{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:19:16Z","timestamp":1787062756543,"version":"build-2736575974"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR061484"],"award-info":[{"award-number":["R01AR061484"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS070328"],"award-info":[{"award-number":["R01NS070328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0482"],"award-info":[{"award-number":["W81XWH-16-1-0482"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13075-017-1485-8","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T06:34:39Z","timestamp":1513665279000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models"],"prefix":"10.1186","volume":"19","author":[{"given":"Jian-lu","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-jing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubryanna","family":"Hettinghouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matin","family":"Lendhey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Schwarzkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oran D.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-ju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"issue":"Suppl 1","key":"1485_CR1","doi-asserted-by":"publisher","first-page":"e000061","DOI":"10.1136\/rmdopen-2015-000061","volume":"1","author":"E Olivotto","year":"2015","unstructured":"Olivotto E, Otero M, Marcu KB, Goldring MB. Pathophysiology of osteoarthritis: canonical NF-kappaB\/IKKbeta-dependent and kinase-independent effects of IKKalpha in cartilage degradation and chondrocyte differentiation. RMD Open. 2015;1 Suppl 1:e000061.","journal-title":"RMD Open"},{"issue":"1","key":"1485_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11420-011-9250-z","volume":"8","author":"MB Goldring","year":"2012","unstructured":"Goldring MB. Articular cartilage degradation in osteoarthritis. HSS J. 2012;8(1):7\u20139.","journal-title":"HSS J"},{"issue":"11","key":"1485_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s11926-013-0375-6","volume":"15","author":"X Houard","year":"2013","unstructured":"Houard X, Goldring MB, Berenbaum F. Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep. 2013;15(11):375.","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"1485_CR4","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.gene.2013.05.069","volume":"527","author":"AS Lee","year":"2013","unstructured":"Lee AS, Ellman MB, Yan D, et al. A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 2013;527(2):440\u20137.","journal-title":"Gene"},{"issue":"11","key":"1485_CR5","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","volume":"18","author":"O Stannus","year":"2010","unstructured":"Stannus O, Jones G, Cicuttini F, et al. Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage. 2010;18(11):1441\u20137.","journal-title":"Osteoarthritis Cartilage"},{"issue":"6028","key":"1485_CR6","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1126\/science.1199214","volume":"332","author":"W Tang","year":"2011","unstructured":"Tang W, Lu Y, Tian QY, et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science. 2011;332(6028):478\u201384.","journal-title":"Science"},{"issue":"2","key":"1485_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1189\/jlb.0812429","volume":"93","author":"J Jian","year":"2013","unstructured":"Jian J, Konopka J, Liu C. Insights into the role of progranulin in immunity, infection, and inflammation. J Leuk Biol. 2013;93(2):199\u2013208.","journal-title":"J Leuk Biol"},{"key":"1485_CR8","doi-asserted-by":"crossref","unstructured":"Jian J, Li G, Hettinghouse A, Liu C. Progranulin: a key player in autoimmune diseases. Cytokine. 2018;101:48-55.","DOI":"10.1016\/j.cyto.2016.08.007"},{"issue":"23","key":"1485_CR9","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1016\/j.febslet.2011.04.065","volume":"585","author":"CJ Liu","year":"2011","unstructured":"Liu CJ. Progranulin: a promising therapeutic target for rheumatoid arthritis. FEBS Lett. 2011;585(23):3675\u201380.","journal-title":"FEBS Lett"},{"issue":"1","key":"1485_CR10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.pharmthera.2011.10.003","volume":"133","author":"CJ Liu","year":"2012","unstructured":"Liu CJ, Bosch X. Progranulin: a growth factor, a novel TNFR ligand and a drug target. Pharmacol Ther. 2012;133(1):124\u201332.","journal-title":"Pharmacol Ther"},{"issue":"12","key":"1485_CR11","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1002\/art.39816","volume":"68","author":"A Williams","year":"2016","unstructured":"Williams A, Wang EC, Thurner L, Liu CJ. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling. Arthritis Rheumatol. 2016;68(12):2845\u201356.","journal-title":"Arthritis Rheumatol"},{"key":"1485_CR12","doi-asserted-by":"publisher","first-page":"20909","DOI":"10.1038\/srep20909","volume":"6","author":"YP Zhao","year":"2016","unstructured":"Zhao YP, Wei JL, Tian QY, et al. Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFalpha signaling. Sci Rep. 2016;6:20909.","journal-title":"Sci Rep"},{"issue":"6","key":"1485_CR13","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1096\/fj.09-144659","volume":"24","author":"JQ Feng","year":"2010","unstructured":"Feng JQ, Guo FJ, Jiang BC, et al. Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1\/2 signaling and JunB transcription factor in chondrogenesis. FASEB J. 2010;24(6):1879\u201392.","journal-title":"FASEB J"},{"issue":"7","key":"1485_CR14","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/art.27491","volume":"62","author":"F Guo","year":"2010","unstructured":"Guo F, Lai Y, Tian Q, Lin EA, Kong L, Liu C. Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein. Arthritis Rheum. 2010;62(7):2023\u201336.","journal-title":"Arthritis Rheum"},{"issue":"11","key":"1485_CR15","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1007\/s13238-015-0213-x","volume":"6","author":"BC Wang","year":"2015","unstructured":"Wang BC, Liu H, Talwar A, Jian J. New discovery rarely runs smooth: an update on progranulin\/TNFR interactions. Protein Cell. 2015;6(11):792\u2013803.","journal-title":"Protein Cell"},{"issue":"12","key":"1485_CR16","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1136\/annrheumdis-2014-205779","volume":"74","author":"YP Zhao","year":"2015","unstructured":"Zhao YP, Liu B, Tian QY, Wei JL, Richbourgh B, Liu CJ. Progranulin protects against osteoarthritis through interacting with TNF-alpha and beta-Catenin signalling. Ann Rheum Dis. 2015;74(12):2244\u201353.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1485_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/nyas.13191","volume":"1383","author":"J Wei","year":"2016","unstructured":"Wei J, Hettinghouse A, Liu C. The role of progranulin in arthritis. Ann N Y Acad Sci. 2016;1383(1):5\u201320.","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"1485_CR18","doi-asserted-by":"publisher","first-page":"523","DOI":"10.5966\/sctm.2014-0200","volume":"4","author":"Q Xia","year":"2015","unstructured":"Xia Q, Zhu S, Wu Y, et al. Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development. Stem Cells Transl Med. 2015;4(5):523\u201331.","journal-title":"Stem Cells Transl Med"},{"key":"1485_CR19","first-page":"e50924","volume":"84","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Liu B, Liu CJ. Establishment of a surgically-induced model in mice to investigate the protective role of progranulin in osteoarthritis. J Vis Exp. 2014;84:e50924.","journal-title":"J Vis Exp"},{"issue":"10","key":"1485_CR20","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1016\/j.joca.2016.05.017","volume":"24","author":"AJ Ramme","year":"2016","unstructured":"Ramme AJ, Lendhey M, Raya JG, Kirsch T, Kennedy OD. A novel rat model for subchondral microdamage in acute knee injury: a potential mechanism in post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2016;24(10):1776\u201385.","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"1485_CR21","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1136\/annrheumdis-2013-203561","volume":"73","author":"Y Lai","year":"2014","unstructured":"Lai Y, Bai X, Zhao Y, et al. ADAMTS-7 forms a positive feedback loop with TNF-alpha in the pathogenesis of osteoarthritis. Ann Rheum Dis. 2014;73(8):1575\u201384.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"1485_CR22","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1186\/s13075-014-0508-y","volume":"16","author":"DJ Leong","year":"2014","unstructured":"Leong DJ, Choudhury M, Hanstein R, et al. Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Arthritis Res Ther. 2014;16(6):508.","journal-title":"Arthritis Res Ther"},{"key":"1485_CR23","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13104-016-1915-8","volume":"9","author":"JN Sleigh","year":"2016","unstructured":"Sleigh JN, Weir GA, Schiavo G. A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia. BMC Res Notes. 2016;9:82.","journal-title":"BMC Res Notes"},{"key":"1485_CR24","doi-asserted-by":"crossref","unstructured":"Lin EA, Kong L, Bai XH, Liu CJ. MiR-199a*, a BMP-2 responsive microRNA, acts as a novel mediator of chondrogenesis via direct targeting to Smad1. J Biol Chem. 2009;284(17):11326\u201335.","DOI":"10.1074\/jbc.M807709200"},{"issue":"Suppl 3","key":"1485_CR25","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","volume":"18","author":"SS Glasson","year":"2010","unstructured":"Glasson SS, Chambers MG, Van Den Berg WB, Little CB. The OARSI histopathology initiative\u2014recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010;18 Suppl 3:S17\u201323.","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"1485_CR26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.tips.2014.03.005","volume":"35","author":"G Zhen","year":"2014","unstructured":"Zhen G, Cao X. Targeting TGFbeta signaling in subchondral bone and articular cartilage homeostasis. Trends Pharmacol Sci. 2014;35(5):227\u201336.","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"1485_CR27","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nm.3143","volume":"19","author":"G Zhen","year":"2013","unstructured":"Zhen G, Wen C, Jia X, et al. Inhibition of TGF-beta signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med. 2013;19(6):704\u201312.","journal-title":"Nat Med"},{"issue":"2","key":"1485_CR28","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1136\/annrheumdis-2013-204111","volume":"73","author":"MA Karsdal","year":"2014","unstructured":"Karsdal MA, Bay-Jensen AC, Lories RJ, et al. The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? Ann Rheum Dis. 2014;73(2):336\u201348.","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"1485_CR29","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.joca.2014.05.023","volume":"22","author":"XL Yuan","year":"2014","unstructured":"Yuan XL, Meng HY, Wang YC, et al. Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies. Osteoarthritis Cartilage. 2014;22(8):1077\u201389.","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"1485_CR30","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1136\/annrheumdis-2015-207923","volume":"75","author":"Z Cui","year":"2016","unstructured":"Cui Z, Crane J, Xie H, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-beta activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016;75(9):1714\u201321.","journal-title":"Ann Rheum Dis"},{"issue":"50","key":"1485_CR31","doi-asserted-by":"publisher","first-page":"20602","DOI":"10.1073\/pnas.1209294110","volume":"109","author":"RE Miller","year":"2012","unstructured":"Miller RE, Tran PB, Das R, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012;109(50):20602\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1485_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33\u201342.","journal-title":"Nat Rev Rheumatol"},{"key":"1485_CR33","first-page":"23","volume":"100","author":"MB Goldring","year":"2004","unstructured":"Goldring MB. Immortalization of human articular chondrocytes for generation of stable, differentiated cell lines. Methods Mol Med. 2004;100:23\u201336.","journal-title":"Methods Mol Med"},{"issue":"6082","key":"1485_CR34","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1126\/science.1215157","volume":"336","author":"K Johnson","year":"2012","unstructured":"Johnson K, Zhu S, Tremblay MS, et al. A stem cell-based approach to cartilage repair. Science. 2012;336(6082):717\u201321.","journal-title":"Science"},{"issue":"5","key":"1485_CR35","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.berh.2006.06.003","volume":"20","author":"MB Goldring","year":"2006","unstructured":"Goldring MB. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol. 2006;20(5):1003\u201325.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"36","key":"1485_CR36","doi-asserted-by":"publisher","first-page":"9599","DOI":"10.1016\/j.biomaterials.2014.07.058","volume":"35","author":"WH Chen","year":"2014","unstructured":"Chen WH, Lo WC, Hsu WC, et al. Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy. Biomaterials. 2014;35(36):9599\u2013607.","journal-title":"Biomaterials"},{"issue":"7","key":"1485_CR37","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11926-016-0590-z","volume":"18","author":"B Poulet","year":"2016","unstructured":"Poulet B. Non-invasive loading model of murine osteoarthritis. Curr Rheumatol Rep. 2016;18(7):40.","journal-title":"Curr Rheumatol Rep"},{"issue":"7","key":"1485_CR38","doi-asserted-by":"publisher","first-page":"493","DOI":"10.2174\/1381612023395664","volume":"8","author":"M Salzet","year":"2002","unstructured":"Salzet M. Leech thrombin inhibitors. Curr Pharm Des. 2002;8(7):493\u2013503.","journal-title":"Curr Pharm Des"},{"issue":"8","key":"1485_CR39","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.joca.2012.05.003","volume":"20","author":"Y Lai","year":"2012","unstructured":"Lai Y, Yu XP, Zhang Y, et al. Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA. Osteoarthritis Cartilage. 2012;20(8):854\u201362.","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"1485_CR40","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/jor.23079","volume":"34","author":"W Zhao","year":"2016","unstructured":"Zhao W, Wang T, Luo Q, et al. Cartilage degeneration and excessive subchondral bone formation in spontaneous osteoarthritis involves altered TGF-beta signaling. J Orthop Res. 2016;34(5):763\u201370.","journal-title":"J Orthop Res"},{"issue":"12","key":"1485_CR41","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/ard.2008.092015","volume":"67","author":"W Zhang","year":"2008","unstructured":"Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008;67(12):1716\u201323.","journal-title":"Ann Rheum Dis"},{"key":"1485_CR42","doi-asserted-by":"crossref","unstructured":"Nwosu LN, Mapp PI, Chapman V, Walsh DA. Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis Cartilage. 2016;24(11):1910-7.","DOI":"10.1016\/j.joca.2016.06.012"},{"issue":"8","key":"1485_CR43","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1002\/art.37989","volume":"65","author":"MH Stradner","year":"2013","unstructured":"Stradner MH, Gruber G, Angerer H, et al. Sphingosine 1-phosphate counteracts the effects of interleukin-1beta in human chondrocytes. Arthritis Rheum. 2013;65(8):2113\u201322.","journal-title":"Arthritis Rheum"},{"issue":"7","key":"1485_CR44","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1002\/art.30333","volume":"63","author":"R Terkeltaub","year":"2011","unstructured":"Terkeltaub R, Yang B, Lotz M, Liu-Bryan R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. Arthritis Rheum. 2011;63(7):1928\u201337.","journal-title":"Arthritis Rheum"},{"key":"1485_CR45","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.nbd.2016.09.010","volume":"96","author":"C Altmann","year":"2016","unstructured":"Altmann C, Hardt S, Fischer C, et al. Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: role of autophagy. Neurobiol Dis. 2016;96:294\u2013311.","journal-title":"Neurobiol Dis."},{"issue":"12","key":"1485_CR46","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1002\/art.39816","volume":"68","author":"A Williams","year":"2016","unstructured":"Williams A, Wang EC, Thurner L, Liu CJ. Review: Novel insights into tumor necrosis factor receptor, death receptor 3, and progranulin pathways in arthritis and bone remodeling. Arthritis Rheumatol. 2016;68(12):2845\u201356.","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"1485_CR47","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1182\/blood-2011-04-325225","volume":"119","author":"BB Aggarwal","year":"2012","unstructured":"Aggarwal BB, Gupta SC, Kim JH. Historical perspectives on tumor necrosis factor and its superfamily: 25\u00a0years later, a golden journey. Blood. 2012;119(3):651\u201365.","journal-title":"Blood"},{"issue":"10","key":"1485_CR48","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1002\/art.38755","volume":"66","author":"FE McCann","year":"2014","unstructured":"McCann FE, Perocheau DP, Ruspi G, et al. Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis. Arthritis Rheumatol. 2014;66(10):2728\u201338.","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"1485_CR49","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/jor.23091","volume":"34","author":"JL Wei","year":"2016","unstructured":"Wei JL, Buza 3rd J, Liu CJ. Does progranulin account for the opposite effects of etanercept and infliximab\/adalimumab in osteoarthritis?: Comment on Olson et al.: \u201cTherapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture\u201d. J Orthop Res. 2016;34(1):12\u20134.","journal-title":"J Orthop Res"},{"issue":"15","key":"1485_CR50","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1161\/01.CIR.0000124227.00670.AB","volume":"109","author":"Y Higuchi","year":"2004","unstructured":"Higuchi Y, McTiernan CF, Frye CB, McGowan BS, Chan TO, Feldman AM. Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy. Circulation. 2004;109(15):1892\u20137.","journal-title":"Circulation"},{"issue":"10","key":"1485_CR51","first-page":"3085","volume":"5","author":"D Yang","year":"2015","unstructured":"Yang D, Wang LL, Dong TT, et al. Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2\/Akt and ERK signaling pathways. Am J Cancer Res. 2015;5(10):3085\u201397.","journal-title":"Am J Cancer Res"},{"issue":"27","key":"1485_CR52","doi-asserted-by":"publisher","first-page":"6412","DOI":"10.1016\/j.biomaterials.2013.05.030","volume":"34","author":"YP Zhao","year":"2013","unstructured":"Zhao YP, Tian QY, Frenkel S, Liu CJ. The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF\/TNFR signaling. Biomaterials. 2013;34(27):6412\u201321.","journal-title":"Biomaterials"},{"key":"1485_CR53","unstructured":"Wang C LX LP, Chen X, Zhou H, Zhang T. An improved method of GST-pull down based on fluorescence detection and its application to the analysis of the interaction between atsttrin and TNFR2. J Tianjin Univ Sci Technol. 2015;30:34\u201340."},{"issue":"3","key":"1485_CR54","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.bbrc.2012.03.111","volume":"421","author":"Y Hattori","year":"2012","unstructured":"Hattori Y, Kojima T, Kato D, Matsubara H, Takigawa M, Ishiguro N. A selective estrogen receptor modulator inhibits tumor necrosis factor-alpha-induced apoptosis through the ERK1\/2 signaling pathway in human chondrocytes. Biochem Biophys Res Commun. 2012;421(3):418\u201324.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"1485_CR55","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/ncprheum0961","volume":"5","author":"CJ Liu","year":"2009","unstructured":"Liu CJ. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. Nat Clin Pract Rheumatol. 2009;5(1):38\u201345.","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"5","key":"1485_CR56","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3109\/03008207.2012.661001","volume":"53","author":"Q Zhang","year":"2012","unstructured":"Zhang Q, Lv H, Chen A, Liu F, Wu X. Efficacy of infliximab in a rabbit model of osteoarthritis. Connect Tissue Res. 2012;53(5):355\u20138.","journal-title":"Connect Tissue Res"},{"issue":"5","key":"1485_CR57","doi-asserted-by":"publisher","first-page":"R206","DOI":"10.1186\/ar4044","volume":"14","author":"WP Maksymowych","year":"2012","unstructured":"Maksymowych WP, Russell AS, Chiu P, et al. Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee. Arthritis Res Ther. 2012;14(5):R206.","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"1485_CR58","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/ard.2008.105775","volume":"69","author":"DM Urech","year":"2010","unstructured":"Urech DM, Feige U, Ewert S, et al. Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF\u03b1 single-chain Fv antibody (ESBA105) designed for local therapeutic use. Ann Rheum Dis. 2010;69(2):443\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"1485_CR59","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/adhm.201500211","volume":"4","author":"Q Wang","year":"2015","unstructured":"Wang Q, Xia Q, Wu Y, et al. 3D-printed atsttrin-incorporated alginate\/hydroxyapatite scaffold promotes bone defect regeneration with TNF\/TNFR signaling involvement. Adv Healthc Mater. 2015;4(11):1701\u20138.","journal-title":"Adv Healthc Mater"},{"issue":"3","key":"1485_CR60","doi-asserted-by":"publisher","first-page":"e92743","DOI":"10.1371\/journal.pone.0092743","volume":"9","author":"C Liu","year":"2014","unstructured":"Liu C, Li XX, Gao W, Liu W, Liu DS. Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity. PLoS One. 2014;9(3):e92743.","journal-title":"PLoS One"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1485-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-017-1485-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-017-1485-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T20:15:52Z","timestamp":1751141752000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-017-1485-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1485"],"URL":"https:\/\/doi.org\/10.1186\/s13075-017-1485-8","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"12 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Acquisition of human cartilage samples from patients receiving total knee joint replacement surgery at New York University, Hospital for Joint Diseases (NY, USA) was conducted in accordance with NYU School of Medicine Institutional Review Board approved protocol (study number i11-01488). Patients received information about the study prior to providing consent for participation in the study. Animal studies were performed under institutional guidelines and in accordance with protocols approved by the Institutional Animal Care and Use Committee, New York University (IA15-01372).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"C-jL is the cofounder of Atreaon, Inc. The other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher's Note"}}],"article-number":"280"}}