{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:58:50Z","timestamp":1778641130369,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Korea Ministry of Health & Welfare","award":["HI14C1277"],"award-info":[{"award-number":["HI14C1277"]}]},{"name":"Korea National Research Council of Science and Technology (KR)","award":["DRC-14-2-KRISS"],"award-info":[{"award-number":["DRC-14-2-KRISS"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1435-5","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T09:52:43Z","timestamp":1507629163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Beh\u00e7et\u2019s disease risk association fine-mapped on the IL23R\u2013IL12RB2 intergenic region in Koreans"],"prefix":"10.1186","volume":"19","author":[{"given":"Eun Ha","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sewon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Ah","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Jung","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Jong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Bong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changwon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Wook","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"1435_CR1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","volume":"341","author":"T Sakane","year":"1999","unstructured":"Sakane T, Takeno M, Suzuki N, Inaba G. Beh\u00e7et\u2019s disease. N Engl J Med. 1999;341:1284\u201391.","journal-title":"N Engl J Med."},{"key":"1435_CR2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","volume":"42","author":"N Mizuki","year":"2010","unstructured":"Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, et al. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh\u00e7et\u2019s disease susceptibility loci. Nat Genet. 2010;42:703\u20136.","journal-title":"Nat Genet."},{"key":"1435_CR3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","volume":"42","author":"EF Remmers","year":"2010","unstructured":"Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh\u00e7et\u2019s disease. Nat Genet. 2010;42:698\u2013702.","journal-title":"Nat Genet."},{"key":"1435_CR4","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1136\/ard.2009.119420","volume":"69","author":"Z Jiang","year":"2010","unstructured":"Jiang Z, Yang P, Hou S, Du L, Xie L, Zhou H, et al. IL-23R gene confers susceptibility to Behcet\u2019s disease in a Chinese Han population. Ann Rheum Dis. 2010;69:1325\u20138.","journal-title":"Ann Rheum Dis."},{"key":"1435_CR5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.humimm.2013.11.009","volume":"75","author":"Z Wu","year":"2014","unstructured":"Wu Z, Zheng W, Xu J, Sun F, Chen H, Li P, et al. IL10 polymorphisms associated with Beh\u00e7et\u2019s disease in Chinese Han. Hum Immunol. 2014;75:271\u20136.","journal-title":"Hum Immunol."},{"key":"1435_CR6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaci.2016.05.024","volume":"139","author":"H Yu","year":"2016","unstructured":"Yu H, Zheng M, Zhang L, Li H, Zhu Y, Cheng L, et al. Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Beh\u00e7et\u2019s disease in Han Chinese. J Allergy Clin Immunol. 2016;139:621\u20137.","journal-title":"J Allergy Clin Immunol."},{"key":"1435_CR7","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1002\/art.34437","volume":"64","author":"JM Xavier","year":"2012","unstructured":"Xavier JM, Shahram F, Davatchi F, Rosa A, Crespo J, Abdollahi BS, et al. Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Beh\u00e7et\u2019s disease. Arthritis Rheum. 2012;64:2761\u201372.","journal-title":"Arthritis Rheum."},{"key":"1435_CR8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00251-015-0841-6","volume":"67","author":"R Carapito","year":"2015","unstructured":"Carapito R, Shahram F, Michel S, Le Gentil M, Radosavljevic M, Meguro A, et al. On the genetics of the Silk Route: association analysis of HLA, IL10, and IL23R-IL12RB2 regions with Beh\u00e7et\u2019s disease in an Iranian population. Immunogenetics. 2015;67:289\u201393.","journal-title":"Immunogenetics."},{"key":"1435_CR9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fimmu.2013.00342","volume":"4","author":"O Khaib Dit Naib","year":"2013","unstructured":"Khaib Dit Naib O, Aribi M, Idder A, Chiali A, Sairi H, Touitou I, et al. Association analysis of IL10, TNF-\u03b1, and IL23R-IL12RB2 SNPs with Beh\u00e7et\u2019s disease risk in Western Algeria. Front Immunol. 2013;4:342.","journal-title":"Front Immunol"},{"key":"1435_CR10","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1002\/art.37708","volume":"64","author":"S Hou","year":"2012","unstructured":"Hou S, Yang Z, Du L, Jiang Z, Shu Q, Chen Y, et al. Identification of a susceptibility locus in STAT4 for Beh\u00e7et\u2019s disease in Han Chinese in a genome-wide association study. Arthritis Rheum. 2012;64:4104\u201313.","journal-title":"Arthritis Rheum."},{"key":"1435_CR11","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/annrheumdis-2011-200288","volume":"72","author":"YJ Lee","year":"2013","unstructured":"Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Choi JY, et al. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet\u2019s disease. Ann Rheum Dis. 2013;72:1510\u20136.","journal-title":"Ann Rheum Dis."},{"key":"1435_CR12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11882-008-0077-8","volume":"8","author":"BD Korman","year":"2008","unstructured":"Korman BD, Kastner DL, Gregersen PK, Remmers EF. STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep. 2008;8:398\u2013403.","journal-title":"Curr Allergy Asthma Rep."},{"key":"1435_CR13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2249.2011.04543.x","volume":"168","author":"J Shimizu","year":"2012","unstructured":"Shimizu J, Takai K, Fujiwara N, Arimitsu N, Ueda Y, Wakisaka S, et al. Excessive CD4+ T cells co-expressing interleukin-17 and interferon-\u03b3 in patients with Beh\u00e7et\u2019s disease. Clin Exp Immunol. 2012;168:68\u201374.","journal-title":"Clin Exp Immunol."},{"key":"1435_CR14","doi-asserted-by":"crossref","unstructured":"Geri G, Terrier B, Rosenzwajg M, Wechsler B, Touzot M, Seilhean D, Tran TA, Bodaghi B, Musset L, Soumelis V, Klatzmann D, Cacoub P, Saadoun D. Critical role of IL-21 in modulating TH17 and regulatory T cells in Beh\u00e7et disease. J Allergy Clin Immunol. 2011;128:655\u201364.","DOI":"10.1016\/j.jaci.2011.05.029"},{"key":"1435_CR15","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/ar3824","volume":"14","author":"S Sugita","year":"2012","unstructured":"Sugita S, Kawazoe Y, Imai A, Yamada Y, Horie S, Mochizuki M. Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Beh\u00e7et\u2019s disease. Arthritis Res Ther. 2012;14:R99.","journal-title":"Arthritis Res Ther."},{"key":"1435_CR16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","volume":"45","author":"Y Kirino","year":"2013","unstructured":"Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, et al. Genome-wide association analysis identifies new susceptibility loci for Beh\u00e7et\u2019s disease and epistasis between HLA-B*51 and ERAP1. Nat Genet. 2013;45:202\u20137.","journal-title":"Nat Genet."},{"key":"1435_CR17","first-page":"1078","volume":"335","author":"Criteria for diagnosis of Beh\u00e7et\u2019s disease","year":"1990","unstructured":"Criteria for diagnosis of Beh\u00e7et\u2019s disease. International Study Group for Beh\u00e7et\u2019s Disease. Lancet. 1990;335:1078\u201380.","journal-title":"Lancet"},{"key":"1435_CR18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.imlet.2014.01.001","volume":"160","author":"F Cavu\u015f","year":"2014","unstructured":"Cavu\u015f F, Ulusoy C, \u00d6r\u00e7en A, G\u00fcl A, T\u00fcz\u00fcn E, Vural B. Increased IL-23 receptor, TNF-\u03b1 and IL-6 expression in individuals with the IL23R-IL12RB2 locus polymorphism. Immunol Lett. 2014;160:96\u20138.","journal-title":"Immunol Lett."},{"issue":"Suppl 77","key":"1435_CR19","first-page":"32","volume":"31","author":"SY Na","year":"2013","unstructured":"Na SY, Park MJ, Park S, Lee ES. Up-regulation of Th17 and related cytokines in Beh\u00e7et\u2019s disease corresponding to disease activity. Clin Exp Rheumatol. 2013;31 Suppl 77:32\u201340.","journal-title":"Clin Exp Rheumatol."},{"issue":"Suppl 60","key":"1435_CR20","first-page":"S16","volume":"28","author":"J Kim","year":"2010","unstructured":"Kim J, Park JA, Lee EY, Lee YJ, Song YW, Lee EB. Imbalance of Th17 to Th1 cells in Beh\u00e7et\u2019s disease. Clin Exp Rheumatol. 2010;28 Suppl 60:S16\u20139.","journal-title":"Clin Exp Rheumatol."}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1435-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T09:53:10Z","timestamp":1507629190000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1435-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,10]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1435"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1435-5","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,10]]},"article-number":"227"}}