{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:26:43Z","timestamp":1788960403879,"version":"build-2803163510"},"reference-count":110,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DA 1143\/4-2"],"award-info":[{"award-number":["DA 1143\/4-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1009\/A11"],"award-info":[{"award-number":["SFB 1009\/A11"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13075-016-1187-7","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T12:25:29Z","timestamp":1480595129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Smad-dependent mechanisms of inflammatory bone destruction"],"prefix":"10.1186","volume":"18","author":[{"given":"Michelle","family":"Fennen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berno","family":"Dankbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"issue":"10","key":"1187_CR1","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/hmg\/8.10.1839","volume":"8","author":"F Lazner","year":"1999","unstructured":"Lazner F, Gowen M, Pavasovic D, Kola I. Osteopetrosis and osteoporosis: two sides of the same coin. Hum Mol Genet. 1999;8(10):1839\u201346.","journal-title":"Hum Mol Genet"},{"key":"1187_CR2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1196\/annals.1365.035","volume":"1092","author":"DJ Hadjidakis","year":"2006","unstructured":"Hadjidakis DJ, Androulakis II. Bone remodeling. Ann N Y Acad Sci. 2006;1092:385\u201396.","journal-title":"Ann N Y Acad Sci."},{"issue":"1","key":"1187_CR3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2005.11.007","volume":"12","author":"T Wada","year":"2006","unstructured":"Wada T, Nakashima T, Hiroshi N, Penninger JM. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 2006;12(1):17\u201325.","journal-title":"Trends Mol Med"},{"issue":"6937","key":"1187_CR4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423(6937):337\u201342. doi: 10.1038\/nature01658 .","journal-title":"Nature"},{"issue":"2","key":"1187_CR5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/rheumatology\/39.2.122","volume":"39","author":"DL Scott","year":"2000","unstructured":"Scott DL, Pugner K, Kaarela K, et al. The links between joint damage and disability in rheumatoid arthritis. Rheumatology (Oxford). 2000;39(2):122\u201332.","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"1187_CR6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/rheumatology\/kel065","volume":"45","author":"LC Huber","year":"2006","unstructured":"Huber LC, Distler O, Tarner I, Gay RE, Gay S, Pap T. Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford). 2006;45(6):669\u201375.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"1187_CR7","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/00002281-200207000-00013","volume":"14","author":"SR Goldring","year":"2002","unstructured":"Goldring SR. Pathogenesis of bone erosions in rheumatoid arthritis. Curr Opin Rheumatol. 2002;14(4):406\u201310.","journal-title":"Curr Opin Rheumatol"},{"issue":"9","key":"1187_CR8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/art.1780270902","volume":"27","author":"M Bromley","year":"1984","unstructured":"Bromley M, Woolley DE. Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint. Arthritis Rheum. 1984;27(9):968\u201375.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"1187_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00223-002-1049-y","volume":"73","author":"SR Goldring","year":"2003","unstructured":"Goldring SR. Inflammatory mediators as essential elements in bone remodeling. Calcif Tissue Int. 2003;73(2):97\u2013100. doi: 10.1007\/s00223-002-1049-y .","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"1187_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jbspin.2007.10.005","volume":"75","author":"K Polzer","year":"2008","unstructured":"Polzer K, Diarra D, Zwerina J, Schett G. Inflammation and destruction of the joints--the wnt pathway. Joint Bone Spine. 2008;75(2):105\u20137. doi: 10.1016\/j.jbspin.2007.10.005 .","journal-title":"Joint Bone Spine"},{"issue":"1","key":"1187_CR11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/ar2110","volume":"9","author":"G Schett","year":"2007","unstructured":"Schett G. Cells of the synovium in rheumatoid arthritis. Osteoclasts Arthritis Res Ther. 2007;9(1):203.","journal-title":"Osteoclasts. Arthritis Res Ther."},{"issue":"3","key":"1187_CR12","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrd3669","volume":"11","author":"K Redlich","year":"2012","unstructured":"Redlich K, Smolen JS. Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov. 2012;11(3):234\u201350. doi: 10.1038\/nrd3669 .","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"1187_CR13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1034\/j.1601-0825.2002.01829.x","volume":"8","author":"T Katagiri","year":"2002","unstructured":"Katagiri T, Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis. 2002;8(3):147\u201359.","journal-title":"Oral Dis"},{"issue":"3","key":"1187_CR14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1006\/bbrc.1998.9723","volume":"252","author":"T Murakami","year":"1998","unstructured":"Murakami T, Yamamoto M, Ono K, et al. Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic\/stromal cells and inhibits the survival of murine osteoclast-like cells. Biochem Biophys Res Commun. 1998;252(3):747\u201352.","journal-title":"Biochem Biophys Res Commun"},{"issue":"42","key":"1187_CR15","doi-asserted-by":"crossref","first-page":"27091","DOI":"10.1074\/jbc.273.42.27091","volume":"273","author":"H Takai","year":"1998","unstructured":"Takai H, Kanematsu M, Yano K, et al. Transforming growth factor-beta stimulates the production of osteoprotegerin\/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J Biol Chem. 1998;273(42):27091\u20136.","journal-title":"J Biol Chem"},{"issue":"10","key":"1187_CR16","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1359\/jbmr.2001.16.10.1787","volume":"16","author":"JM Quinn","year":"2001","unstructured":"Quinn JM, Itoh K, Udagawa N, et al. Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions. J Bone Miner Res. 2001;16(10):1787\u201394. doi: 10.1359\/jbmr.2001.16.10.1787 .","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"1187_CR17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar2165","volume":"9","author":"BF Boyce","year":"2007","unstructured":"Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007;9 Suppl 1:S1.","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"1187_CR18","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1128\/MCB.22.4.992-1000.2002","volume":"22","author":"J Mizukami","year":"2002","unstructured":"Mizukami J, Takaesu G, Akatsuka H, et al. Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol. 2002;22(4):992\u20131000.","journal-title":"Mol Cell Biol"},{"issue":"12","key":"1187_CR19","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1074\/jbc.274.12.7724","volume":"274","author":"BG Darnay","year":"1999","unstructured":"Darnay BG, Ni J, Moore PA, Aggarwal BB. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. identification of a novel TRAF6 interaction motif. J Biol Chem. 1999;274(12):7724\u201331.","journal-title":"J Biol Chem"},{"issue":"7","key":"1187_CR20","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/jbmr.357","volume":"26","author":"T Yasui","year":"2011","unstructured":"Yasui T, Kadono Y, Nakamura M, et al. Regulation of RANKL-induced osteoclastogenesis by TGF-beta through molecular interaction between Smad3 and Traf6. J Bone Miner Res. 2011;26(7):1447\u201356. doi: 10.1002\/jbmr.357 .","journal-title":"J Bone Miner Res"},{"issue":"4","key":"1187_CR21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","volume":"7","author":"H Takayanagi","year":"2007","unstructured":"Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 2007;7(4):292\u2013304.","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"1187_CR22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","volume":"3","author":"H Takayanagi","year":"2002","unstructured":"Takayanagi H, Kim S, Koga T, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. 2002;3(6):889\u2013901.","journal-title":"Dev Cell"},{"issue":"6","key":"1187_CR23","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S1097-2765(00)80232-4","volume":"4","author":"BR Wong","year":"1999","unstructured":"Wong BR, Besser D, Kim N, et al. TRANCE, a TNF family member, activates akt\/PKB through a signaling complex involving TRAF6 and c-src. Mol Cell. 1999;4(6):1041\u20139.","journal-title":"Mol Cell"},{"issue":"1","key":"1187_CR24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/wdev.86","volume":"2","author":"A Weiss","year":"2013","unstructured":"Weiss A, Attisano L. The TGFbeta superfamily signaling pathway. Wiley Interdiscip Rev Dev Biol. 2013;2(1):47\u201363. doi: 10.1002\/wdev.86 .","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"14","key":"1187_CR25","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.febslet.2012.05.010","volume":"586","author":"P Xu","year":"2012","unstructured":"Xu P, Liu J, Derynck R. Post-translational regulation of TGF-beta receptor and smad signaling. FEBS Lett. 2012;586(14):1871\u201384. doi: 10.1016\/j.febslet.2012.05.010 .","journal-title":"FEBS Lett"},{"key":"1187_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/9780470015902.a0002330.pub3","author":"DJJ Gorter de","year":"2001","unstructured":"de Gorter DJJ, van Bezooijen RL, ten Dijke P. Bone morphogenetic proteins and their receptors. eLS. 2001. doi: 10.1002\/9780470015902.a0002330.pub3 .","journal-title":"eLS"},{"issue":"10","key":"1187_CR27","doi-asserted-by":"publisher","first-page":"a011197","DOI":"10.1101\/cshperspect.a011197","volume":"5","author":"JL Wrana","year":"2013","unstructured":"Wrana JL. Signaling by the TGFbeta superfamily. Cold Spring Harb Perspect Biol. 2013;5(10):a011197. doi: 10.1101\/cshperspect.a011197 .","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"5","key":"1187_CR28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tibs.2004.03.008","volume":"29","author":"P Dijke ten","year":"2004","unstructured":"ten Dijke P, Hill CS. New insights into TGF-\u03b2\u2013Smad signalling. Trends Biochem Sci. 2004;29(5):265\u201373.","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"1187_CR29","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"J Massague","year":"2012","unstructured":"Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol. 2012;13(10):616\u201330. doi: 10.1038\/nrm3434 .","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"16","key":"1187_CR30","doi-asserted-by":"publisher","first-page":"12477","DOI":"10.1074\/jbc.C100008200","volume":"276","author":"T Ebisawa","year":"2001","unstructured":"Ebisawa T, Fukuchi M, Murakami G, et al. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem. 2001;276(16):12477\u201380. doi: 10.1074\/jbc.C100008200 .","journal-title":"J Biol Chem"},{"issue":"6","key":"1187_CR31","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S1097-2765(00)00134-9","volume":"6","author":"P Kavsak","year":"2000","unstructured":"Kavsak P, Rasmussen RK, Causing CG, et al. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell. 2000;6(6):1365\u201375.","journal-title":"Mol Cell"},{"key":"1187_CR32","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fphys.2015.00082","volume":"6","author":"XM Meng","year":"2015","unstructured":"Meng XM, Tang PM, Li J, Lan HY. TGF-beta\/smad signaling in renal fibrosis. Front Physiol. 2015;6:82. doi: 10.3389\/fphys.2015.00082 .","journal-title":"Front Physiol."},{"issue":"6","key":"1187_CR33","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1210\/er.2004-0001","volume":"26","author":"K Janssens","year":"2005","unstructured":"Janssens K, ten Dijke P, Janssens S, Van Hul W. Transforming growth factor-beta1 to the bone. Endocr Rev. 2005;26(6):743\u201374.","journal-title":"Endocr Rev"},{"issue":"3","key":"1187_CR34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.reuma.2014.01.009","volume":"10","author":"E Gonzalo-Gil","year":"2014","unstructured":"Gonzalo-Gil E, Galindo-Izquierdo M. Role of transforming growth factor-beta (TGF) beta in the physiopathology of rheumatoid arthritis. Reumatol Clin. 2014;10(3):174\u20139. doi: 10.1016\/j.reuma.2014.01.009 .","journal-title":"Reumatol Clin"},{"issue":"4","key":"1187_CR35","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1083\/jcb.115.4.1091","volume":"115","author":"RW Pelton","year":"1991","unstructured":"Pelton RW, Saxena B, Jones M, et al. Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol. 1991;115(4):1091\u2013105.","journal-title":"J Cell Biol"},{"issue":"2","key":"1187_CR36","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.108.2.661","volume":"108","author":"NL Thompson","year":"1989","unstructured":"Thompson NL, Flanders KC, Smith JM, et al. Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice. J Cell Biol. 1989;108(2):661\u20139.","journal-title":"J Cell Biol"},{"issue":"Pt 13","key":"1187_CR37","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1242\/jcs.113.13.2445","volume":"113","author":"K Fuller","year":"2000","unstructured":"Fuller K, Lean JM, Bayley KE, et al. A role for TGFbeta(1) in osteoclast differentiation and survival. J Cell Sci. 2000;113(Pt 13):2445\u201353.","journal-title":"J Cell Sci"},{"issue":"2","key":"1187_CR38","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jcb.1200","volume":"83","author":"T Yan","year":"2001","unstructured":"Yan T, Riggs B, Boyle W, Khosla S. Regulation of osteoclastogenesis and RANK expression by TGF-\u03b21. J Cell Biochem. 2001;83(2):320\u20135.","journal-title":"J Cell Biochem"},{"issue":"5","key":"1187_CR39","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/jbmr.2418","volume":"30","author":"Y Omata","year":"2015","unstructured":"Omata Y, Yasui T, Hirose J, et al. Genomewide comprehensive analysis reveals critical cooperation between smad and c-fos in RANKL-induced osteoclastogenesis. J Bone Miner Res. 2015;30(5):869\u201377. doi: 10.1002\/jbmr.2418 .","journal-title":"J Bone Miner Res"},{"issue":"15","key":"1187_CR40","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1016\/j.yexcr.2008.06.006","volume":"314","author":"A Gingery","year":"2008","unstructured":"Gingery A, Bradley EW, Pederson L, et al. TGF-beta coordinately activates TAK1\/MEK\/AKT\/NFkB and SMAD pathways to promote osteoclast survival. Exp Cell Res. 2008;314(15):2725\u201338. doi: 10.1016\/j.yexcr.2008.06.006 .","journal-title":"Exp Cell Res"},{"issue":"2","key":"1187_CR41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/clin.1995.1114","volume":"76","author":"Z Szekanecz","year":"1995","unstructured":"Szekanecz Z, Haines GK, Harlow LA, et al. Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis: Possible interactions in the pathogenesis of the disease. Clin Immunol Immunopathol. 1995;76(2):187\u201394.","journal-title":"Clin Immunol Immunopathol"},{"issue":"2","key":"1187_CR42","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1365-2249.1990.tb03331.x","volume":"81","author":"FM Brennan","year":"1990","unstructured":"Brennan FM, Chantry D, Turner M, et al. Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: Lack of effect on spontaneous cytokine production in joint cell cultures. Clin Exp Immunol. 1990;81(2):278\u201385.","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"1187_CR43","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1073\/pnas.88.7.2918","volume":"88","author":"AP Kuruvilla","year":"1991","unstructured":"Kuruvilla AP, Shah R, Hochwald GM, et al. Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice. Proc Natl Acad Sci U S A. 1991;88(7):2918\u201321.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"1187_CR44","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1002\/art.30326","volume":"63","author":"MJ Park","year":"2011","unstructured":"Park MJ, Park HS, Cho ML, et al. Transforming growth factor beta-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of treg\/Th17 cells and osteoclastogenesis. Arthritis Rheum. 2011;63(6):1668\u201380. doi: 10.1002\/art.30326 .","journal-title":"Arthritis Rheum"},{"issue":"6","key":"1187_CR45","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1172\/JCI19112","volume":"112","author":"D Sancho","year":"2003","unstructured":"Sancho D, Gomez M, Viedma F, et al. CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. J Clin Invest. 2003;112(6):872\u201382. doi: 10.1172\/JCI19112 .","journal-title":"J Clin Invest"},{"issue":"2","key":"1187_CR46","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/cei.12179","volume":"174","author":"E Gonzalo-Gil","year":"2013","unstructured":"Gonzalo-Gil E, Criado G, Santiago B, et al. Transforming growth factor (TGF)-beta signalling is increased in rheumatoid synovium but TGF-beta blockade does not modify experimental arthritis. Clin Exp Immunol. 2013;174(2):245\u201355. doi: 10.1111\/cei.12179 .","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"1187_CR47","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1084\/jem.173.5.1121","volume":"173","author":"RA Fava","year":"1991","unstructured":"Fava RA, Olsen NJ, Postlethwaite AE, et al. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: Implications for TGF-beta-driven synovial inflammation and hyperplasia. J Exp Med. 1991;173(5):1121\u201332.","journal-title":"J Exp Med"},{"issue":"1","key":"1187_CR48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1084\/jem.177.1.225","volume":"177","author":"SM Wahl","year":"1993","unstructured":"Wahl SM, Allen JB, Costa GL, et al. Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. J Exp Med. 1993;177(1):225\u201330.","journal-title":"J Exp Med"},{"issue":"3","key":"1187_CR49","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2249.2002.01785.x","volume":"127","author":"H Cheon","year":"2002","unstructured":"Cheon H, Yu SJ, Yoo DH, et al. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol. 2002;127(3):547\u201352.","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"1187_CR50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/intimm\/dxl128","volume":"19","author":"M Sakuma","year":"2007","unstructured":"Sakuma M, Hatsushika K, Koyama K, et al. TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol. 2007;19(2):117\u201326.","journal-title":"Int Immunol"},{"issue":"1","key":"1187_CR51","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1136\/annrheumdis-2014-205790","volume":"75","author":"SM Stanford","year":"2016","unstructured":"Stanford SM, Aleman Muench GR, Bartok B, et al. TGFbeta responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Ann Rheum Dis. 2016;75(1):295\u2013302. doi: 10.1136\/annrheumdis-2014-205790 .","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"1187_CR52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cyto.2007.09.014","volume":"41","author":"E Lubberts","year":"2008","unstructured":"Lubberts E. IL-17\/Th17 targeting: on the road to prevent chronic destructive arthritis? Cytokine. 2008;41(2):84\u201391.","journal-title":"Cytokine"},{"issue":"3","key":"1187_CR53","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.immuni.2011.03.005","volume":"34","author":"I Gutcher","year":"2011","unstructured":"Gutcher I, Donkor MK, Ma Q, et al. Autocrine transforming growth factor-\u03b21 promotes in vivo Th17 cell differentiation. Immunity. 2011;34(3):396\u2013408.","journal-title":"Immunity"},{"key":"1187_CR54","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3389\/fimmu.2015.00640","volume":"6","author":"A Wakkach","year":"2015","unstructured":"Wakkach A, Rouleau M, Blin-Wakkach C. Osteoimmune interactions in inflammatory bowel disease: Central role of bone marrow Th17 TNF\u03b1 cells in osteoclastogenesis. Front Immunol. 2015;6:640.","journal-title":"Front Immunol."},{"issue":"7","key":"1187_CR55","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrrheum.2015.53","volume":"11","author":"E Lubberts","year":"2015","unstructured":"Lubberts E. The IL-23-IL-17 axis in inflammatory arthritis. Nat Rev Rheumatol. 2015;11(7):415\u201329.","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"1187_CR56","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/1381612820666140825122247","volume":"21","author":"E Lubberts","year":"2015","unstructured":"Lubberts E. Role of T lymphocytes in the development of rheumatoid arthritis. implications for treatment. Curr Pharm Des. 2015;21(2):142\u20136.","journal-title":"Curr Pharm Des"},{"issue":"7090","key":"1187_CR57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"E Bettelli","year":"2006","unstructured":"Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235\u20138.","journal-title":"Nature"},{"issue":"6","key":"1187_CR58","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","volume":"126","author":"II Ivanov","year":"2006","unstructured":"Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor ROR\u03b3t directs the differentiation program of proinflammatory IL-17\u00a0T helper cells. Cell. 2006;126(6):1121\u201333.","journal-title":"Cell"},{"issue":"9","key":"1187_CR59","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/ni0907-903","volume":"8","author":"A Laurence","year":"2007","unstructured":"Laurence A, O\u2019Shea JJ. TH-17 differentiation: of mice and men. Nat Immunol. 2007;8(9):903\u20135.","journal-title":"Nat Immunol"},{"issue":"9","key":"1187_CR60","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ni1496","volume":"8","author":"EV Acosta-Rodriguez","year":"2007","unstructured":"Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1\u03b2 and 6 but not transforming growth factor-\u03b2 are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8(9):942\u20139.","journal-title":"Nat Immunol"},{"issue":"5","key":"1187_CR61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2502","volume":"10","author":"IE Adamopoulos","year":"2008","unstructured":"Adamopoulos IE, Bowman EP. Immune regulation of bone loss by Th17 cells. Arthritis Res Ther. 2008;10(5):1.","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"1187_CR62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","volume":"24","author":"M Veldhoen","year":"2006","unstructured":"Veldhoen M, Hocking RJ, Atkins CJ, et al. TGF\u03b2 in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24(2):179\u201389.","journal-title":"Immunity"},{"issue":"6","key":"1187_CR63","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.smim.2007.10.012","volume":"19","author":"MJ McGeachy","year":"2007","unstructured":"McGeachy MJ, Cua DJ. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin Immunol. 2007;19(6):372\u20136.","journal-title":"Semin Immunol"},{"issue":"5","key":"1187_CR64","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11926-009-0052-y","volume":"11","author":"SL Gaffen","year":"2009","unstructured":"Gaffen SL. The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr Rheumatol Rep. 2009;11(5):365\u201370.","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"1187_CR65","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ni0309-236","volume":"10","author":"Y Chung","year":"2009","unstructured":"Chung Y, Dong C. Don\u2019t leave home without it: The IL-23 visa to TH-17 cells. Nat Immunol. 2009;10(3):236\u20138.","journal-title":"Nat Immunol"},{"issue":"3","key":"1187_CR66","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1074\/jbc.M207577200","volume":"278","author":"S Aggarwal","year":"2003","unstructured":"Aggarwal S, Ghilardi N, Xie MH, et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003;278(3):1910\u20134. doi: 10.1074\/jbc.M207577200 .","journal-title":"J Biol Chem"},{"issue":"10","key":"1187_CR67","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni.2416","volume":"13","author":"Y Lee","year":"2012","unstructured":"Lee Y, Awasthi A, Yosef N, et al. Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012;13(10):991\u20139.","journal-title":"Nat Immunol"},{"issue":"5","key":"1187_CR68","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nri2295","volume":"8","author":"C Dong","year":"2008","unstructured":"Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol. 2008;8(5):337\u201348.","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"1187_CR69","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","volume":"203","author":"K Sato","year":"2006","unstructured":"Sato K, Suematsu A, Okamoto K, et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med. 2006;203(12):2673\u201382.","journal-title":"J Exp Med"},{"issue":"11","key":"1187_CR70","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.4049\/jimmunol.180.11.7423","volume":"180","author":"J Pene","year":"2008","unstructured":"Pene J, Chevalier S, Preisser L, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol. 2008;180(11):7423\u201330.","journal-title":"J Immunol"},{"issue":"9","key":"1187_CR71","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1172\/JCI5703","volume":"103","author":"S Kotake","year":"1999","unstructured":"Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 1999;103(9):1345\u201352. doi: 10.1172\/JCI5703 .","journal-title":"J Clin Invest"},{"issue":"7","key":"1187_CR72","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","volume":"160","author":"DV Jovanovic","year":"1998","unstructured":"Jovanovic DV, Di Battista JA, Martel-Pelletier J, et al. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol. 1998;160(7):3513\u201321.","journal-title":"J Immunol"},{"issue":"1","key":"1187_CR73","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/art.38896","volume":"67","author":"JA Fischer","year":"2015","unstructured":"Fischer JA, Hueber AJ, Wilson S, et al. Combined inhibition of tumor necrosis factor \u03b1 and Interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: development and characterization of a novel bispecific antibody. Arthritis Rheumatol. 2015;67(1):51\u201362.","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"1187_CR74","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/eji.201141871","volume":"42","author":"K Zwerina","year":"2012","unstructured":"Zwerina K, Koenders M, Hueber A, et al. Anti IL-17A therapy inhibits bone loss in TNF-\u03b1-mediated murine arthritis by modulation of the t-cell balance. Eur J Immunol. 2012;42(2):413\u201323.","journal-title":"Eur J Immunol"},{"issue":"6628","key":"1187_CR75","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/387083a0","volume":"387","author":"AC McPherron","year":"1997","unstructured":"McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997;387(6628):83\u201390. doi: 10.1038\/387083a0 .","journal-title":"Nature"},{"issue":"23","key":"1187_CR76","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1073\/pnas.94.23.12457","volume":"94","author":"AC McPherron","year":"1997","unstructured":"McPherron AC, Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci U S A. 1997;94(23):12457\u201361.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9-10","key":"1187_CR77","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.nmd.2007.06.008","volume":"17","author":"GD Shelton","year":"2007","unstructured":"Shelton GD, Engvall E. Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene. Neuromuscul Disord. 2007;17(9-10):721\u20132.","journal-title":"Neuromuscul Disord"},{"issue":"5","key":"1187_CR78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0030079","volume":"3","author":"DS Mosher","year":"2007","unstructured":"Mosher DS, Quignon P, Bustamante CD, et al. A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet. 2007;3(5), e79.","journal-title":"PLoS Genet"},{"key":"1187_CR79","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/j.bone.2007.12.076","volume":"42","author":"P Bialek","year":"2008","unstructured":"Bialek P, Parkington J, Warner L, et al. Mice treated with a myostatin\/GDF-8 decoy receptor, ActRIIB-fc, exhibit a tremendous increase in bone mass. Bone. 2008;42:S46.","journal-title":"Bone."},{"issue":"1","key":"1187_CR80","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bone.2008.08.126","volume":"44","author":"E Kellum","year":"2009","unstructured":"Kellum E, Starr H, Arounleut P, et al. Myostatin (GDF-8) deficiency increases fracture callus size, sox-5 expression, and callus bone volume. Bone. 2009;44(1):17\u201323. doi: 10.1016\/j.bone.2008.08.126 .","journal-title":"Bone"},{"issue":"3","key":"1187_CR81","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1359\/jbmr.2002.17.3.513","volume":"17","author":"TJ Cho","year":"2002","unstructured":"Cho TJ, Gerstenfeld LC, Einhorn TA. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res. 2002;17(3):513\u201320. doi: 10.1359\/jbmr.2002.17.3.513 .","journal-title":"J Bone Miner Res"},{"key":"1187_CR82","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1146\/annurev.cellbio.20.012103.135836","volume":"20","author":"SJ Lee","year":"2004","unstructured":"Lee SJ. Regulation of muscle mass by myostatin. Annu Rev Cell Dev Biol. 2004;20:61\u201386. doi: 10.1146\/annurev.cellbio.20.012103.135836 .","journal-title":"Annu Rev Cell Dev Biol."},{"issue":"9","key":"1187_CR83","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.cellsig.2011.05.003","volume":"23","author":"Z Huang","year":"2011","unstructured":"Huang Z, Chen X, Chen D. Myostatin: a novel insight into its role in metabolism, signal pathways, and expression regulation. Cell Signal. 2011;23(9):1441\u20136. doi: 10.1016\/j.cellsig.2011.05.003 .","journal-title":"Cell Signal"},{"issue":"14","key":"1187_CR84","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s00018-008-8077-3","volume":"65","author":"L Bradley","year":"2008","unstructured":"Bradley L, Yaworsky PJ, Walsh FS. Myostatin as a therapeutic target for musculoskeletal disease. Cell Mol Life Sci. 2008;65(14):2119\u201324. doi: 10.1007\/s00018-008-8077-3 .","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"1187_CR85","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cyto.2004.03.007","volume":"26","author":"X Zhu","year":"2004","unstructured":"Zhu X, Topouzis S, Liang LF, Stotish RL. Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism. Cytokine. 2004;26(6):262\u201372. doi: 10.1016\/j.cyto.2004.03.007 .","journal-title":"Cytokine"},{"issue":"9","key":"1187_CR86","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/nm.3917","volume":"21","author":"B Dankbar","year":"2015","unstructured":"Dankbar B, Fennen M, Brunert D, et al. Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med. 2015;21(9):1085\u201390. doi: 10.1038\/nm.3917 .","journal-title":"Nat Med"},{"issue":"13","key":"1187_CR87","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1002\/j.1460-2075.1991.tb04978.x","volume":"10","author":"J Keffer","year":"1991","unstructured":"Keffer J, Probert L, Cazlaris H, et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 1991;10(13):4025\u201331.","journal-title":"EMBO J"},{"issue":"2","key":"1187_CR88","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/(SICI)1097-4644(19991101)75:23.0.CO;2-T","volume":"75","author":"T Ikenoue","year":"1999","unstructured":"Ikenoue T, Jingushi S, Urabe K, et al. Inhibitory effects of activin-A on osteoblast differentiation during cultures of fetal rat calvarial cells. J Cell Biochem. 1999;75(2):206\u201314. doi: 10.1002\/(SICI)1097-4644(19991101)75:23.0.CO;2-T .","journal-title":"J Cell Biochem"},{"issue":"1","key":"1187_CR89","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1006\/bbrc.2000.2075","volume":"268","author":"K Fuller","year":"2000","unstructured":"Fuller K, Bayley KE, Chambers TJ. Activin A is an essential cofactor for osteoclast induction. Biochem Biophys Res Commun. 2000;268(1):2\u20137. doi: 10.1006\/bbrc.2000.2075 .","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"1187_CR90","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1002\/art.11249","volume":"48","author":"F Ota","year":"2003","unstructured":"Ota F, Maeshima A, Yamashita S, et al. Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2003;48(9):2442\u20139. doi: 10.1002\/art.11249 .","journal-title":"Arthritis Rheum"},{"issue":"3","key":"1187_CR91","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/path.4466","volume":"235","author":"B Soler Palacios","year":"2015","unstructured":"Soler Palacios B, Estrada-Capetillo L, Izquierdo E, et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. J Pathol. 2015;235(3):515\u201326. doi: 10.1002\/path.4466 .","journal-title":"J Pathol"},{"issue":"2","key":"1187_CR92","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/jcp.1113","volume":"188","author":"Y Murase","year":"2001","unstructured":"Murase Y, Okahashi N, Koseki T, et al. Possible involvement of protein kinases and Smad2 signaling pathways on osteoclast differentiation enhanced by activin A. J Cell Physiol. 2001;188(2):236\u201342.","journal-title":"J Cell Physiol"},{"issue":"1","key":"1187_CR93","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/jcb.10613","volume":"90","author":"T Sugatani","year":"2003","unstructured":"Sugatani T, Alvarez UM, Hruska KA. Activin A stimulates IkappaB-alpha\/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. J Cell Biochem. 2003;90(1):59\u201367. doi: 10.1002\/jcb.10613 .","journal-title":"J Cell Biochem"},{"issue":"1","key":"1187_CR94","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1210\/endo.143.1.8580","volume":"143","author":"D Gaddy-Kurten","year":"2002","unstructured":"Gaddy-Kurten D, Coker JK, Abe E, Jilka RL, Manolagas SC. Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures. Endocrinology. 2002;143(1):74\u201383. doi: 10.1210\/endo.143.1.8580 .","journal-title":"Endocrinology"},{"issue":"2","key":"1187_CR95","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S8756-3282(99)00152-0","volume":"25","author":"R Sakai","year":"1999","unstructured":"Sakai R, Miwa K, Eto Y. Local administration of activin promotes fracture healing in the rat fibula fracture model. Bone. 1999;25(2):191\u20136.","journal-title":"Bone"},{"issue":"11","key":"1187_CR96","doi-asserted-by":"publisher","first-page":"5124","DOI":"10.1073\/pnas.0911929107","volume":"107","author":"S Vallet","year":"2010","unstructured":"Vallet S, Mukherjee S, Vaghela N, et al. Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A. 2010;107(11):5124\u20139. doi: 10.1073\/pnas.0911929107 .","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"1187_CR97","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1002\/jbmr.142","volume":"25","author":"AD Chantry","year":"2010","unstructured":"Chantry AD, Heath D, Mulivor AW, et al. Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo. J Bone Miner Res. 2010;25(12):2633\u201346. doi: 10.1002\/jbmr.142 .","journal-title":"J Bone Miner Res"},{"issue":"11","key":"1187_CR98","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1096\/fj.07-8080com","volume":"21","author":"M Eijken","year":"2007","unstructured":"Eijken M, Swagemakers S, Koedam M, et al. The activin A-follistatin system: Potent regulator of human extracellular matrix mineralization. FASEB J. 2007;21(11):2949\u201360.","journal-title":"FASEB J"},{"issue":"1","key":"1187_CR99","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1507\/endocrj.KR-110","volume":"55","author":"K Tsuchida","year":"2008","unstructured":"Tsuchida K, Nakatani M, Uezumi A, et al. Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer. Endocr J. 2008;55(1):11\u201321.","journal-title":"Endocr J"},{"issue":"4","key":"1187_CR100","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1242\/jcs.157834","volume":"128","author":"TW Fowler","year":"2015","unstructured":"Fowler TW, Kamalakar A, Akel NS, et al. Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci. 2015;128(4):683\u201394. doi: 10.1242\/jcs.157834 .","journal-title":"J Cell Sci"},{"issue":"303","key":"1187_CR101","doi-asserted-by":"publisher","first-page":"303ra137","DOI":"10.1126\/scitranslmed.aac4358","volume":"7","author":"SJ Hatsell","year":"2015","unstructured":"Hatsell SJ, Idone V, Wolken DM, et al. ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Sci Transl Med. 2015;7(303):303ra137. doi: 10.1126\/scitranslmed.aac4358 .","journal-title":"Sci Transl Med"},{"issue":"50","key":"1187_CR102","doi-asserted-by":"publisher","first-page":"15438","DOI":"10.1073\/pnas.1510540112","volume":"112","author":"K Hino","year":"2015","unstructured":"Hino K, Ikeya M, Horigome K, et al. Neofunction of ACVR1 in fibrodysplasia ossificans progressiva. Proc Natl Acad Sci U S A. 2015;112(50):15438\u201343. doi: 10.1073\/pnas.1510540112 .","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1187_CR103","doi-asserted-by":"publisher","unstructured":"de Gorter, David Jan Jozef, S\u00e1nchez-Duffhues G, ten Dijke P. Promiscuous signaling of ligands via mutant ALK2 in fibrodysplasia ossificans progressiva. Recept Clin Invest. 2016;3(2):e1356. doi: 10.14800\/rci.1356 .","DOI":"10.14800\/rci.1356"},{"issue":"24","key":"1187_CR104","doi-asserted-by":"publisher","first-page":"16966","DOI":"10.1074\/jbc.M113.526038","volume":"289","author":"M Yano","year":"2014","unstructured":"Yano M, Kawao N, Okumoto K, et al. Fibrodysplasia ossificans progressiva-related activated activin-like kinase signaling enhances osteoclast formation during heterotopic ossification in muscle tissues. J Biol Chem. 2014;289(24):16966\u201377. doi: 10.1074\/jbc.M113.526038 .","journal-title":"J Biol Chem"},{"issue":"2","key":"1187_CR105","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/art.20811","volume":"52","author":"PV Kasperkovitz","year":"2005","unstructured":"Kasperkovitz PV, Timmer TC, Smeets TJ, et al. Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis. Arthritis Rheum. 2005;52(2):430\u201341. doi: 10.1002\/art.20811 .","journal-title":"Arthritis Rheum"},{"issue":"3","key":"1187_CR106","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1756-185X.2010.01532.x","volume":"13","author":"SS El-Gendi","year":"2010","unstructured":"El-Gendi SS, Moniem AE, Tawfik NM, et al. Value of serum and synovial fluid activin A and inhibin A in some rheumatic diseases. Int J Rheum Dis. 2010;13(3):273\u20139. doi: 10.1111\/j.1756-185X.2010.01532.x .","journal-title":"Int J Rheum Dis"},{"issue":"19","key":"1187_CR107","doi-asserted-by":"publisher","first-page":"5092","DOI":"10.1182\/blood-2010-09-306993","volume":"117","author":"E Sierra-Filardi","year":"2011","unstructured":"Sierra-Filardi E, Puig-Kroger A, Blanco FJ, et al. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood. 2011;117(19):5092\u2013101. doi: 10.1182\/blood-2010-09-306993 .","journal-title":"Blood"},{"issue":"1","key":"1187_CR108","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s10753-013-9727-7","volume":"37","author":"F Dong","year":"2014","unstructured":"Dong F, He X, Activin A. A potential therapeutic target for characterizing and stopping joint pain early in rheumatoid arthritis patients. Inflammation. 2014;37(1):170\u20136. doi: 10.1007\/s10753-013-9727-7 .","journal-title":"Inflammation"},{"issue":"8","key":"1187_CR109","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1002\/art.23653","volume":"58","author":"M Tunyogi-Csapo","year":"2008","unstructured":"Tunyogi-Csapo M, Kis-Toth K, Radacs M, et al. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 2008;58(8):2397\u2013408. doi: 10.1002\/art.23653 .","journal-title":"Arthritis Rheum"},{"issue":"6","key":"1187_CR110","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1136\/annrheumdis-2014-207137","volume":"75","author":"L Danks","year":"2016","unstructured":"Danks L, Komatsu N, Guerrini MM, et al. RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation. Ann Rheum Dis. 2016;75(6):1187\u201395. doi: 10.1136\/annrheumdis-2014-207137 .","journal-title":"Ann Rheum Dis"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-016-1187-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T04:19:39Z","timestamp":1692591579000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-016-1187-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":110,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1187"],"URL":"https:\/\/doi.org\/10.1186\/s13075-016-1187-7","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"article-number":"279"}}