{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:01:42Z","timestamp":1773842502206,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI308"],"award-info":[{"award-number":["KLI308"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1448-0","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T10:48:18Z","timestamp":1508842098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ultrasound verified inflammation and structural damage in patients with hereditary haemochromatosis-related arthropathy"],"prefix":"10.1186","volume":"19","author":[{"given":"Christian","family":"Dejaco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stadlmayr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Duftner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Trimmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rusmir","family":"Husic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Krones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Zandieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Husar-Memmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Zollner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Gretler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Ficjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Datz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Axman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Zwerina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"1448_CR1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0168-8278(97)80312-1","volume":"27","author":"C Datz","year":"1997","unstructured":"Datz C, Lalloz MR, Vogel W, Graziadei I, Hackl F, Vautier G, et al. Predominance of the HLA-H Cys282Tyr mutation in Austrian patients with genetic haemochromatosis. J Hepatol. 1997;27:773\u20139.","journal-title":"J Hepatol"},{"key":"1448_CR2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jcp.20315","volume":"204","author":"S Ludwiczek","year":"2005","unstructured":"Ludwiczek S, Theurl I, Bahram S, Schumann K, Weiss G. Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. J Cell Physiol. 2005;204:489\u201399.","journal-title":"J Cell Physiol"},{"key":"1448_CR3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1365-2036.2012.05051.x","volume":"35","author":"A Siddique","year":"2012","unstructured":"Siddique A, Kowdley KV. Review article: the iron overload syndromes. Aliment Pharmacol Ther. 2012;35:876\u201393.","journal-title":"Aliment Pharmacol Ther"},{"key":"1448_CR4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2036.2007.03387.x","volume":"26","author":"WJ Griffiths","year":"2007","unstructured":"Griffiths WJ. Review article: the genetic basis of haemochromatosis. Aliment Pharmacol Ther. 2007;26:331\u201342.","journal-title":"Aliment Pharmacol Ther"},{"key":"1448_CR5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1749-6632.1988.tb55508.x","volume":"526","author":"HR Schumacher","year":"1988","unstructured":"Schumacher HR, Straka PC, Krikker MA, Dudley AT. The arthropathy of hemochromatosis. Recent studies. Ann NY Acad Sci. 1988;526:224\u201333.","journal-title":"Ann NY Acad Sci"},{"key":"1448_CR6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00393-009-0590-8","volume":"69","author":"J Zwerina","year":"2010","unstructured":"Zwerina J, Dallos T. Osteoarthritis in hereditary metabolic diseases. Z Rheumatol. 2010;69:227\u201335. quiz 236.","journal-title":"Z Rheumatol"},{"key":"1448_CR7","first-page":"71","volume":"39","author":"CJ Atkins","year":"1970","unstructured":"Atkins CJ, McIvor J, Smith PM, Hamilton E, Williams R. Chondrocalcinosis and arthropathy: studies in haemochromatosis and in idiopathic chondrocalcinosis. Q J Med. 1970;39:71\u201382.","journal-title":"Q J Med"},{"key":"1448_CR8","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s003300050274","volume":"7","author":"HJ Jager","year":"1997","unstructured":"Jager HJ, Mehring U, Gotz GF, Neise M, Erlemann R, Kapp HJ, et al. Radiological features of the visceral and skeletal involvement of hemochromatosis. Eur Radiol. 1997;7:1199\u2013206.","journal-title":"Eur Radiol"},{"key":"1448_CR9","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1136\/ard.2009.122119","volume":"69","author":"T Dallos","year":"2010","unstructured":"Dallos T, Sahinbegovic E, Aigner E, Axmann R, Schoniger-Hekele M, Karonitsch T, et al. Validation of a radiographic scoring system for haemochromatosis arthropathy. Ann Rheum Dis. 2010;69:2145\u201351.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR10","first-page":"196","volume":"30","author":"H Schmid","year":"2003","unstructured":"Schmid H, Struppler C, Braun GS, Kellner W, Kellner H. Ankle and hindfoot arthropathy in hereditary hemochromatosis. J Rheumatol. 2003;30:196\u20139.","journal-title":"J Rheumatol"},{"key":"1448_CR11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/MPH.0b013e31806451e4","volume":"29","author":"M Karimi","year":"2007","unstructured":"Karimi M, Jamalian N, Rasekhi A, Kashef S. Magnetic resonance imaging (MRI) findings of joints in young beta-thalassemia major patients: fluid surrounding the scaphoid bone: a novel finding, as the possible effect of secondary hemochromatosis. J Pediatr Hematol Oncol. 2007;29:393\u20138.","journal-title":"J Pediatr Hematol Oncol"},{"key":"1448_CR12","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1002\/art.27712","volume":"62","author":"E Sahinbegovic","year":"2010","unstructured":"Sahinbegovic E, Dallos T, Aigner E, Axmann R, Manger B, Englbrecht M, et al. Musculoskeletal disease burden of hereditary hemochromatosis. Arthritis Rheum. 2010;62:3792\u20138.","journal-title":"Arthritis Rheum"},{"key":"1448_CR13","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.1780331101","volume":"33","author":"R Altman","year":"1990","unstructured":"Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990;33:1601\u201310.","journal-title":"Arthritis Rheum"},{"key":"1448_CR14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/annrheumdis-2012-203073","volume":"73","author":"R Husic","year":"2014","unstructured":"Husic R, Gretler J, Felber A, Graninger WB, Duftner C, Hermann J, et al. Disparity between ultrasound and clinical findings in psoriatic arthritis. Ann Rheum Dis. 2014;73:1529\u201336.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/ard.60.7.641","volume":"60","author":"M Backhaus","year":"2001","unstructured":"Backhaus M, Burmester GR, Gerber T, Grassi W, Machold KP, Swen WA, et al. Guidelines for musculoskeletal ultrasound in rheumatology. Ann Rheum Dis. 2001;60:641\u20139.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR16","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.semarthrit.2011.09.005","volume":"41","author":"C Dejaco","year":"2012","unstructured":"Dejaco C, Duftner C, Wipfler-Freissmuth E, Weiss H, Graninger WB, Schirmer M. Ultrasound-defined remission and active disease in rheumatoid arthritis: association with clinical and serologic parameters. Semin Arthritis Rheum. 2012;41:761\u20137.","journal-title":"Semin Arthritis Rheum"},{"key":"1448_CR17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/acr.21574","volume":"64","author":"W Hartung","year":"2012","unstructured":"Hartung W, Kellner H, Strunk J, Sattler H, Schmidt WA, Ehrenstein B, et al. Development and evaluation of a novel ultrasound score for large joints in rheumatoid arthritis: one year of experience in daily clinical practice. Arthritis Care Res (Hoboken). 2012;64:675\u201382.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1448_CR18","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1136\/ard.2011.152926","volume":"70","author":"HB Hammer","year":"2011","unstructured":"Hammer HB, Bolton-King P, Bakkeheim V, Berg TH, Sundt E, Kongtorp AK, et al. Examination of intra and interrater reliability with a new ultrasonographic reference atlas for scoring of synovitis in patients with rheumatoid arthritis. Ann Rheum Dis. 2011;70:1995\u20138.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s13075-014-0476-2","volume":"16","author":"A Ficjan","year":"2014","unstructured":"Ficjan A, Husic R, Gretler J, Lackner A, Graninger WB, Gutierrez M, et al. Ultrasound composite scores for the assessment of inflammatory and structural pathologies in psoriatic arthritis (PsASon-Score). Arthritis Res Ther. 2014;16:476.","journal-title":"Arthritis Res Ther"},{"key":"1448_CR20","first-page":"2485","volume":"32","author":"RJ Wakefield","year":"2005","unstructured":"Wakefield RJ, Balint PV, Szkudlarek M, Filippucci E, Backhaus M, D\u2019Agostino MA, et al. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol. 2005;32:2485\u20137.","journal-title":"J Rheumatol"},{"key":"1448_CR21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1136\/ard.2010.132423","volume":"70","author":"S Finzel","year":"2011","unstructured":"Finzel S, Englbrecht M, Engelke K, Stach C, Schett G. A comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis. Ann Rheum Dis. 2011;70:122\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.semarthrit.2006.08.001","volume":"36","author":"W Grassi","year":"2006","unstructured":"Grassi W, Meenagh G, Pascual E, Filippucci E. \u201cCrystal clear\u201d-sonographic assessment of gout and calcium pyrophosphate deposition disease. Semin Arthritis Rheum. 2006;36:197\u2013202.","journal-title":"Semin Arthritis Rheum"},{"key":"1448_CR23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.amjmed.2010.01.024","volume":"123","author":"E Sahinbegovic","year":"2010","unstructured":"Sahinbegovic E, Dallos T, Aigner E, Axmann R, Engelbrecht M, Schoniger-Hekele M, et al. Hereditary hemochromatosis as a risk factor for joint replacement surgery. Am J Med. 2010;123:659\u201362.","journal-title":"Am J Med"},{"key":"1448_CR24","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/rheumatology\/kex069","volume":"56","author":"AR Oke","year":"2017","unstructured":"Oke AR, Wong E, McCrae F, Young-Min S. Hereditary hemochromatosis arthropathy and Doppler ultrasound findings of synovitis. Rheumatology. 2017;56:1240\u20131.","journal-title":"Rheumatology"},{"key":"1448_CR25","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1007\/s00296-013-2694-3","volume":"33","author":"K Frenzen","year":"2013","unstructured":"Frenzen K, Sch\u00e4fer C, Key\u00dfer G. Erosive and inflammatory joint changes in hereditary hemochromatosis arthropathy detected by low-field magnetic resonance imaging. Rheumatol Int. 2013;33:2061\u20137.","journal-title":"Rheumatol Int"},{"key":"1448_CR26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/acr.20501","volume":"64","author":"GJ Carroll","year":"2012","unstructured":"Carroll GJ, Breidahl WH, Olynyk JK. Characteristics of the arthropathy described in hereditary hemochromatosis. Arthritis Care Res (Hoboken). 2012;64:9\u201314.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1448_CR27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11926-013-0393-4","volume":"16","author":"E Husar-Memmer","year":"2014","unstructured":"Husar-Memmer E, Stadlmayr A, Datz C, Zwerina J. HFE-related hemochromatosis: an update for the rheumatologist. Curr Rheumatol Rep. 2014;16:393.","journal-title":"Curr Rheumatol Rep"},{"key":"1448_CR28","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/ard.2009.120204","volume":"69","author":"GR Heiland","year":"2010","unstructured":"Heiland GR, Aigner E, Dallos T, Sahinbegovic E, Krenn V, Thaler C, et al. Synovial immunopathology in haemochromatosis arthropathy. Ann Rheum Dis. 2010;69:1214\u20139.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR29","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1136\/annrheumdis-2012-201620","volume":"72","author":"JS Smolen","year":"2013","unstructured":"Smolen JS, van der Heijde DM, Keystone EC, van Vollenhoven RF, Goldring MB, Gu\u00e9rette B, et al. Association of joint space narrowing with impairment of physical function and work ability in patients with early rheumatoid arthritis: protection beyond disease control by adalimumab plus methotrexate. Ann Rheum Dis. 2013;72:1156\u201362.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR30","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1136\/annrheumdis-2014-205585","volume":"74","author":"P Mandl","year":"2014","unstructured":"Mandl P, Supp G, Baksa G, Radner H, Studenic P, Gyebnar J, et al. Relationship between radiographic joint space narrowing, sonographic cartilage thickness and anatomy in rheumatoid arthritis and control joints. Ann Rheum Dis. 2014;74:2022\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR31","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/annrheumdis-2015-207241","volume":"75","author":"A Mathiessen","year":"2016","unstructured":"Mathiessen A, Slatkowsky-Christensen B, Kvien TK, Hammer HB, Haugen IK. Ultrasound-detected inflammation predicts radiographic progression in hand osteoarthritis after 5\u2005years. Ann Rheum Dis. 2016;75:825\u201330.","journal-title":"Ann Rheum Dis"},{"key":"1448_CR32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00256-006-0196-z","volume":"36","author":"S Bajaj","year":"2007","unstructured":"Bajaj S, Lopez-Ben R, Oster R, Alarcon GS. Ultrasound detects rapid progression of erosive disease in early rheumatoid arthritis: a prospective longitudinal study. Skeletal Radiol. 2007;36:123\u20138.","journal-title":"Skeletal Radiol"},{"key":"1448_CR33","doi-asserted-by":"crossref","unstructured":"Mancarella L, Addimanda O, Cavallari C, Meliconi R. Synovial inflammation drives structural damage in hand osteoarthritis: a narrative literature review. Curr. Rheumatol. Rev. 2016 [Epub ahead of print].","DOI":"10.2174\/1573397112666160909105903"},{"key":"1448_CR34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12891-016-0900-7","volume":"17","author":"A McBride","year":"2016","unstructured":"McBride A, Khan HI, Aitken D, Chou L, Ding C, Blizzard L, et al. Does cartilage volume measurement or radiographic osteoarthritis at baseline independently predict ten-year cartilage volume loss? BMC Musculoskelet Disord. 2016;17:54.","journal-title":"BMC Musculoskelet Disord"},{"key":"1448_CR35","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3899\/jrheum.141067","volume":"42","author":"S Ottaviani","year":"2015","unstructured":"Ottaviani S, Juge P-A, Aubrun A, Palazzo E, Dieude P. Sensitivity and reproducibility of ultrasonography in calcium pyrophosphate crystal deposition in knee cartilage: a cross-sectional study. J Rheumatol. 2015;42:1511\u20133.","journal-title":"J Rheumatol"},{"key":"1448_CR36","doi-asserted-by":"crossref","first-page":"e000339","DOI":"10.1136\/rmdopen-2016-000339","volume":"2","author":"Y Wu","year":"2016","unstructured":"Wu Y, Chen K, Terkeltaub R. Systematic review and quality analysis of emerging diagnostic measures for calcium pyrophosphate crystal deposition disease. RMD Open. 2016;2:e000339.","journal-title":"RMD Open"},{"key":"1448_CR37","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/rheumatology\/kes392","volume":"52","author":"T Dallos","year":"2013","unstructured":"Dallos T, Sahinbegovic E, Stamm T, Aigner E, Axmann R, Stadlmayr A, et al. Idiopathic hand osteoarthritis vs haemochromatosis arthropathy\u2013a clinical, functional and radiographic study. Rheumatology. 2013;52:910\u20135.","journal-title":"Rheumatology"},{"key":"1448_CR38","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/art.30094","volume":"63","author":"GJ Carroll","year":"2011","unstructured":"Carroll GJ, Breidahl WH, Bulsara MK, Olynyk JK. Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load. Arthritis Rheum. 2011;63:286\u201394.","journal-title":"Arthritis Rheum"},{"key":"1448_CR39","first-page":"153","volume":"35","author":"L Valenti","year":"2008","unstructured":"Valenti L, Fracanzani AL, Rossi V, Rampini C, Pulixi E, Varenna M, et al. The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload. J Rheumatol. 2008;35:153\u20138.","journal-title":"J Rheumatol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1448-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T22:55:05Z","timestamp":1570229705000},"score":1,"resource":{"primary":{"URL":"http:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1448-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,24]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1448"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1448-0","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,24]]},"article-number":"243"}}