{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T17:14:06Z","timestamp":1774199646204,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1370-5","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T08:37:39Z","timestamp":1499330259000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The \u201cmyth\u201d of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?"],"prefix":"10.1186","volume":"19","author":[{"given":"Marco","family":"Matucci-Cerinic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Manetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Bruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Chora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bellando-Randone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Lepri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amato","family":"De Paulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Guiducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"1370_CR1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/j.1582-4934.2010.01027.x","volume":"14","author":"M Manetti","year":"2010","unstructured":"Manetti M, Guiducci S, Ibba-Manneschi L, Matucci-Cerinic M. Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis. J Cell Mol Med. 2010;14:1241\u201354.","journal-title":"J Cell Mol Med"},{"key":"1370_CR2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11926-011-0219-1","volume":"14","author":"BJ Rabquer","year":"2012","unstructured":"Rabquer BJ, Koch AE. Angiogenesis and vasculopathy in systemic sclerosis: evolving concepts. Curr Rheumatol Rep. 2012;14:56\u201363.","journal-title":"Curr Rheumatol Rep"},{"key":"1370_CR3","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/art.37988","volume":"65","author":"M Matucci-Cerinic","year":"2013","unstructured":"Matucci-Cerinic M, Kahaleh B, Wigley FM. Evidence that systemic sclerosis is a vascular disease. Arthritis Rheum. 2013;65:1953\u201362.","journal-title":"Arthritis Rheum"},{"key":"1370_CR4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13075-016-0937-x","volume":"18","author":"M Manetti","year":"2016","unstructured":"Manetti M, Guiducci S, Matucci-Cerinic M. The crowded crossroad to angiogenesis in systemic sclerosis: where is the key to the problem? Arthritis Res Ther. 2016;18:36.","journal-title":"Arthritis Res Ther"},{"key":"1370_CR5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0140-6736(04)16853-0","volume":"364","author":"M Kuwana","year":"2004","unstructured":"Kuwana M, Okazaki Y, Yasuoka H, Kawakami Y, Ikeda Y. Defective vasculogenesis in systemic sclerosis. Lancet. 2004;364:603\u201310.","journal-title":"Lancet"},{"key":"1370_CR6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12891-016-1197-2","volume":"17","author":"S Patschan","year":"2016","unstructured":"Patschan S, Tampe D, M\u00fcller C, Seitz C, Herink C, et al. Early endothelial progenitor cells (eEPCs) in systemic sclerosis (SSc)\u2014dynamics of cellular regeneration and mesenchymal transdifferentiation. BMC Musculoskelet Disord. 2016;17:339.","journal-title":"BMC Musculoskelet Disord"},{"key":"1370_CR7","first-page":"175","volume":"28","author":"Y Yamaguchi","year":"2013","unstructured":"Yamaguchi Y, Kuwana M. Proangiogenic hematopoietic cells of monocytic origin: roles in vascular regeneration and pathogenic processes of systemic sclerosis. Histol Histopathol. 2013;28:175\u201383.","journal-title":"Histol Histopathol"},{"key":"1370_CR8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13075-015-0848-2","volume":"17","author":"D Hirigoyen","year":"2015","unstructured":"Hirigoyen D, Burgos PI, Mezzano V, Duran J, Barrientos M, Saez CG, et al. Inhibition of angiogenesis by platelets in systemic sclerosis patients. Arthritis Res Ther. 2015;17:332.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"1370_CR9","doi-asserted-by":"crossref","first-page":"e1452","DOI":"10.1371\/journal.pone.0001452","volume":"3","author":"JN Fleming","year":"2008","unstructured":"Fleming JN, Nash RA, McLeod DO, Fiorentino DF, Shulman HM, Connolly MK, et al. Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS One. 2008;3(1):e1452.","journal-title":"PLoS One"},{"issue":"5","key":"1370_CR10","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/annrheumdis-2016-210229","volume":"76","author":"M Manetti","year":"2017","unstructured":"Manetti M, Romano E, Rosa I, Guiducci S, Bellando-Randone S, De Paulis A, et al. Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis. Ann Rheum Dis. 2017;76(5):924\u201334.","journal-title":"Ann Rheum Dis"},{"key":"1370_CR11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.RES.0000134644.89917.96","volume":"95","author":"O Distler","year":"2004","unstructured":"Distler O, Distler JH, Scheid A, Acker T, Hirth A, Rethage J, et al. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res. 2004;95:109\u201316.","journal-title":"Circ Res"},{"key":"1370_CR12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrrheum.2010.102","volume":"6","author":"M Trojanowska","year":"2010","unstructured":"Trojanowska M. Cellular and molecular aspects of vascular dysfunction in systemic sclerosis. Nat Rev Rheumatol. 2010;6:453\u201360.","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"1370_CR13","first-page":"421","volume":"26","author":"T Nevskaya","year":"2008","unstructured":"Nevskaya T, Bykovskaia S, Lyssuk E, Shakhov I, Zaprjagaeva M, Mach E, et al. Circulating endothelial progenitor cells in systemic sclerosis: relation to impaired angiogenesis and cardiovascular manifestations. Clin Exp Rheumatol. 2008;26(3):421\u20139.","journal-title":"Clin Exp Rheumatol"},{"key":"1370_CR14","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar596","volume":"4","author":"O Distler","year":"2002","unstructured":"Distler O, Del Rosso A, Giacomelli R, Cipriani P, Conforti ML, Guiducci S, et al. Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res. 2002;4:R11.","journal-title":"Arthritis Res"},{"key":"1370_CR15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1046\/j.1440-1681.1999.02992.x","volume":"26","author":"DV Faller","year":"1999","unstructured":"Faller DV. Endothelial cell responses to hypoxic stress. Clin Exp Pharmacol Physiol. 1999;26:74\u201384.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1370_CR16","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/rheumatology\/kev399","volume":"55","author":"PS Tsou","year":"2016","unstructured":"Tsou PS, Rabquer BJ, Ohara RA, Stinson WA, Campbel PL, et al. Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines. Rheumatology. 2016;55:745\u201354.","journal-title":"Rheumatology"},{"key":"1370_CR17","doi-asserted-by":"publisher","unstructured":"Toyama T, Asano Y, Miyagawa T, Nakamura K, Hirabayashi M, Yamashita T, et al. The impact of transcriptional factor Fli1 deficiency on the regulation of angiogenesis. Exp Dermatol. 2017. doi:\n10.1111\/exd.13341\n\n. [Epub ahead of print]","DOI":"10.1111\/exd.13341"},{"key":"1370_CR18","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1084\/jem.20160247","volume":"214","author":"T Takahashi","year":"2017","unstructured":"Takahashi T, Asano Y, Sugawara K, Yamashita T, Nakamura K, Saigusa R, et al. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma. J Exp Med. 2017;214:1129\u201351.","journal-title":"J Exp Med"},{"key":"1370_CR19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/rheumatology\/keu296","volume":"54","author":"C Bruni","year":"2015","unstructured":"Bruni C, Guiducci S, Bellando-Randone S, Lepri G, Braschi F, Fiori G, et al. Digital ulcers as a sentinel sign for early internal organ involvement in very early systemic sclerosis. Rheumatology (Oxford). 2015;54:72\u20136.","journal-title":"Rheumatology (Oxford)"},{"key":"1370_CR20","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1136\/annrheumdis-2012-203183","volume":"72","author":"M Manetti","year":"2013","unstructured":"Manetti M, Guiducci S, Romano E, Bellando-Randone S, Lepri G, Bruni C, et al. Increased plasma levels of the VEGF165b splice variant are associated with the severity of nailfold capillary loss in systemic sclerosis. Ann Rheum Dis. 2013;72:1425\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"1370_CR21","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1136\/annrheumdis-2013-203535","volume":"73","author":"B Maurer","year":"2014","unstructured":"Maurer B, Distler A, Suliman YA, Gay RE, Michel BA, Gay S, et al. Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis. Ann Rheum Dis. 2014;73(10):1880\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1370_CR22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.17219\/acem\/32484","volume":"25","author":"SS Koca","year":"2016","unstructured":"Koca SS, Ozgen M, Dagli AF, Gozel N, Ozercan IH, Isik A. The protective effects of bevacizumab in bleomycin-induced experimental scleroderma. Adv Clin Exp Med. 2016;25:249\u201353.","journal-title":"Adv Clin Exp Med"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1370-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T08:37:44Z","timestamp":1499330264000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1370-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,6]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1370"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1370-5","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,6]]},"article-number":"162"}}