{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:40:48Z","timestamp":1787020848304,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STO 824\/3-1"],"award-info":[{"award-number":["STO 824\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005295","name":"Staedtler Stiftung","doi-asserted-by":"publisher","award":["WW\/eh 13\/17"],"award-info":[{"award-number":["WW\/eh 13\/17"]}],"id":[{"id":"10.13039\/501100005295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13075-018-1583-2","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:08:15Z","timestamp":1525252095000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis"],"prefix":"10.1186","volume":"20","author":[{"given":"Fritz","family":"Seuffert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Weidner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Baum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-0961","authenticated-orcid":false,"given":"Michael","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"issue":"23","key":"1583_CR1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205\u201319.","journal-title":"N Engl J Med"},{"issue":"7033","key":"1583_CR2","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nature03417","volume":"434","author":"H Stanton","year":"2005","unstructured":"Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature. 2005;434(7033):648\u201352.","journal-title":"Nature"},{"issue":"5","key":"1583_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/s13075-014-0429-9","volume":"16","author":"CM Dancevic","year":"2014","unstructured":"Dancevic CM, McCulloch DR. Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis. Arthritis Res Ther. 2014;16(5):429.","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"1583_CR4","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1002\/art.10593","volume":"46","author":"M Sen","year":"2002","unstructured":"Sen M, Reifert J, Lauterbach K, Wolf V, Rubin JS, Corr M, Carson DA. Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum. 2002;46(11):2867\u201377.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"1583_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","volume":"15","author":"PM van der Kraan","year":"2007","unstructured":"van der Kraan PM, van den Berg WB. Osteophytes: relevance and biology. Osteoarthritis Cartilage. 2007;15(3):237\u201344.","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"1583_CR6","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1242\/bio.201411031","volume":"4","author":"J Park","year":"2015","unstructured":"Park J, Gebhardt M, Golovchenko S, Perez-Branguli F, Hattori T, Hartmann C, Zhou X, deCrombrugghe B, Stock M, Schneider H, et al. Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage. Biology Open. 2015;4(5):608\u201321.","journal-title":"Biology Open"},{"issue":"11","key":"1583_CR7","doi-asserted-by":"publisher","first-page":"7082","DOI":"10.1074\/jbc.M702792200","volume":"283","author":"C Surmann-Schmitt","year":"2008","unstructured":"Surmann-Schmitt C, Dietz U, Kireva T, Adam N, Park J, Tagariello A, Onnerfjord P, Heinegard D, Schlotzer-Schrehardt U, Deutzmann R, et al. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. J Biol Chem. 2008;283(11):7082\u201393.","journal-title":"J Biol Chem"},{"issue":"6","key":"1583_CR8","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1002\/art.40042","volume":"69","author":"M Stock","year":"2017","unstructured":"Stock M, Menges S, Eitzinger N, Gesslein M, Botschner R, Wormser L, Distler A, Schlotzer-Schrehardt U, Dietel K, Distler J, et al. A dual role of upper zone of growth plate and cartilage matrix-associated protein in human and mouse osteoarthritic cartilage: inhibition of aggrecanases and promotion of bone turnover. Arthritis Rheumatol. 2017;69(6):1233\u201345.","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"1583_CR9","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.bone.2011.11.017","volume":"50","author":"N Eitzinger","year":"2012","unstructured":"Eitzinger N, Surmann-Schmitt C, Bosl M, Schett G, Engelke K, Hess A, von der Mark K, Stock M. Ucma is not necessary for normal development of the mouse skeleton. Bone. 2012;50(3):670\u201380.","journal-title":"Bone"},{"issue":"1","key":"1583_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.matbio.2007.07.004","volume":"27","author":"A Tagariello","year":"2008","unstructured":"Tagariello A, Luther J, Streiter M, Didt-Koziel L, Wuelling M, Surmann-Schmitt C, Stock M, Adam N, Vortkamp A, Winterpacht A. Ucma\u2014a novel secreted factor represents a highly specific marker for distal chondrocytes. Matrix Biol. 2008;27(1):3\u201311.","journal-title":"Matrix Biol"},{"issue":"7\u20138","key":"1583_CR11","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.matbio.2011.07.002","volume":"30","author":"CD Neacsu","year":"2011","unstructured":"Neacsu CD, Grosch M, Tejada M, Winterpacht A, Paulsson M, Wagener R, Tagariello A. Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate gamma-carboxylation. Matrix Biol. 2011;30(7\u20138):369\u201378.","journal-title":"Matrix Biol"},{"issue":"3","key":"1583_CR12","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/jcb.22290","volume":"108","author":"C Surmann-Schmitt","year":"2009","unstructured":"Surmann-Schmitt C, Widmann N, Mallein-Gerin F, von der Mark K, Stock M. Stable subclones of the chondrogenic murine cell line MC615 mimic distinct stages of chondrocyte differentiation. J Cell Biochem. 2009;108(3):589\u201399.","journal-title":"J Cell Biochem"},{"issue":"4","key":"1583_CR13","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S1074-7613(00)80045-X","volume":"10","author":"AS Korganow","year":"1999","unstructured":"Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity. 1999;10(4):451\u201361.","journal-title":"Immunity"},{"issue":"3","key":"1583_CR14","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1136\/ard.2010.148262","volume":"71","author":"G Ruiz-Heiland","year":"2012","unstructured":"Ruiz-Heiland G, Horn A, Zerr P, Hofstetter W, Baum W, Stock M, Distler JH, Nimmerjahn F, Schett G, Zwerina J. Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis. Ann Rheum Dis. 2012;71(3):400\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"1583_CR15","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1002\/art.38054","volume":"65","author":"M Stock","year":"2013","unstructured":"Stock M, Bohm C, Scholtysek C, Englbrecht M, Furnrohr BG, Klinger P, Gelse K, Gayetskyy S, Engelke K, Billmeier U, et al. Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor alpha-mediated experimental arthritis. Arthritis Rheum. 2013;65(9):2310\u201322.","journal-title":"Arthritis Rheum"},{"issue":"5","key":"1583_CR16","doi-asserted-by":"publisher","first-page":"e0155936","DOI":"10.1371\/journal.pone.0155936","volume":"11","author":"J Tuncel","year":"2016","unstructured":"Tuncel J, Haag S, Hoffmann MH, Yau AC, Hultqvist M, Olofsson P, Backlund J, Nandakumar KS, Weidner D, Fischer A, et al. Animal models of rheumatoid arthritis (I): pristane-induced arthritis in the rat. PLoS One. 2016;11(5):e0155936.","journal-title":"PLoS One"},{"issue":"42","key":"1583_CR17","doi-asserted-by":"publisher","first-page":"31790","DOI":"10.1074\/jbc.M603419200","volume":"281","author":"M Schmidl","year":"2006","unstructured":"Schmidl M, Adam N, Surmann-Schmitt C, Hattori T, Stock M, Dietz U, de Crombrugghe B, Poschl E, von der Mark K. Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo. J Biol Chem. 2006;281(42):31790\u2013800.","journal-title":"J Biol Chem"},{"issue":"7033","key":"1583_CR18","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nature03369","volume":"434","author":"SS Glasson","year":"2005","unstructured":"Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, Flannery CR, Peluso D, Kanki K, Yang Z, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005;434(7033):644\u20138.","journal-title":"Nature"},{"issue":"2","key":"1583_CR19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/art.22334","volume":"56","author":"RH Song","year":"2007","unstructured":"Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum. 2007;56(2):575\u201385.","journal-title":"Arthritis Rheum"},{"issue":"8","key":"1583_CR20","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.joca.2015.02.778","volume":"23","author":"J Larkin","year":"2015","unstructured":"Larkin J, Lohr TA, Elefante L, Shearin J, Matico R, Su JL, Xue Y, Liu F, Genell C, Miller RE, et al. Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis Cartilage. 2015;23(8):1254\u201366.","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"1583_CR21","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.joca.2013.08.015","volume":"21","author":"R Chiusaroli","year":"2013","unstructured":"Chiusaroli R, Visentini M, Galimberti C, Casseler C, Mennuni L, Covaceuszach S, Lanza M, Ugolini G, Caselli G, Rovati LC, et al. Targeting of ADAMTS5\u2019s ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Osteoarthritis Cartilage. 2013;21(11):1807\u201310.","journal-title":"Osteoarthritis Cartilage"},{"issue":"16","key":"1583_CR22","doi-asserted-by":"publisher","first-page":"12501","DOI":"10.1074\/jbc.C000848200","volume":"276","author":"M Kashiwagi","year":"2001","unstructured":"Kashiwagi M, Tortorella M, Nagase H, Brew K. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem. 2001;276(16):12501\u20134.","journal-title":"J Biol Chem"},{"issue":"8","key":"1583_CR23","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.matbio.2009.07.005","volume":"28","author":"L Troeberg","year":"2009","unstructured":"Troeberg L, Fushimi K, Scilabra SD, Nakamura H, Dive V, Thogersen IB, Enghild JJ, Nagase H. The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. Matrix Biol. 2009;28(8):463\u20139.","journal-title":"Matrix Biol"},{"issue":"3","key":"1583_CR24","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1159\/000341438","volume":"30","author":"J Sylvester","year":"2012","unstructured":"Sylvester J, El Mabrouk M, Ahmad R, Chaudry A, Zafarullah M. Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases. Cell Physiol Biochem. 2012;30(3):563\u201374.","journal-title":"Cell Physiol Biochem"},{"key":"1583_CR25","doi-asserted-by":"crossref","unstructured":"Cavaco S, Viegas CS, Rafael MS, Ramos A, Magalh\u00e3es J, Blanco FJ, Vermeer C, Simes DC. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cell Mol Life Sci. 2016;73(5):1051\u201365.","DOI":"10.1007\/s00018-015-2033-9"},{"issue":"5","key":"1583_CR26","doi-asserted-by":"publisher","first-page":"e0177829","DOI":"10.1371\/journal.pone.0177829","volume":"12","author":"CSB Viegas","year":"2017","unstructured":"Viegas CSB, Costa RM, Santos L, Videira PA, Silva Z, Araujo N, Macedo AL, Matos AP, Vermeer C, Simes DC. Gla-rich protein function as an anti-inflammatory agent in monocytes\/macrophages: Implications for calcification-related chronic inflammatory diseases. PLoS One. 2017;12(5):e0177829.","journal-title":"PLoS One"},{"issue":"8","key":"1583_CR27","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1210\/endo.143.8.8954","volume":"143","author":"X Li","year":"2002","unstructured":"Li X, Udagawa N, Itoh K, Suda K, Murase Y, Nishihara T, Suda T, Takahashi N. p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. Endocrinology. 2002;143(8):3105\u201313.","journal-title":"Endocrinology"},{"issue":"1","key":"1583_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S8756-3282(01)00657-3","volume":"30","author":"SE Lee","year":"2002","unstructured":"Lee SE, Woo KM, Kim SY, Kim HM, Kwack K, Lee ZH, Kim HH. The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation. Bone. 2002;30(1):71\u20137.","journal-title":"Bone"},{"issue":"8","key":"1583_CR29","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/j.joca.2015.03.035","volume":"23","author":"YJ Lee","year":"2015","unstructured":"Lee YJ, Park SY, Lee SJ, Boo YC, Choi JY, Kim JE. Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation. Osteoarthritis Cartilage. 2015;23(8):1421\u201331.","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1583-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-018-1583-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1583-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T19:24:23Z","timestamp":1556738663000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-018-1583-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1583"],"URL":"https:\/\/doi.org\/10.1186\/s13075-018-1583-2","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,2]]},"assertion":[{"value":"18 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study does not involve human participants, human data or human tissue. All experiments involving animals were performed with the approval of the local ethics authorities (Government of Mittelfranken, Ansbach, Germany) and according to the regulations of the animal facilities in Germany.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"88"}}