{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:33:42Z","timestamp":1789832022942,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research","award":["26461469"],"award-info":[{"award-number":["26461469"]}]},{"name":"Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research","award":["26461468"],"award-info":[{"award-number":["26461468"]}]},{"name":"Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research","award":["26713036"],"award-info":[{"award-number":["26713036"]}]},{"name":"Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research","award":["15K15374"],"award-info":[{"award-number":["15K15374"]}]},{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Takeda Science Foundation, and Yokohama Foundation for Advancement of Medical Science."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13075-016-1115-x","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T07:32:50Z","timestamp":1475479970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Continuous evolution of clinical phenotype in 578 Japanese patients with Beh\u00e7et\u2019s disease: a retrospective observational study"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-661X","authenticated-orcid":false,"given":"Yohei","family":"Kirino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Ideguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Takeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Higashitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kunishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Takase-Minegishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maasa","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Asami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeaki","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Yoshimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ihata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhisa","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Ishigatsubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"issue":"17","key":"1115_CR1","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.2165\/11641370-000000000-00000","volume":"72","author":"SR Dalvi","year":"2012","unstructured":"Dalvi SR, Yildirim R, Yazici Y. Behcet's Syndrome. Drugs. 2012;72(17):2223\u201341.","journal-title":"Drugs"},{"issue":"1","key":"1115_CR2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0003-9969(90)90113-O","volume":"35","author":"E Isogai","year":"1990","unstructured":"Isogai E, Ohno S, Kotake S, Isogai H, Tsurumizu T, Fujii N, Yokota K, Syuto B, Yamaguchi M, Matsuda H, et al. Chemiluminescence of neutrophils from patients with Behcet's disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora. Arch Oral Biol. 1990;35(1):43\u20138.","journal-title":"Arch Oral Biol"},{"issue":"1","key":"1115_CR3","first-page":"21","volume":"8","author":"S Sohn","year":"1998","unstructured":"Sohn S, Lee ES, Bang D, Lee S. Behcet's disease-like symptoms induced by the Herpes simplex virus in ICR mice. Eur J Dermatol. 1998;8(1):21\u20133.","journal-title":"Eur J Dermatol"},{"issue":"20","key":"1115_CR4","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1073\/pnas.1306352110","volume":"110","author":"Y Kirino","year":"2013","unstructured":"Kirino Y, Zhou Q, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Ugurlu S, Erer B, Abaci N, et al. Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease. Proc Natl Acad Sci U S A. 2013;110(20):8134\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1115_CR5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"JL Round","year":"2009","unstructured":"Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9(5):313\u201323.","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"1115_CR6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.autrev.2014.11.009","volume":"14","author":"C Consolandi","year":"2015","unstructured":"Consolandi C, Turroni S, Emmi G, Severgnini M, Fiori J, Peano C, Biagi E, Grassi A, Rampelli S, Silvestri E, et al. Behcet's syndrome patients exhibit specific microbiome signature. Autoimmun Rev. 2015;14(4):269\u201376.","journal-title":"Autoimmun Rev"},{"issue":"4","key":"1115_CR7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1076\/ocii.11.4.277.18260","volume":"11","author":"T Wakabayashi","year":"2003","unstructured":"Wakabayashi T, Morimura Y, Miyamoto Y, Okada AA. Changing patterns of intraocular inflammatory disease in Japan. Ocul Immunol Inflamm. 2003;11(4):277\u201386.","journal-title":"Ocul Immunol Inflamm"},{"key":"1115_CR8","doi-asserted-by":"crossref","unstructured":"Ideguchi H, Suda A, Takeno M, Ueda A, Ohno S, Ishigatsubo Y. Behcet disease: evolution of clinical manifestations. Medicine (Baltimore). 2011;90(2):125-132.","DOI":"10.1097\/MD.0b013e318211bf28"},{"issue":"2","key":"1115_CR9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/bjd.12661","volume":"170","author":"DY Kim","year":"2014","unstructured":"Kim DY, Choi MJ, Cho S, Kim DW, Bang D. Changing clinical expression of Behcet disease in Korea during three decades (1983-2012): chronological analysis of 3674 hospital-based patients. Br J Dermatol. 2014;170(2):458\u201361.","journal-title":"Br J Dermatol"},{"key":"1115_CR10","first-page":"8","volume-title":"Guide for the diagnosis of Beh\u00e7et\u2019s disease","author":"Y Mizushima","year":"1987","unstructured":"Mizushima Y, Inaba G, Mimura Y. Guide for the diagnosis of Beh\u00e7et\u2019s disease. Japan: Report of Beh\u00e7et\u2019s Disease Research; 1987. p. 8\u201317."},{"key":"1115_CR11","unstructured":"Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet. 1990;335(8697):1078\u201380."},{"issue":"9","key":"1115_CR12","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1002\/art.27568","volume":"62","author":"D Saadoun","year":"2010","unstructured":"Saadoun D, Wechsler B, Desseaux K, Le Thi HD, Amoura Z, Resche-Rigon M, Cacoub P. Mortality in Behcet's disease. Arthritis Rheum. 2010;62(9):2806\u201312.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"1115_CR13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/rheumatology\/keu247","volume":"54","author":"NG Bonitsis","year":"2015","unstructured":"Bonitsis NG, Luong Nguyen LB, LaValley MP, Papoutsis N, Altenburg A, Kotter I, Micheli C, Maldini C, Mahr A, Zouboulis CC. Gender-specific differences in Adamantiades-Behcet's disease manifestations: an analysis of the German registry and meta-analysis of data from the literature. Rheumatology (Oxford). 2015;54(1):121\u201333.","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"1115_CR14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/rheumatology\/ker428","volume":"51","author":"C Maldini","year":"2012","unstructured":"Maldini C, Lavalley MP, Cheminant M, de Menthon M, Mahr A. Relationships of HLA-B51 or B5 genotype with Behcet's disease clinical characteristics: systematic review and meta-analyses of observational studies. Rheumatology (Oxford). 2012;51(5):887\u2013900.","journal-title":"Rheumatology (Oxford)"},{"key":"1115_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-4-431-54487-6","volume-title":"Beh\u00e7et's Disease: From Genetics to Therapies","author":"Y Ishigatsubo","year":"2015","unstructured":"Ishigatsubo Y, Takeno M. Overview. In: Ishigatsubo Y, editor. Beh\u00e7et's Disease: From Genetics to Therapies. Tokyo: Springer Japan; 2015. p. 1\u201320."},{"issue":"6","key":"1115_CR16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00296-013-2838-5","volume":"34","author":"H Ideguchi","year":"2014","unstructured":"Ideguchi H, Suda A, Takeno M, Miyagi R, Ueda A, Ohno S, Ishigatsubo Y. Gastrointestinal manifestations of Behcet's disease in Japan: a study of 43 patients. Rheumatol Int. 2014;34(6):851\u20136.","journal-title":"Rheumatol Int"},{"issue":"4","key":"1115_CR17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/art.1780400425","volume":"40","author":"V Hamuryudan","year":"1997","unstructured":"Hamuryudan V, Ozyazgan Y, Hizli N, Mat C, Yurdakul S, Tuzun Y, Senocak M, Yazici H. Azathioprine in Behcet's syndrome: effects on long-term prognosis. Arthritis Rheum. 1997;40(4):769\u201374.","journal-title":"Arthritis Rheum"},{"issue":"4","key":"1115_CR18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1755-3768.2008.01282.x","volume":"87","author":"H Kitamei","year":"2009","unstructured":"Kitamei H, Kitaichi N, Namba K, Kotake S, Goda C, Kitamura M, Miyazaki A, Ohno S. Clinical features of intraocular inflammation in Hokkaido, Japan. Acta Ophthalmol. 2009;87(4):424\u20138.","journal-title":"Acta Ophthalmol"},{"issue":"12","key":"1115_CR19","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1002\/art.24149","volume":"58","author":"A Mahr","year":"2008","unstructured":"Mahr A, Belarbi L, Wechsler B, Jeanneret D, Dhote R, Fain O, Lhote F, Ramanoelina J, Coste J, Guillevin L. Population-based prevalence study of Behcet's disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum. 2008;58(12):3951\u20139.","journal-title":"Arthritis Rheum"},{"issue":"7","key":"1115_CR20","first-page":"244","volume":"34","author":"T Hirohata","year":"1975","unstructured":"Hirohata T, Kuratsune M, Nomura A, Jimi S. Prevalence of Behcet's syndrome in Hawaii with particular reference to the comparison of the Japanese in Hawaii and Japan. Hawaii Med J. 1975;34(7):244\u20136.","journal-title":"Hawaii Med J"},{"issue":"6","key":"1115_CR21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3349\/ymj.1997.38.6.411","volume":"38","author":"CC Zouboulis","year":"1997","unstructured":"Zouboulis CC, Kotter I, Djawari D, Kirch W, Kohl PK, Ochsendorf FR, Keitel W, Stadler R, Wollina U, Proksch E, et al. Epidemiological features of Adamantiades-Behcet's disease in Germany and in Europe. Yonsei Med J. 1997;38(6):411\u201322.","journal-title":"Yonsei Med J"},{"issue":"1","key":"1115_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03009740600991927","volume":"36","author":"KA Lewis","year":"2007","unstructured":"Lewis KA, Graham EM, Stanford MR. Systematic review of ethnic variation in the phenotype of Behcet's disease. Scand J Rheumatol. 2007;36(1):1\u20136.","journal-title":"Scand J Rheumatol"},{"issue":"4 Suppl 45","key":"1115_CR23","first-page":"S27","volume":"25","author":"G Mumcu","year":"2007","unstructured":"Mumcu G, Inanc N, Yavuz S, Direskeneli H. The role of infectious agents in the pathogenesis, clinical manifestations and treatment strategies in Behcet's disease. Clin Exp Rheumatol. 2007;25(4 Suppl 45):S27\u201333.","journal-title":"Clin Exp Rheumatol"},{"issue":"4 Suppl 60","key":"1115_CR24","first-page":"S2","volume":"28","author":"H Behcet","year":"2010","unstructured":"Behcet H, Matteson EL. On relapsing, aphthous ulcers of the mouth, eye and genitalia caused by a virus. Clin Exp Rheumatol. 2010;28(4 Suppl 60):S2\u20135.","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"1115_CR25","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/IAI.59.4.1434-1441.1991","volume":"59","author":"T Lehner","year":"1991","unstructured":"Lehner T, Lavery E, Smith R, van der Zee R, Mizushima Y, Shinnick T. Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behcet's syndrome. Infect Immun. 1991;59(4):1434\u201341.","journal-title":"Infect Immun"},{"issue":"5 Suppl 24","key":"1115_CR26","first-page":"S77","volume":"19","author":"SW Rizvi","year":"2001","unstructured":"Rizvi SW, McGrath Jr H. The therapeutic effect of cigarette smoking on oral\/genital aphthosis and other manifestations of Behcet's disease. Clin Exp Rheumatol. 2001;19(5 Suppl 24):S77\u20138.","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"1115_CR27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/imr.12379","volume":"269","author":"AI Catrina","year":"2016","unstructured":"Catrina AI, Joshua V, Klareskog L, Malmstrom V. Mechanisms involved in triggering rheumatoid arthritis. Immunol Rev. 2016;269(1):162\u201374.","journal-title":"Immunol Rev"},{"issue":"6","key":"1115_CR28","first-page":"1029","volume":"15","author":"Y Mizushima","year":"1988","unstructured":"Mizushima Y, Matsuda T, Hoshi K, Ohno S. Induction of Behcet's disease symptoms after dental treatment and streptococcal antigen skin test. J Rheumatol. 1988;15(6):1029\u201330.","journal-title":"J Rheumatol"},{"issue":"1","key":"1115_CR29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3346\/jkms.2010.25.1.185","volume":"25","author":"SM Choi","year":"2010","unstructured":"Choi SM, Choi YJ, Kim JT, Lee SH, Park MS, Kim BC, Kim MK, Cho KH. A case of recurrent neuro-Behcet's disease after tooth extraction. J Korean Med Sci. 2010;25(1):185\u20137.","journal-title":"J Korean Med Sci"},{"issue":"8","key":"1115_CR30","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","volume":"42","author":"EF Remmers","year":"2010","unstructured":"Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease. Nat Genet. 2010;42(8):698\u2013702.","journal-title":"Nat Genet"},{"issue":"8","key":"1115_CR31","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","volume":"42","author":"N Mizuki","year":"2010","unstructured":"Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K, et al. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. Nat Genet. 2010;42(8):703\u20136.","journal-title":"Nat Genet"},{"issue":"10","key":"1115_CR32","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1038\/ajg.2009.331","volume":"104","author":"JH Cheon","year":"2009","unstructured":"Cheon JH, Kim ES, Shin SJ, Kim TI, Lee KM, Kim SW, Kim JS, Kim YS, Choi CH, Ye BD, et al. Development and validation of novel diagnostic criteria for intestinal Behcet's disease in Korean patients with ileocolonic ulcers. Am J Gastroenterol. 2009;104(10):2492\u20139.","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"1115_CR33","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/ajcn\/63.5.741","volume":"63","author":"R Shoda","year":"1996","unstructured":"Shoda R, Matsueda K, Yamato S, Umeda N. Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. Am J Clin Nutr. 1996;63(5):741\u20135.","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"1115_CR34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00535-009-0057-3","volume":"44","author":"K Asakura","year":"2009","unstructured":"Asakura K, Nishiwaki Y, Inoue N, Hibi T, Watanabe M, Takebayashi T. Prevalence of ulcerative colitis and Crohn's disease in Japan. J Gastroenterol. 2009;44(7):659\u201365.","journal-title":"J Gastroenterol"},{"issue":"3 Suppl 77","key":"1115_CR35","first-page":"96","volume":"31","author":"C Magro-Checa","year":"2013","unstructured":"Magro-Checa C, Salvatierra J, Rosales-Alexander JL, Orgaz-Molina J, Raya-Alvarez E. Life-threatening vasculo-Behcet following discontinuation of infliximab after three years of complete remission. Clin Exp Rheumatol. 2013;31(3 Suppl 77):96\u20138.","journal-title":"Clin Exp Rheumatol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-016-1115-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:26:27Z","timestamp":1692509187000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-016-1115-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1115"],"URL":"https:\/\/doi.org\/10.1186\/s13075-016-1115-x","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]},"article-number":"217"}}