{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:41:09Z","timestamp":1793853669395,"version":"4.6.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000940","name":"Arthritis Australia","doi-asserted-by":"publisher","award":["1757679"],"award-info":[{"award-number":["1757679"]}],"id":[{"id":"10.13039\/501100000940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1043147"],"award-info":[{"award-number":["1043147"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1043147"],"award-info":[{"award-number":["1043147"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Senior Principal Research Fellowship"],"award-info":[{"award-number":["Senior Principal Research Fellowship"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["IRTG 2168"],"award-info":[{"award-number":["IRTG 2168"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13075-018-1560-9","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T11:20:15Z","timestamp":1524136815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["CCL17 blockade as a therapy for osteoarthritis pain and disease"],"prefix":"10.1186","volume":"20","author":[{"given":"Ming-Chin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Achuthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Fleetwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"F\u00f6rster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"1560_CR1","doi-asserted-by":"publisher","first-page":"16044","DOI":"10.1038\/boneres.2016.44","volume":"5","author":"D Chen","year":"2017","unstructured":"Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL, Im HJ. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res. 2017;5:16044.","journal-title":"Bone Res."},{"key":"1560_CR2","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1136\/ard.2004.025270","volume":"64","author":"MJ Benito","year":"2005","unstructured":"Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005;64:1263\u20137.","journal-title":"Ann Rheum Dis."},{"key":"1560_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nrrheum.2014.162","volume":"11","author":"R Liu-Bryan","year":"2015","unstructured":"Liu-Bryan R, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015;11:35\u201344.","journal-title":"Nat Rev Rheumatol."},{"key":"1560_CR4","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.2174\/1381612821666150310144940","volume":"21","author":"CY Wenham","year":"2015","unstructured":"Wenham CY, McDermott M, Conaghan PG. Biological therapies in osteoarthritis. Curr Pharm Des. 2015;21:2206\u201315.","journal-title":"Curr Pharm Des."},{"key":"1560_CR5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","volume":"19","author":"A Mathiessen","year":"2017","unstructured":"Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther. 2017;19:18.","journal-title":"Arthritis Res Ther."},{"key":"1560_CR6","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","volume":"12","author":"WH Robinson","year":"2016","unstructured":"Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, Sokolove J. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12:580\u201392.","journal-title":"Nat Rev Rheumatol."},{"key":"1560_CR7","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.joca.2005.03.004","volume":"13","author":"S Kamekura","year":"2005","unstructured":"Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, Uchida M, Ogata N, Seichi A, Nakamura K, Kawaguchi H. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthr Cartil. 2005;13:632\u201341.","journal-title":"Osteoarthr Cartil."},{"key":"1560_CR8","doi-asserted-by":"publisher","first-page":"R199","DOI":"10.1186\/ar4037","volume":"14","author":"AD Cook","year":"2012","unstructured":"Cook AD, Pobjoy J, Steidl S, Durr M, Braine EL, Turner AL, Lacey DC, Hamilton JA. Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther. 2012;14:R199.","journal-title":"Arthritis Res Ther."},{"key":"1560_CR9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/art.22337","volume":"56","author":"AB Blom","year":"2007","unstructured":"Blom AB, van Lent PL, Libregts S, Holthuysen AE, van der Kraan PM, van Rooijen N, van den Berg WB. Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. Arthritis Rheum. 2007;56:147\u201357.","journal-title":"Arthritis Rheum."},{"key":"1560_CR10","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.joca.2007.08.005","volume":"16","author":"SM Botter","year":"2008","unstructured":"Botter SM, van Osch GJ, Waarsing JH, van der Linden JC, Verhaar JA, Pols HA, van Leeuwen JP, Weinans H. Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis. Osteoarthr Cartil. 2008;16:506\u201314.","journal-title":"Osteoarthr Cartil."},{"key":"1560_CR11","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.joca.2004.03.003","volume":"12","author":"AB Blom","year":"2004","unstructured":"Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, van den Berg WB. Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthr Cartil. 2004;12:627\u201335.","journal-title":"Osteoarthr Cartil."},{"key":"1560_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/art.11422","volume":"50","author":"PL van Lent","year":"2004","unstructured":"van Lent PL, Blom AB, van der Kraan P, Holthuysen AE, Vitters E, van Rooijen N, Smeets RL, Nabbe KC, van den Berg WB. Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. Arthritis Rheum. 2004;50:103\u201311.","journal-title":"Arthritis Rheum."},{"key":"1560_CR13","doi-asserted-by":"publisher","first-page":"R10","DOI":"10.1186\/ar4436","volume":"16","author":"S Adaes","year":"2014","unstructured":"Adaes S, Mendonca M, Santos TN, Castro-Lopes JM, Ferreira-Gomes J, Neto FL. Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis. Arthritis Res Ther. 2014;16:R10.","journal-title":"Arthritis Res Ther."},{"key":"1560_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/rheumatology\/keu328","volume":"54","author":"D McGonagle","year":"2015","unstructured":"McGonagle D, Hermann KG, Tan AL. Differentiation between osteoarthritis and psoriatic arthritis: implications for pathogenesis and treatment in the biologic therapy era. Rheumatology. 2015;54:29\u201338.","journal-title":"Rheumatology."},{"key":"1560_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nrd.2016.231","volume":"16","author":"JA Hamilton","year":"2017","unstructured":"Hamilton JA, Cook AD, Tak PP. Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases. Nat Rev Drug Discov. 2017;16:53\u201370.","journal-title":"Nat Rev Drug Discov."},{"key":"1560_CR16","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nri2356","volume":"8","author":"JA Hamilton","year":"2008","unstructured":"Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008;8:533\u201344.","journal-title":"Nat Rev Immunol."},{"key":"1560_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1136\/annrheumdis-2012-201703","volume":"72","author":"AD Cook","year":"2013","unstructured":"Cook AD, Pobjoy J, Sarros S, Steidl S, Durr M, Lacey DC, Hamilton JA. Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheum Dis. 2013;72:265\u201370.","journal-title":"Ann Rheum Dis."},{"key":"1560_CR18","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1172\/JCI87828","volume":"126","author":"A Achuthan","year":"2016","unstructured":"Achuthan A, Cook AD, Lee MC, Saleh R, Khiew HW, Chang MW, Louis C, Fleetwood AJ, Lacey DC, Christensen AD, Frye AT, Lam PY, Kusano H, Nomura K, Steiner N, Forster I, Nutt SL, Olshansky M, Turner SJ, Hamilton JA. Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest. 2016;126:3453\u201366.","journal-title":"J Clin Invest."},{"key":"1560_CR19","doi-asserted-by":"crossref","unstructured":"Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA. Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res. 2001;3:293\u20138.","DOI":"10.1186\/ar318"},{"key":"1560_CR20","doi-asserted-by":"crossref","unstructured":"Cook AD, Lee MC, Saleh R, Khiew HW, Christensen AD, Achuthan A, Fleetwood AJ, Lacey DC, Smith JE, F\u00f6rster I, Hamilton JA. TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17. JCI Insight 2018;3:e99249.","DOI":"10.1172\/jci.insight.99249"},{"key":"1560_CR21","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1002\/eji.1830271020","volume":"27","author":"H Korner","year":"1997","unstructured":"Korner H, Cook M, Riminton DS, Lemckert FA, Hoek RM, Ledermann B, Kontgen F, Fazekas de St Groth B, Sedgwick JD. Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol. 1997;27:2600\u20139.","journal-title":"Eur J Immunol."},{"key":"1560_CR22","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1084\/jem.191.10.1755","volume":"191","author":"Y Chvatchko","year":"2000","unstructured":"Chvatchko Y, Hoogewerf AJ, Meyer A, Alouani S, Juillard P, Buser R, Conquet F, Proudfoot AE, Wells TN, Power CA. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J Exp Med. 2000;191:1755\u201364.","journal-title":"J Exp Med."},{"key":"1560_CR23","doi-asserted-by":"publisher","first-page":"5592","DOI":"10.1073\/pnas.91.12.5592","volume":"91","author":"E Stanley","year":"1994","unstructured":"Stanley E, Lieschke GJ, Grail D, Metcalf D, Hodgson G, Gall JA, Maher DW, Cebon J, Sinickas V, Dunn AR. Granulocyte\/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci USA. 1994;91:5592\u20136.","journal-title":"Proc Natl Acad Sci USA."},{"key":"1560_CR24","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1126\/science.275.5299.540","volume":"275","author":"HW Mittrucker","year":"1997","unstructured":"Mittrucker HW, Matsuyama T, Grossman A, Kundig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW. Requirement for the transcription factor LSIRF\/IRF4 for mature B and T lymphocyte function. Science. 1997;275:540\u20133.","journal-title":"Science."},{"key":"1560_CR25","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1084\/jem.20021859","volume":"197","author":"J Alferink","year":"2003","unstructured":"Alferink J, Lieberam I, Reindl W, Behrens A, Weiss S, Huser N, Gerauer K, Ross R, Reske-Kunz AB, Ahmad-Nejad P, Wagner H, Forster I. Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J Exp Med. 2003;197:585\u201399.","journal-title":"J Exp Med."},{"key":"1560_CR26","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1016\/j.joca.2017.07.012","volume":"25","author":"MH van den Bosch","year":"2017","unstructured":"van den Bosch MH, Blom AB, Kram V, Maeda A, Sikka S, Gabet Y, Kilts TM, van den Berg WB, van Lent PL, van der Kraan PM, Young MF. WISP1\/CCN4 aggravates cartilage degeneration in experimental osteoarthritis. Osteoarthr Cartil. 2017;25:1900\u201311.","journal-title":"Osteoarthr Cartil."},{"key":"1560_CR27","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1002\/art.23870","volume":"58","author":"JJ Inglis","year":"2008","unstructured":"Inglis JJ, McNamee KE, Chia SL, Essex D, Feldmann M, Williams RO, Hunt SP, Vincent T. Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system. Arthritis Rheum. 2008;58:3110\u20139.","journal-title":"Arthritis Rheum."},{"key":"1560_CR28","doi-asserted-by":"crossref","unstructured":"Lee MC, McCubbin JA, Christensen AD, Poole DP, Rajasekhar P, Lieu T, Bunnett NW, Garcia-Caraballo S, Erickson A, Brierley SM, Saleh R, Achuthan A, Fleetwood AJ, Anderson RL, Hamilton JA, Cook AD. G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease. The Journal of Immunology 2017;198(9):3565\u2013575.","DOI":"10.4049\/jimmunol.1602127"},{"key":"1560_CR29","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.1002\/art.34626","volume":"64","author":"M ter Huurne","year":"2012","unstructured":"ter Huurne M, Schelbergen R, Blattes R, Blom A, de Munter W, Grevers LC, Jeanson J, Noel D, Casteilla L, Jorgensen C, van den Berg W, van Lent PL. Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. Arthritis Rheum. 2012;64:3604\u201313.","journal-title":"Arthritis Rheum."},{"issue":"Suppl 3","key":"1560_CR30","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","volume":"18","author":"SS Glasson","year":"2010","unstructured":"Glasson SS, Chambers MG, Van Den Berg WB, Little CB. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthr Cartil. 2010;18(Suppl 3):S17\u201323.","journal-title":"Osteoarthr Cartil."},{"key":"1560_CR31","doi-asserted-by":"publisher","first-page":"e81465","DOI":"10.1371\/journal.pone.0081465","volume":"8","author":"S Santulli-Marotto","year":"2013","unstructured":"Santulli-Marotto S, Boakye K, Lacy E, Wu SJ, Luongo J, Kavalkovich K, Coelho A, Hogaboam CM, Ryan M. Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung. PLoS One. 2013;8:e81465.","journal-title":"PLoS One."},{"key":"1560_CR32","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/ni.1920","volume":"11","author":"T Satoh","year":"2010","unstructured":"Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 2010;11:936\u201344.","journal-title":"Nat Immunol."},{"key":"1560_CR33","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","volume":"51","author":"CR Scanzello","year":"2012","unstructured":"Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51:249\u201357.","journal-title":"Bone."},{"key":"1560_CR34","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s13075-016-1185-9","volume":"18","author":"AD Cook","year":"2016","unstructured":"Cook AD, Louis C, Robinson MJ, Saleh R, Sleeman MA, Hamilton JA. Granulocyte macrophage colony-stimulating factor receptor alpha expression and its targeting in antigen-induced arthritis and inflammation. Arthritis Res Ther. 2016;18:287.","journal-title":"Arthritis Res Ther."},{"key":"1560_CR35","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1084\/jem.20170689","volume":"214","author":"A Anzai","year":"2017","unstructured":"Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J Exp Med. 2017;214:3293\u2013310.","journal-title":"J Exp Med."},{"key":"1560_CR36","doi-asserted-by":"publisher","first-page":"4895050","DOI":"10.1155\/2016\/4895050","volume":"2016","author":"BJ Rose","year":"2016","unstructured":"Rose BJ, Kooyman DL. A Tale of Two Joints: The role of matrix metalloproteases in cartilage biology. Dis Markers. 2016;2016:4895050.","journal-title":"Dis Markers."},{"key":"1560_CR37","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.joca.2016.09.009","volume":"25","author":"SC van Dalen","year":"2017","unstructured":"van Dalen SC, Blom AB, Sloetjes AW, Helsen MM, Roth J, Vogl T, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, van den Bosch MH, van Lent PL. Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis. Osteoarthr Cartil. 2017;25:385\u201396.","journal-title":"Osteoarthr Cartil."},{"key":"1560_CR38","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1002\/art.34315","volume":"64","author":"PL van Lent","year":"2012","unstructured":"van Lent PL, Blom AB, Schelbergen RF, Sloetjes A, Lafeber FP, Lems WF, Cats H, Vogl T, Roth J, van den Berg WB. Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis Rheum. 2012;64:1466\u201376.","journal-title":"Arthritis Rheum."},{"key":"1560_CR39","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/BOR.0b013e32830aba34","volume":"20","author":"CR Scanzello","year":"2008","unstructured":"Scanzello CR, Plaas A, Crow MK. Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol. 2008;20:565\u201372.","journal-title":"Curr Opin Rheumatol."},{"key":"1560_CR40","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1084\/jem.194.6.847","volume":"194","author":"A Iellem","year":"2001","unstructured":"Iellem A, Mariani M, Lang R, Recalde H, Panina-Bordignon P, Sinigaglia F, D'Ambrosio D. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med. 2001;194:847\u201353.","journal-title":"J Exp Med."},{"key":"1560_CR41","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.4049\/jimmunol.172.3.1407","volume":"172","author":"T Katakura","year":"2004","unstructured":"Katakura T, Miyazaki M, Kobayashi M, Herndon DN, Suzuki F. CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages. J Immunol. 2004;172:1407\u201313.","journal-title":"J Immunol."},{"key":"1560_CR42","doi-asserted-by":"publisher","first-page":"8736","DOI":"10.1073\/pnas.0906126107","volume":"107","author":"S Stutte","year":"2010","unstructured":"Stutte S, Quast T, Gerbitzki N, Savinko T, Novak N, Reifenberger J, Homey B, Kolanus W, Alenius H, Forster I. Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells. Proc Natl Acad Sci USA. 2010;107:8736\u201341.","journal-title":"Proc Natl Acad Sci USA."},{"key":"1560_CR43","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1053\/j.gastro.2011.10.027","volume":"142","author":"AF Heiseke","year":"2012","unstructured":"Heiseke AF, Faul AC, Lehr HA, Forster I, Schmid RM, Krug AB, Reindl W. CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. Gastroenterology. 2012;142:335\u201345.","journal-title":"Gastroenterology"},{"key":"1560_CR44","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1172\/JCI44925","volume":"121","author":"C Weber","year":"2011","unstructured":"Weber C, Meiler S, Doring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Forster I, Zenke M, Hieronymus T, Junt T, Zernecke A. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest. 2011;121:2898\u2013910.","journal-title":"J Clin Invest."},{"key":"1560_CR45","first-page":"2369","volume":"30","author":"H Okamoto","year":"2003","unstructured":"Okamoto H, Koizumi K, Yamanaka H, Saito T, Kamatani N. A role for TARC\/CCL17, a CC chemokine, in systemic lupus erythematosus. J Rheumatol. 2003;30:2369\u201373.","journal-title":"J Rheumatol."},{"key":"1560_CR46","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3109\/03009742.2016.1158311","volume":"46","author":"MR Hillen","year":"2017","unstructured":"Hillen MR, Moret FM, van der Wurff-Jacobs K, Radstake T, Hack CE, Lafeber F, van Roon J. Targeting CD1c-expressing classical dendritic cells to prevent thymus and activation-regulated chemokine (TARC)-mediated T-cell chemotaxis in rheumatoid arthritis. Scand J Rheumatol. 2017;46:11\u20136.","journal-title":"Scand J Rheumatol."},{"key":"1560_CR47","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1523\/JNEUROSCI.21-14-05027.2001","volume":"21","author":"SB Oh","year":"2001","unstructured":"Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci. 2001;21:5027\u201335.","journal-title":"J Neurosci."},{"key":"1560_CR48","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fnmol.2014.00087","volume":"7","author":"M Thakur","year":"2014","unstructured":"Thakur M, Crow M, Richards N, Davey GI, Levine E, Kelleher JH, Agley CC, Denk F, Harridge SD, McMahon SB. Defining the nociceptor transcriptome. Front Mol Neurosci. 2014;7:87.","journal-title":"Front Mol Neurosci."},{"key":"1560_CR49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/cr.2015.149","volume":"26","author":"CL Li","year":"2016","unstructured":"Li CL, Li KC, Wu D, Chen Y, Luo H, Zhao JR, Wang SS, Sun MM, Lu YJ, Zhong YQ, Hu XY, Hou R, Zhou BB, Bao L, Xiao HS, Zhang X. Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res. 2016;26:83\u2013102.","journal-title":"Cell Res."},{"key":"1560_CR50","doi-asserted-by":"crossref","unstructured":"Cook AD, Christensen AD, Tewari D, SB MM, Hamilton JA. Immune Cytokines and Their Receptors in Inflammatory Pain. Trends Immunol. 2018;10:29-38.","DOI":"10.1016\/j.it.2017.12.003"},{"key":"1560_CR51","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jneumeth.2012.05.025","volume":"209","author":"S Etemad","year":"2012","unstructured":"Etemad S, Zamin RM, Ruitenberg MJ, Filgueira L. A novel in vitro human microglia model: characterization of human monocyte-derived microglia. J Neurosci Methods. 2012;209:79\u201389.","journal-title":"J Neurosci Methods."},{"key":"1560_CR52","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1172\/JCI10564","volume":"107","author":"LA Neuhold","year":"2001","unstructured":"Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, Turner J, Wu W, Billinghurst C, Meijers T, Poole AR, Babij P, DeGennaro LJ. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest. 2001;107:35\u201344.","journal-title":"J Clin Invest."},{"key":"1560_CR53","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.joca.2011.01.022","volume":"19","author":"WB van den Berg","year":"2011","unstructured":"van den Berg WB. Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthr Cartil. 2011;19:338\u201341.","journal-title":"Osteoarthr Cartil."},{"key":"1560_CR54","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/art.27290","volume":"62","author":"J Bondeson","year":"2010","unstructured":"Bondeson J, Blom AB, Wainwright S, Hughes C, Caterson B, van den Berg WB. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum. 2010;62:647\u201357.","journal-title":"Arthritis Rheum."},{"key":"1560_CR55","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1002\/art.40206","volume":"69","author":"MH van den Bosch","year":"2017","unstructured":"van den Bosch MH, Blom AB, van de Loo FA, Koenders MI, Lafeber FP, van den Berg WB, van der Kraan PM, van Lent PL. Brief report: induction of matrix metalloproteinase expression by synovial wnt signaling and association with disease progression in early symptomatic osteoarthritis. Arthritis Rheumatol. 2017;69:1978\u201383.","journal-title":"Arthritis Rheumatol."},{"key":"1560_CR56","doi-asserted-by":"crossref","first-page":"47637","DOI":"10.18632\/oncotarget.10256","volume":"7","author":"B Ou","year":"2016","unstructured":"Ou B, Zhao J, Guan S, Feng H, Wangpu X, Zhu C, Zong Y, Ma J, Sun J, Shen X, Zheng M, Lu A. CCR4 promotes metastasis via ERK\/NF-kappaB\/MMP13 pathway and acts downstream of TNF-alpha in colorectal cancer. Oncotarget. 2016;7:47637\u201349.","journal-title":"Oncotarget."},{"key":"1560_CR57","doi-asserted-by":"publisher","unstructured":"Li CM, Hou L, Zhang H, Zhang WY. CCL17 Induces trophoblast migration and invasion by regulating matrix metalloproteinase and integrin expression in human first-trimester placenta. Reprod Sci. 2014; https:\/\/doi.org\/10.1177\/1933719113519170 .","DOI":"10.1177\/1933719113519170"},{"key":"1560_CR58","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.gene.2013.05.069","volume":"527","author":"AS Lee","year":"2013","unstructured":"Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, Im HJ. A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 2013;527:440\u20137.","journal-title":"Gene."},{"key":"1560_CR59","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1182\/blood.V76.10.1989.1989","volume":"76","author":"T Leizer","year":"1990","unstructured":"Leizer T, Cebon J, Layton JE, Hamilton JA. Cytokine regulation of colony-stimulating factor production in cultured human synovial fibroblasts: I. Induction of GM-CSF and G-CSF production by interleukin-1 and tumor necrosis factor. Blood. 1990;76:1989\u201396.","journal-title":"Blood."},{"key":"1560_CR60","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.4049\/jimmunol.147.4.1238","volume":"147","author":"IK Campbell","year":"1991","unstructured":"Campbell IK, Novak U, Cebon J, Layton JE, Hamilton JA. Human articular cartilage and chondrocytes produce hemopoietic colony-stimulating factors in culture in response to IL-1. J Immunol. 1991;147:1238\u201346.","journal-title":"J Immunol."},{"key":"1560_CR61","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.1002\/art.21495","volume":"52","author":"KE Lawlor","year":"2005","unstructured":"Lawlor KE, Wong PK, Campbell IK, van Rooijen N, Wicks IP. Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor. Arthritis Rheum. 2005;52:3749\u201354.","journal-title":"Arthritis Rheum."},{"key":"1560_CR62","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/1529-0131(200101)44:1<111::AID-ANR15>3.0.CO;2-1","volume":"44","author":"YH Yang","year":"2001","unstructured":"Yang YH, Hamilton JA. Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor. Arthritis Rheum. 2001;44:111\u20139.","journal-title":"Arthritis Rheum."},{"key":"1560_CR63","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pain.2010.03.002","volume":"149","author":"KE McNamee","year":"2010","unstructured":"McNamee KE, Burleigh A, Gompels LL, Feldmann M, Allen SJ, Williams RO, Dawbarn D, Vincent TL, Inglis JJ. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain. 2010;149:386\u201392.","journal-title":"Pain."},{"key":"1560_CR64","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nrrheum.2013.44","volume":"9","author":"X Chevalier","year":"2013","unstructured":"Chevalier X, Eymard F, Richette P. Biologic agents in osteoarthritis: hopes and disappointments. Nat Rev Rheumatol. 2013;9:400\u201310.","journal-title":"Nat Rev Rheumatol."},{"key":"1560_CR65","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s11926-012-0279-x","volume":"14","author":"HG Schaible","year":"2012","unstructured":"Schaible HG. Mechanisms of chronic pain in osteoarthritis. Curr Rheumatol Rep. 2012;14:549\u201356.","journal-title":"Curr Rheumatol Rep."},{"key":"1560_CR66","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.bone.2016.01.019","volume":"85","author":"M Rahmati","year":"2016","unstructured":"Rahmati M, Mobasheri A, Mozafari M. Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects, and future challenges. Bone. 2016;85:81\u201390.","journal-title":"Bone."},{"key":"1560_CR67","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1586\/1744666X.2015.1024110","volume":"11","author":"JA Hamilton","year":"2015","unstructured":"Hamilton JA. GM-CSF as a target in inflammatory\/autoimmune disease: current evidence and future therapeutic potential. Expert Rev Clin Immunol. 2015;11:457\u201365.","journal-title":"Expert Rev Clin Immunol."}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1560-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-018-1560-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1560-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T02:07:22Z","timestamp":1693620442000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-018-1560-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,5]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1560"],"URL":"https:\/\/doi.org\/10.1186\/s13075-018-1560-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732995466.793552567","asserted-by":"object"}]},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,5]]},"assertion":[{"value":"6 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Experiments were approved by The University of Melbourne Animal Ethics Committee.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"62"}}