{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:45:17Z","timestamp":1794440717669,"version":"4.9.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01-AR-060604"],"award-info":[{"award-number":["R01-AR-060604"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","award":["IRG"],"award-info":[{"award-number":["IRG"]}],"id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1260-x","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T21:21:47Z","timestamp":1489440107000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Chromatin landscapes and genetic risk for juvenile idiopathic arthritis"],"prefix":"10.1186","volume":"19","author":[{"given":"Lisha","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karstin","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiping","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"1260_CR1","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/art.24450","volume":"60","author":"JN Jarvis","year":"2009","unstructured":"Jarvis JN, Jiang K, Frank MB, Knowlton N, Aggarwal A, Wallace CA, McKee R, Chaser B, Tung C, Smith LB, et al. Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 2009;60:1488\u201395.","journal-title":"Arthritis Rheum"},{"key":"1260_CR2","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1002\/art.24298","volume":"60","author":"N Knowlton","year":"2009","unstructured":"Knowlton N, Jiang K, Frank MB, Aggarwal A, Wallace C, McKee R, Chaser B, Tung C, Smith L, Chen Y, et al. The meaning of clinical remission in polyarticular juvenile idiopathic arthritis: gene expression profiling in peripheral blood mononuclear cells identifies distinct disease states. Arthritis Rheum. 2009;60:892\u2013900.","journal-title":"Arthritis Rheum"},{"key":"1260_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13075-016-1059-1","volume":"18","author":"K Jiang","year":"2016","unstructured":"Jiang K, Wong L, Sawle AD, Frank MB, Chen Y, Wallace CA, Jarvis JN. Whole blood expression profiling from the TREAT trial: insights for the pathogenesis of polyarticular juvenile idiopathic arthritis. Arthritis Res Ther. 2016;18:157.","journal-title":"Arthritis Res Ther"},{"key":"1260_CR4","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/ar4280","volume":"15","author":"K Jiang","year":"2013","unstructured":"Jiang K, Frank M, Chen Y, Osban J, Jarvis JN. Genomic characterization of remission in juvenile idiopathic arthritis. Arthritis Res Ther. 2013;15:R100.","journal-title":"Arthritis Res Ther"},{"key":"1260_CR5","doi-asserted-by":"publisher","first-page":"R154","DOI":"10.1186\/ar2048","volume":"8","author":"JN Jarvis","year":"2006","unstructured":"Jarvis JN, Petty HR, Tang Y, Frank MB, Tessier PA, Dozmorov I, Jiang K, Kindzelski A, Chen Y, Cadwell C, et al. Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther. 2006;8:R154.","journal-title":"Arthritis Res Ther"},{"key":"1260_CR6","doi-asserted-by":"publisher","first-page":"e147","DOI":"10.1093\/nar\/gnh146","volume":"32","author":"I Dozmorov","year":"2004","unstructured":"Dozmorov I, Knowlton N, Tang Y, Shields A, Pathipvanich P, Jarvis JN, Centola M. Hypervariable genes\u2013experimental error or hidden dynamics. Nucleic Acids Res. 2004;32:e147.","journal-title":"Nucleic Acids Res"},{"key":"1260_CR7","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrg2223","volume":"9","author":"S Komili","year":"2008","unstructured":"Komili S, Silver PA. Coupling and coordination in gene expression processes: a systems biology view. Nat Rev Genet. 2008;9:38\u201348.","journal-title":"Nat Rev Genet"},{"key":"1260_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jaut.2015.08.002","volume":"64","author":"AO Hersh","year":"2015","unstructured":"Hersh AO, Prahalad S. Immunogenetics of juvenile idiopathic arthritis: A comprehensive review. J Autoimmun. 2015;64:113\u201324.","journal-title":"J Autoimmun"},{"key":"1260_CR9","first-page":"73","volume":"1","author":"MP Herlin","year":"2014","unstructured":"Herlin MP, Petersen MB, Herlin T. Update on genetic susceptibility and pathogenesis in juvenile idiopathic arthritis.EMJ. Rheumatol. 2014;1:73\u201383.","journal-title":"Rheumatol"},{"key":"1260_CR10","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/FPC.0b013e32833f2cd0","volume":"20","author":"H Moncrieffe","year":"2010","unstructured":"Moncrieffe H, Hinks A, Ursu S, Kassoumeri L, Etheridge A, Hubank M, Martin P, Weiler T, Glass DN, Thompson SD, et al. Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenet Genomics. 2010;20:665\u201376.","journal-title":"Pharmacogenet Genomics"},{"key":"1260_CR11","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/ng.2614","volume":"45","author":"A Hinks","year":"2013","unstructured":"Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, et al. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet. 2013;45:664\u20139.","journal-title":"Nat Genet"},{"key":"1260_CR12","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1126\/science.1222794","volume":"337","author":"MT Maurano","year":"2012","unstructured":"Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science. 2012;337:1190\u20135.","journal-title":"Science"},{"key":"1260_CR13","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1101\/gr.136127.111","volume":"22","author":"MA Schaub","year":"2012","unstructured":"Schaub MA, Boyle AP, Kundaje A, Batzoglou S, Snyder M. Linking disease associations with regulatory information in the human genome. Genome Res. 2012;22:1748\u201359.","journal-title":"Genome Res"},{"key":"1260_CR14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature13835","volume":"518","author":"KK Farh","year":"2015","unstructured":"Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015;518:337\u201343.","journal-title":"Nature"},{"key":"1260_CR15","doi-asserted-by":"publisher","first-page":"10069","DOI":"10.1038\/ncomms10069","volume":"6","author":"P Martin","year":"2015","unstructured":"Martin P, McGovern A, Orozco G, Duffus K, Yarwood A, Schoenfelder S, Cooper NJ, Barton A, Wallace C, Fraser P, et al. Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci. Nat Commun. 2015;6:10069.","journal-title":"Nat Commun"},{"key":"1260_CR16","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/art.39135","volume":"67","author":"K Jiang","year":"2015","unstructured":"Jiang K, Zhu L, Buck MJ, Chen Y, Carrier B, Liu T, Jarvis JN. Disease-associated single-nucleotide polymorphisms from noncoding regions in juvenile idiopathic arthritis are located within or adjacent to functional genomic elements of human neutrophils and CD4+ T cells. Arthritis Rheumatol. 2015;67:1966\u201377.","journal-title":"Arthritis Rheumatol"},{"key":"1260_CR17","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/00002281-200009000-00012","volume":"12","author":"AA Grom","year":"2000","unstructured":"Grom AA, Hirsch R. T-cell and T-cell receptor abnormalities in the immunopathogenesis of juvenile rheumatoid arthritis. Curr Opin Rheumatol. 2000;12:420\u20134.","journal-title":"Curr Opin Rheumatol"},{"key":"1260_CR18","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/BOR.0000000000000204","volume":"27","author":"A Huttenlocher","year":"2015","unstructured":"Huttenlocher A, Smith JA. Neutrophils in pediatric autoimmune disease. Curr Opin Rheumatol. 2015;27:500\u20134.","journal-title":"Curr Opin Rheumatol"},{"key":"1260_CR19","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","volume":"24","author":"AD Johnson","year":"2008","unstructured":"Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PI. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics. 2008;24:2938\u20139.","journal-title":"Bioinformatics"},{"key":"1260_CR20","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s13075-016-1169-9","volume":"18","author":"JS Hui-Yuen","year":"2016","unstructured":"Hui-Yuen JS, Zhu L, Wong LP, Jiang K, Chen Y, Liu T, Jarvis JN. Chromatin landscapes and genetic risk in systemic lupus. Arthritis Res Ther. 2016;18:281.","journal-title":"Arthritis Res Ther"},{"key":"1260_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12920-015-0128-7","volume":"8","author":"K Jiang","year":"2015","unstructured":"Jiang K, Sun X, Chen Y, Shen Y, Jarvis JN. RNA sequencing from human neutrophils reveals distinct transcriptional differences associated with chronic inflammatory states. BMC Med Genomics. 2015;8:55.","journal-title":"BMC Med Genomics"},{"key":"1260_CR22","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841\u20132.","journal-title":"Bioinformatics"},{"key":"1260_CR23","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/cr.2012.15","volume":"22","author":"I Chepelev","year":"2012","unstructured":"Chepelev I, Wei G, Wangsa D, Tang Q, Zhao K. Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res. 2012;22:490\u2013503.","journal-title":"Cell Res"},{"key":"1260_CR24","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nrg2884","volume":"11","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H. Analysing biological pathways in genome-wide association studies. Nat Rev Genet. 2010;11:843\u201354.","journal-title":"Nat Rev Genet"},{"key":"1260_CR25","doi-asserted-by":"publisher","first-page":"e100887","DOI":"10.1371\/journal.pone.0100887","volume":"9","author":"A Brodie","year":"2014","unstructured":"Brodie A, Tovia-Brodie O, Ofran Y. Large scale analysis of phenotype-pathway relationships based on GWAS results. PLoS One. 2014;9:e100887.","journal-title":"PLoS One"},{"key":"1260_CR26","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1093\/nar\/gkw500","volume":"44","author":"A Brodie","year":"2016","unstructured":"Brodie A, Azaria JR, Ofran Y. How far from the SNP may the causative genes be? Nucleic Acids Res. 2016;44:6046\u201354.","journal-title":"Nucleic Acids Res"},{"key":"1260_CR27","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/1529-0131(200201)46:1<232::AID-ART10059>3.0.CO;2-B","volume":"46","author":"C Meazza","year":"2002","unstructured":"Meazza C, Travaglino P, Pignatti P, Magni-Manzoni S, Ravelli A, Martini A, De Benedetti F. Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46:232\u20137.","journal-title":"Arthritis Rheum"},{"key":"1260_CR28","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1056\/NEJM200003163421103","volume":"342","author":"DJ Lovell","year":"2000","unstructured":"Lovell DJ, Giannini EH, Reiff A, Cawkwell GD, Silverman ED, Nocton JJ, Stein LD, Gedalia A, Ilowite NT, Wallace CA, et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. N Engl J Med. 2000;342:763\u20139.","journal-title":"N Engl J Med"},{"key":"1260_CR29","doi-asserted-by":"publisher","first-page":"21931","DOI":"10.1073\/pnas.1016071107","volume":"107","author":"MP Creyghton","year":"2010","unstructured":"Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A. 2010;107:21931\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1260_CR30","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nrg2814","volume":"11","author":"RP Alexander","year":"2010","unstructured":"Alexander RP, Fang G, Rozowsky J, Snyder M, Gerstein MB. Annotating non-coding regions of the genome. Nat Rev Genet. 2010;11:559\u201371.","journal-title":"Nat Rev Genet"},{"key":"1260_CR31","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1002\/art.27424","volume":"62","author":"JA Hollenbach","year":"2010","unstructured":"Hollenbach JA, Thompson SD, Bugawan TL, Ryan M, Sudman M, Marion M, Langefeld CD, Thomson G, Erlich HA, Glass DN. Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum. 2010;62:1781\u201391.","journal-title":"Arthritis Rheum"},{"key":"1260_CR32","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/nprot.2013.092","volume":"8","author":"H Mi","year":"2013","unstructured":"Mi H, Muruganujan A, Casagrande JT, Thomas PD. Large-scale gene function analysis with the PANTHER classification system. Nat Protoc. 2013;8:1551\u201366.","journal-title":"Nat Protoc"},{"key":"1260_CR33","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ng.3242","volume":"47","author":"K Michailidou","year":"2015","unstructured":"Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush MJ, Maranian MJ, Bolla MK, Wang Q, Shah M, et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat Genet. 2015;47:373\u201380.","journal-title":"Nat Genet"},{"key":"1260_CR34","doi-asserted-by":"crossref","unstructured":"The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 2012;489:57\u201374.","DOI":"10.1038\/nature11247"},{"key":"1260_CR35","doi-asserted-by":"publisher","unstructured":"Gandin V, Sikstrom K, Alain T, Morita M, McLaughlan S, Larsson O, Topisirovic I. Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale. J Vis Exp. 2014;17. doi: 10.3791\/51455 .","DOI":"10.3791\/51455"},{"key":"1260_CR36","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nri3884","volume":"15","author":"DR Winter","year":"2015","unstructured":"Winter DR, Jung S, Amit I. Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape. Nat Rev Immunol. 2015;15:585\u201394.","journal-title":"Nat Rev Immunol"},{"key":"1260_CR37","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/MIB.0000000000000297","volume":"21","author":"MR Spalinger","year":"2015","unstructured":"Spalinger MR, McCole DF, Rogler G, Scharl M. Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation. Inflamm Bowel Dis. 2015;21:645\u201355.","journal-title":"Inflamm Bowel Dis"},{"key":"1260_CR38","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrg3682","volume":"15","author":"D Shlyueva","year":"2014","unstructured":"Shlyueva D, Stampfel G, Stark A. Transcriptional enhancers: from properties to genome-wide predictions. Nat Rev Genet. 2014;15:272\u201386.","journal-title":"Nat Rev Genet"},{"key":"1260_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cell.2014.02.009","volume":"157","author":"M Levine","year":"2014","unstructured":"Levine M, Cattoglio C, Tjian R. Looping back to leap forward: transcription enters a new era. Cell. 2014;157:13\u201325.","journal-title":"Cell"},{"issue":"Suppl 12","key":"1260_CR40","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1471-2164-15-S12-S11","volume":"15","author":"G Li","year":"2014","unstructured":"Li G, Cai L, Chang H, Hong P, Zhou Q, Kulakova EV, Kolchanov NA, Ruan Y. Chromatin interaction analysis with paired-end tag (ChIA-PET) sequencing technology and application. BMC Genomics. 2014;15 Suppl 12:S11.","journal-title":"BMC Genomics"},{"key":"1260_CR41","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1038\/nsmb.2449","volume":"19","author":"GL Brien","year":"2012","unstructured":"Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, et al. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol. 2012;19:1273\u201381.","journal-title":"Nat Struct Mol Biol"},{"key":"1260_CR42","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1242\/jcs.115.9.1825","volume":"115","author":"YY Ou","year":"2002","unstructured":"Ou YY, Mack GJ, Zhang M, Rattner JB. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. J Cell Sci. 2002;115:1825\u201335.","journal-title":"J Cell Sci"},{"key":"1260_CR43","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/BOR.0b013e3283563363","volume":"24","author":"D Liang","year":"2012","unstructured":"Liang D, Shen N. MicroRNA involvement in lupus: the beginning of a new tale. Curr Opin Rheumatol. 2012;24:489\u201398.","journal-title":"Curr Opin Rheumatol"},{"key":"1260_CR44","doi-asserted-by":"publisher","first-page":"27453","DOI":"10.1038\/srep27453","volume":"6","author":"Z Hu","year":"2016","unstructured":"Hu Z, Jiang K, Frank MB, Chen Y, Jarvis JN. Complexity and specificity of the neutrophil transcriptomes in juvenile idiopathic arthritis. Sci Rep. 2016;6:27453.","journal-title":"Sci Rep"},{"key":"1260_CR45","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4161\/epi.26830","volume":"9","author":"LC Li","year":"2014","unstructured":"Li LC. Chromatin remodeling by the small RNA machinery in mammalian cells. Epigenetics. 2014;9:45\u201352.","journal-title":"Epigenetics"},{"key":"1260_CR46","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1101\/gr.133546.111","volume":"22","author":"RY Birnbaum","year":"2012","unstructured":"Birnbaum RY, Clowney EJ, Agamy O, Kim MJ, Zhao J, Yamanaka T, Pappalardo Z, Clarke SL, Wenger AM, Nguyen L, et al. Coding exons function as tissue-specific enhancers of nearby genes. Genome Res. 2012;22:1059\u201368.","journal-title":"Genome Res"},{"key":"1260_CR47","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrg.2016.4","volume":"17","author":"W Li","year":"2016","unstructured":"Li W, Notani D, Rosenfeld MG. Enhancers as non-coding RNA transcription units: recent insights and future perspectives. Nat Rev Genet. 2016;17:207\u201323.","journal-title":"Nat Rev Genet"},{"key":"1260_CR48","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13073-016-0277-0","volume":"8","author":"N Ahituv","year":"2016","unstructured":"Ahituv N. Exonic enhancers: proceed with caution in exome and genome sequencing studies. Genome Med. 2016;8:14.","journal-title":"Genome Med"},{"key":"1260_CR49","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nrg2904","volume":"12","author":"A Pauli","year":"2011","unstructured":"Pauli A, Rinn JL, Schier AF. Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet. 2011;12:136\u201349.","journal-title":"Nat Rev Genet"},{"key":"1260_CR50","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.cell.2013.06.052","volume":"154","author":"JJ Wong","year":"2013","unstructured":"Wong JJ, Ritchie W, Ebner OA, Selbach M, Wong JW, Huang Y, Gao D, Pinello N, Gonzalez M, Baidya K, et al. Orchestrated intron retention regulates normal granulocyte differentiation. Cell. 2013;154:583\u201395.","journal-title":"Cell"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1260-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-017-1260-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1260-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T22:32:31Z","timestamp":1658788351000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1260-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1260"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1260-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/075721","asserted-by":"object"}]},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"30 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"57"}}