{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:43:00Z","timestamp":1792428180620,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1342-9","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T12:24:07Z","timestamp":1496751847000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation"],"prefix":"10.1186","volume":"19","author":[{"given":"Walter P.","family":"Maksymowych","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wichuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Szumski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack F.","family":"Bukowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"1342_CR1","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1002\/art.27571","volume":"62","author":"U Weber","year":"2010","unstructured":"Weber U, Lambert RGW, \u00d8stergaard M, Hodler J, Pedersen SJ, Maksymowych WP. The diagnostic utility of magnetic resonance imaging in spondylarthritis: an international multicenter evaluation of one hundred eighty-seven subjects. Arthritis Rheum. 2010;62:3048\u201358.","journal-title":"Arthritis Rheum"},{"key":"1342_CR2","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/rheumatology\/ket164","volume":"52","author":"R Berg van den","year":"2013","unstructured":"van den Berg R, de Hooge M, van Gaalen F, Reijnierse M, Huizinga T, van der Heijde D. Percentage of patients with spondyloarthritis in patients referred because of chronic back pain and performance of classification criteria: experience from the Spondyloarthritis Caught Early (SPACE) cohort. Rheumatology. 2013;52:1492\u20139 [Erratum in: Rheumatology. 2015;54:1336].","journal-title":"Rheumatology"},{"key":"1342_CR3","first-page":"1953","volume":"26","author":"J Oostveen","year":"1999","unstructured":"Oostveen J, Prevo R, den Boer J, van de Laar M. Early detection of sacroiliitis on magnetic resonance imaging and subsequent development of sacroiliitis on plain radiography. A prospective, longitudinal study. J Rheumatol. 1999;26:1953\u20138.","journal-title":"J Rheumatol"},{"key":"1342_CR4","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1002\/art.24024","volume":"58","author":"AN Bennett","year":"2008","unstructured":"Bennett AN, McGonagle D, O\u2019Connor P, Hensor EMA, Sivera F, Coates LC, et al. Severity of baseline magnetic resonance imaging\u2013evident sacroiliitis and HLA\u2013B27 status in early inflammatory back pain predict radiographically evident ankylosing spondylitis at eight years. Arthritis Rheum. 2008;58:3413\u20138.","journal-title":"Arthritis Rheum"},{"key":"1342_CR5","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/ard.2005.044206","volume":"65","author":"L Heuft-Dorenbosch","year":"2006","unstructured":"Heuft-Dorenbosch L, Landew\u00e9 R, Weijers R, Wanders A, Houben H, van der Linden S, et al. Combining information obtained from magnetic resonance imaging and conventional radiographs to detect sacroiliitis in patients with recent onset inflammatory back pain. Ann Rheum Dis. 2006;65:804\u20138.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR6","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/ard.2008.104018","volume":"68 Suppl 2","author":"J Sieper","year":"2009","unstructured":"Sieper J, Rudwaleit M, Baraliakos X, Brandt J, Braun J, Burgos-Vargas R, et al. The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis. 2009;68 Suppl 2:ii1\u201344.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/ard.2009.108217","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Landew\u00e9 R, van der Heijde D, Listing J, Brandt J, Braun J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis. 2009;68:770\u20136.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR8","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, van der Heijde D, Landew\u00e9 R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;68:777\u201383.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR9","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1002\/art.38792","volume":"66","author":"WP Maksymowych","year":"2014","unstructured":"Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ. Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis. Arthritis Rheum. 2014;66:2958\u201367.","journal-title":"Arthritis Rheum"},{"key":"1342_CR10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3899\/jrheum.140519","volume":"42","author":"WP Maksymowych","year":"2015","unstructured":"Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ. Development and preliminary validation of the Spondyloarthritis Research Consortium of Canada Magnetic Resonance Imaging Sacroiliac Joint Structural Score. J Rheumatol. 2015;42:79\u201386.","journal-title":"J Rheumatol"},{"key":"1342_CR11","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1136\/ard.2009.110767","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Jurik AG, Hermann K-GA, Landew\u00e9 R, van der Heijde D, Baraliakos X, et al. Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS\/OMERACT MRI group. Ann Rheum Dis. 2009;68:1520\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR12","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/ar3854","volume":"14","author":"U Weber","year":"2012","unstructured":"Weber U, Pedersen S, Ostergaard M, Rufibach K, Lambert R, Maksymowych W. Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? A cross-sectional study. Arthritis Res Ther. 2012;14:R124.","journal-title":"Arthritis Res Ther"},{"key":"1342_CR13","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1136\/ard.2010.147033","volume":"70","author":"I-H Song","year":"2011","unstructured":"Song I-H, Hermann KG, Haibel H, Althoff CE, Poddubnyy D, Listing J, et al. Relationship between active inflammatory lesions in the spine and sacroiliac joints and new development of chronic lesions on whole-body MRI in early axial spondyloarthritis: results of the ESTHER trial at week 48. Ann Rheum Dis. 2011;70:1257\u201363.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR14","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1002\/art.38721","volume":"66","author":"M Dougados","year":"2014","unstructured":"Dougados M, van der Heijde D, Sieper J, Braun J, Maksymowych WP, Citera G, et al. Symptomatic efficacy of etanercept and its effects on objective signs of inflammation in early nonradiographic axial spondyloarthritis: a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2014;66:2091\u2013102.","journal-title":"Arthritis Rheum"},{"key":"1342_CR15","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1136\/annrheumdis-2015-207596","volume":"75","author":"WP Maksymowych","year":"2016","unstructured":"Maksymowych WP, Dougados M, van der Heijde D, Sieper J, Braun J, Citera G, et al. Clinical and MRI responses to etanercept in early non-radiographic axial spondyloarthritis: 48-week results from the EMBARK study. Ann Rheum Dis. 2016;75:1328\u201335.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/art.21337","volume":"53","author":"WP Maksymowych","year":"2005","unstructured":"Maksymowych WP, Inman RD, Salonen D, Dhillon SS, Krishnananthan R, Stone M, et al. Spondyloarthritis Research Consortium of Canada magnetic resonance imaging index for assessment of spinal inflammation in ankylosing spondylitis. Arthritis Rheum. 2005;53:502\u20139.","journal-title":"Arthritis Rheum"},{"key":"1342_CR17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/art.21445","volume":"53","author":"WP Maksymowych","year":"2005","unstructured":"Maksymowych WP, Inman RD, Salonen D, Dhillon SS, Williams M, Stone M, et al. Spondyloarthritis Research Consortium of Canada magnetic resonance imaging index for assessment of sacroiliac joint inflammation in ankylosing spondylitis. Arthritis Rheum. 2005;53:703\u20139.","journal-title":"Arthritis Rheum"},{"key":"1342_CR18","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3899\/jrheum.091043","volume":"37","author":"WP Maksymowych","year":"2010","unstructured":"Maksymowych WP, Salonen D, Inman RD, Rahman P, Lambert RGW. Low-dose infliximab (3 mg\/kg) significantly reduces spinal inflammation on magnetic resonance imaging in patients with ankylosing spondylitis: a randomized placebo-controlled study. J Rheum. 2010;37:1728\u201334.","journal-title":"J Rheum"},{"key":"1342_CR19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/art.38283","volume":"66","author":"D Heijde van der","year":"2014","unstructured":"van der Heijde D, Sieper J, Maksymowych WP, Brown MA, Lambert RGW, Rathmann SS, et al. Spinal inflammation in the absence of sacroiliac joint inflammation on magnetic resonance imaging in patients with active nonradiographic axial spondyloarthritis. Arthritis Rheum. 2014;66:667\u201373.","journal-title":"Arthritis Rheum"},{"key":"1342_CR20","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3899\/jrheum.140806","volume":"42","author":"R Berg van den","year":"2015","unstructured":"van den Berg R, de Hooge M, Bakker PAC, van Gaalen F, Navarro-Comp\u00e1n V, Fagerli KM, et al. Metric properties of the SPARCC score of the sacroiliac joints \u2014 data from baseline, 3-month, and 12-month follow up in the SPACE cohort. J Rheumatol. 2015;42:1186\u201393.","journal-title":"J Rheumatol"},{"key":"1342_CR21","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/ar4548","volume":"16","author":"SJ Pedersen","year":"2014","unstructured":"Pedersen SJ, Wichuk S, Chiowchanwisawakit P, Lambert RG, Maksymowych WP. Tumor necrosis factor inhibitor therapy but not standard therapy is associated with resolution of erosion in the sacroiliac joints of patients with axial spondyloarthritis. Arthritis Res Ther. 2014;16:R100. doi: 10.1186\/ar4548 .","journal-title":"Arthritis Res Ther"},{"key":"1342_CR22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/annrheumdis-2014-eular.5393","volume":"73 Suppl 2","author":"WP Maksymowych","year":"2014","unstructured":"Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ. Fat metaplasia in the sacroiliac joints on MRI is associated with radiographic status and progression in the spine of patients with axial spondyloarthritis. Ann Rheum Dis. 2014;73 Suppl 2:214. Abstract THU0106.","journal-title":"Ann Rheum Dis"},{"key":"1342_CR23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/annrheumdis-2011-200859","volume":"72","author":"WP Maksymowych","year":"2013","unstructured":"Maksymowych WP, Morency N, Conner-Spady B, Lambert RG. Suppression of inflammation and effects on new bone formation in ankylosing spondylitis: evidence for a window of opportunity in disease modification. Ann Rheum Dis. 2013;72:23\u20138.","journal-title":"Ann Rheum Dis"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1342-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:30:47Z","timestamp":1750293047000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1342-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,6]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1342"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1342-9","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,6]]},"article-number":"126"}}