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The animal study in this research was approved by the Animal Experimental Ethics Committee of the Chinese University of Hong Kong (ref. 13\/044\/GRF-5 and 13\/044\/GRF-5). The clinical specimen study was approved by the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee (ethical approval code CRE-2013.248) or the First Affiliated Hospital of Guangzhou University of Chinese Medicine Clinical Research Ethics Committee (ethical approval code YJ-2015.034), and informed consent was obtained from each donor.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"163"}}