{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:28:48Z","timestamp":1790512128188,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20506"],"award-info":[{"award-number":["20506"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-016-1218-4","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T23:22:17Z","timestamp":1485300137000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Persistent stromal fibroblast activation is present in chronic tendinopathy"],"prefix":"10.1186","volume":"19","author":[{"given":"Stephanie G.","family":"Dakin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hussein","family":"Al-Mossawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hedley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando O.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Wheway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"issue":"9995","key":"1218_CR1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","volume":"386","author":"Global Burden of Disease Study C","year":"2015","unstructured":"Global Burden of Disease Study C. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743\u2013800.","journal-title":"Lancet"},{"issue":"80","key":"1218_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta19800","volume":"19","author":"AJ Carr","year":"2015","unstructured":"Carr AJ, Cooper CD, Campbell MK, Rees JL, Moser J, Beard DJ, Fitzpatrick R, Gray A, Dawson J, Murphy J, et al. Clinical effectiveness and cost-effectiveness of open and arthroscopic rotator cuff repair (the UK Rotator Cuff Surgery (UKUFF) randomised trial). Health Technol Assess. 2015;19(80):1\u2013218.","journal-title":"Health Technol Assess"},{"issue":"8","key":"1218_CR3","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1097\/00005768-199808000-00001","volume":"30","author":"LC Almekinders","year":"1998","unstructured":"Almekinders LC, Temple JD. Etiology, diagnosis, and treatment of tendonitis: an analysis of the literature. Med Sci Sports Exerc. 1998;30(8):1183\u201390.","journal-title":"Med Sci Sports Exerc"},{"issue":"7","key":"1218_CR4","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1302\/0301-620X.91B7.22353","volume":"91","author":"SE Gwilym","year":"2009","unstructured":"Gwilym SE, Watkins B, Cooper CD, Harvie P, Auplish S, Pollard TC, Rees JL, Carr AJ. Genetic influences in the progression of tears of the rotator cuff. J Bone Joint Surg Br. 2009;91(7):915\u20137.","journal-title":"J Bone Joint Surg Br"},{"issue":"3","key":"1218_CR5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1302\/0301-620X.91B3.21652","volume":"91","author":"NL Millar","year":"2009","unstructured":"Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA. Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg Br. 2009;91(3):417\u201324.","journal-title":"J Bone Joint Surg Br"},{"issue":"10","key":"1218_CR6","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1177\/0363546510372613","volume":"38","author":"NL Millar","year":"2010","unstructured":"Millar NL, Hueber AJ, Reilly JH, Xu Y, Fazzi UG, Murrell GA, McInnes IB. Inflammation is present in early human tendinopathy. Am J Sports Med. 2010;38(10):2085\u201391.","journal-title":"Am J Sports Med"},{"key":"1218_CR7","doi-asserted-by":"crossref","first-page":"481206","DOI":"10.1155\/2014\/481206","volume":"2014","author":"AL Campbell","year":"2014","unstructured":"Campbell AL, Smith NC, Reilly JH, Kerr SC, Leach WJ, Fazzi UG, Rooney BP, Murrell GA, Millar NL. IL-21 receptor expression in human tendinopathy. Mediators Inflamm. 2014;2014:481206.","journal-title":"Mediators Inflamm"},{"issue":"311","key":"1218_CR8","doi-asserted-by":"crossref","first-page":"311ra173","DOI":"10.1126\/scitranslmed.aac4269","volume":"7","author":"SG Dakin","year":"2015","unstructured":"Dakin SG, Martinez FO, Yapp C, Wells G, Oppermann U, Dean BJ, Smith RD, Wheway K, Watkins B, Roche L, et al. Inflammation activation and resolution in human tendon disease. Sci Transl Med. 2015;7(311):311ra173.","journal-title":"Sci Transl Med"},{"issue":"4","key":"1218_CR9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","volume":"22","author":"CD Buckley","year":"2001","unstructured":"Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol. 2001;22(4):199\u2013204.","journal-title":"Trends Immunol"},{"issue":"25","key":"1218_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399402005264","volume":"4","author":"MR Douglas","year":"2002","unstructured":"Douglas MR, Morrison KE, Salmon M, Buckley CD. Why does inflammation persist: a dominant role for the stromal microenvironment? Expert Rev Mol Med. 2002;4(25):1\u201318.","journal-title":"Expert Rev Mol Med"},{"issue":"Suppl 2","key":"1218_CR11","doi-asserted-by":"crossref","first-page":"ii92","DOI":"10.1136\/ard.2004.028332","volume":"63","author":"CD Buckley","year":"2004","unstructured":"Buckley CD, Filer A, Haworth O, Parsonage G, Salmon M. Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease. Ann Rheum Dis. 2004;63 Suppl 2:ii92\u20135.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"1218_CR12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.berh.2014.10.022","volume":"28","author":"R Patel","year":"2014","unstructured":"Patel R, Filer A, Barone F, Buckley CD. Stroma: fertile soil for inflammation. Best Pract Res Clin Rheumatol. 2014;28(4):565\u201376.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"3","key":"1218_CR13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.coph.2013.02.006","volume":"13","author":"A Filer","year":"2013","unstructured":"Filer A. The fibroblast as a therapeutic target in rheumatoid arthritis. Curr Opin Pharmacol. 2013;13(3):413\u20139.","journal-title":"Curr Opin Pharmacol"},{"issue":"46","key":"1218_CR14","doi-asserted-by":"crossref","first-page":"17965","DOI":"10.1073\/pnas.0705647104","volume":"104","author":"B Tomkowicz","year":"2007","unstructured":"Tomkowicz B, Rybinski K, Foley B, Ebel W, Kline B, Routhier E, Sass P, Nicolaides NC, Grasso L, Zhou Y. Interaction of endosialin\/TEM1 with extracellular matrix proteins mediates cell adhesion and migration. Proc Natl Acad Sci U S A. 2007;104(46):17965\u201370.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1218_CR15","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mvr.2008.07.008","volume":"76","author":"RG Bagley","year":"2008","unstructured":"Bagley RG, Honma N, Weber W, Boutin P, Rouleau C, Shankara S, Kataoka S, Ishida I, Roberts BL, Teicher BA. Endosialin\/TEM 1\/CD248 is a pericyte marker of embryonic and tumor neovascularization. Microvasc Res. 2008;76(3):180\u20138.","journal-title":"Microvasc Res"},{"issue":"2","key":"1218_CR16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ki.2011.103","volume":"80","author":"SW Smith","year":"2011","unstructured":"Smith SW, Eardley KS, Croft AP, Nwosu J, Howie AJ, Cockwell P, Isacke CM, Buckley CD, Savage CO. CD248+ stromal cells are associated with progressive chronic kidney disease. Kidney Int. 2011;80(2):199\u2013207.","journal-title":"Kidney Int"},{"issue":"4","key":"1218_CR17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1302\/0301-620X.78B4.0780593","volume":"78","author":"J Dawson","year":"1996","unstructured":"Dawson J, Fitzpatrick R, Carr A. Questionnaire on the perceptions of patients about shoulder surgery. J Bone Joint Surg Br. 1996;78(4):593\u2013600.","journal-title":"J Bone Joint Surg Br"},{"key":"1218_CR18","first-page":"78","volume":"173","author":"M Post","year":"1983","unstructured":"Post M, Silver R, Singh M. Rotator cuff tear. Diagnosis and treatment. Clin Orthop Relat Res. 1983;173:78\u201391.","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"1218_CR19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.oto.2013.05.003","volume":"23","author":"RJ Murphy","year":"2013","unstructured":"Murphy RJ, Floyd Dean BJ, Wheway K, Watkins B, Morrey ME, Carr AJ. A novel minimally invasive ultrasound-guided technique to biopsy supraspinatus tendon. Oper Tech Orthop. 2013;23(2):56\u201362.","journal-title":"Oper Tech Orthop"},{"issue":"2","key":"1218_CR20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.orthres.2003.08.005","volume":"22","author":"JL Cook","year":"2004","unstructured":"Cook JL, Feller JA, Bonar SF, Khan KM. Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes\u2019 patellar tendons. J Orthop Res. 2004;22(2):334\u20138.","journal-title":"J Orthop Res"},{"issue":"2","key":"1218_CR21","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1186\/ar3274","volume":"13","author":"AK Ekwall","year":"2011","unstructured":"Ekwall AK, Eisler T, Anderberg C, Jin C, Karlsson N, Brisslert M, Bokarewa MI. The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis. Arthritis Res Ther. 2011;13(2):R40.","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"1218_CR22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ccr.2006.03.010","volume":"9","author":"A Wicki","year":"2006","unstructured":"Wicki A, Lehembre F, Wick N, Hantusch B, Kerjaschki D, Christofori G. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell. 2006;9(4):261\u201372.","journal-title":"Cancer Cell"},{"issue":"7","key":"1218_CR23","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1136\/gutjnl-2014-308325","volume":"65","author":"A Wilhelm","year":"2016","unstructured":"Wilhelm A, Aldridge V, Haldar D, Naylor AJ, Weston CJ, Hedegaard D, Garg A, Fear J, Reynolds GM, Croft AP, et al. CD248\/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. Gut. 2016;65(7):1175\u201385.","journal-title":"Gut"},{"issue":"5","key":"1218_CR24","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","volume":"6","author":"R Kalluri","year":"2006","unstructured":"Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006;6(5):392\u2013401.","journal-title":"Nat Rev Cancer"},{"issue":"21","key":"1218_CR25","doi-asserted-by":"crossref","first-page":"15674","DOI":"10.1074\/jbc.M109.077503","volume":"285","author":"CT Thorpe","year":"2010","unstructured":"Thorpe CT, Streeter I, Pinchbeck GL, Goodship AE, Clegg PD, Birch HL. Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging. J Biol Chem. 2010;285(21):15674\u201381.","journal-title":"J Biol Chem"},{"issue":"5","key":"1218_CR26","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1096\/fj.12-225599","volume":"27","author":"KM Heinemeier","year":"2013","unstructured":"Heinemeier KM, Schjerling P, Heinemeier J, Magnusson SP, Kjaer M. Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb 14C. FASEB J. 2013;27(5):2074\u20139.","journal-title":"FASEB J"},{"issue":"4","key":"1218_CR27","first-page":"482","volume":"1","author":"P Cirri","year":"2011","unstructured":"Cirri P, Chiarugi P. Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res. 2011;1(4):482\u201397.","journal-title":"Am J Cancer Res"},{"key":"1218_CR28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fonc.2014.00062","volume":"4","author":"M Augsten","year":"2014","unstructured":"Augsten M. Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment. Front Oncol. 2014;4:62.","journal-title":"Front Oncol"},{"issue":"9","key":"1218_CR29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.autrev.2011.04.001","volume":"10","author":"C Ospelt","year":"2011","unstructured":"Ospelt C, Reedquist KA, Gay S, Tak PP. Inflammatory memories: is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis? Autoimmun Rev. 2011;10(9):519\u201324.","journal-title":"Autoimmun Rev"},{"key":"1218_CR30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/01.blo.0000126337.65685.e4","volume":"422","author":"JH Wang","year":"2004","unstructured":"Wang JH, Li Z, Yang G, Khan M. Repetitively stretched tendon fibroblasts produce inflammatory mediators. Clin Orthop Relat Res. 2004;422:243\u201350.","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"1218_CR31","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/jcb.10534","volume":"89","author":"M Tsuzaki","year":"2003","unstructured":"Tsuzaki M, Bynum D, Almekinders L, Yang X, Faber J, Banes AJ. ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells. J Cell Biochem. 2003;89(3):556\u201362.","journal-title":"J Cell Biochem"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-016-1218-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T15:35:19Z","timestamp":1749915319000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-016-1218-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,25]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1218"],"URL":"https:\/\/doi.org\/10.1186\/s13075-016-1218-4","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,25]]},"article-number":"16"}}