{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:41:31Z","timestamp":1788309691636,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0871-3","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T23:53:03Z","timestamp":1450223583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Serological epitope profile of anti-Ro52\u2013positive patients with systemic autoimmune rheumatic diseases"],"prefix":"10.1186","volume":"17","author":[{"given":"Maria","family":"Infantino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Meacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Benucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Morozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Tonutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilina","family":"Tampoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Atzeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piercarlo","family":"Sarzi-Puttini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Bizzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"871_CR1","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1084\/jem.167.5.1560","volume":"167","author":"E Ben-Chetrit","year":"1988","unstructured":"Ben-Chetrit E, Chan EK, Sullivan KF, Tan EM. A 52-kD protein is a novel component of the SS-A\/Ro antigenic particle. J Exp Med. 1988;167:1560\u201371.","journal-title":"J Exp Med"},{"key":"871_CR2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1172\/JCI115003","volume":"87","author":"EK Chan","year":"1991","unstructured":"Chan EK, Hamel JC, Buyon JP, Tan EM. Molecular definition and sequence motifs of the 52-kD component of human SS-A\/Ro autoantigen. J Clin Invest. 1991;87:68\u201376.","journal-title":"J Clin Invest"},{"key":"871_CR3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1172\/JCI114968","volume":"87","author":"K Itoh","year":"1991","unstructured":"Itoh K, Itoh Y, Frank MB. Protein heterogeneity in the human Ro\/SSA ribonucleoproteins: the 52- and 60-kD Ro\/SSA autoantigens are encoded by separate genes. J Clin Invest. 1991;87:177\u201386.","journal-title":"J Clin Invest"},{"key":"871_CR4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2249.1995.tb03728.x","volume":"100","author":"G Boire","year":"1995","unstructured":"Boire G, Gendron M, Monast N, Bastin B, M\u00e9nard HA. Purification of antigenically intact Ro ribonucleoproteins; biochemical and immunological evidence that the 52-kD protein is not a Ro protein. Clin Exp Immunol. 1995;100:489\u201398.","journal-title":"Clin Exp Immunol"},{"key":"871_CR5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2249.1991.tb05780.x","volume":"86","author":"RL Slobbe","year":"1991","unstructured":"Slobbe RL, Pruijn GJ, Damen WG, van der Kemp JW, van Venrooij WJ. Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these proteins. Clin Exp Immunol. 1991;86:99\u2013105. A published erratum appears in Clin Exp Immunol 1992;87:336.","journal-title":"Clin Exp Immunol"},{"key":"871_CR6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/pgmj.2009.089656","volume":"86","author":"M Dugar","year":"2010","unstructured":"Dugar M, Cox S, Limaye V, Gordon TP, Roberts-Thomson PJ. Diagnostic utility of anti-Ro52 detection in systemic autoimmunity. Postgrad Med J. 2010;86:79\u201382.","journal-title":"Postgrad Med J"},{"key":"871_CR7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/ard.60.2.116","volume":"60","author":"R Brouwer","year":"2001","unstructured":"Brouwer R, Hengstman GJ, Vree Egberts W, Ehrfeld H, Bozic B, Ghirardello A, et al. Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis. 2001;60:116\u201323.","journal-title":"Ann Rheum Dis"},{"key":"871_CR8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11926-013-0335-1","volume":"15","author":"A Ghirardello","year":"2013","unstructured":"Ghirardello A, Bassi N, Palma L, Borella E, Domeneghetti M, Punzi L, et al. Autoantibodies in polymyositis and dermatomyositis. Curr Rheumatol Rep. 2013;15:335.","journal-title":"Curr Rheumatol Rep"},{"key":"871_CR9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.autrev.2011.03.004","volume":"10","author":"P Ghillani","year":"2011","unstructured":"Ghillani P, Andr\u00e9 C, Toly C, Rouquette AM, Bengoufa D, Nicaise P, et al. Clinical significance of anti-Ro52 (TRIM21) antibodies non-associated with anti-SSA 60\u00a0kDa antibodies: results of a multicentric study. Autoimmun Rev. 2011;10:509\u201313.","journal-title":"Autoimmun Rev"},{"issue":"Suppl 1","key":"871_CR10","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1016\/S0168-8278(07)62258-2","volume":"46","author":"C Liaskos","year":"2007","unstructured":"Liaskos C, Bogdanos DP, Rigopoulou EI, Norman GL, Shums Z, Al-Chalabi T, et al. Antibody responses specific for soluble liver antigen co-occur with Ro-52 autoantibodies in patients with autoimmune hepatitis [poster 660]. J Hepatol. 2007;46 Suppl 1:S250.","journal-title":"J Hepatol"},{"key":"871_CR11","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/rheumatology\/kep145","volume":"48","author":"B Hervier","year":"2009","unstructured":"Hervier B, Rimbert M, Colonna F, Hamidou MA, Audrain M. Clinical significance of anti-Ro\/SSA-52\u00a0kDa antibodies: a retrospective monocentric study. Rheumatology. 2009;48:964\u20137.","journal-title":"Rheumatology"},{"key":"871_CR12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2340\/00015555-0473","volume":"88","author":"K Popovic","year":"2008","unstructured":"Popovic K, Wahren-Herlenius M, Nyberg F. Clinical follow-up of 102 anti-Ro\/SSA-positive patients with dermatological manifestations. Acta Derm Venereol. 2008;88:370\u20135.","journal-title":"Acta Derm Venereol"},{"key":"871_CR13","doi-asserted-by":"crossref","first-page":"R30","DOI":"10.1186\/ar3258","volume":"13","author":"C Eriksson","year":"2011","unstructured":"Eriksson C, Kokkonen H, Johansson M, Hallmans G, Wadell G, Rantap\u00e4\u00e4-Dahlqvist S. Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden. Arthritis Res Ther. 2011;13:R30.","journal-title":"Arthritis Res Ther"},{"key":"871_CR14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/jaut.1998.0265","volume":"12","author":"MB Frank","year":"1999","unstructured":"Frank MB, McCubbin V, Trieu E, Wu Y, Isenberg DA, Targoff IN. The association of anti-Ro52 autoantibodies with myositis and scleroderma autoantibodies. J Autoimmun. 1999;12:137\u201342.","journal-title":"J Autoimmun"},{"key":"871_CR15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s13317-014-0060-4","volume":"5","author":"A Ghirardello","year":"2014","unstructured":"Ghirardello A, Borella E, Beggio M, Franceschini F, Fredi M, Doria A. Myositis autoantibodies and clinical phenotypes. Auto Immun Highlights. 2014;5:69\u201375.","journal-title":"Auto Immun Highlights"},{"key":"871_CR16","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/art.10232","volume":"46","author":"S Salomonsson","year":"2002","unstructured":"Salomonsson S, D\u00f6rner T, Theander E, Bremme K, Larsson P, Wahren-Herlenius M. A serologic marker for fetal risk of congenital heart block. Arthritis Rheum. 2002;46:1233\u201341.","journal-title":"Arthritis Rheum"},{"key":"871_CR17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/ar3787","volume":"14","author":"A Ambrosi","year":"2012","unstructured":"Ambrosi A, Wahren-Herlenius M. Congenital heart block: evidence for a pathogenic role of maternal autoantibodies. Arthritis Res Ther. 2012;14:208.","journal-title":"Arthritis Res Ther"},{"key":"871_CR18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/uog.7343","volume":"34","author":"G Bergman","year":"2009","unstructured":"Bergman G, Eliasson H, Bremme K, Wahren-Herlenius M, Sonesson SE. Anti-Ro52\/SSA antibody-exposed fetuses with prolonged atrioventricular time intervals show signs of decreased cardiac performance. Ultrasound Obstet Gynecol. 2009;34:543\u20139.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"871_CR19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.autrev.2010.09.005","volume":"10","author":"C Defendenti","year":"2011","unstructured":"Defendenti C, Atzeni F, Spina MF, Grosso S, Cereda A, Guercilena G, et al. Clinical and laboratory aspects of Ro\/SSA-52 autoantibodies. Autoimmun Rev. 2011;10:150\u20134.","journal-title":"Autoimmun Rev"},{"key":"871_CR20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jaut.2012.01.014","volume":"39","author":"V Oke","year":"2012","unstructured":"Oke V, Wahren-Herlenius M. The immunobiology of Ro52 (TRIM21) in autoimmunity: a critical review. J Autoimmun. 2012;39:77\u201382.","journal-title":"J Autoimmun"},{"key":"871_CR21","first-page":"145","volume":"2","author":"PD Burbelo","year":"2010","unstructured":"Burbelo PD, Ching KH, Han BL, Bush ER, Reeves WH, Iadarola MJ. Extraordinary antigenicity of the human Ro52 autoantigen. Am J Transl Res. 2010;2:145\u201355.","journal-title":"Am J Transl Res"},{"key":"871_CR22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2249.1993.tb03436.x","volume":"94","author":"B Bozic","year":"1993","unstructured":"Bozic B, Pruijn GJ, Rozman B, van Venrooij WJ. Sera from patients with rheumatic diseases recognize different epitope regions on the 52-kD Ro\/SS-A protein. Clin Exp Immunol. 1993;94:227\u201335.","journal-title":"Clin Exp Immunol"},{"key":"871_CR23","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.autrev.2009.02.010","volume":"8","author":"J Schulte-Pelkum","year":"2009","unstructured":"Schulte-Pelkum J, Fritzler M, Mahler M. Latest update on the Ro\/SS-A autoantibody system. Autoimmun Rev. 2009;8:632\u20137.","journal-title":"Autoimmun Rev"},{"key":"871_CR24","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1093\/rheumatology\/keq281","volume":"49","author":"A Ghirardello","year":"2010","unstructured":"Ghirardello A, Rampudda M, Ekholm L, Bassi N, Tarricone E, Zampieri S, et al. Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay. Rheumatology (Oxford). 2010;49:2370\u20134.","journal-title":"Rheumatology (Oxford)"},{"key":"871_CR25","doi-asserted-by":"crossref","first-page":"978202","DOI":"10.1155\/2013\/978202","volume":"2013","author":"M Infantino","year":"2013","unstructured":"Infantino M, Bentow C, Seaman A, Benucci M, Atzeni F, Sarzi-Puttini P, et al. Highlights on novel technologies for the detection of antibodies to Ro60, Ro52, and SS-B. Clin Dev Immunol. 2013;2013:978202.","journal-title":"Clin Dev Immunol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0871-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T05:02:36Z","timestamp":1692162156000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["871"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0871-3","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"365"}}