{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:56Z","timestamp":1790812736715,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T00:00:00Z","timestamp":1463788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T00:00:00Z","timestamp":1463788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13075-016-1013-2","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T05:33:44Z","timestamp":1463981624000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis"],"prefix":"10.1186","volume":"18","author":[{"given":"Masaru","family":"Takeshita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Shimazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Otomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Kabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Narimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,21]]},"reference":[{"key":"1013_CR1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205\u201319.","journal-title":"N Engl J Med."},{"key":"1013_CR2","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1136\/ard.2009.123976","volume":"69","author":"M Schoels","year":"2010","unstructured":"Schoels M, Knevel R, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas DT, et al. Evidence for treating rheumatoid arthritis to target: results of a systematic literature search. Ann Rheum Dis. 2010;69:638\u201343.","journal-title":"Ann Rheum Dis."},{"key":"1013_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/annrheumdis-2015-207524","volume":"75","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Breedveld FC, Burmester GR, Bykerk V, Dougados M, Emery P, et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75:3\u201315.","journal-title":"Ann Rheum Dis."},{"key":"1013_CR4","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1002\/1529-0131(199810)41:10<1845::AID-ART17>3.3.CO;2-B","volume":"41","author":"AM van Gestel","year":"1998","unstructured":"van Gestel AM, Haagsma CJ, van Riel PL. Validation of rheumatoid arthritis improvement criteria that include simplified joint counts. Arthritis Rheum. 1998;41:1845\u201350.","journal-title":"Arthritis Rheum."},{"key":"1013_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"ML Prevoo","year":"1995","unstructured":"Prevoo ML, van \u2019t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:44\u20138.","journal-title":"Arthritis Rheum"},{"key":"1013_CR6","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/rheumatology\/keg072","volume":"42","author":"JS Smolen","year":"2003","unstructured":"Smolen JS. A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology. 2003;42:244\u201357.","journal-title":"Rheumatology."},{"key":"1013_CR7","doi-asserted-by":"publisher","first-page":"R796","DOI":"10.1186\/ar1740","volume":"7","author":"D Aletaha","year":"2005","unstructured":"Aletaha D, Nell VP, Stamm T, Uffmann M, Pflugbeil S, Machold K, et al. Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther. 2005;7:R796\u2013806.","journal-title":"Arthritis Res Ther."},{"key":"1013_CR8","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1016\/S0021-9258(18)67011-5","volume":"261","author":"Y Okada","year":"1986","unstructured":"Okada Y, Nagase H, Harris Jr ED. A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components: purification and characterization. J Biol Chem. 1986;261:14245\u201355.","journal-title":"J Biol Chem."},{"key":"1013_CR9","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1136\/ard.59.6.455","volume":"59","author":"Y Yoshihara","year":"2000","unstructured":"Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K, et al. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis. 2000;59:455\u201361.","journal-title":"Ann Rheum Dis."},{"key":"1013_CR10","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1136\/ard.61.2.161","volume":"61","author":"C Ribbens","year":"2002","unstructured":"Ribbens C, Martin y Porras M, Franchimont N, Kaiser MJ, Jaspar JM, Damas P, et al. Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Ann Rheum Dis. 2002;61:161\u20136.","journal-title":"Ann Rheum Dis"},{"key":"1013_CR11","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1136\/ard.53.11.768","volume":"53","author":"DJ Taylor","year":"1994","unstructured":"Taylor DJ, Cheung NT, Dawes PT. Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity. Ann Rheum Dis. 1994;53:768\u201372.","journal-title":"Ann Rheum Dis."},{"key":"1013_CR12","first-page":"251","volume":"26","author":"G Keyszer","year":"1999","unstructured":"Keyszer G, Lambiri I, Nagel R, Keysser C, Keysser M, Gromnica-Ihle E, et al. Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1\/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers. J Rheumatol. 1999;26:251\u20138.","journal-title":"J Rheumatol"},{"key":"1013_CR13","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s00296-007-0338-1","volume":"27","author":"A Ate\u015f","year":"2007","unstructured":"Ate\u015f A, T\u00fcrk\u00e7apar N, Olmez U, Tiryaki O, D\u00fczg\u00fcn N, U\u011fuz E, et al. Serum pro-matrix metalloproteinase-3 as an indicator of disease activity and severity in rheumatoid arthritis: comparison with traditional markers. Rheumatol Int. 2007;27:715\u201322.","journal-title":"Rheumatol Int."},{"key":"1013_CR14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/978-1-4939-1292-6_23","volume":"1200","author":"A Kuno","year":"2014","unstructured":"Kuno A, Matsuda A, Unno S, Tan B, Hirabayashi J, Narimatsu H. Differential glycan analysis of an endogenous glycoprotein: toward clinical implementation\u2014from sample pretreatment to data standardization. Methods Mol Biol. 2014;1200:265\u201385.","journal-title":"Methods Mol Biol."},{"key":"1013_CR15","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1111\/j.1572-0241.1999.01378.x","volume":"94","author":"K Hayashi","year":"1999","unstructured":"Hayashi K, Kumada T, Nakano S, Takeda I, Sugiyama K, Kiriyama S, et al. Usefulness of measurement of Lens culinaris agglutinin-reactive fraction of \u03b1-fetoprotein as a marker of prognosis and recurrence of small hepatocellular carcinoma. Am J Gastroenterol. 1999;94:3028\u201333.","journal-title":"Am J Gastroenterol."},{"key":"1013_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1586\/14789450.2014.897611","volume":"11","author":"HA Badr","year":"2014","unstructured":"Badr HA, Alsadek DM, Darwish AA, Elsayed AI, Bekmanov BO, Khussainova EM, et al. Lectin approaches for glycoproteomics in FDA-approved cancer biomarkers. Expert Rev Proteomics. 2014;11:227\u201336.","journal-title":"Expert Rev Proteomics."},{"key":"1013_CR17","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/srep01065","volume":"3","author":"A Kuno","year":"2013","unstructured":"Kuno A, Ikehara Y, Tanaka Y, Ito K, Matsuda A, Sekiya S, et al. A serum \u201csweet-doughnut\u201d protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis. Sci Rep. 2013;3:1065.","journal-title":"Sci Rep."},{"key":"1013_CR18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1023\/B:GLYC.0000014085.00706.d4","volume":"19","author":"A Grassadonia","year":"2004","unstructured":"Grassadonia A, Tinari N, Iurisci I, Piccolo E, Cumashi A, Innominato P, et al. 90 K (Mac-2 BP) and galectins in tumor progression and metastasis. Glycoconj J. 2004;19:551\u20136.","journal-title":"Glycoconj J."},{"key":"1013_CR19","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham 3rd CO, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69:1580\u20138.","journal-title":"Ann Rheum Dis."},{"key":"1013_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091079","volume":"9","author":"Y Narimatsu","year":"2014","unstructured":"Narimatsu Y, Kuno A, Ito H, Kaji H, Kaneko S, Usui J, et al. IgA nephropathy caused by unusual polymerization of IgA1 with aberrant N-glycosylation in a patient with monoclonal immunoglobulin deposition disease. PLoS One. 2014;9:e91079.","journal-title":"PLoS One."},{"key":"1013_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1074\/mcp.M800308-MCP200","volume":"8","author":"A Kuno","year":"2009","unstructured":"Kuno A, Kato Y, Matsuda A, Kaneko MK, Ito H, Amano K, et al. Focused differential glycan analysis with the platform antibody-assisted lectin profiling for glycan-related biomarker verification. Mol Cell Proteomics. 2009;8:99\u2013108.","journal-title":"Mol Cell Proteomics."},{"key":"1013_CR22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.colsurfb.2008.01.013","volume":"64","author":"K Nishio","year":"2008","unstructured":"Nishio K, Masaike Y, Ikeda M, Narimatsu H, Gokon N, Tsubouchi S, et al. Development of novel magnetic nano-carriers for high-performance affinity purification. Colloids Surf B Biointerfaces. 2008;64:162\u20139.","journal-title":"Colloids Surf B Biointerfaces."},{"key":"1013_CR23","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1023\/A:1018558225454","volume":"14","author":"F Yagi","year":"1997","unstructured":"Yagi F, Miyamoto M, Abe T, Minami Y, Tadera K, Goldstein IJ. Purification and carbohydrate-binding specificity of Agrocybe cylindracea lectin. Glycoconj J. 1997;14:281\u20138.","journal-title":"Glycoconj J."},{"key":"1013_CR24","doi-asserted-by":"publisher","first-page":"7274","DOI":"10.1021\/acs.analchem.5b01329","volume":"87","author":"A Matsuda","year":"2015","unstructured":"Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, et al. Lectin microarray-based sero-biomarker verification targeting aberrant O-linked glycosylation on mucin 1. Anal Chem. 2015;87:7274\u201381.","journal-title":"Anal Chem."},{"key":"1013_CR25","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/316452a0","volume":"316","author":"RB Parekh","year":"1985","unstructured":"Parekh RB, Dwek RA, Sutton BJ, Fernandes DL, Leung A, Stanworth D, et al. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature. 1985;316:452\u20137.","journal-title":"Nature."},{"key":"1013_CR26","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1021\/pr900913k","volume":"9","author":"Y Wada","year":"2010","unstructured":"Wada Y, Tajiri M, Ohshima S. Quantitation of saccharide compositions of O-glycans by mass spectrometry of glycopeptides and its application to rheumatoid arthritis. J Proteome Res. 2010;9:1367\u201373.","journal-title":"J Proteome Res."},{"key":"1013_CR27","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1136\/annrheumdis-2014-206598","volume":"75","author":"Y Rombouts","year":"2016","unstructured":"Rombouts Y, Willemze A, van Beers JJ, Shi J, Kerkman PF, van Toorn L, et al. Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis. Ann Rheum Dis. 2016;75:578\u201385.","journal-title":"Ann Rheum Dis."},{"key":"1013_CR28","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1002\/acr.21767","volume":"64","author":"JR Curtis","year":"2012","unstructured":"Curtis JR, van der Helm-van Mil AH, Knevel R, Huizinga TW, Haney DJ, Shen Y, et al. Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity. Arthritis Care Res (Hoboken). 2012;64:1794\u2013803.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1013_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060635","volume":"8","author":"M Centola","year":"2013","unstructured":"Centola M, Cavet G, Shen Y, Ramanujan S, Knowlton N, Swan KA, et al. Development of a multi-biomarker disease activity test for rheumatoid arthritis. PLoS One. 2013;8, e60635.","journal-title":"PLoS One."},{"key":"1013_CR30","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1136\/ard.2009.118919","volume":"69","author":"S Serada","year":"2010","unstructured":"Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, et al. iTRAQ-based proteomic identification of leucine-rich \u03b1-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases. Ann Rheum Dis. 2010;69:770\u20134.","journal-title":"Ann Rheum Dis."},{"key":"1013_CR31","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1093\/rheumatology\/38.11.1081","volume":"38","author":"MD Posthumus","year":"1999","unstructured":"Posthumus MD, Limburg PC, Westra J, Cats HA, Stewart RE, van Leeuwen MA, et al. Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis. Rheumatology (Oxford). 1999;38:1081\u20137.","journal-title":"Rheumatology (Oxford)"},{"key":"1013_CR32","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1002\/art.22923","volume":"56","author":"S Young-Min","year":"2007","unstructured":"Young-Min S, Cawston T, Marshall N, Coady D, Christgau S, Saxne T, et al. Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers. Arthritis Rheum. 2007;56:3236\u201347.","journal-title":"Arthritis Rheum."},{"key":"1013_CR33","doi-asserted-by":"publisher","first-page":"R30","DOI":"10.1186\/ar3734","volume":"14","author":"M Houseman","year":"2012","unstructured":"Houseman M, Potter C, Marshall N, Lakey R, Cawston T, Griffiths I, et al. Baseline serum MMP-3 levels in patients with rheumatoid arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Arthritis Res Ther. 2012;14:R30.","journal-title":"Arthritis Res Ther."}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-016-1013-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-016-1013-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-016-1013-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-016-1013-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T21:56:24Z","timestamp":1656539784000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-016-1013-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,21]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1013"],"URL":"https:\/\/doi.org\/10.1186\/s13075-016-1013-2","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,21]]},"assertion":[{"value":"24 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"112"}}