{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:28:19Z","timestamp":1777411699802,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15657398"],"award-info":[{"award-number":["15657398"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13075-018-1738-1","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T11:51:31Z","timestamp":1542714691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan"],"prefix":"10.1186","volume":"20","author":[{"given":"Yushiro","family":"Endo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-4428","authenticated-orcid":false,"given":"Tomohiro","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sosuke","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayuko","family":"Takatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimasa","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remi","family":"Sumiyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Igawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ya","family":"Kawashiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Origuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunaga","family":"Agematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yachie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Masumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Migita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"issue":"4","key":"1738_CR1","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","volume":"90","author":"The International FMF Consortium","year":"1997","unstructured":"Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium. Cell 1997, 90(4):797\u2013807.","journal-title":"Cell"},{"issue":"1","key":"1738_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ng0997-25","volume":"17","author":"French FMF Consortium","year":"1997","unstructured":"French FMF Consortium. A candidate gene for familial Mediterranean fever. Nat Genet. 1997;17(1):25\u201331.","journal-title":"Nat Genet"},{"issue":"4","key":"1738_CR3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/00005792-199807000-00005","volume":"77","author":"J Samuels","year":"1998","unstructured":"Samuels J, Aksentijevich I, Torosyan Y, Centola M, Deng Z, Sood R, Kastner DL. Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health. Medicine (Baltimore). 1998;77(4):268\u201397.","journal-title":"Medicine (Baltimore)"},{"issue":"9515","key":"1738_CR4","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/S0140-6736(06)68430-4","volume":"367","author":"H El-Shanti","year":"2006","unstructured":"El-Shanti H, Majeed HA, El-Khateeb M. Familial mediterranean fever in Arabs. Lancet. 2006;367(9515):1016\u201324.","journal-title":"Lancet"},{"issue":"2","key":"1738_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0002-9343(67)90167-2","volume":"43","author":"E Sohar","year":"1967","unstructured":"Sohar E, Gafni J, Pras M, Heller H. Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med. 1967;43(2):227\u201353.","journal-title":"Am J Med"},{"issue":"2","key":"1738_CR6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1053\/sarh.2000.16646","volume":"30","author":"HA Majeed","year":"2000","unstructured":"Majeed HA, Al-Qudah AK, Qubain H, Shahin HM. The clinical patterns of myalgia in children with familial Mediterranean fever. Semin Arthritis Rheum. 2000;30(2):138\u201343.","journal-title":"Semin Arthritis Rheum"},{"issue":"10","key":"1738_CR7","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1002\/art.1780401023","volume":"40","author":"A Livneh","year":"1997","unstructured":"Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, Migdal A, Padeh S, Pras M. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997;40(10):1879\u201385.","journal-title":"Arthritis Rheum"},{"issue":"6","key":"1738_CR8","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1002\/art.24570","volume":"60","author":"D Marek-Yagel","year":"2009","unstructured":"Marek-Yagel D, Berkun Y, Padeh S, Abu A, Reznik-Wolf H, Livneh A, Pras M, Pras E. Clinical disease among patients heterozygous for familial Mediterranean fever. Arthritis Rheum. 2009;60(6):1862\u20136.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"1738_CR9","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1097\/MD.0000000000000029","volume":"93","author":"K Migita","year":"2014","unstructured":"Migita K, Agematsu K, Yazaki M, Nonaka F, Nakamura A, Toma T, Kishida D, Uehara R, Nakamura Y, Jiuchi Y, et al. Familial Mediterranean fever: genotype-phenotype correlations in Japanese patients. Medicine (Baltimore). 2014;93(3):158\u201364.","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"1738_CR10","first-page":"403","volume":"108","author":"E Ben-Chetrit","year":"2001","unstructured":"Ben-Chetrit E, Ben-Chetrit A. Familial Mediterranean fever and menstruation. BJOG. 2001;108(4):403\u20137.","journal-title":"BJOG"},{"issue":"4\u20135","key":"1738_CR11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.autrev.2014.01.045","volume":"13","author":"Y Berkun","year":"2014","unstructured":"Berkun Y, Eisenstein EM. Diagnostic criteria of familial Mediterranean fever. Autoimmun Rev. 2014;13(4\u20135):388\u201390.","journal-title":"Autoimmun Rev"},{"issue":"10","key":"1738_CR12","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/art.24458","volume":"61","author":"E Ben-Chetrit","year":"2009","unstructured":"Ben-Chetrit E, Touitou I. Familial mediterranean Fever in the world. Arthritis Rheum. 2009;61(10):1447\u201353.","journal-title":"Arthritis Rheum"},{"issue":"6","key":"1738_CR13","first-page":"1324","volume":"29","author":"K Shinozaki","year":"2002","unstructured":"Shinozaki K, Agematsu K, Yasui K, Nagumo H, Naitoh H, Naganuma K, Komiyama A. Familial Mediterranean fever in 2 Japanese families. J Rheumatol. 2002;29(6):1324\u20135.","journal-title":"J Rheumatol"},{"issue":"1","key":"1738_CR14","first-page":"13","volume":"26","author":"N Tomiyama","year":"2008","unstructured":"Tomiyama N, Higashiuesato Y, Oda T, Baba E, Harada M, Azuma M, Yamashita T, Uehara K, Miyazato A, Hatta K, et al. MEFV mutation analysis of familial Mediterranean fever in Japan. Clin Exp Rheumatol. 2008;26(1):13\u20137.","journal-title":"Clin Exp Rheumatol"},{"issue":"8","key":"1738_CR15","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.3899\/jrheum.081278","volume":"36","author":"A Tsuchiya-Suzuki","year":"2009","unstructured":"Tsuchiya-Suzuki A, Yazaki M, Nakamura A, Yamazaki K, Agematsu K, Matsuda M, Ikeda S. Clinical and genetic features of familial Mediterranean fever in Japan. J Rheumatol. 2009;36(8):1671\u20136.","journal-title":"J Rheumatol"},{"key":"1738_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13075-016-1071-5","volume":"18","author":"K Migita","year":"2016","unstructured":"Migita K, Izumi Y, Jiuchi Y, Iwanaga N, Kawahara C, Agematsu K, Yachie A, Masumoto J, Fujikawa K, Yamasaki S, et al. Familial Mediterranean fever is no longer a rare disease in Japan. Arthritis Res Ther. 2016;18:175.","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"1738_CR17","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1186\/s13075-014-0439-7","volume":"16","author":"D Kishida","year":"2014","unstructured":"Kishida D, Nakamura A, Yazaki M, Tsuchiya-Suzuki A, Matsuda M, Ikeda S. Genotype-phenotype correlation in Japanese patients with familial Mediterranean fever: differences in genotype and clinical features between Japanese and Mediterranean populations. Arthritis Res Ther. 2014;16(5):439.","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"1738_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/MD.0b013e318277cf75","volume":"91","author":"K Migita","year":"2012","unstructured":"Migita K, Uehara R, Nakamura Y, Yasunami M, Tsuchiya-Suzuki A, Yazaki M, Nakamura A, Masumoto J, Yachie A, Furukawa H, et al. Familial Mediterranean fever in Japan. Medicine (Baltimore). 2012;91(6):337\u201343.","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"1738_CR19","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3899\/jrheum.110700","volume":"39","author":"K Migita","year":"2012","unstructured":"Migita K, Ida H, Moriuchi H, Agematsu K. Clinical relevance of MEFV gene mutations in Japanese patients with unexplained fever. J Rheumatol. 2012;39(4):875\u20137.","journal-title":"J Rheumatol"},{"issue":"2","key":"1738_CR20","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1742-1241.2004.00294.x","volume":"59","author":"M Sayarlioglu","year":"2005","unstructured":"Sayarlioglu M, Cefle A, Inanc M, Kamali S, Dalkilic E, Gul A, Ocal L, Aral O, Konice M. Characteristics of patients with adult-onset familial Mediterranean fever in Turkey: analysis of 401 cases. Int J Clin Pract. 2005;59(2):202\u20135.","journal-title":"Int J Clin Pract"},{"issue":"1","key":"1738_CR21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/(SICI)1096-8628(19991105)87:1<30::AID-AJMG6>3.0.CO;2-B","volume":"87","author":"N Tamir","year":"1999","unstructured":"Tamir N, Langevitz P, Zemer D, Pras E, Shinar Y, Padeh S, Zaks N, Pras M, Livneh A. Late-onset familial Mediterranean fever (FMF): a subset with distinct clinical, demographic, and molecular genetic characteristics. Am J Med Genet. 1999;87(1):30\u20135.","journal-title":"Am J Med Genet"},{"issue":"1","key":"1738_CR22","first-page":"50","volume":"3","author":"H Nobakht","year":"2011","unstructured":"Nobakht H, Zamani F, Ajdarkosh H, Mohamadzadeh Z, Fereshtehnejad S, Nassaji M. Adult-onset familial Mediterranean fever in northwestern Iran; clinical feature and treatment outcome. Middle East J Dig Dis. 2011;3(1):50\u20135.","journal-title":"Middle East J Dig Dis"},{"issue":"3","key":"1738_CR23","first-page":"347","volume":"12","author":"M Rozenbaum","year":"1994","unstructured":"Rozenbaum M, Rosner I. The clinical features of Familial Mediterranean Fever of elderly onset. Clin Exp Rheumatol. 1994;12(3):347\u20138.","journal-title":"Clin Exp Rheumatol"},{"issue":"11","key":"1738_CR24","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1093\/rheumatology\/kep296","volume":"48","author":"E Ben-Chetrit","year":"2009","unstructured":"Ben-Chetrit E, Peleg H, Aamar S, Heyman SN. The spectrum of MEFV clinical presentations\u2014is it familial Mediterranean fever only? Rheumatology (Oxford). 2009;48(11):1455\u20139.","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"1738_CR25","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1136\/ard.2009.113415","volume":"69","author":"JG Ryan","year":"2010","unstructured":"Ryan JG, Masters SL, Booty MG, Habal N, Alexander JD, Barham BK, Remmers EF, Barron KS, Kastner DL, Aksentijevich I. Clinical features and functional significance of the P369S\/R408Q variant in pyrin, the familial Mediterranean fever protein. Ann Rheum Dis. 2010;69(7):1383\u20138.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1738_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.autrev.2012.07.019","volume":"12","author":"A Soriano","year":"2012","unstructured":"Soriano A, Manna R. Familial Mediterranean fever: new phenotypes. Autoimmun Rev. 2012;12(1):31\u20137.","journal-title":"Autoimmun Rev"},{"issue":"1","key":"1738_CR27","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.autrev.2012.07.025","volume":"12","author":"M Lidar","year":"2012","unstructured":"Lidar M, Yonath H, Shechter N, Sikron F, Sadetzki S, Langevitz P, Livneh A, Pras E. Incomplete response to colchicine in M694V homozygote FMF patients. Autoimmun Rev. 2012;12(1):72\u20136.","journal-title":"Autoimmun Rev"},{"issue":"7","key":"1738_CR28","first-page":"1703","volume":"27","author":"Y Shinar","year":"2000","unstructured":"Shinar Y, Livneh A, Langevitz P, Zaks N, Aksentijevich I, Koziol DE, Kastner DL, Pras M, Pras E. Genotype-phenotype assessment of common genotypes among patients with familial Mediterranean fever. J Rheumatol. 2000;27(7):1703\u20137.","journal-title":"J Rheumatol"},{"key":"1738_CR29","first-page":"1","volume":"35","author":"A Gedalia","year":"1992","unstructured":"Gedalia A, Adar A, Gorodischer R. Familial Mediterranean fever in children. J Rheumatol Suppl. 1992;35:1\u20139.","journal-title":"J Rheumatol Suppl"},{"issue":"8","key":"1738_CR30","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/j.1651-2227.1993.tb18045.x","volume":"82","author":"U Saatci","year":"1993","unstructured":"Saatci U, Bakkaloglu A, Ozen S, Besbas N. Familial Mediterranean fever and amyloidosis in children. Acta Paediatr. 1993;82(8):705\u20136.","journal-title":"Acta Paediatr"},{"issue":"6","key":"1738_CR31","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/00005792-197411000-00005","volume":"53","author":"AD Schwabe","year":"1974","unstructured":"Schwabe AD, Peters RS. Familial Mediterranean Fever in Armenians. Analysis of 100 cases. Medicine (Baltimore). 1974;53(6):453\u201362.","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"1738_CR32","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1002\/art.1780340806","volume":"34","author":"D Zemer","year":"1991","unstructured":"Zemer D, Livneh A, Danon YL, Pras M, Sohar E. Long-term colchicine treatment in children with familial Mediterranean fever. Arthritis Rheum. 1991;34(8):973\u20137.","journal-title":"Arthritis Rheum"},{"key":"1738_CR33","doi-asserted-by":"publisher","unstructured":"Kriegshauser G, Enko D, Hayrapetyan H, Atoyan S, Oberkanins C, 687 Sarkisian T. Clinical and genetic heterogeneity in a large cohort of 688 Armenian patients with late-onset familial Mediterranean fever. Genet 689 Med. Mar 15. \n                    https:\/\/doi.org\/10.1038\/gim.2018.46\n                    \n                  .","DOI":"10.1038\/gim.2018.46"},{"issue":"1","key":"1738_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.md.0000152370.84628.0c","volume":"84","author":"M Tunca","year":"2005","unstructured":"Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, Tutar E, Ozen S, Topaloglu R, Yilmaz E, et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore). 2005;84(1):1\u201311.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"1738_CR35","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3899\/jrheum.090273","volume":"37","author":"O Soylemezoglu","year":"2010","unstructured":"Soylemezoglu O, Arga M, Fidan K, Gonen S, Emeksiz HC, Hasanoglu E, Buyan N. Unresponsiveness to colchicine therapy in patients with familial Mediterranean fever homozygous for the M694V mutation. J Rheumatol. 2010;37(1):182\u20139.","journal-title":"J Rheumatol"},{"issue":"4","key":"1738_CR36","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1136\/annrheumdis-2014-206844","volume":"74","author":"G Giancane","year":"2015","unstructured":"Giancane G, Ter Haar NM, Wulffraat N, Vastert SJ, Barron K, Hentgen V, Kallinich T, Ozdogan H, Anton J, Brogan P, et al. Evidence-based recommendations for genetic diagnosis of familial Mediterranean fever. Ann Rheum Dis. 2015;74(4):635\u201341.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"1738_CR37","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s00296-012-2609-8","volume":"33","author":"Fulya Cosan","year":"2012","unstructured":"Cosan F, Emrence Z, Erbag G, Azakli H, Yilmazer B, Yazici A, Ekmekci SS, Abaci N, Ustek D, Cefle A: The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still's disease. Rheumatol Int 2013, 33(7):1675\u20131680.","journal-title":"Rheumatology International"},{"issue":"7","key":"1738_CR38","doi-asserted-by":"publisher","first-page":"e0132704","DOI":"10.1371\/journal.pone.0132704","volume":"10","author":"Ziyan Wu","year":"2015","unstructured":"Wu Z, Zhang S, Li J, Chen S, Li P, Sun F, Wen X, Zheng W, Zhang F, Li Y: Association between MEFV Mutations M694V and M680I and Behcet's Disease: A Meta-Analysis. PLoS One. 2015;10(7):e0132704.","journal-title":"PLOS ONE"},{"issue":"7","key":"1738_CR39","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1136\/ard.2004.029447","volume":"64","author":"E Rabinovich","year":"2005","unstructured":"Rabinovich E, Livneh A, Langevitz P, Brezniak N, Shinar E, Pras M, Shinar Y: Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. Ann Rheum Dis 2005;64(7):1009\u20131014.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"7","key":"1738_CR40","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1177\/0961203314560203","volume":"24","author":"R Deniz","year":"2014","unstructured":"Deniz R, Ozen G, Yilmaz-Oner S, Alibaz-Oner F, Erzik C, Aydin SZ, Inanc N, Eren F, Bayalan F, Direskeneli H et al: Familial Mediterranean fever gene (MEFV) mutations and disease severity in systemic lupus erythematosus (SLE): implications for the role of the E148Q MEFV allele in inflammation. Lupus 2015;24(7):705\u2013711.","journal-title":"Lupus"},{"issue":"6","key":"1738_CR41","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1136\/annrheumdis-2015-208671","volume":"75","author":"Erkan Demirkaya","year":"2016","unstructured":"Demirkaya E, Acikel C, Hashkes P, Gattorno M, Gul A, Ozdogan H, Turker T, Karadag O, Livneh A, Ben-Chetrit E et al: Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF). Ann Rheum Dis 2016, 75(6):1051\u20131056.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1738_CR42","unstructured":"Ben-Chetrit E, Ozdogan H: Non-response to colchicine in FMF--definition, causes and suggested solutions. Clin Exp Rheumatol. 2008;26(4 Suppl 50):S49\u201351."}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1738-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-018-1738-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1738-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T13:59:11Z","timestamp":1589551151000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-018-1738-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1738"],"URL":"https:\/\/doi.org\/10.1186\/s13075-018-1738-1","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]},"assertion":[{"value":"14 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the medical ethics committee of Nagasaki University. All patients gave signed informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consented to publication of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"257"}}