{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:23:54Z","timestamp":1778718234748,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council (GB)","doi-asserted-by":"publisher","award":["MR\/J002747\/1"],"award-info":[{"award-number":["MR\/J002747\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK (GB)","doi-asserted-by":"publisher","award":["20205"],"award-info":[{"award-number":["20205"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13075-015-0898-5","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T01:19:06Z","timestamp":1450919946000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage"],"prefix":"10.1186","volume":"17","author":[{"given":"Ngee Han","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonia L.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahuva","family":"Nissim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,12,25]]},"reference":[{"key":"898_CR1","first-page":"376","volume":"6","author":"SR Goldring","year":"2006","unstructured":"Goldring SR, Goldring MB. Clinical aspects, pathology and pathophysiology of osteoarthritis. J Musculoskelet Neuronal Interact. 2006;6:376\u20138.","journal-title":"J Musculoskelet Neuronal Interact."},{"key":"898_CR2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/138945007779940160","volume":"8","author":"HI Roach","year":"2007","unstructured":"Roach HI, Aigner T, Soder S, Haag J, Welkerling H. Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets. Curr Drug Targets. 2007;8:271\u201382.","journal-title":"Curr Drug Targets."},{"key":"898_CR3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrrheum.2013.72","volume":"9","author":"CB Little","year":"2013","unstructured":"Little CB, Hunter DJ. Post-traumatic osteoarthritis: from mouse models to clinical trials. Nat Rev Rheumatol. 2013;9:485\u201397.","journal-title":"Nat Rev Rheumatol."},{"key":"898_CR4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.autrev.2012.10.003","volume":"12","author":"S Frisenda","year":"2013","unstructured":"Frisenda S, Perricone C, Valesini G. Cartilage as a target of autoimmunity: a thin layer. Autoimmun Rev. 2013;12:591\u20138.","journal-title":"Autoimmun Rev."},{"key":"898_CR5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2010.01.013","volume":"18","author":"W Zhang","year":"2010","unstructured":"Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III. Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. 2010;18:476\u201399.","journal-title":"Osteoarthritis Cartilage"},{"key":"898_CR6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.joca.2011.02.002","volume":"19","author":"VB Kraus","year":"2011","unstructured":"Kraus VB. Osteoarthritis year 2010 in review: biochemical markers. Osteoarthritis Cartilage. 2011;19:346\u201353.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.joca.2010.08.019","volume":"19","author":"VB Kraus","year":"2011","unstructured":"Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, et al. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage. 2011;19:515\u201342.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.joca.2014.02.007","volume":"22","author":"AM Valdes","year":"2014","unstructured":"Valdes AM, Meulenbelt I, Chassaing E, Arden NK, Bierma-Zeinstra S, Hart D, et al. Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis. Osteoarthritis Cartilage. 2014;22:683\u20139.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.berh.2014.02.002","volume":"28","author":"FW Roemer","year":"2014","unstructured":"Roemer FW, Eckstein F, Hayashi D, Guermazi A. The role of imaging in osteoarthritis. Best Pract Res Clin Rheumatol. 2014;28:31\u201360.","journal-title":"Best Pract Res Clin Rheumatol."},{"key":"898_CR10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.joca.2010.10.029","volume":"19","author":"DJ Hunter","year":"2011","unstructured":"Hunter DJ, Zhang W, Conaghan PG, Hirko K, Menashe L, Li L, et al. Systematic review of the concurrent and predictive validity of MRI biomarkers in OA. Osteoarthritis Cartilage. 2011;19:557\u201388.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR11","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s00247-013-2872-1","volume":"44","author":"AS Doria","year":"2014","unstructured":"Doria AS, Zhang N, Lundin B, Hilliard P, Man C, Weiss R, et al. Quantitative versus semiquantitative MR imaging of cartilage in blood-induced arthritic ankles: preliminary findings. Pediatr Radiol. 2014;44:576\u201386.","journal-title":"Pediatr Radiol."},{"key":"898_CR12","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.joca.2014.06.023","volume":"22","author":"F Eckstein","year":"2014","unstructured":"Eckstein F, Guermazi A, Gold G, Duryea J, Hellio Le Graverand MP, Wirth W, et al. Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Osteoarthritis Cartilage. 2014;22:1516\u201332.","journal-title":"Osteoarthritis Cartilage"},{"key":"898_CR13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrrheum.2013.198","volume":"10","author":"F Eckstein","year":"2014","unstructured":"Eckstein F, Kwoh CK. Imaging in rheumatology in 2013. From images to data to theory. Nat Rev Rheumatol. 2014;10:69\u201370.","journal-title":"Nat Rev Rheumatol"},{"key":"898_CR14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/annrheumdis-2014-205310","volume":"73","author":"F Eckstein","year":"2014","unstructured":"Eckstein F, Kwoh CK, Link TM, Investigators OAI. Imaging research results from the osteoarthritis initiative (OAI): a review and lessons learned 10 years after start of enrolment. Ann Rheum Dis. 2014;73:1289\u2013300.","journal-title":"Ann Rheum Dis"},{"key":"898_CR15","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1148\/radiol.14140991","volume":"274","author":"FW Roemer","year":"2015","unstructured":"Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Wang Z, et al. Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year? Radiology. 2015;274:810\u201320.","journal-title":"Radiology."},{"key":"898_CR16","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.joca.2014.06.005","volume":"22","author":"CY Wenham","year":"2014","unstructured":"Wenham CY, Grainger AJ, Conaghan PG. The role of imaging modalities in the diagnosis, differential diagnosis and clinical assessment of peripheral joint osteoarthritis. Osteoarthritis Cartilage. 2014;22:1692\u2013702.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR17","doi-asserted-by":"crossref","first-page":"210","DOI":"10.22203\/eCM.v020a17","volume":"20","author":"F Dell'accio","year":"2010","unstructured":"Dell'accio F, Vincent TL. Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions. Eur Cell Mater. 2010;20:210\u20137.","journal-title":"Eur Cell Mater."},{"key":"898_CR18","first-page":"77","volume":"64","author":"S Abramson","year":"2006","unstructured":"Abramson S, Krasnokutsky S. Biomarkers in osteoarthritis. Bull NYU Hosp Jt Dis. 2006;64:77\u201381.","journal-title":"Bull NYU Hosp Jt Dis."},{"key":"898_CR19","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.23870","volume":"58","author":"JJ Inglis","year":"2008","unstructured":"Inglis JJ, McNamee KE, Chia SL, Essex D, Feldmann M, Williams RO, et al. Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system. Arthritis Rheum. 2008;58:3110\u20139.","journal-title":"Arthritis Rheum."},{"key":"898_CR20","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","volume":"60","author":"CB Little","year":"2009","unstructured":"Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 2009;60:3723\u201333.","journal-title":"Arthritis Rheum."},{"key":"898_CR21","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/art.27346","volume":"62","author":"C Hughes","year":"2010","unstructured":"Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, et al. Human single-chain variable fragment that specifically targets arthritic cartilage. Arthritis Rheum. 2010;62:1007\u201316.","journal-title":"Arthritis Rheum."},{"key":"898_CR22","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1186\/ar4613","volume":"16","author":"C Hughes","year":"2014","unstructured":"Hughes C, Sette A, Seed M, D'Acquisto F, Manzo A, Vincent TL, et al. Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency. Arthritis Res Ther. 2014;16:R151.","journal-title":"Arthritis Res Ther."},{"key":"898_CR23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0076-6879(96)67007-4","volume":"267","author":"JL Harrison","year":"1996","unstructured":"Harrison JL, Williams SC, Winter G, Nissim A. Screening of phage antibody libraries. Methods Enzymol. 1996;267:83\u2013109.","journal-title":"Methods Enzymol."},{"key":"898_CR24","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.joca.2014.09.009","volume":"22","author":"FJ Blanco","year":"2014","unstructured":"Blanco FJ. Osteoarthritis year in review 2014: we need more biochemical biomarkers in qualification phase. Osteoarthritis Cartilage. 2014;22:2025\u201332.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2106\/00004623-197153010-00007","volume":"53","author":"L Rosenberg","year":"1971","unstructured":"Rosenberg L. Chemical basis for the histological use of safranin O in the study of articular cartilage. J Bone Joint Surg Am. 1971;53:69\u201382.","journal-title":"J Bone Joint Surg Am."},{"key":"898_CR26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joca.2005.04.002","volume":"13","author":"Y Henrotin","year":"2005","unstructured":"Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage. 2005;13:643\u201354.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1074\/mcp.M800292-MCP200","volume":"8","author":"C Ruiz-Romero","year":"2009","unstructured":"Ruiz-Romero C, Calamia V, Mateos J, Carreira V, Martinez-Gomariz M, Fernandez M, et al. Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance. Mol Cell Proteomics. 2009;8:172\u201389.","journal-title":"Mol Cell Proteomics."},{"key":"898_CR28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrrheum.2010.213","volume":"7","author":"FJ Blanco","year":"2011","unstructured":"Blanco FJ, Rego I, Ruiz-Romero C. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol. 2011;7:161\u20139.","journal-title":"Nat Rev Rheumatol."},{"key":"898_CR29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cger.2010.03.002","volume":"26","author":"RF Loeser","year":"2010","unstructured":"Loeser RF. Age-related changes in the musculoskeletal system and the development of osteoarthritis. Clin Geriatr Med. 2010;26:371\u201386.","journal-title":"Clin Geriatr Med."},{"key":"898_CR30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.berh.2009.08.006","volume":"24","author":"A Shane Anderson","year":"2010","unstructured":"Shane Anderson A, Loeser RF. Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol. 2010;24:15\u201326.","journal-title":"Best Pract Res Clin Rheumatol."},{"key":"898_CR31","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/1947603513495889","volume":"4","author":"JA Buckwalter","year":"2013","unstructured":"Buckwalter JA, Anderson DD, Brown TD, Tochigi Y, Martin JA. The roles of mechanical stresses in the pathogenesis of osteoarthritis: implications for treatment of joint injuries. Cartilage. 2013;4:286\u201394.","journal-title":"Cartilage."},{"key":"898_CR32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11010-014-2187-z","volume":"397","author":"KN Reed","year":"2014","unstructured":"Reed KN, Wilson G, Pearsall A, Grishko VI. The role of mitochondrial reactive oxygen species in cartilage matrix destruction. Mol Cell Biochem. 2014;397:195\u2013201.","journal-title":"Mol Cell Biochem."},{"key":"898_CR33","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/ard.2009.117416","volume":"69","author":"I Rego-Perez","year":"2010","unstructured":"Rego-Perez I, Fernandez-Moreno M, Deberg M, Pertega S, Fenandez-Lopez C, Oreiro N, et al. Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis. Ann Rheum Dis. 2010;69:910\u20137.","journal-title":"Ann Rheum Dis."},{"key":"898_CR34","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/ard.2010.133637","volume":"70","author":"I Rego-Perez","year":"2011","unstructured":"Rego-Perez I, Fernandez-Moreno M, Deberg M, Pertega S, Fernandez-Lopez C, Oreiro N, et al. Mitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis. Ann Rheum Dis. 2011;70:646\u201352.","journal-title":"Ann Rheum Dis."},{"key":"898_CR35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ncprheum0534","volume":"3","author":"T Aigner","year":"2007","unstructured":"Aigner T, Soder S, Gebhard PM, McAlinden A, Haag J. Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis\u2014structure, chaos and senescence. Nat Clin Pract Rheumatol. 2007;3:391\u20139.","journal-title":"Nat Clin Pract Rheumatol."},{"key":"898_CR36","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nbt1142","volume":"23","author":"P Holliger","year":"2005","unstructured":"Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat Biotechnol. 2005;23:1126\u201336.","journal-title":"Nat Biotechnol."},{"key":"898_CR37","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.joca.2015.02.004","volume":"23","author":"A Guermazi","year":"2015","unstructured":"Guermazi A, Eckstein F, Hunter D, Roemer F. 7th International Workshop on Osteoarthritis Imaging report: \u201cimaging in OA\u2014now is the time to move ahead\u201d. Osteoarthritis Cartilage. 2015;23:888\u201396.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR38","first-page":"114","volume":"11","author":"A Migliore","year":"2014","unstructured":"Migliore A, Massafra U. Towards the identification of early stage osteoarthritis. Clin Cases Miner Bone Metab. 2014;11:114\u20136.","journal-title":"Clin Cases Miner Bone Metab."},{"key":"898_CR39","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.joca.2013.05.018","volume":"21","author":"T Thote","year":"2013","unstructured":"Thote T, Lin AS, Raji Y, Moran S, Stevens HY, Hart M, et al. Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration. Osteoarthritis Cartilage. 2013;21:1132\u201341.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR40","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.joca.2014.07.014","volume":"22","author":"P Das Neves Borges","year":"2014","unstructured":"Das Neves Borges P, Forte AE, Vincent TL, Dini D, Marenzana M. Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics. Osteoarthritis Cartilage. 2014;22:1419\u201328.","journal-title":"Osteoarthritis Cartilage"},{"key":"898_CR41","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/art.38957","volume":"67","author":"AA Leahy","year":"2015","unstructured":"Leahy AA, Esfahani SA, Foote AT, Hui CK, Rainbow RS, Nakamura DS, et al. Analysis of the trajectory of osteoarthritis development in a mouse model by serial near-infrared fluorescence imaging of matrix metalloproteinase activities. Arthritis Rheumatol. 2015;67:442\u201353.","journal-title":"Arthritis Rheumatol."},{"key":"898_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2310\/7290.2014.00001","volume":"13","author":"EA Vermeij","year":"2014","unstructured":"Vermeij EA, Koenders MI, Blom AB, Arntz OJ, Bennink MB, van den Berg WB, et al. In vivo molecular imaging of cathepsin and matrix metalloproteinase activity discriminates between arthritic and osteoarthritic processes in mice. Mol Imaging. 2014;13:1\u201310.","journal-title":"Mol Imaging."},{"key":"898_CR43","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.joca.2014.04.006","volume":"22","author":"NH Lim","year":"2014","unstructured":"Lim NH, Meinjohanns E, Meldal M, Bou-Gharios G, Nagase H. In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis. Osteoarthritis Cartilage. 2014;22:862\u20138.","journal-title":"Osteoarthritis Cartilage."},{"key":"898_CR44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jor.22223","volume":"31","author":"KJ Wolff","year":"2013","unstructured":"Wolff KJ, Ramakrishnan PS, Brouillette MJ, Journot BJ, McKinley TO, Buckwalter JA, et al. Mechanical stress and ATP synthesis are coupled by mitochondrial oxidants in articular cartilage. J Orthop Res. 2013;31:191\u20136.","journal-title":"J Orthop Res."}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-015-0898-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T18:58:28Z","timestamp":1567450708000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.com\/content\/17\/1\/376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["898"],"URL":"https:\/\/doi.org\/10.1186\/s13075-015-0898-5","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"376"}}