{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T14:34:51Z","timestamp":1794062091785,"version":"4.8.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IRCCS Istituto Auxologico Italiano","award":["Ricerca Corrente 2013"],"award-info":[{"award-number":["Ricerca Corrente 2013"]}]},{"name":"University of Milan, Department of Clinical Sciences and Community Health","award":["Progetto Azione A Giovani Ricercatori"],"award-info":[{"award-number":["Progetto Azione A Giovani Ricercatori"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13075-018-1689-6","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T14:40:05Z","timestamp":1535553605000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts"],"prefix":"10.1186","volume":"20","author":[{"given":"Elena","family":"Raschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-9632","authenticated-orcid":false,"given":"Cecilia Beatrice","family":"Chighizola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cesana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Privitera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ingegnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Mastaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Meroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Orietta","family":"Borghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"1689_CR1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","volume":"390","author":"CP Denton","year":"2017","unstructured":"Denton CP, Khanna D. Systemic sclerosis. Lancet. 2017;390:1685\u201399.","journal-title":"Lancet"},{"key":"1689_CR2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.autrev.2012.05.011","volume":"12","author":"S Mehra","year":"2013","unstructured":"Mehra S, Walker J, Patterson K, Fritzler MJ. Autoantibodies in systemic sclerosis. Autoimmun Rev. 2013;12:350\u20134.","journal-title":"Autoimmun Rev"},{"key":"1689_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fimmu.2015.00167","volume":"6","author":"C Kayser","year":"2015","unstructured":"Kayser C, Fritzler MJ. Autoantibodies in systemic sclerosis: unanswered questions. Front Immunol. 2015;6:167.","journal-title":"Front Immunol"},{"key":"1689_CR4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrrheum.2009.238","volume":"6","author":"SI Nihtyanova","year":"2010","unstructured":"Nihtyanova SI, Denton CP. Autoantibodies as predictive tools in systemic sclerosis. Nat Rev Rheumatol. 2010;6:112\u20136.","journal-title":"Nat Rev Rheumatol"},{"key":"1689_CR5","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1002\/acr.22304","volume":"66","author":"G Valentini","year":"2014","unstructured":"Valentini G, Marcoccia A, Cuomo G, Vettori S, Iudici M, Bondanini F, et al. Early systemic sclerosis: analysis of the disease course in patients with marker autoantibody and\/or capillaroscopic positivity. Arthritis Care Res. 2014;66:1520\u20137.","journal-title":"Arthritis Care Res"},{"key":"1689_CR6","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1002\/art.39728","volume":"68","author":"MM Luchetti","year":"2016","unstructured":"Luchetti MM, Moroncini G, Jose Escamez M, Svegliati Baroni S, Spadoni T, Grieco A, et al. Induction of scleroderma fibrosis in skin-humanized mice by administration of anti-platelet-derived growth factor receptor agonistic autoantibodies. Arthritis Rheumatol. 2016;68:2263\u201373.","journal-title":"Arthritis Rheumatol"},{"key":"1689_CR7","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1002\/art.20515","volume":"50","author":"J H\u00e9nault","year":"2004","unstructured":"H\u00e9nault J, Tremblay ML, Clement I, Raymond Y, Senecal J-L. Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis. Arthritis Rheum. 2004;50:3265\u201374.","journal-title":"Arthritis Rheum"},{"key":"1689_CR8","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1002\/art.21646","volume":"54","author":"J H\u00e9nault","year":"2006","unstructured":"H\u00e9nault J, Robitaille G, Sen\u00e9cal J-L, Raymond Y. DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti\u2013topoisomerase I autoantibodies from systemic sclerosis patients. Arthritis Rheum. 2006;54:963\u201373.","journal-title":"Arthritis Rheum"},{"key":"1689_CR9","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1002\/art.24765","volume":"60","author":"G Robitaille","year":"2009","unstructured":"Robitaille G, Christin M-S, Cl\u00e9ment I, Sen\u00e9cal J-L, Raymond Y. Nuclear autoantigen CENP-B transactivation of the epidermal growth factor receptor via chemokine receptor 3 in vascular smooth muscle cells. Arthritis Rheum. 2009;60:2805\u201316.","journal-title":"Arthritis Rheum"},{"key":"1689_CR10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/ard.62.1.37","volume":"62","author":"J R\u00f6nnelid","year":"2003","unstructured":"R\u00f6nnelid J, Tejde A, Mathsson L, Nilsson-Ekdahl K, Nilsson B. Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE. Ann Rheum Dis. 2003;62:37\u201342.","journal-title":"Ann Rheum Dis"},{"key":"1689_CR11","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1365-2249.2006.03313.x","volume":"147","author":"L Mathsson","year":"2007","unstructured":"Mathsson L, Ahlin E, Sj\u00f6wall C, Skogh T, R\u00f6nnelid J. Cytokine induction by circulating immune complexes and signs of in-vivo complement activation in systemic lupus erythematosus are associated with the occurrence of anti-Sj\u00f6gren's syndrome A antibodies. Clin Exp Immunol. 2007;147:513\u201320.","journal-title":"Clin Exp Immunol"},{"key":"1689_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0896-8411(91)90016-6","volume":"4","author":"B Bendaoud","year":"1991","unstructured":"Bendaoud B, Pennec YL, Lelong A, Le Noac'h JF, Magadur G, Jouquan J, et al. IgA-containing immune complexes in the circulation of patients with primary Sj\u00f6gren's syndrome. J Autoimmun. 1991;4:177\u201384.","journal-title":"J Autoimmun"},{"key":"1689_CR13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13075-015-0523-7","volume":"17","author":"VA Manivel","year":"2015","unstructured":"Manivel VA, Sohrabian A, Wick MC, Mullazehi M, H\u00e5kansson LD, R\u00f6nnelid J. Anti-type II collagen immune complex-induced granulocyte reactivity is associated with joint erosions in RA patients with anti-collagen antibodies. Arthritis Res Ther. 2015;17:8.","journal-title":"Arthritis Res Ther."},{"key":"1689_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.bbapap.2005.03.007","volume":"1749","author":"A Czubaty","year":"2005","unstructured":"Czubaty A, Girstun A, Kowalska-Loth B, Trzci\u0144ska AM, Purta E, Winczura A, et al. Proteomic analysis of complexes formed by human topoisomerase I. Biochim Biophys Acta. 2005;1749:133\u201341.","journal-title":"Biochim Biophys Acta"},{"key":"1689_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.coi.2010.11.006","volume":"23","author":"SE Ewald","year":"2011","unstructured":"Ewald SE, Barton GM. Nucleic acid sensing toll-like receptors in autoimmunity. Curr Opin Immunol. 2011;23:3\u20139.","journal-title":"Curr Opin Immunol"},{"key":"1689_CR16","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","volume":"72","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2013;72:1747\u201355.","journal-title":"Ann Rheum Dis"},{"key":"1689_CR17","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 1988;15:202\u20135.","journal-title":"J Rheumatol"},{"key":"1689_CR18","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725.","journal-title":"Arthritis Rheum"},{"key":"1689_CR19","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295\u2013306.","journal-title":"J Thromb Haemost"},{"key":"1689_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0022-1759(86)90028-1","volume":"89","author":"LC Pontes-de-Carvalho","year":"1986","unstructured":"Pontes-de-Carvalho LC, Lannes-Vieira J, Giovanni-de-Simone S, Galv\u00e3o-Castro B. A protein A-binding, polyethylene glycol precipitation-based immunoradiometric assay. Application to the detection of immune complexes and C3 in human sera and of private antigens in cross-reacting parasite extracts. J Immunol Methods. 1986;89:27\u201335.","journal-title":"J Immunol Methods"},{"key":"1689_CR21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0022-1759(01)00370-2","volume":"253","author":"SA Stanilova","year":"2001","unstructured":"Stanilova SA, Slavov ES. Comparative study of circulating immune complexes quantity detection by three assays-CIF-ELISA, C1q-ELISA and anti-C3 ELISA. J Immunol Methods. 2001;253:13\u201321.","journal-title":"J Immunol Methods"},{"key":"1689_CR22","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1177\/0961203311434938","volume":"21","author":"E Ahlin","year":"2012","unstructured":"Ahlin E, Mathsson L, Eloranta ML, Jonsdottir T, Gunnarsson I, R\u00f6nnblom L, et al. Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE. Lupus. 2012;21:586\u201395.","journal-title":"Lupus"},{"key":"1689_CR23","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/art.1780400322","volume":"40","author":"N Del Papa","year":"1997","unstructured":"Del Papa N, Guidali L, Sala A, Buccellati C, Khamashta MA, Ichikawa K, et al. Endothelial cells as target for antiphospholipid antibodies. Human polyclonal and monoclonal anti-beta 2-glycoprotein I antibodies react in vitro with endothelial cells through adherent beta 2-glycoprotein I and induce endothelial activation. Arthritis Rheum. 1997;40:551\u201361.","journal-title":"Arthritis Rheum"},{"key":"1689_CR24","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1002\/art.1780251004","volume":"25","author":"JR Seibold","year":"1982","unstructured":"Seibold JR, Medsger TA, Winkelstein A, Kelly RH, Rodnan GP. Immune complexes in progressive systemic sclerosis (scleroderma). Arthritis Rheum. 1982;25:1167\u201373.","journal-title":"Arthritis Rheum"},{"key":"1689_CR25","first-page":"133","volume":"10","author":"P Hughes","year":"1983","unstructured":"Hughes P, Cunningham J, Day M, Fitzgerald JC, French MA, Wright JK, et al. Immune complexes in systemic sclerosis; detection by C1q binding, K-cell inhibition and Raji cell radioimmunoassays. J Clin Lab Immunol. 1983;10:133\u20138.","journal-title":"J Clin Lab Immunol"},{"key":"1689_CR26","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1002\/art.1780251005","volume":"25","author":"K Siminovitich","year":"1982","unstructured":"Siminovitich K, Klein M, Pruzanski W, Wilkinson S, Lee P, Yoon SJ, et al. Circulating immune complexes in patients with progressive systemic sclerosis. Arthritis Rheum. 1982;25:1174\u20139.","journal-title":"Arthritis Rheum"},{"key":"1689_CR27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1136\/ard.44.2.89","volume":"44","author":"MA French","year":"1985","unstructured":"French MA, Harrison G, Penning CA, Cunningham J, Hughes P, Rowell NR. Serum immune complexes in systemic sclerosis: relationship with precipitating nuclear antibodies. Ann Rheum Dis. 1985;44:89\u201392.","journal-title":"Ann Rheum Dis"},{"key":"1689_CR28","first-page":"38","volume":"3","author":"RI Schwarz","year":"2015","unstructured":"Schwarz RI. Collagen I and the fibroblast: high protein expression requires a new paradigm of post-transcriptional, feedback regulation. Biochem Biophys Rep. 2015;3:38\u201344.","journal-title":"Biochem Biophys Rep"},{"key":"1689_CR29","doi-asserted-by":"publisher","first-page":"e0114017","DOI":"10.1371\/journal.pone.0114017","volume":"10","author":"ME Johnson","year":"2015","unstructured":"Johnson ME, Mahoney JM, Taroni J, Sargent JL, Marmarelis E, Wu MR, et al. Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts. PLoS One. 2015;10:e0114017.","journal-title":"PLoS One"},{"key":"1689_CR30","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/rheumatology\/kei244","volume":"45","author":"FK Tan","year":"2006","unstructured":"Tan FK, Zhou X, Mayes MD, Gourh P, Guo X, Marcum C, et al. Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients. Rheumatology (Oxford). 2006;45:694\u2013702.","journal-title":"Rheumatology (Oxford)"},{"key":"1689_CR31","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1002\/art.23486","volume":"58","author":"D Kim","year":"2008","unstructured":"Kim D, Peck A, Santer D, Patole P, Schwartz SM, Molitor JA, et al. Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis. Arthritis Rheum. 2008;58:2163\u201373.","journal-title":"Arthritis Rheum"},{"key":"1689_CR32","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1136\/ard.2009.121400","volume":"69","author":"M-L Eloranta","year":"2010","unstructured":"Eloranta M-L, Franck-Larsson K, L\u00f6vgren T, Kalamajski S, R\u00f6nnblom A, Rubin K, et al. Type I interferon system activation and association with disease manifestations in systemic sclerosis. Ann Rheum Dis. 2010;69:1396\u2013402.","journal-title":"Ann Rheum Dis"},{"key":"1689_CR33","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1186\/ar3221","volume":"13","author":"SK Agarwal","year":"2011","unstructured":"Agarwal SK, Wu M, Livingston CK, Parks DH, Mayes MD, Arnett FC, et al. Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts. Arthritis Res Ther. 2011;13:R3.","journal-title":"Arthritis Res Ther"},{"key":"1689_CR34","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.4049\/jimmunol.1300376","volume":"191","author":"F Fang","year":"2013","unstructured":"Fang F, Ooka K, Sun X, Shah R, Bhattacharyya S, Wei J, et al. A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling. J Immunol. 2013;191:2956\u201366.","journal-title":"J Immunol"},{"key":"1689_CR35","doi-asserted-by":"publisher","unstructured":"Oku K, Atsumi T. Systemic lupus erythematosus: nothing stale her infinite variety. Mod Rheumatol. 2018;27:1\u201320. \n                    https:\/\/doi.org\/10.1080\/14397595.2018.1494239\n                    \n                  .","DOI":"10.1080\/14397595.2018.1494239"},{"key":"1689_CR36","doi-asserted-by":"publisher","first-page":"17103","DOI":"10.1038\/nrdp.2017.103","volume":"4","author":"K Schreiber","year":"2018","unstructured":"Schreiber K, Sciascia S, de Groot PG, Devreese K, Jacobsen S, Ruiz-Irastorza G, Salmon JE, Shoenfeld Y, Shovman O, Hunt BJ. Antiphospholipid syndrome. Nat Rev Dis Primers. 2018;4:17103.","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"1689_CR37","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","volume":"22","author":"GC Tsokos","year":"2016","unstructured":"Tsokos GC, Lo MS, Costa Reis P, Sullivan KE. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. 2016;22(12):716\u201330.","journal-title":"Nat Rev Rheumatol"},{"key":"1689_CR38","doi-asserted-by":"publisher","unstructured":"Meroni PL, Borghi MO, Grossi C, Chighizola CB, Durigutto P, Tedesco F. Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases? Nat Rev Rheumatol. 2018;14(7):433\u201340. \n                    https:\/\/doi.org\/10.1038\/s41584-018-0032-6\n                    \n                  .","DOI":"10.1038\/s41584-018-0032-6"},{"key":"1689_CR39","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s002770050396","volume":"76","author":"JE Gessner","year":"1998","unstructured":"Gessner JE, Heiken H, Tamm A, Schmidt RE. The IgG Fc receptor family. Ann Hematol. 1998;76:231\u201348.","journal-title":"Ann Hematol"},{"key":"1689_CR40","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s11926-014-0474-z","volume":"17","author":"S Bhattacharyya","year":"2015","unstructured":"Bhattacharyya S, Varga J. Emerging roles of innate immune signaling and toll-like receptors in fibrosis and systemic sclerosis. Curr Rheumatol Rep. 2015;17:474\u20139.","journal-title":"Curr Rheumatol Rep"},{"key":"1689_CR41","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/01.shk.0000225404.51320.82","volume":"26","author":"M Yu","year":"2006","unstructured":"Yu M, Wang H, Ding A, Golenbock DT, Latz E, Czura CJ, et al. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock. 2006;26:174\u20139.","journal-title":"Shock"},{"key":"1689_CR42","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/labinvest.2013.61","volume":"93","author":"W Sun","year":"2013","unstructured":"Sun W, Jiao Y, Cui B, Gao X, Xia Y, Zhao Y. Immune complexes activate human endothelium involving the cell-signaling HMGB1-RAGE axis in the pathogenesis of lupus vasculitis. Lab Investig. 2013;93:626\u201338.","journal-title":"Lab Investig"},{"key":"1689_CR43","doi-asserted-by":"publisher","unstructured":"Yoshizaki A, Taniguchi T, Saigusa R, Fukasawa T, Ebata S, Numajiri H, et al. Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells. Ann Rheum Dis. 2016;75(10):1858\u201365. \n                    https:\/\/doi.org\/10.1136\/annrheumdis-2015-207405\n                    \n                  .","DOI":"10.1136\/annrheumdis-2015-207405"},{"key":"1689_CR44","doi-asserted-by":"publisher","first-page":"458","DOI":"10.3899\/jrheum.130376","volume":"41","author":"GM Palomino","year":"2014","unstructured":"Palomino GM, Bassi CL, Wastowski IJ, Xavier DJ, Lucisano-Valim YM, Crispim JC, et al. Patients with systemic sclerosis present increased DNA damage differentially associated with DNA repair gene polymorphisms. J Rheumatol. 2014;41:458\u201365.","journal-title":"J Rheumatol"},{"key":"1689_CR45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ajhg.2013.12.002","volume":"94","author":"MD Mayes","year":"2014","unstructured":"Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X, Chen WV, et al. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am J Hum Genet. 2014;94:47\u201361.","journal-title":"Am J Hum Genet"},{"key":"1689_CR46","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/jid.2013.423","volume":"134","author":"A Farina","year":"2014","unstructured":"Farina A, Cirone M, York M, Lenna S, Padilla C, Mclaughlin S, et al. Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma. J Invest Dermatol. 2014;134:954\u201364.","journal-title":"J Invest Dermatol"},{"key":"1689_CR47","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1002\/art.27549","volume":"62","author":"AA Shah","year":"2010","unstructured":"Shah AA, Rosen A, Hummers L, Wigley F, Casciola-Rosen L. Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I\/III antibodies. Arthritis Rheum. 2010;62:2787\u201395.","journal-title":"Arthritis Rheum"},{"key":"1689_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar4486","volume":"16","author":"P Moinzadeh","year":"2014","unstructured":"Moinzadeh P, Fonseca C, Hellmich M, Shah AA, Chighizola C, Denton CP, et al. Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma. Arthritis Res Ther. 2014;16:1\u201310.","journal-title":"Arthritis Res Ther"},{"key":"1689_CR49","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1126\/science.1246886","volume":"343","author":"CG Joseph","year":"2014","unstructured":"Joseph CG, Darrah E, Shah AA, Skora AD, Casciola-Rosen LA, Wigley FM, et al. Association of the autoimmune disease scleroderma with an immunologic response to cancer. Science. 2014;343:152\u20137.","journal-title":"Science"},{"key":"1689_CR50","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s11926-015-0505-4","volume":"17","author":"A Kill","year":"2015","unstructured":"Kill A, Riemekasten G. Functional autoantibodies in systemic sclerosis pathogenesis. Curr Rheumatol Rep. 2015;17:34.","journal-title":"Curr Rheumatol Rep"},{"key":"1689_CR51","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1093\/rheumatology\/kem241","volume":"46","author":"S Fineschi","year":"2007","unstructured":"Fineschi S, Cozzi F, Burger D, Dayer JM, Meroni PL, Chizzolini C. Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-I production in dermal fibroblasts. Rheumatol. 2007;46:1779\u201385.","journal-title":"Rheumatol"},{"key":"1689_CR52","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1002\/art.24049","volume":"5","author":"S Fineschi","year":"2008","unstructured":"Fineschi S, Goffin L, Rezzonico R, Cozzi F, Dayer JM, Meroni PL, et al. Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4. Arthritis Rheum. 2008;5:3913\u201323.","journal-title":"Arthritis Rheum"},{"key":"1689_CR53","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.3899\/jrheum.100316","volume":"37","author":"A Ceribelli","year":"2010","unstructured":"Ceribelli A, Cavazzana I, Franceschini F, Air\u00f2 P, Tincani A, Cattaneo R, et al. Anti-Th\/To are common antinucleolar autoantibodies in Italian patients with scleroderma. J Rheumatol. 2010;37:2071\u20135.","journal-title":"J Rheumatol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1689-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-018-1689-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1689-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T19:11:15Z","timestamp":1567019475000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-018-1689-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1689"],"URL":"https:\/\/doi.org\/10.1186\/s13075-018-1689-6","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]},"assertion":[{"value":"12 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the ethical Committee \u201cMilano Area B\u201d, opinion number 426, July 8, 2014. All patients provided written informed consent to participate.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consent to the publication of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"187"}}