{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:50:51Z","timestamp":1787500251821,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"UCB Pharma Inc."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1430-x","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T07:01:53Z","timestamp":1507100513000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Assessment of 3-month changes in bone microstructure under anti-TNF\u03b1 therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT)"],"prefix":"10.1186","volume":"19","author":[{"given":"Tomohiro","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Heilmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Burghardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattagan","family":"Chanchek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Imboden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"issue":"23","key":"1430_CR1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205\u201319.","journal-title":"N Engl J Med"},{"issue":"2","key":"1430_CR2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/rheumatology\/kel237","volume":"46","author":"KP Machold","year":"2007","unstructured":"Machold KP, Stamm TA, Nell VP, Pflugbeil S, Aletaha D, Steiner G, Uffmann M, Smolen JS. Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease. Rheumatology (Oxford). 2007;46(2):342\u20139.","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"1430_CR3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","volume":"8","author":"G Schett","year":"2012","unstructured":"Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012;8(11):656\u201364.","journal-title":"Nat Rev Rheumatol"},{"issue":"22","key":"1430_CR4","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM200011303432202","volume":"343","author":"PE Lipsky","year":"2000","unstructured":"Lipsky PE, van der Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, Smolen JS, Weisman M, Emery P, Feldmann M, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med. 2000;343(22):1594\u2013602.","journal-title":"N Engl J Med"},{"issue":"5","key":"1430_CR5","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/art.20217","volume":"50","author":"EC Keystone","year":"2004","unstructured":"Keystone EC, Kavanaugh AF, Sharp JT, Tannenbaum H, Hua Y, Teoh LS, Fischkoff SA, Chartash EK. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum. 2004;50(5):1400\u201311.","journal-title":"Arthritis Rheum"},{"issue":"9410","key":"1430_CR6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0140-6736(04)15640-7","volume":"363","author":"L Klareskog","year":"2004","unstructured":"Klareskog L, van der Heijde D, de Jager JP, Gough A, Kalden J, Malaise M, Martin Mola E, Pavelka K, Sany J, Settas L, et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet. 2004;363(9410):675\u201381.","journal-title":"Lancet"},{"issue":"5","key":"1430_CR7","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/art.30263","volume":"63","author":"P Emery","year":"2011","unstructured":"Emery P, Fleischmann R, van der Heijde D, Keystone EC, Genovese MC, Conaghan PG, Hsia EC, Xu W, Baratelle A, Beutler A, et al. The effects of golimumab on radiographic progression in rheumatoid arthritis: results of randomized controlled studies of golimumab before methotrexate therapy and golimumab after methotrexate therapy. Arthritis Rheum. 2011;63(5):1200\u201310.","journal-title":"Arthritis Rheum"},{"issue":"11","key":"1430_CR8","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1136\/annrheumdis-2013-203444","volume":"73","author":"JF Baker","year":"2014","unstructured":"Baker JF, Ostergaard M, Emery P, Hsia EC, Lu J, Baker DG, Conaghan PG. Early MRI measures independently predict 1-year and 2-year radiographic progression in rheumatoid arthritis: secondary analysis from a large clinical trial. Ann Rheum Dis. 2014;73(11):1968\u201374.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1430_CR9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/14397595.2015.1069471","volume":"26","author":"T Hirota","year":"2016","unstructured":"Hirota T, Suzuki T, Ogishima H, Hagiwara S, Ebe H, Takahashi H, Yokosawa M, Umeda N, Kondo Y, Tsuboi H, et al. Evaluation of changes in magnetic resonance images following 24 and 52\u00a0weeks of treatment of rheumatoid arthritis with infliximab, tocilizumab, or abatacept. Mod Rheumatol. 2016;26(1):29\u201335.","journal-title":"Mod Rheumatol"},{"issue":"2","key":"1430_CR10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrrheum.2014.145-c1","volume":"11","author":"C Barnabe","year":"2015","unstructured":"Barnabe C, Finzel S, Stok KS, Geusens P. High-resolution peripheral quantitative CT in rheumatology. Nat Rev Rheumatol. 2015;11(2):123.","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"1430_CR11","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/annrheumdis-2012-202958","volume":"73","author":"A Kleyer","year":"2014","unstructured":"Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, Araujo E, Hueber AJ, Harre U, Engelke K, et al. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2014;73(5):854\u201360.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1430_CR12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1136\/ard.2010.132423","volume":"70","author":"S Finzel","year":"2011","unstructured":"Finzel S, Englbrecht M, Engelke K, Stach C, Schett G. A comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis. Ann Rheum Dis. 2011;70(1):122\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1430_CR13","doi-asserted-by":"crossref","unstructured":"Finzel S, Sahinbegovic E, Kocijan R, Engelke K, Englbrecht M, Schett G. Inflammatory bone spur formation in psoriatic arthritis is different from bone spur formation in hand osteoarthritis. Arthritis Rheum. 2014, 66(11):2968-75.","DOI":"10.1002\/art.38794"},{"issue":"10","key":"1430_CR14","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1136\/ard.2008.097048","volume":"68","author":"U Moller Dohn","year":"2009","unstructured":"Moller Dohn U, Boonen A, Hetland ML, Hansen MS, Knudsen LS, Hansen A, Madsen OR, Hasselquist M, Moller JM, Ostergaard M. Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1\u00a0year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure. Ann Rheum Dis. 2009;68(10):1585\u201390.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"1430_CR15","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT. Bingham 3rd CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569\u201381.","journal-title":"Arthritis Rheum"},{"issue":"6","key":"1430_CR16","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1136\/ard.2007.084459","volume":"68","author":"G Wells","year":"2009","unstructured":"Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, Aletaha D, van Riel PL. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis. 2009;68(6):954\u201360.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"1430_CR17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3899\/jrheum.120780","volume":"40","author":"W Srikhum","year":"2013","unstructured":"Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis. J Rheumatol. 2013;40(4):408\u201316.","journal-title":"J Rheumatol"},{"issue":"12","key":"1430_CR18","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","volume":"90","author":"S Boutroy","year":"2005","unstructured":"Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005;90(12):6508\u201315.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1430_CR19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bone.2011.10.003","volume":"50","author":"JB Pialat","year":"2012","unstructured":"Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S. Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture. Bone. 2012;50(1):111\u20138.","journal-title":"Bone"},{"issue":"5-6","key":"1430_CR20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/THC-1998-65-606","volume":"6","author":"A Laib","year":"1998","unstructured":"Laib A, Hauselmann HJ, Ruegsegger P. In vivo high resolution 3D-QCT of the human forearm. Technol Health Care. 1998;6(5-6):329\u201337.","journal-title":"Technol Health Care"},{"key":"1430_CR21","doi-asserted-by":"crossref","unstructured":"Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution-peripheral quantitative computed tomography. Int J Rheum Dis. 2017;20(3):353\u2013362.","DOI":"10.1111\/1756-185X.12558"},{"issue":"12","key":"1430_CR22","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1007\/s10439-013-0871-x","volume":"41","author":"AJ Burghardt","year":"2013","unstructured":"Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Ann Biomed Eng. 2013;41(12):2553\u201364.","journal-title":"Ann Biomed Eng"},{"issue":"7","key":"1430_CR23","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3899\/jrheum.120218","volume":"39","author":"C Barnabe","year":"2012","unstructured":"Barnabe C, Feehan L. High-resolution peripheral quantitative computed tomography imaging protocol for metacarpophalangeal joints in inflammatory arthritis: the SPECTRA collaboration. J Rheumatol. 2012;39(7):1494\u20135.","journal-title":"J Rheumatol"},{"issue":"8646","key":"1430_CR24","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0140-6736(89)92442-2","volume":"1","author":"DM Heijde van der","year":"1989","unstructured":"van der Heijde DM, van Riel PL, Nuver-Zwart IH, Gribnau FW, vad de Putte LB. Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis. Lancet. 1989;1(8646):1036\u20138.","journal-title":"Lancet"},{"issue":"7","key":"1430_CR25","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1136\/ard.62.7.597","volume":"62","author":"PA Ory","year":"2003","unstructured":"Ory PA. Interpreting radiographic data in rheumatoid arthritis. Ann Rheum Dis. 2003;62(7):597\u2013604.","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"1430_CR26","doi-asserted-by":"crossref","first-page":"i11","DOI":"10.1136\/ard.2004.031815","volume":"64","author":"P Conaghan","year":"2005","unstructured":"Conaghan P, Bird P, Ejbjerg B, O'Connor P, Peterfy C, McQueen F, Lassere M, Emery P, Shnier R, Edmonds J, et al. The EULAR-OMERACT rheumatoid arthritis MRI reference image atlas: the metacarpophalangeal joints. Ann Rheum Dis. 2005;64 Suppl 1:i11\u201321.","journal-title":"Ann Rheum Dis."},{"issue":"Suppl 1","key":"1430_CR27","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1136\/ard.2004.031773","volume":"64","author":"M Ostergaard","year":"2005","unstructured":"Ostergaard M, Edmonds J, McQueen F, Peterfy C, Lassere M, Ejbjerg B, Bird P, Emery P, Genant H, Conaghan P. An introduction to the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas. Ann Rheum Dis. 2005;64 Suppl 1:i3\u20137.","journal-title":"Ann Rheum Dis."},{"issue":"9","key":"1430_CR28","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1136\/ard.2010.148395","volume":"70","author":"S Finzel","year":"2011","unstructured":"Finzel S, Rech J, Schmidt S, Engelke K, Englbrecht M, Stach C, Schett G. Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion. Ann Rheum Dis. 2011;70(9):1587\u201393.","journal-title":"Ann Rheum Dis"},{"issue":"6937","key":"1430_CR29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423(6937):337\u201342.","journal-title":"Nature"},{"issue":"2","key":"1430_CR30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.rdc.2010.03.003","volume":"36","author":"S Karmakar","year":"2010","unstructured":"Karmakar S, Kay J, Gravallese EM. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin North Am. 2010;36(2):385\u2013404.","journal-title":"Rheum Dis Clin North Am"},{"key":"1430_CR31","doi-asserted-by":"crossref","unstructured":"Yue J, Griffith JF, Xiao F, Shi L, Wang D, Shen J, Wong P, Li EK, Li M, Li TK, et al. Repair of bone erosion in rheumatoid arthritis by denosumab: a high-resolution peripheral quantitative computed tomography study. Arthritis Care Res. 2017;69(8):1156\u20131163.","DOI":"10.1002\/acr.23133"},{"issue":"Suppl 1","key":"1430_CR32","doi-asserted-by":"crossref","first-page":"i116","DOI":"10.1136\/ard.2010.140525","volume":"70","author":"D Heijde van der","year":"2011","unstructured":"van der Heijde D. Erosions versus joint space narrowing in rheumatoid arthritis: what do we know? Ann Rheum Dis. 2011;70 Suppl 1:i116\u20138.","journal-title":"Ann Rheum Dis."},{"issue":"9","key":"1430_CR33","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/rheumatology\/kev031","volume":"54","author":"A Regensburger","year":"2015","unstructured":"Regensburger A, Rech J, Englbrecht M, Finzel S, Kraus S, Hecht K, Kleyer A, Haschka J, Hueber AJ, Cavallaro A, et al. A comparative analysis of magnetic resonance imaging and high-resolution peripheral quantitative computed tomography of the hand for the detection of erosion repair in rheumatoid arthritis. Rheumatology (Oxford). 2015;54(9):1573\u201381.","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"1430_CR34","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/rheumatology\/kew445","volume":"56","author":"TG Woodworth","year":"2017","unstructured":"Woodworth TG, Morgacheva O, Pimienta OL, Troum OM, Ranganath VK, Furst DE. Examining the validity of the rheumatoid arthritis magnetic resonance imaging score according to the OMERACT filter-a systemic literature review. Rheumatology. 2017;56(7):1177\u201388.","journal-title":"Rheumatology"},{"issue":"3","key":"1430_CR35","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1186\/ar4235","volume":"15","author":"S Aschenberg","year":"2013","unstructured":"Aschenberg S, Finzel S, Schmidt S, Kraus S, Engelke K, Englbrecht M, Rech J, Schett G. Catabolic and anabolic periarticular bone changes in patients with rheumatoid arthritis: a computed tomography study on the role of age, disease duration and bone markers. Arthritis Res Ther. 2013;15(3):R62.","journal-title":"Arthritis Res Ther"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1430-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T14:18:04Z","timestamp":1603030684000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1430-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,4]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1430"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1430-x","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,4]]},"article-number":"222"}}