2008;283:6790\u20138. doi: 10.1074\/jbc.M709909200 .","journal-title":"J Biol Chem"},{"key":"870_CR25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00296-012-2385-5","volume":"33","author":"YE Park","year":"2013","unstructured":"Park YE, Kim GT, Lee SG, Park SH, Baek SH, Kim SI, et al. IL-32 aggravates synovial inflammation and bone destruction and increases synovial natural killer cells in experimental arthritis models. Rheumatol Int. 2013;33:671\u20139. doi: 10.1007\/s00296-012-2385-5 .","journal-title":"Rheumatol Int"},{"key":"870_CR26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/path.2899","volume":"224","author":"HJ Jeong","year":"2011","unstructured":"Jeong HJ, Shin SY, Oh HA, Kim MH, Cho JS, Kim HM. IL-32 up-regulation is associated with inflammatory cytokine production in allergic rhinitis. J Pathol. 2011;224:553\u201363. doi: 10.1002\/path.2899 .","journal-title":"J Pathol"},{"key":"870_CR27","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1210\/endo.141.11.7739","volume":"141","author":"L Gilbert","year":"2000","unstructured":"Gilbert L, He X, Farmer P, Boden S, Kozlowski M, Rubin J, et al. Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology. 2000;141:3956\u201364. doi: 10.1210\/endo.141.11.7739 .","journal-title":"Endocrinology"},{"key":"870_CR28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S8756-3282(97)00038-0","volume":"21","author":"T Nakase","year":"1997","unstructured":"Nakase T, Takaoka K, Masuhara K, Shimizu K, Yoshikawa H, Ochi T. Interleukin-1 beta enhances and tumor necrosis factor-alpha inhibits bone morphogenetic protein-2-induced alkaline phosphatase activity in MC3T3-E1 osteoblastic cells. Bone. 1997;21:17\u201321.","journal-title":"Bone"},{"key":"870_CR29","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/art.23471","volume":"58","author":"D Heijde van der","year":"2008","unstructured":"van der Heijde D, Landewe R, Einstein S, Ory P, Vosse D, Ni L, et al. Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum. 2008;58:1324\u201331. doi: 10.1002\/art.23471 .","journal-title":"Arthritis Rheum"},{"key":"870_CR30","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1002\/art.21913","volume":"54","author":"D Heijde van der","year":"2006","unstructured":"van der Heijde D, Kivitz A, Schiff MH, Sieper J, Dijkmans BA, Braun J, et al. Efficacy and safety of adalimumab in patients with ankylosing spondylitis: results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2006;54:2136\u201346. doi: 10.1002\/art.21913 .","journal-title":"Arthritis Rheum"},{"key":"870_CR31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/ard.2008.094490","volume":"68","author":"EH Halvorsen","year":"2009","unstructured":"Halvorsen EH, Haavardsholm EA, Pollmann S, Boonen A, van der Heijde D, Kvien TK, et al. Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents. Ann Rheum Dis. 2009;68:249\u201352. doi: 10.1136\/ard.2008.094490 .","journal-title":"Ann Rheum Dis"},{"key":"870_CR32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/03009742.2013.805241","volume":"43","author":"M Korkosz","year":"2014","unstructured":"Korkosz M, Gasowski J, Leszczynski P, Pawlak-Bus K, Jeka S, Siedlar M, et al. Effect of tumour necrosis factor-alpha inhibitor on serum level of dickkopf-1 protein and bone morphogenetic protein-7 in ankylosing spondylitis patients with high disease activity. Scand J Rheumatol. 2014;43:43\u20138. doi: 10.3109\/03009742.2013.805241 .","journal-title":"Scand J Rheumatol"},{"key":"870_CR33","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.38070","volume":"65","author":"N Haroon","year":"2013","unstructured":"Haroon N, Inman RD, Learch TJ, Weisman MH, Lee M, Rahbar MH, et al. The impact of tumor necrosis factor alpha inhibitors on radiographic progression in ankylosing spondylitis. Arthritis Rheum. 2013;65:2645\u201354. doi: 10.1002\/art.38070 .","journal-title":"Arthritis Rheum"},{"key":"870_CR34","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/ard.2008.102046","volume":"69","author":"S Uderhardt","year":"2010","unstructured":"Uderhardt S, Diarra D, Katzenbeisser J, David JP, Zwerina J, Richards W, et al. Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis. 2010;69:592\u20137. doi: 10.1136\/ard.2008.102046 .","journal-title":"Ann Rheum Dis"},{"key":"870_CR35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/art.27231","volume":"62","author":"D Daoussis","year":"2010","unstructured":"Daoussis D, Liossis SN, Solomou EE, Tsanaktsi A, Bounia K, Karampetsou M, et al. Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis. Arthritis Rheum. 2010;62:150\u20138. doi: 10.1002\/art.27231 .","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0870-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T21:06:29Z","timestamp":1718226389000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["870"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0870-4","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"350"}}