{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:11:37Z","timestamp":1760267497494,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"the Korea Healthcare Technology R&D Project of the Ministry for Health & Welfare","award":["HI13C2124"],"award-info":[{"award-number":["HI13C2124"]}]},{"name":"the Bio-Synergy Research Project of the Ministry of Science, ICT and Future Planning through the National Research Foundation","award":["NRF-2012M3A9C4048759"],"award-info":[{"award-number":["NRF-2012M3A9C4048759"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1414-x","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T20:56:38Z","timestamp":1508878598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Biological function integrated prediction of severe radiographic progression in rheumatoid arthritis: a nested case control study"],"prefix":"10.1186","volume":"19","author":[{"given":"Young Bin","family":"Joo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngho","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwangwoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Ah","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seunghun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Young","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Soon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwan-Su","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4658-1093","authenticated-orcid":false,"given":"Sang-Cheol","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,25]]},"reference":[{"key":"1414_CR1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrrheum.2016.176","volume":"13","author":"K Kim","year":"2017","unstructured":"Kim K, Bang SY, Lee HS, Bae SC. Update on the genetic architecture of rheumatoid arthritis. Nat Rev Rheumatol. 2017;13:13\u201324.","journal-title":"Nat Rev Rheumatol"},{"key":"1414_CR2","first-page":"280","volume":"4","author":"L Hou","year":"2013","unstructured":"Hou L, Zhao H. A review of post-GWAS prioritization approaches. Front Genet. 2013;4:280.","journal-title":"Front Genet"},{"key":"1414_CR3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/annrheumdis-2011-200627","volume":"71","author":"R Knevel","year":"2012","unstructured":"Knevel R, Grondal G, Huizinga TW, Visser AW, Jonsson H, Vikingsson A, Geirsson AJ, Steinsson K, van der Helm-van Mil AH. Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study. Ann Rheum Dis. 2012;71:707\u20139.","journal-title":"Ann Rheum Dis"},{"key":"1414_CR4","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/annrheumdis-2013-204277","volume":"74","author":"HW Steenbergen van","year":"2015","unstructured":"van Steenbergen HW, Tsonaka R, Huizinga TW, le Cessie S, van der Helm-van Mil AH. Predicting the severity of joint damage in rheumatoid arthritis; the contribution of genetic factors. Ann Rheum Dis. 2015;74:876\u201382.","journal-title":"Ann Rheum Dis"},{"key":"1414_CR5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315\u201324.","journal-title":"Arthritis Rheum"},{"key":"1414_CR6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4078\/jkra.2009.16.3.204","volume":"16","author":"YJ Kim","year":"2009","unstructured":"Kim YJ, Choi CB, Sung YK, Lee HS, Bae SC. Characteristics of Korean patients with RA: a single center cohort study. J Korean Rheum Assoc. 2009;16:204\u201312.","journal-title":"J Korean Rheum Assoc"},{"key":"1414_CR7","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa073491","volume":"357","author":"RM Plenge","year":"2007","unstructured":"Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, et al. TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med. 2007;357:1199\u2013209.","journal-title":"N Engl J Med"},{"key":"1414_CR8","first-page":"261","volume":"27","author":"D Heijde van der","year":"2000","unstructured":"van der Heijde D. How to read radiographs according to the Sharp\/van der Heijde method. J Rheumatol. 2000;27:261\u20133.","journal-title":"J Rheumatol"},{"issue":"Suppl 2","key":"1414_CR9","doi-asserted-by":"crossref","first-page":"ii64","DOI":"10.1136\/ard.61.suppl_2.ii64","volume":"61","author":"V Strand","year":"2002","unstructured":"Strand V, Landewe R, van der Heijde D. Using estimated yearly progression rates to compare radiographic data across recent randomised controlled trials in rheumatoid arthritis. Ann Rheum Dis. 2002;61 Suppl 2:ii64\u201366.","journal-title":"Ann Rheum Dis"},{"key":"1414_CR10","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1136\/annrheumdis-2013-204050","volume":"73","author":"R Knevel","year":"2014","unstructured":"Knevel R, Klein K, Somers K, Ospelt C, Houwing-Duistermaat JJ, van Nies JA, de Rooy DP, de Bock L, Kurreeman FA, Schonkeren J, et al. Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis. Ann Rheum Dis. 2014;73:2038\u201346.","journal-title":"Ann Rheum Dis"},{"key":"1414_CR11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13182","volume":"507","author":"AR Forrest","year":"2014","unstructured":"Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, et al. A promoter-level mammalian expression atlas. Nature. 2014;507:462\u201370.","journal-title":"Nature"},{"key":"1414_CR12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/nar\/gkg129","volume":"31","author":"D Karolchik","year":"2003","unstructured":"Karolchik D, Baertsch R, Diekhans M, Furey TS, Hinrichs A, Lu YT, Roskin KM, Schwartz M, Sugnet CW, Thomas DJ, et al. The UCSC Genome Browser Database. Nucleic Acids Res. 2003;31:51\u20134.","journal-title":"Nucleic Acids Res"},{"key":"1414_CR13","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","volume":"34","author":"S Griffiths-Jones","year":"2006","unstructured":"Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006;34:D140\u20134.","journal-title":"Nucleic Acids Res"},{"key":"1414_CR14","doi-asserted-by":"crossref","first-page":"D163","DOI":"10.1093\/nar\/gkq1107","volume":"39","author":"SD Hsu","year":"2011","unstructured":"Hsu SD, Lin FM, Wu WY, Liang C, Huang WC, Chan WL, Tsai WT, Chen GZ, Lee CJ, Chiu CM, et al. miRTarBase: a database curates experimentally validated microRNA-target interactions. Nucleic Acids Res. 2011;39:D163\u2013169.","journal-title":"Nucleic Acids Res"},{"key":"1414_CR15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/bioinformatics\/btr678","volume":"28","author":"K Xia","year":"2012","unstructured":"Xia K, Shabalin AA, Huang S, Madar V, Zhou YH, Wang W, Zou F, Sun W, Sullivan PF, Wright FA. seeQTL: a searchable database for human eQTLs. Bioinformatics. 2012;28:451\u20132.","journal-title":"Bioinformatics"},{"key":"1414_CR16","doi-asserted-by":"crossref","unstructured":"GTEx Consortium. The Genotype-Tissue Expression (GTEx) project. Nat Genet. 2013;45:580\u20135.","DOI":"10.1038\/ng.2653"},{"key":"1414_CR17","doi-asserted-by":"crossref","first-page":"e1005223","DOI":"10.1371\/journal.pgen.1005223","volume":"11","author":"HJ Westra","year":"2015","unstructured":"Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al. Cell specific eQTL analysis without sorting cells. PLoS Genet. 2015;11:e1005223.","journal-title":"PLoS Genet"},{"key":"1414_CR18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.smim.2015.03.003","volume":"27","author":"PL Jager De","year":"2015","unstructured":"De Jager PL, Hacohen N, Mathis D, Regev A, Stranger BE, Benoist C. ImmVar project: Insights and design considerations for future studies of \u201chealthy\u201d immune variation. Semin Immunol. 2015;27:51\u20137.","journal-title":"Semin Immunol"},{"key":"1414_CR19","doi-asserted-by":"crossref","first-page":"e31826","DOI":"10.1371\/journal.pone.0031826","volume":"7","author":"MH Schaefer","year":"2012","unstructured":"Schaefer MH, Fontaine JF, Vinayagam A, Porras P, Wanker EE, Andrade-Navarro MA. HIPPIE: Integrating protein interaction networks with experiment based quality scores. PLoS One. 2012;7:e31826.","journal-title":"PLoS One"},{"key":"1414_CR20","doi-asserted-by":"crossref","first-page":"bav028","DOI":"10.1093\/database\/bav028","volume":"2015","author":"J Pinero","year":"2015","unstructured":"Pinero J, Queralt-Rosinach N, Bravo A, Deu-Pons J, Bauer-Mehren A, Baron M, Sanz F, Furlong LI. DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. Database (Oxford). 2015;2015:bav028.","journal-title":"Database (Oxford)"},{"key":"1414_CR21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/sj.ejhg.5201585","volume":"14","author":"MA Driel van","year":"2006","unstructured":"van Driel MA, Bruggeman J, Vriend G, Brunner HG, Leunissen JA. A text-mining analysis of the human phenome. Eur J Hum Genet. 2006;14:535\u201342.","journal-title":"Eur J Hum Genet"},{"key":"1414_CR22","doi-asserted-by":"crossref","first-page":"e1000641","DOI":"10.1371\/journal.pcbi.1000641","volume":"6","author":"O Vanunu","year":"2010","unstructured":"Vanunu O, Magger O, Ruppin E, Shlomi T, Sharan R. Associating genes and protein complexes with disease via network propagation. PLoS Comput Biol. 2010;6:e1000641.","journal-title":"PLoS Comput Biol"},{"key":"1414_CR23","doi-asserted-by":"crossref","first-page":"W201","DOI":"10.1093\/nar\/gkq513","volume":"38","author":"SF Saccone","year":"2010","unstructured":"Saccone SF, Bolze R, Thomas P, Quan J, Mehta G, Deelman E, Tischfield JA, Rice JP. SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res. 2010;38:W201\u2013209.","journal-title":"Nucleic Acids Res"},{"key":"1414_CR24","doi-asserted-by":"publisher","unstructured":"Joo YB, Bang SY, Ryu JA, Lee S, Lee HS, Bae SC. Predictors of severe radiographic progression in patients with early rheumatoid arthritis: Prospective observational cohort study. Int J Rheum Dis. 2017. doi:\n10.1111\/1756-185X.13054\n\n. [Epub ahead of Print]","DOI":"10.1111\/1756-185X.13054"},{"key":"1414_CR25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.gene.2012.11.067","volume":"518","author":"HM Wang","year":"2013","unstructured":"Wang HM, Chang TH, Lin FM, Chao TH, Huang WC, Liang C, Chu CF, Chiu CM, Wu WY, Chen MC, et al. A new method for post Genome-Wide Association Study (GWAS) analysis of colorectal cancer in Taiwan. Gene. 2013;518:107\u201313.","journal-title":"Gene"},{"key":"1414_CR26","doi-asserted-by":"crossref","unstructured":"Sille FC, Thomas R, Smith MT, Conde L, Skibola CF. Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia. PLoS One. 2012;7(e29632).","DOI":"10.1371\/journal.pone.0029632"},{"key":"1414_CR27","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ijrobp.2013.11.216","volume":"88","author":"RJ Klement","year":"2014","unstructured":"Klement RJ, Allgauer M, Appold S, Dieckmann K, Ernst I, Ganswindt U, Holy R, Nestle U, Nevinny-Stickel M, Semrau S, et al. Support vector machine-based prediction of local tumor control after stereotactic body radiation therapy for early-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014;88:732\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1414_CR28","doi-asserted-by":"crossref","first-page":"R34","DOI":"10.1186\/bcr1997","volume":"10","author":"E Nimeus-Malmstrom","year":"2008","unstructured":"Nimeus-Malmstrom E, Krogh M, Malmstrom P, Strand C, Fredriksson I, Karlsson P, Nordenskjold B, Stal O, Ostberg G, Peterson C, et al. Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy. Breast Cancer Res. 2008;10:R34.","journal-title":"Breast Cancer Res"},{"key":"1414_CR29","doi-asserted-by":"crossref","unstructured":"Wan XB, Zhao Y, Fan XJ, Cai HM, Zhang Y, Chen MY, Xu J, Wu XY, Li HB, Zeng YX, et al. Molecular prognostic prediction for locally advanced nasopharyngeal carcinoma by support vector machine integrated approach. PLoS One. 2012;7(e31989).","DOI":"10.1371\/journal.pone.0031989"},{"key":"1414_CR30","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3109\/02841861003649224","volume":"49","author":"IE Naqa","year":"2010","unstructured":"Naqa IE, Deasy JO, Mu Y, Huang E, Hope AJ, Lindsay PE, Apte A, Alaly J, Bradley JD. Datamining approaches for modeling tumor control probability. Acta Oncol. 2010;49:1363\u201373.","journal-title":"Acta Oncol"},{"key":"1414_CR31","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1118\/1.2776669","volume":"34","author":"S Chen","year":"2007","unstructured":"Chen S, Zhou S, Yin FF, Marks LB, Das SK. Investigation of the support vector machine algorithm to predict lung radiation-induced pneumonitis. Med Phys. 2007;34:3808\u201314.","journal-title":"Med Phys"},{"key":"1414_CR32","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1118\/1.2996012","volume":"35","author":"SK Das","year":"2008","unstructured":"Das SK, Chen S, Deasy JO, Zhou S, Yin FF, Marks LB. Combining multiple models to generate consensus: application to radiation-induced pneumonitis prediction. Med Phys. 2008;35:5098\u2013109.","journal-title":"Med Phys"},{"key":"1414_CR33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.coi.2014.09.007","volume":"31","author":"V Kumar","year":"2014","unstructured":"Kumar V, Wijmenga C, Xavier RJ. Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism. Curr Opin Immunol. 2014;31:51\u20137.","journal-title":"Curr Opin Immunol"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1414-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T20:57:12Z","timestamp":1508878632000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1414-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,25]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1414"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1414-x","relation":{},"ISSN":["1478-6362"],"issn-type":[{"type":"electronic","value":"1478-6362"}],"subject":[],"published":{"date-parts":[[2017,10,25]]},"article-number":"244"}}