{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:48:37Z","timestamp":1785235717198,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["258814"],"award-info":[{"award-number":["258814"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["292701"],"award-info":[{"award-number":["292701"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Research Funding (ERVA)","award":["13856"],"award-info":[{"award-number":["13856"]}]},{"name":"Turku University Hospital, Diagnostic and related services"},{"name":"Drug Research Doctoral Programme, University of Turku Graduate School"},{"name":"Turku Doctoral Programme for Molecular Medicine, University of Turku Graduate School"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1460-4","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T06:38:26Z","timestamp":1511332706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice"],"prefix":"10.1186","volume":"19","author":[{"given":"Riikka","family":"Siitonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annukka","family":"Pietik\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Liljenb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meeri","family":"K\u00e4kel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirva","family":"S\u00f6derstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirpa","family":"Jalkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Hyt\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Roivainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"1460_CR1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(11)60103-7","volume":"379","author":"G Stanek","year":"2012","unstructured":"Stanek G, Wormser GP, Gray J, Strle F. Lyme borreliosis. Lancet. 2012;379:461\u201373.","journal-title":"Lancet."},{"key":"1460_CR2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00002281-200207000-00010","volume":"14","author":"J Coburn","year":"2002","unstructured":"Coburn J, Medrano M, Cugini C. Borrelia burgdorferi and its tropisms for adhesion molecules in the joint. Curr Opin Rheumatol. 2002;14:394\u20138.","journal-title":"Curr Opin Rheumatol."},{"key":"1460_CR3","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/art.38756","volume":"66","author":"LK Bockenstedt","year":"2014","unstructured":"Bockenstedt LK, Wormser GP. Review: unraveling Lyme disease. Arthritis Rheumatol. 2014;66:2313\u201323.","journal-title":"Arthritis Rheumatol."},{"key":"1460_CR4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.idc.2015.02.004","volume":"29","author":"SL Arvikar","year":"2015","unstructured":"Arvikar SL, Steere AC. Diagnosis and treatment of Lyme arthritis. Infect Dis Clin North Am. 2015;29:269\u201380.","journal-title":"Infect Dis Clin North Am."},{"key":"1460_CR5","first-page":"959","volume":"143","author":"SW Barthold","year":"1993","unstructured":"Barthold SW, de Souza MS, Janotka JL, Smith AL, Persing DH. Chronic Lyme borreliosis in the laboratory mouse. Am J Pathol. 1993;143:959\u201371.","journal-title":"Am J Pathol."},{"key":"1460_CR6","doi-asserted-by":"crossref","first-page":"e1000169","DOI":"10.1371\/journal.ppat.1000169","volume":"4","author":"MU Norman","year":"2008","unstructured":"Norman MU, Moriarty TJ, Dresser AR, Millen B, Kubes P, Chaconas G. Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host. PLoS Pathog. 2008;4:e1000169.","journal-title":"PLoS Pathog."},{"key":"1460_CR7","doi-asserted-by":"crossref","first-page":"e1000090","DOI":"10.1371\/journal.ppat.1000090","volume":"4","author":"TJ Moriarty","year":"2008","unstructured":"Moriarty TJ, Norman MU, Colarusso P, Bankhead T, Kubes P, Chaconas G. Real-time high resolution 3D imaging of the Lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathog. 2008;4:e1000090.","journal-title":"PLoS Pathog."},{"key":"1460_CR8","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1172\/JCI58813","volume":"122","author":"LK Bockenstedt","year":"2012","unstructured":"Bockenstedt LK, Gonzalez DG, Haberman AM, Belperron AA. Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy. J Clin Invest. 2012;122:2652\u201360.","journal-title":"J Clin Invest."},{"key":"1460_CR9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2958.2011.07801.x","volume":"82","author":"JA Hyde","year":"2011","unstructured":"Hyde JA, Weening EH, Chang M, Trzeciakowski JP, H\u00f6\u00f6k M, Cirillo JD, et al. Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity. Mol Microbiol. 2011;82:99\u2013113.","journal-title":"Mol Microbiol."},{"key":"1460_CR10","first-page":"623036","volume":"2013","author":"AWJM Glaudemans","year":"2013","unstructured":"Glaudemans AWJM, de Vries EFJ, Galli F, Dierckx RAJO, Slart RHJA, Signore A. The use of 18F-FDG-PET\/CT for diagnosis and treatment monitoring of inflammatory and infectious diseases. Clin Dev Immunol. 2013;2013:623036.","journal-title":"Clin Dev Immunol."},{"key":"1460_CR11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s12149-011-0521-z","volume":"25","author":"A Signore","year":"2011","unstructured":"Signore A, Glaudemans AWJM. The molecular imaging approach to image infections and inflammation by nuclear medicine techniques. Ann Nucl Med. 2011;25:681\u2013700.","journal-title":"Ann Nucl Med."},{"issue":"Suppl 1","key":"1460_CR12","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1007\/s00259-011-1987-6","volume":"39","author":"A Roivainen","year":"2012","unstructured":"Roivainen A, Jalkanen S, Nanni C. Gallium-labelled peptides for imaging of inflammation. Eur J Nucl Med Mol Imaging. 2012;39 Suppl 1:S68\u201377.","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"1460_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2191-219X-3-1","volume":"3","author":"A Autio","year":"2013","unstructured":"Autio A, Jalkanen S, Roivainen A. Nuclear imaging of inflammation: homing-associated molecules as targets. EJNMMI Res. 2013;3:1.","journal-title":"EJNMMI Res."},{"key":"1460_CR14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1126\/science.1529341","volume":"257","author":"M Salmi","year":"1992","unstructured":"Salmi M, Jalkanen S. A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans. Science. 1992;257:1407\u20139.","journal-title":"Science."},{"key":"1460_CR15","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nri1705","volume":"5","author":"M Salmi","year":"2005","unstructured":"Salmi M, Jalkanen S. Cell-surface enzymes in control of leukocyte trafficking. Nat Rev Immunol. 2005;5:760\u201371.","journal-title":"Nat Rev Immunol."},{"key":"1460_CR16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0002-9440(10)64558-0","volume":"157","author":"K Jaakkola","year":"2000","unstructured":"Jaakkola K, Nikula T, Holopainen R, V\u00e4h\u00e4silta T, Matikainen MT, Laukkanen ML, et al. In vivo detection of vascular adhesion protein-1 in experimental inflammation. Am J Pathol. 2000;157:463\u201371.","journal-title":"Am J Pathol."},{"key":"1460_CR17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00259-007-0637-5","volume":"35","author":"P Lankinen","year":"2008","unstructured":"Lankinen P, M\u00e4kinen TJ, P\u00f6yh\u00f6nen TA, Virsu P, Salom\u00e4ki S, Hakanen AJ, et al. 68Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones. Eur J Nucl Med Mol Imaging. 2008;35:352\u201364.","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"1460_CR18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.nucmedbio.2009.04.008","volume":"36","author":"T Ujula","year":"2009","unstructured":"Ujula T, Salom\u00e4ki S, Virsu P, Lankinen P, M\u00e4kinen TJ, Autio A, et al. Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis. Nucl Med Biol. 2009;36:631\u201341.","journal-title":"Nucl Med Biol."},{"key":"1460_CR19","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1007\/s00259-010-1497-y","volume":"37","author":"A Autio","year":"2010","unstructured":"Autio A, Ujula T, Luoto P, Salom\u00e4ki S, Jalkanen S, Roivainen A. PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG. Eur J Nucl Med Mol Imaging. 2010;37:1918\u201325.","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"1460_CR20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2191-219X-1-10","volume":"1","author":"A Autio","year":"2011","unstructured":"Autio A, Henttinen T, Sipil\u00e4 HJ, Jalkanen S, Roivainen A. Mini-PEG spacering of VAP-1-targeting 68Ga-DOTAVAP-P1 peptide improves PET imaging of inflammation. EJNMMI Res. 2011;1:10.","journal-title":"EJNMMI Res."},{"key":"1460_CR21","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2967\/jnumed.113.120295","volume":"54","author":"A Autio","year":"2013","unstructured":"Autio A, Vainio PJ, Suilamo S, Mali A, Vainio J, Saanijoki T, et al. Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation. J Nucl Med. 2013;54:1315\u20139.","journal-title":"J Nucl Med."},{"key":"1460_CR22","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1182\/blood-2010-09-311076","volume":"118","author":"K Aalto","year":"2011","unstructured":"Aalto K, Autio A, Kiss EA, Elima K, Nymalm Y, Veres TZ, et al. Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer. Blood. 2011;118:3725\u201333.","journal-title":"Blood."},{"key":"1460_CR23","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1182\/blood-2009-04-219253","volume":"114","author":"E Kivi","year":"2009","unstructured":"Kivi E, Elima K, Aalto K, Nymalm Y, Auvinen K, Koivunen E, et al. Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate. Blood. 2009;114:5385\u201392.","journal-title":"Blood."},{"key":"1460_CR24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13550-014-0045-3","volume":"4","author":"H Ahtinen","year":"2014","unstructured":"Ahtinen H, Kulkova J, Lindholm L, Eerola E, Hakanen AJ, Moritz N, et al. 68Ga-DOTA-Siglec-9 PET\/CT imaging of peri-implant tissue responses and staphylococcal infections. EJNMMI Res. 2014;4:45.","journal-title":"EJNMMI Res."},{"key":"1460_CR25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s13075-015-0826-8","volume":"17","author":"H Virtanen","year":"2015","unstructured":"Virtanen H, Autio A, Siitonen R, Liljenb\u00e4ck H, Saanijoki T, Lankinen P, et al. 68Ga-DOTA-Siglec-9 \u2013 a new imaging tool to detect synovitis. Arthritis Res Ther. 2015;17:308.","journal-title":"Arthritis Res Ther."},{"key":"1460_CR26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/15419069409004433","volume":"2","author":"E B\u00f6ggemeyer","year":"1994","unstructured":"B\u00f6ggemeyer E, Stehle T, Schaible UE, Hahne M, Vestweber D, Simon MM. Borrelia burgdorferi upregulates the adhesion molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on mouse endothelioma cells in vitro. Cell Adhes Commun. 1994;2:145\u201357.","journal-title":"Cell Adhes Commun."},{"key":"1460_CR27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/15419069409014211","volume":"2","author":"UE Schaible","year":"1994","unstructured":"Schaible UE, Vestweber D, Butcher EG, Stehle T, Simon MM. Expression of endothelial cell adhesion molecules in joints and heart during Borrelia burgdorferi infection of mice. Cell Adhes Commun. 1994;2:465\u201379.","journal-title":"Cell Adhes Commun."},{"key":"1460_CR28","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1128\/IAI.69.3.1774-1780.2001","volume":"69","author":"E Akin","year":"2001","unstructured":"Akin E, Aversa J, Steere AC. Expression of adhesion molecules in synovia of patients with treatment-resistant Lyme arthritis. Infect Immun. 2001;69:1774\u201380.","journal-title":"Infect Immun."},{"key":"1460_CR29","first-page":"18","volume":"6","author":"J Retamal","year":"2016","unstructured":"Retamal J, S\u00f6rensen J, Lubberink M, Suarez-Sipmann F, Borges JB, Feinstein R, et al. Feasibility of 68Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome. Am J Nucl Med Mol Imaging. 2016;6:18\u201331.","journal-title":"Am J Nucl Med Mol Imaging."},{"key":"1460_CR30","first-page":"263","volume":"139","author":"SW Barthold","year":"1991","unstructured":"Barthold SW, Persing DH, Armstrong AL, Peeples RA. Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice. Am J Pathol. 1991;139:263\u201373.","journal-title":"Am J Pathol."},{"key":"1460_CR31","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1128\/AAC.01050-07","volume":"52","author":"E Hodzic","year":"2008","unstructured":"Hodzic E, Feng S, Holden K, Freet KJ, Barthold SW. Persistence of Borrelia burgdorferi following antibiotic treatment in mice. Antimicrob Agents Chemother. 2008;52:1728\u201336.","journal-title":"Antimicrob Agents Chemother."},{"key":"1460_CR32","doi-asserted-by":"crossref","first-page":"e0121512","DOI":"10.1371\/journal.pone.0121512","volume":"10","author":"J Salo","year":"2015","unstructured":"Salo J, Jaatinen A, S\u00f6derstr\u00f6m M, Viljanen MK, Hyt\u00f6nen J. Decorin binding proteins of Borrelia burgdorferi promote arthritis development and joint specific post-treatment DNA persistence in mice. PLoS One. 2015;10:e0121512.","journal-title":"PLoS One."},{"key":"1460_CR33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.7150\/thno.6592","volume":"3","author":"C Wu","year":"2013","unstructured":"Wu C, Li F, Niu G, Chen X. PET imaging of inflammation biomarkers. Theranostics. 2013;3:448\u201366.","journal-title":"Theranostics."},{"key":"1460_CR34","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/00006231-200208000-00011","volume":"23","author":"A Newberg","year":"2002","unstructured":"Newberg A, Hassan A, Alavi A. Cerebral metabolic changes associated with Lyme disease. Nucl Med Commun. 2002;23:773\u20137.","journal-title":"Nucl Med Commun."},{"key":"1460_CR35","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s00234-005-1440-2","volume":"47","author":"P Kalina","year":"2005","unstructured":"Kalina P, Decker A, Kornel E, Halperin JJ. Lyme disease of the brainstem. Neuroradiology. 2005;47:903\u20137.","journal-title":"Neuroradiology."},{"key":"1460_CR36","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3171\/jns.2005.102.5.0927","volume":"102","author":"M Plotkin","year":"2005","unstructured":"Plotkin M, Hautzel H, Krause BJ, Mohr S, Langen KJ, M\u00fcller HW. Fluorine-18-labeled fluorodeoxyglucose-positron emission tomography studies of acute brainstem Lyme neuroborreliosis. J Neurosurg. 2005;102:927\u20139.","journal-title":"J Neurosurg."},{"key":"1460_CR37","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1016\/j.jinf.2005.02.014","volume":"51","author":"A Aigelsreiter","year":"2005","unstructured":"Aigelsreiter A, Pump A, Buchh\u00e4usl W, Sch\u00f6nfelder M, Beham-Schmid C, Cerroni L, et al. Successful antibiotic treatment of borreliosis associated pseudolymphomatous systemic infiltrates. J Infect. 2005;51:e203\u20136.","journal-title":"J Infect."},{"key":"1460_CR38","doi-asserted-by":"publisher","unstructured":"Pietik\u00e4inen A, Siitonen R, Liljenb\u00e4ck H, Eskola O, S\u00f6derstr\u00f6m M, Roivainen A, et al. In vivo imaging of Lyme arthritis in mice by [18F]fluorodeoxyglucose positron emission tomography\/computed tomography. Scand J Rheumatol. 2017:1\u201311. doi:\n10.1080\/03009742.2017.1287306\n\n.","DOI":"10.1080\/03009742.2017.1287306"},{"key":"1460_CR39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejmech.2017.03.060","volume":"133","author":"J Dutta","year":"2017","unstructured":"Dutta J, Naicker T, Ebenhan T, Kruger HG, Arvidsson PI, Govender T. Synthetic approaches to radiochemical probes for imaging of bacterial infections. Eur J Med Chem. 2017;133:287\u2013308.","journal-title":"Eur J Med Chem."},{"key":"1460_CR40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/j.ro.2016.07.001","volume":"52","author":"CM Connolly","year":"2017","unstructured":"Connolly CM, Donohoe KJ. Nuclear medicine imaging of infection. Semin Roentgenol. 2017;52:114\u20139.","journal-title":"Semin Roentgenol."},{"key":"1460_CR41","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2967\/jnumed.109.072462","volume":"51","author":"M Petrik","year":"2010","unstructured":"Petrik M, Haas H, Dobrozemsky G, Lass-Fl\u00f6rl C, Helbok A, Blatzer M, et al. 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med. 2010;51:639\u201345.","journal-title":"J Nucl Med."},{"key":"1460_CR42","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1128\/AAC.01146-15","volume":"59","author":"VP DeMarco","year":"2015","unstructured":"DeMarco VP, Ordonez AA, Klunk M, Prideaux B, Wang H, Zhuo Z, et al. Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging. Antimicrob Agents Chemother. 2015;59:5768\u201374.","journal-title":"Antimicrob Agents Chemother."},{"key":"1460_CR43","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1128\/AAC.01644-12","volume":"56","author":"EA Weinstein","year":"2012","unstructured":"Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, et al. Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice. Antimicrob Agents Chemother. 2012;56:6284\u201390.","journal-title":"Antimicrob Agents Chemother."},{"key":"1460_CR44","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1002\/art.11282","volume":"48","author":"A Roivainen","year":"2003","unstructured":"Roivainen A, Parkkola R, Yli-Kerttula T, Lehikoinen P, Viljanen T, M\u00f6tt\u00f6nen T, et al. Use of positron emission tomography with methyl-11C-choline and 2-18F-fluoro-2-deoxy-d-glucose in comparison with magnetic resonance imaging for the assessment of inflammatory proliferation of synovium. Arthritis Rheum. 2003;48:3077\u201384.","journal-title":"Arthritis Rheum."},{"key":"1460_CR45","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1002\/art.23955","volume":"58","author":"CJ Laken Van Der","year":"2008","unstructured":"Van Der Laken CJ, Elzinga EH, Kropholler MA, Molthoff CFM, Van Der Heijden JW, Maruyama K, et al. Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography. Arthritis Rheum. 2008;58:3350\u20135.","journal-title":"Arthritis Rheum."},{"key":"1460_CR46","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1093\/rheumatology\/kew484","volume":"56","author":"N Narayan","year":"2017","unstructured":"Narayan N, Owen DR, Taylor PC. Advances in positron emission tomography for the imaging of rheumatoid arthritis. Rheumatology (Oxford). 2017;56:1837\u201346.","journal-title":"Rheumatology (Oxford)"},{"key":"1460_CR47","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1086\/513873","volume":"195","author":"H Yrj\u00e4n\u00e4inen","year":"2007","unstructured":"Yrj\u00e4n\u00e4inen H, Hyt\u00f6nen J, Song XR, Oksi J, Hartiala K, Viljanen MK. Anti-tumor necrosis factor-alpha treatment activates Borrelia burgdorferi spirochetes 4\u00a0weeks after ceftriaxone treatment in C3H\/He mice. J Infect Dis. 2007;195:1489\u201396.","journal-title":"J Infect Dis."},{"key":"1460_CR48","first-page":"661","volume":"41","author":"ME Phelps","year":"2000","unstructured":"Phelps ME. PET: the merging of biology and imaging into molecular imaging. J Nucl Med. 2000;41:661\u201381.","journal-title":"J Nucl Med."}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1460-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T12:07:01Z","timestamp":1526645221000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1460-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1460"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1460-4","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,22]]},"article-number":"254"}}