{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:21:29Z","timestamp":1780647689749,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13075-018-1724-7","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T06:52:55Z","timestamp":1538549575000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database"],"prefix":"10.1186","volume":"20","author":[{"name":"REGISPONSER group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ar\u00e9valo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Gratac\u00f3s Masmitj\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Calvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Orellana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desir\u00e9e","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Carreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Larrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Collantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Font","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"1724_CR1","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/acr.22730","volume":"68","author":"R Castillo-Ortiz","year":"2016","unstructured":"Castillo-Ortiz R, Landew\u00e9 v d H, Dougados v d B, et al. Work outcome in patients with Ankylosing Spondylitis: results from a 12-year follow-up of an international study. Arthritis Care Res. 2016;68:544\u201352.","journal-title":"Arthritis Care Res"},{"key":"1724_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/00002281-199507000-00001","volume":"7","author":"M Khan","year":"1995","unstructured":"Khan M. HLA-B27 and its subtypes in world populations. Curr Opin Rheumatol. 1995;7:263\u20139.","journal-title":"Curr Opin Rheumatol"},{"key":"1724_CR3","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1002\/acr.22831","volume":"68","author":"C Stolwijk","year":"2016","unstructured":"Stolwijk C, van Onna M, Boonen A, van Tubergen A. Global prevalence of spondyloarthritis: a systematic review and meta-regression analysis. Arthritis Care Res. 2016;68:1320\u201331.","journal-title":"Arthritis Care Res"},{"issue":"5393","key":"1724_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/242121a0","volume":"242","author":"MF Caffrey","year":"1973","unstructured":"Caffrey MF, James DC. Human lymphocyte antigen association in Ankylosing Spondylitis. Nature. 1973;242(5393):121.","journal-title":"Nature"},{"key":"1724_CR5","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1136\/ard.2011.152975","volume":"70","author":"H Chung","year":"2011","unstructured":"Chung H, Machado P, van der Heijde D, D\u2019Agostino M-A, Dougados M. HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis. Ann RheumDis. 2011;70:1930\u20136.","journal-title":"Ann RheumDis"},{"key":"1724_CR6","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/art.24483","volume":"60","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Haibel H, Baraliakos X, Listing J, M\u00e4rker-Hermann E, Zeidler H, et al. The early disease stage in axial spondyloarthritis: results from the German spondyloarthritis inception cohort. Arthritis Rheumatism. 2009;60:717\u201327.","journal-title":"Arthritis Rheumatism"},{"key":"1724_CR7","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/art.1780200401","volume":"20","author":"M Khan","year":"1977","unstructured":"Khan M, Kushner I, Braun W. Comparison of clinical features in HLA-B27 positive and negative patients with Ankylosing Spondylitis. Arthritis Rheumatism. 1977;20:909\u201312.","journal-title":"Arthritis Rheumatism"},{"key":"1724_CR8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00296-002-0237-4","volume":"23","author":"E Feldtkeller","year":"2002","unstructured":"Feldtkeller E, Khan M, van der Heijde D, van der Linden S, Braun J. Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with Ankylosing Spondylitis. Rheumatol Int. 2002;23:61\u20136.","journal-title":"Rheumatol Int"},{"issue":"5","key":"1724_CR9","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/tan.12186","volume":"82","author":"M Yang","year":"2013","unstructured":"Yang M, Xu M, Pan X, Hu Z, Li Q, Wei Y, et al. Epidemiological comparison of clinical manifestations according to HLA-B*27 carrier status of Chinese Ankylosing Spondylitis patients. Tissue Antigen. 2013;82(5):338\u201343.","journal-title":"Tissue Antigen"},{"issue":"7","key":"1724_CR10","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1002\/art.24585","volume":"61","author":"MM Ward","year":"2009","unstructured":"Ward MM, Hendrey MR, Malley JD, Learch TJ, Davis JC Jr, Reveille JD, et al. Clinical and immunogenetic prognostic factors for radiographic severity in Ankylosing Spondylitis. Arthritis Rheum. 2009;61(7):859\u201366.","journal-title":"Arthritis Rheum"},{"key":"1724_CR11","first-page":"22","volume":"30","author":"J Xiong","year":"2014","unstructured":"Xiong J, Chen J, Tu J, Ye W, Zhang Z, Liu Q, et al. Association of HLA-B27 status and gender with sacroiliitis in patients with Ankylosing Spondylitis. Pak J Med Sci. 2014;30:22\u20137.","journal-title":"Pak J Med Sci"},{"issue":"7","key":"1724_CR12","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1136\/annrheumdis-2013-204835","volume":"74","author":"A Cortes","year":"2015","unstructured":"Cortes A, Maksymowych WP, Wordsworth BP, Inman RD, Danoy P, Rahman P, et al. Association study of genes related to bone formation and resorption and the extent of radiographic change in Ankylosing Spondylitis. Ann Rheum Dis. 2015;74(7):1387\u201393.","journal-title":"Ann Rheum Dis"},{"key":"1724_CR13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11926-017-0654-8","volume":"19","author":"N Akko\u00e7","year":"2017","unstructured":"Akko\u00e7 N, Yarkan H, Kenar G, Khan M. Ankylosing Spondylitis: HLA-B*27-positive versus HLA-B*27-negative disease. Curr Rheumatol Rep. 2017;19:26.","journal-title":"Curr Rheumatol Rep"},{"key":"1724_CR14","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1093\/rheumatology\/kem084","volume":"46","author":"E Collantes","year":"2007","unstructured":"Collantes E, Zarco P, Mu\u00f1oz E, Juanola X, Mulero J, Fern\u00e1ndez-Sueiro JL, et al. Disease pattern of spondyloarthropathies in Spain: description of the first registry (REGISPONSER). Rheumatology. 2007;46:1309\u201315.","journal-title":"Rheumatology"},{"issue":"1","key":"1724_CR15","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1136\/annrheumdis-2013-203582","volume":"74","author":"C Stolwijk","year":"2015","unstructured":"Stolwijk C, van Tubergen A, Castillo-Ortiz JD, Boonen A. Prevalence of extra-articular manifestations in patients with Ankylosing Spondylitis: a systematic review and meta-analysis. Ann Rheum Dis. 2015;74(1):65\u201373.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1724_CR16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1136\/annrheumdis-2013-204055","volume":"74","author":"Sofia Ramiro","year":"2013","unstructured":"Ramiro S, Stolwijk C, van Tubergen A, van der Heijde D, Dougados M, van den Bosch F, et al. Evolution of radiographic damage in Ankylosing Spondylitis: a 12 year prospective follow-up of the OASIS study. Ann Rheum Dis. 2015;74(1):52-9.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1724_CR17","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13075-016-1093-z","volume":"18","author":"J Winter","year":"2016","unstructured":"Winter J, Mens L, Heijde D, Landew\u00e9 R, Baeten D. Prevalence of peripheral and extra-articular disease in Ankylosing Spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis. Arthritis Res Ther. 2016;18:196.","journal-title":"Arthritis Res Ther"},{"key":"1724_CR18","first-page":"1","volume":"12","author":"EM D'Ambrosio","year":"2016","unstructured":"D'Ambrosio EM, La Cava M, Tortorella P, Gharbiya M, Campanella M, Iannetti L. Clinical features and complications of the HLA-B27-associated acute anterior uveitis: a meta-analysis. Semin Ophthalmol. 2016;12:1\u201313.","journal-title":"Semin Ophthalmol"},{"key":"1724_CR19","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.reuma.2015.11.008","volume":"12","author":"E Valls Pascual","year":"2016","unstructured":"Valls Pascual E, Fontanilla Ortega P, Vicens Bernabeu E, Mart\u00ednez-Costa L, Blanco Alonso R. Caracter\u00edsticas cl\u00ednicas, tratamiento y complicaciones oculares de uve\u00edtis anterior asociada y no asociada a HLA-B27. Reumatol Clin. 2016;12:244\u20137.","journal-title":"Reumatol Clin"},{"key":"1724_CR20","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1136\/ard.2004.020503","volume":"64","author":"MC Creemers","year":"2005","unstructured":"Creemers MC, Franssen MJ, van't Hof MA, Gribnau FW, van de Putte LB, van Riel PL. Assessment of outcome in Ankylosing Spondylitis: an extended radiographic scoring system. Ann Rheum Dis. 2005;64:127\u20139.","journal-title":"Ann Rheum Dis"}],"updated-by":[{"DOI":"10.1186\/s13075-020-02237-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000}}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1724-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-018-1724-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1724-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T06:02:34Z","timestamp":1591855354000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-018-1724-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1724"],"URL":"https:\/\/doi.org\/10.1186\/s13075-018-1724-7","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s13075-020-02237-5","asserted-by":"object"}]},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,3]]},"assertion":[{"value":"3 October 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2020","order":2,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":3,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An amendment to this paper has been published and can be accessed via the original article.","order":4,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All patients included signed an informed consent to participate in REGISPONSER and the project was approved by the ethical committee of all participant hospitals.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"221"}}