{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:40:14Z","timestamp":1788964814666,"version":"build-2803163510"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13075-018-1605-0","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T10:07:53Z","timestamp":1528193273000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The effects of upper and lower limb exercise on the microvascular reactivity in limited cutaneous systemic sclerosis patients"],"prefix":"10.1186","volume":"20","author":[{"given":"A.","family":"Mitropoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gumber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Crank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Akil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-4403","authenticated-orcid":false,"given":"M.","family":"Klonizakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"1605_CR1","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"36","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med. 2009;36:1989\u20132003.","journal-title":"N Engl J Med"},{"key":"1605_CR2","first-page":"1375","volume-title":"Rheumatology","author":"MBSR Bolster","year":"2008","unstructured":"Bolster MBSR. Clinical features of systemic sclerosis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology. 6th ed. Philadelphia: Mosby Elsevier; 2008. p. 1375\u201385.","edition":"6"},{"key":"1605_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.7326\/0003-4819-140-1-200401060-00010","volume":"140","author":"SA Jimenez","year":"2004","unstructured":"Jimenez SA, Derk CT. Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med. 2004;140:37\u201350.","journal-title":"Ann Intern Med"},{"key":"1605_CR4","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1172\/JCI31139","volume":"117","author":"J Varga","year":"2007","unstructured":"Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007;117:557\u201367.","journal-title":"J Clin Invest"},{"key":"1605_CR5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1136\/bmj.310.6982.795","volume":"310","author":"DA Isenberg","year":"1995","unstructured":"Isenberg DA, Black C. ABC of Rheumatology. Raynaud's phenomenon, scleroderma, and overlap syndromes. BMJ. 1995;310:795\u20138.","journal-title":"BMJ"},{"key":"1605_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.vph.2015.05.015","volume":"71","author":"N Kavian","year":"2015","unstructured":"Kavian N, Batteux F. Macro- and microvascular disease in systemic sclerosis. Vasc Pharmacol. 2015;71:16\u201323.","journal-title":"Vasc Pharmacol"},{"key":"1605_CR7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S0140-6736(04)16864-5","volume":"364","author":"B Kahaleh","year":"2004","unstructured":"Kahaleh B. Progress in research into systemic sclerosis. Lancet. 2004;364:561\u20132.","journal-title":"Lancet"},{"key":"1605_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1093\/brheum\/45.suppl_1.i33","volume":"45","author":"C Sunderk\u00f6tter","year":"2006","unstructured":"Sunderk\u00f6tter C, Riemekasten G. Pathophysiology and clinical consequences of Raynaud\u2019s phenomenon related to systemic sclerosis. Rheumatology (Oxford). 2006;45:33\u20135.","journal-title":"Rheumatology (Oxford)"},{"key":"1605_CR9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/art.1780340405","volume":"34","author":"RD Altman","year":"1991","unstructured":"Altman RD, Medsger TA Jr, Bloch DA, Michel BA. Predictors of survival in systemic sclerosis (scleroderma). Arthritis Rheum. 1991;34:403\u201313.","journal-title":"Arthritis Rheum"},{"key":"1605_CR10","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2165\/00003495-200767040-00003","volume":"67","author":"JE Pope","year":"2007","unstructured":"Pope JE. The diagnosis and treatment of Raynaud's phenomenon: a practical approach. Drugs. 2007;67:517\u201325.","journal-title":"Drugs"},{"key":"1605_CR11","volume-title":"Prescription Cost Analysis for England 2015","author":"Prescribing & Medicines Team Health and Social Care Information Centre","year":"2016","unstructured":"Prescribing & Medicines Team Health and Social Care Information Centre. Prescription Cost Analysis for England 2015. 2016. \n                    https:\/\/digital.nhs.uk\/catalogue\/PUB20200\n                    \n                  . Accessed 07 May 2016."},{"key":"1605_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s40279-015-0321-z","volume":"45","author":"JS Ramos","year":"2015","unstructured":"Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports Med. 2015;45:679\u201392.","journal-title":"Sports Med"},{"key":"1605_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cardfail.2011.10.010","volume":"18","author":"P Meyer","year":"2012","unstructured":"Meyer P, Normandin E, Gayda M, Billon G, Guiraud T, Bosquet L, et al. High-intensity interval exercise in chronic heart failure: protocol optimization. J Card Fail. 2012;18:126\u201333.","journal-title":"J Card Fail"},{"key":"1605_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/cpf.12262","volume":"37","author":"A Smith-Ryan","year":"2017","unstructured":"Smith-Ryan A. Enjoyment of high-intensity interval training in an overweight\/obese cohort: a short report. Clin Physiol Funct Imaging. 2017;37:89\u201393.","journal-title":"Clin Physiol Funct Imaging"},{"key":"1605_CR15","doi-asserted-by":"publisher","first-page":"587","DOI":"10.2165\/11631910-000000000-00000","volume":"42","author":"T Guiraud","year":"2012","unstructured":"Guiraud T, Nigam A, Gremeaux V, Meyer P, Juneau M, Bosquet L. High-intensity interval training in cardiac rehabilitation. Sports Med. 2012;42:587\u2013605.","journal-title":"Sports Med"},{"key":"1605_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.2165\/11630910-000000000-00000","volume":"42","author":"HS Kessler","year":"2012","unstructured":"Kessler HS, Sisson SB, Short KR. The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med. 2012;42:489\u2013509.","journal-title":"Sports Med"},{"key":"1605_CR17","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","volume":"65","author":"F Hoogen","year":"2013","unstructured":"Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology\/European League Against Rheumatism Collaborative Initiative. Arthritis Rheum. 2013;65:2737\u201347.","journal-title":"Arthritis Rheum"},{"key":"1605_CR18","first-page":"90","volume":"5","author":"GA Borg","year":"1973","unstructured":"Borg GA. Perceived exertion: a note on \u201chistory\u201d and methods. Med Sci Sports. 1973;5:90\u20133.","journal-title":"Med Sci Sports"},{"key":"1605_CR19","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1080\/026404101317108453","volume":"19","author":"PM Smith","year":"2001","unstructured":"Smith PM, Price MJ, Doherty M. The influence of crank rate on peak oxygen consumption during arm crank ergometry. J Sports Sci. 2001;19:955\u201360.","journal-title":"J Sports Sci"},{"key":"1605_CR20","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1080\/02640410600831955","volume":"25","author":"PM Smith","year":"2007","unstructured":"Smith PM, Doherty M, Price MJ. The effect of crank rate strategy on peak aerobic power and peak physiological responses during arm crank ergometry. J Sports Sci. 2007;25:711\u20138.","journal-title":"J Sports Sci"},{"key":"1605_CR21","first-page":"141","volume-title":"Principles of exercise testing and interpretation : including pathophysiology and clinical applications","author":"K Wasserman","year":"2012","unstructured":"Wasserman K. In: Hansen JE, Sue DY, Stringer WW, Sietsema KE, Sun XG, Whipp BJ, editors. Principles of exercise testing and interpretation : including pathophysiology and clinical applications. London: Wolters Kluwer\/Lippincott Williams & Wilkins; 2012. p. 141\u20132."},{"key":"1605_CR22","first-page":"S53","volume":"29","author":"K Deuschle","year":"2011","unstructured":"Deuschle K, Weinert K, Becker MO, Backhaus M, Huscher D, Riemekasten G. Six-minute walk distance as a marker for disability and complaints in patients with systemic sclerosis. Clin Exp Rheumatol. 2011;29:S53\u20139.","journal-title":"Clin Exp Rheumatol"},{"key":"1605_CR23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.mvr.2009.03.002","volume":"78","author":"M Klonizakis","year":"2009","unstructured":"Klonizakis M, Tew G, Michaels J, Saxton J. Exercise training improves cutaneous microvascular endothelial function in post- surgical varicose vein patients. Microvasc Res. 2009;78:67\u201370.","journal-title":"Microvasc Res"},{"key":"1605_CR24","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.mvr.2008.09.009","volume":"77","author":"M Klonizakis","year":"2009","unstructured":"Klonizakis M, Tew G, Michaels J, Saxton J. Impaired microvascular endothelial function is restored by acute lower-limb exercise in post-surgical varicose vein patients. Microvasc Res. 2009;77:158\u201362.","journal-title":"Microvasc Res"},{"key":"1605_CR25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.mvr.2016.05.001","volume":"107","author":"R Wasilewski","year":"2016","unstructured":"Wasilewski R, Ubara EO, Klonizakis M. Assessing the effects of a short-term green tea intervention in skin microvascular function and oxygen tension in older and younger adults. Microvasc Res. 2016;107:65\u201371.","journal-title":"Microvasc Res"},{"key":"1605_CR26","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1097\/00005650-199711000-00002","volume":"35","author":"P Dolan","year":"1997","unstructured":"Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997;35:1095\u2013108.","journal-title":"Med Care"},{"key":"1605_CR27","doi-asserted-by":"publisher","first-page":"e114541","DOI":"10.1371\/journal.pone.0114541","volume":"9","author":"ME Jung","year":"2014","unstructured":"Jung ME, Bourne JE, Little JP. Where does HIT fit? An examination of the affective response to high-intensity intervals in comparison to continuous moderate- and continuous vigorous-intensity exercise in the exercise intensity-affect continuum. PLoS One. 2014;9:e114541.","journal-title":"PLoS One"},{"key":"1605_CR28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1080\/026404101317015410","volume":"19","author":"DR Mullineaux","year":"2001","unstructured":"Mullineaux DR, Bartlett RM, Bennett S. Research design and statistics in biomechanics and motor control. J Sports Sci. 2001;19:739\u201360.","journal-title":"J Sports Sci"},{"key":"1605_CR29","first-page":"558","volume":"16","author":"A Mitropoulos","year":"2017","unstructured":"Mitropoulos A, Gumber A, Crank H, Klonizakis M. Validation of an arm crank ergometer test for use in sedentary adults. J Sports Sci Med. 2017;16:558\u201364.","journal-title":"J Sports Sci Med"},{"key":"1605_CR30","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1136\/annrheumdis-2013-203291","volume":"73","author":"GS Metsios","year":"2014","unstructured":"Metsios GS, Stavropoulos-Kalinoglou A, Veldhuijzen vZ, Nightingale P, Sandoo A, Dimitroulas T, et al. Individualised exercise improves endothelial function in patients with rheumatoid arthritis. Ann Rheum Dis. 2014;73:748.","journal-title":"Ann Rheum Dis"},{"key":"1605_CR31","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1249\/MSS.0000000000000705","volume":"47","author":"I Dias","year":"2015","unstructured":"Dias I, Farinatti P, De Souza MG, Manhanini DP, Balthazar E, Dantas DL, et al. Effects of resistance training on obese adolescents. Med Sci Sports Exerc. 2015;47:2636\u201344.","journal-title":"Med Sci Sports Exerc"},{"key":"1605_CR32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1152\/japplphysiol.01096.2007","volume":"104","author":"M Laughlin","year":"2008","unstructured":"Laughlin M, Newcomer S, Bender S. Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype. J Appl Physiol. 2008;104:588.","journal-title":"J Appl Physiol"},{"key":"1605_CR33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0014-5793(90)81445-T","volume":"275","author":"R Busse","year":"1990","unstructured":"Busse R, M\u00fclsch A. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett. 1990;275:87\u201390.","journal-title":"FEBS Lett"},{"key":"1605_CR34","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1172\/JCI9551","volume":"105","author":"T Fukai","year":"2000","unstructured":"Fukai T, Siegfried MR, Ushio-Fukai M, Cheng Y, Kojda G, Harrison DG. Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J Clin Invest. 2000;105:1631.","journal-title":"J Clin Invest"},{"key":"1605_CR35","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ehj.2003.10.029","volume":"25","author":"V Adams","year":"2004","unstructured":"Adams V, Linke A, Krankel N, Erbs S, Gummert J, Mohr F, et al. Impact of regular physical activity on the expression of angiotensin II receptors and activity of NADPH oxidase in the left mammarial artery of patients with coronary artery disease. Eur Heart J. 2004;25:224.","journal-title":"Eur Heart J"},{"key":"1605_CR36","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1249\/01.mss.0000273010.06226.99","volume":"39","author":"PU Wisloff","year":"2007","unstructured":"Wisloff PU, Stoylen MA, Loennechen EJ, Bruvold AM, Rognmo JO, Haram LP, et al. Superior cardiovascular effect of aerobic interval-training versus moderate continuous training in elderly heart failure patients. Med Sci Sports Exerc. 2007;39:S32.","journal-title":"Med Sci Sports Exerc"},{"key":"1605_CR37","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1161\/CIRCULATIONAHA.108.772822","volume":"118","author":"AE Tj\u00f8nna","year":"2008","unstructured":"Tj\u00f8nna AE, Lee SJ, Rognmo \u00d8, St\u00f8len TO, Bye A, Haram PM, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation. 2008;118:346\u201354.","journal-title":"Circulation"},{"key":"1605_CR38","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1111\/sms.12112","volume":"24","author":"W Mitranun","year":"2014","unstructured":"Mitranun W, Deerochanawong C, Tanaka H, Suksom D. Continuous vs interval training on glycemic control and macro- and microvascular reactivity in type 2 diabetic patients. Scand J Med Sci Sports. 2014;24:e69\u201376.","journal-title":"Scand J Med Sci Sports"},{"key":"1605_CR39","first-page":"234Y44","volume":"94","author":"MH Laughlin","year":"2003","unstructured":"Laughlin MH, Rubin LJ, Rush JW, Price EM, Schrage WG, Woodman CR. Short-term training enhances endothelium-dependent dilation of coronary arteries, not arterioles. J Appl Physiol. 2003;94:234Y44.","journal-title":"J Appl Physiol"},{"key":"1605_CR40","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1161\/01.ATV.16.10.1256","volume":"16","author":"F Tronc","year":"1996","unstructured":"Tronc F, Wassef M, Esposito B, Henrion D, Glagov S, Tedgui A. Role of NO in flow-induced remodeling of the rabbit common carotid artery. Arterioscler Thromb Vasc Biol. 1996;16:1256\u201362.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1605_CR41","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.mvr.2011.01.008","volume":"81","author":"M Klonizakis","year":"2011","unstructured":"Klonizakis M, Winter E. Effects of arm-cranking exercise in cutaneous microcirculation in older, sedentary people. Microvasc Res. 2011;81:331\u20136.","journal-title":"Microvasc Res"},{"key":"1605_CR42","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1152\/jappl.1986.61.2.673","volume":"61","author":"LI Sinoway","year":"1986","unstructured":"Sinoway LI, Musch TI, Minotti JR, Zelis R. Enhanced maximal metabolic vasodilatation in the dominant forearms of tennis players. J Appl Physiol (1985). 1986;61:673\u20138.","journal-title":"J Appl Physiol (1985)"},{"key":"1605_CR43","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1152\/jappl.1994.77.4.1829","volume":"77","author":"DJ Green","year":"1994","unstructured":"Green DJ, Cable NT, Fox C, Rankin JM, Taylor RR. Modification of forearm resistance vessels by exercise training in young men. J Appl Physiol (Bethesda, MD: 1985). 1994;77:1829.","journal-title":"J Appl Physiol (Bethesda, MD: 1985)"},{"key":"1605_CR44","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1152\/jappl.1996.81.2.943","volume":"81","author":"DJ Green","year":"1996","unstructured":"Green DJ, Fowler DT, O'Driscoll JG, Blanksby BA, Taylor RR. Endothelium-derived nitric oxide activity in forearm vessels of tennis players. J Appl Physiol (Bethesda, MD.: 1985). 1996;81:943.","journal-title":"J Appl Physiol (Bethesda, MD.: 1985)"},{"key":"1605_CR45","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijcard.2009.09.548","volume":"141","author":"F Ribeiro","year":"2010","unstructured":"Ribeiro F, Alves AJ, Duarte JA, Oliveira J. Is exercise training an effective therapy targeting endothelial dysfunction and vascular wall inflammation? Int J Cardiol. 2010;141:214\u201321.","journal-title":"Int J Cardiol"},{"key":"1605_CR46","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10237-011-0319-x","volume":"11","author":"L Liu","year":"2012","unstructured":"Liu L, Yu B, Chen J, Tang Z, Zong C, Shen D, et al. Different effects of intermittent and continuous fluid shear stresses on osteogenic differentiation of human mesenchymal stem cells. Biomech Model Mechanobiol. 2012;11:391\u2013401.","journal-title":"Biomech Model Mechanobiol"},{"key":"1605_CR47","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2217\/ijr.10.17","volume":"5","author":"Z Mcmahan","year":"2010","unstructured":"Mcmahan Z, Wigley F. Raynaud\u2019s phenomenon and digital ischemia: a practical approach to risk stratification, diagnosis and management. Int J Clin Rheumatol. 2010;5:355\u201370.","journal-title":"Int J Clin Rheumatol"},{"key":"1605_CR48","first-page":"P578","volume":"54","author":"KM Ingraham","year":"2006","unstructured":"Ingraham KM, Steen VD. Morbidity of digital tip ulcerations in scleroderma. Arth Rheum. 2006;54:P578.","journal-title":"Arth Rheum"},{"key":"1605_CR49","unstructured":"Vitielo M, Abuchar A, Santana N, Dehesa L, Kerdel FA. An update on the treatment of the cutaneous manifestations of systemic sclerosis: The dermatologist's point of view. J Clin Aesthet Dermatol. 2012;5:33\u201343."},{"key":"1605_CR50","first-page":"CD000953","volume":"2","author":"J Pope","year":"2000","unstructured":"Pope J, Fenlon D, Thompson A, Shea B, Furst D, Wells GA, et al. Iloprost and cisaprost for Raynaud's phenomenon in progressive systemic sclerosis. Cochrane Database Syst Rev. 2000;2:CD000953.","journal-title":"Cochrane Database Syst Rev"},{"key":"1605_CR51","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/art.1780350614","volume":"35","author":"FM Wigley","year":"1992","unstructured":"Wigley FM, Wise RA, Miller R, Needleman BW, Spence RJ. Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis. Arthritis Rheum. 1992;35:688\u201393.","journal-title":"Arthritis Rheum"},{"key":"1605_CR52","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/msc.1185","volume":"15","author":"NC Oliveira","year":"2017","unstructured":"Oliveira NC, Portes LA, Pettersson H, Alexanderson H, Bostr\u00f6m C. Aerobic and resistance exercise in systemic sclerosis: state of the art. Musculoskeletal Care. 2017;15:316\u201323.","journal-title":"Musculoskeletal Care"},{"key":"1605_CR53","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00421-012-2421-x","volume":"113","author":"J Scherr","year":"2013","unstructured":"Scherr J, Wolfarth B, Christle JW, Pressler A, Wagenpfeil S, Halle M. Associations between Borg's rating of perceived exertion and physiological measures of exercise intensity. Eur J Appl Physiol. 2013;113:147\u201355.","journal-title":"Eur J Appl Physiol"},{"key":"1605_CR54","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S1440-2440(01)80005-0","volume":"4","author":"CM Blanchard","year":"2001","unstructured":"Blanchard CM, Rodgers WM, Spence JC, Courneya KS. Feeling state responses to acute exercise of high and low intensity. J Sci Med Sport. 2001;4:30\u20138.","journal-title":"J Sci Med Sport"},{"key":"1605_CR55","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1016\/S1728-869X(09)60021-6","volume":"7","author":"G Parfitt","year":"2009","unstructured":"Parfitt G, Hughes S. The exercise intensity\u2013affect relationship: evidence and implications for exercise behavior. J Exerc Sci Fit. 2009;7:S34\u201341.","journal-title":"J Exerc Sci Fit"},{"key":"1605_CR56","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1093\/rheumatology\/keh124","volume":"43","author":"RJ Allcock","year":"2004","unstructured":"Allcock RJ, Forrest I, Corris PA, Crook PR, Griffiths ID. A study of the prevalence of systemic sclerosis in northeast England. Rheumatology (Oxford). 2004;43:596\u2013602.","journal-title":"Rheumatology (Oxford)"},{"key":"1605_CR57","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1475-097X.1994.tb00488.x","volume":"14","author":"L Brudin","year":"1994","unstructured":"Brudin L, Berg S, Ekberg P, Castenfors J. Is transcutaneous PO2 monitoring during exercise a reliable alternative to arterial PO2 measurements? Clin Physiol. 1994;14:47\u201352.","journal-title":"Clin Physiol"},{"key":"1605_CR58","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1053\/apmr.2001.26248","volume":"82","author":"C Plan\u00e8s","year":"2001","unstructured":"Plan\u00e8s C, Leroy M, Foray E, Raffestin B. Arterial blood gases during exercise: validity of transcutaneous measurements. Arch Phys Med Rehabil. 2001;82:1686\u201391.","journal-title":"Arch Phys Med Rehabil"},{"key":"1605_CR59","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1053\/rmed.1999.0714","volume":"94","author":"R Carter","year":"2000","unstructured":"Carter R, Banham SW. Use of transcutaneous oxygen and carbon dioxide tensions for assessing indices of gas exchange during exercise testing. Respir Med. 2000;94:350\u20135.","journal-title":"Respir Med"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1605-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-018-1605-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1605-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T19:14:45Z","timestamp":1559675685000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-018-1605-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1605"],"URL":"https:\/\/doi.org\/10.1186\/s13075-018-1605-0","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]},"assertion":[{"value":"2 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All the patients before their participation to the study were signed informed consent according to the health research authority NHS, UK.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"112"}}