{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:14:53Z","timestamp":1784560493547,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Partly funded by the Dutch Arthritis Association","award":["8-1-306"],"award-info":[{"award-number":["8-1-306"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13075-018-1767-9","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T12:22:25Z","timestamp":1545222145000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The value of joint ultrasonography in predicting arthritis in seropositive patients with arthralgia: a prospective cohort study"],"prefix":"10.1186","volume":"20","author":[{"given":"Marian H.","family":"van Beers-Tas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies B.","family":"Blanken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M. J.","family":"Nielen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franktien","family":"Turkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conny J.","family":"van der Laken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Meursinge Reynders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirkjan","family":"van Schaardenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"issue":"2","key":"1767_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/art.20018","volume":"50","author":"MM Nielen","year":"2004","unstructured":"Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, Habibuw MR, Vandenbroucke JP, Dijkmans BA. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50(2):380\u20136.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"1767_CR2","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1136\/ard.2008.105759","volume":"69","author":"WH Bos","year":"2010","unstructured":"Bos WH, Wolbink GJ, Boers M, Tijhuis GJ, de Vries N, van der Horst-Bruinsma IE, Tak PP, van de Stadt RJ, van der Laken CJ, Dijkmans BA, et al. Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study. Ann Rheum Dis. 2010;69(3):490\u20134.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"1767_CR3","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1002\/art.11223","volume":"48","author":"S Rantapaa-Dahlqvist","year":"2003","unstructured":"Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, Sundin U, van Venrooij WJ. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48(10):2741\u20139.","journal-title":"Arthritis Rheum"},{"issue":"12","key":"1767_CR4","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1136\/annrheumdis-2012-202127","volume":"72","author":"LA van de Stadt","year":"2013","unstructured":"van de Stadt LA, Witte BI, Bos WH, van Schaardenburg D. A prediction rule for the development of arthritis in seropositive arthralgia patients. Ann Rheum Dis. 2013;72(12):1920\u20136.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"1767_CR5","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1093\/rheumatology\/keh199","volume":"43","author":"VP Nell","year":"2004","unstructured":"Nell VP, Machold KP, Eberl G, Stamm TA, Uffmann M, Smolen JS. Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology (Oxford). 2004;43(7):906\u201314.","journal-title":"Rheumatology (Oxford)"},{"issue":"10","key":"1767_CR6","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1136\/annrheumdis-2012-202254","volume":"72","author":"MJ de Hair","year":"2013","unstructured":"de Hair MJ, Landewe RB, van de Sande MG, van Schaardenburg D, van Baarsen LG, Gerlag DM, Tak PP. Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann Rheum Dis. 2013;72(10):1654\u20138.","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"1767_CR7","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1136\/annrheumdis-2013-205009","volume":"74","author":"JA Sparks","year":"2015","unstructured":"Sparks JA, Chen CY, Jiang X, Askling J, Hiraki LT, Malspeis S, Klareskog L, Alfredsson L, Costenbader KH, Karlson EW. Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history. Ann Rheum Dis. 2015;74(8):1522\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1767_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/annrheumdis-2012-202481","volume":"73","author":"M Lahiri","year":"2014","unstructured":"Lahiri M, Luben RN, Morgan C, Bunn DK, Marshall T, Lunt M, Verstappen SM, Symmons DP, Khaw KT, Wareham N, et al. Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register--the EPIC-2-NOAR Study). Ann Rheum Dis. 2014;73(1):219\u201326.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"1767_CR9","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1136\/annrheumdis-2014-205227","volume":"74","author":"C Rakieh","year":"2015","unstructured":"Rakieh C, Nam JL, Hunt L, Hensor EM, Das S, Bissell LA, Villeneuve E, McGonagle D, Hodgson R, Grainger A, et al. Predicting the development of clinical arthritis in anti-CCP positive individuals with non-specific musculoskeletal symptoms: a prospective observational cohort study. Ann Rheum Dis. 2015;74(9):1659\u201366.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"1767_CR10","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1136\/ard.2010.131573","volume":"70","author":"A Filer","year":"2011","unstructured":"Filer A, de Pablo P, Allen G, Nightingale P, Jordan A, Jobanputra P, Bowman S, Buckley CD, Raza K. Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis. Ann Rheum Dis. 2011;70(3):500\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"1767_CR11","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00296-016-3587-z","volume":"37","author":"PR Lage-Hansen","year":"2017","unstructured":"Lage-Hansen PR, Lindegaard H, Chrysidis S, Terslev L. The role of ultrasound in diagnosing rheumatoid arthritis, what do we know? An updated review. Rheumatol Int. 2017;37(2):179\u201387.","journal-title":"Rheumatol Int"},{"issue":"12","key":"1767_CR12","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1093\/rheumatology\/keu211","volume":"53","author":"P Mandl","year":"2014","unstructured":"Mandl P, Kurucz R, Niedermayer D, Balint PV, Smolen JS. Contributions of ultrasound beyond clinical data in assessing inflammatory disease activity in rheumatoid arthritis: current insights and future prospects. Rheumatology (Oxford). 2014;53(12):2136\u201342.","journal-title":"Rheumatology (Oxford)"},{"issue":"9","key":"1767_CR13","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s10067-013-2291-6","volume":"32","author":"RM Chakr","year":"2013","unstructured":"Chakr RM, Mendonca JA, Brenol CV, Xavier RM, Brenol JC. Assessing rheumatoid arthritis disease activity with ultrasound. Clin Rheumatol. 2013;32(9):1249\u201354.","journal-title":"Clin Rheumatol"},{"issue":"6","key":"1767_CR14","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1136\/annrheumdis-2012-203158","volume":"72","author":"AN Colebatch","year":"2013","unstructured":"Colebatch AN, Edwards CJ, Ostergaard M, van der Heijde D, Balint PV, D'Agostino MA, Forslind K, Grassi W, Haavardsholm EA, Haugeberg G, et al. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis. 2013;72(6):804\u201314.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1767_CR15","doi-asserted-by":"publisher","first-page":"e000394","DOI":"10.1136\/rmdopen-2016-000394","volume":"3","author":"SC Horton","year":"2017","unstructured":"Horton SC, Tan AL, Wakefield RJ, Freeston JE, Buch MH, Emery P. Ultrasound-detectable grey scale synovitis predicts future fulfilment of the 2010 ACR\/EULAR RA classification criteria in patients with new-onset undifferentiated arthritis. RMD Open. 2017;3(1):e000394.","journal-title":"RMD Open"},{"issue":"3","key":"1767_CR16","doi-asserted-by":"publisher","first-page":"R98","DOI":"10.1186\/ar3028","volume":"12","author":"LA van de Stadt","year":"2010","unstructured":"van de Stadt LA, Bos WH, Meursinge Reynders M, Wieringa H, Turkstra F, van der Laken CJ, van Schaardenburg D. The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study. Arthritis Res Ther. 2010;12(3):R98.","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"1767_CR17","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1136\/ard.2008.106658","volume":"69","author":"JE Freeston","year":"2010","unstructured":"Freeston JE, Wakefield RJ, Conaghan PG, Hensor EM, Stewart SP, Emery P. A diagnostic algorithm for persistence of very early inflammatory arthritis: the utility of power Doppler ultrasound when added to conventional assessment tools. Ann Rheum Dis. 2010;69(2):417\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"1767_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jbspin.2016.05.011","volume":"84","author":"P Zufferey","year":"2017","unstructured":"Zufferey P, Rebell C, Benaim C, Ziswiler HR, Dumusc A, So A. Ultrasound can be useful to predict an evolution towards rheumatoid arthritis in patients with inflammatory polyarthralgia without anticitrullinated antibodies. Joint Bone Spine. 2017;84(3):299\u2013303.","journal-title":"Joint Bone Spine"},{"issue":"12","key":"1767_CR19","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1136\/annrheumdis-2015-208235","volume":"75","author":"JL Nam","year":"2016","unstructured":"Nam JL, Hensor EM, Hunt L, Conaghan PG, Wakefield RJ, Emery P. Ultrasound findings predict progression to inflammatory arthritis in anti-CCP antibody-positive patients without clinical synovitis. Ann Rheum Dis. 2016;75(12):2060\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1767_CR20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.berh.2017.09.002","volume":"31","author":"JL Nam","year":"2017","unstructured":"Nam JL, D'Agostino MA. Role of ultrasound imaging in individuals at risk of RA. Best Pract Res Clin Rheumatol. 2017;31(1):71\u20139.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"9","key":"1767_CR21","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.3899\/jrheum.110424","volume":"38","author":"P Mandl","year":"2011","unstructured":"Mandl P, Naredo E, Wakefield RJ, Conaghan PG, D'Agostino MA, Force OUT. A systematic literature review analysis of ultrasound joint count and scoring systems to assess synovitis in rheumatoid arthritis according to the OMERACT filter. J Rheumatol. 2011;38(9):2055\u201362.","journal-title":"J Rheumatol"},{"issue":"4","key":"1767_CR22","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/art.10877","volume":"48","author":"M Szkudlarek","year":"2003","unstructured":"Szkudlarek M, Court-Payen M, Jacobsen S, Klarlund M, Thomsen HS, Ostergaard M. Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis. Arthritis Rheum. 2003;48(4):955\u201362.","journal-title":"Arthritis Rheum"},{"issue":"10","key":"1767_CR23","first-page":"S352","volume":"64","author":"MA D'Agostino","year":"2012","unstructured":"D'Agostino MA, Wakefield R, Hammer HB, Vittecoq O, Galeazzi M, Balint P, Filippucci E, Moller I, Iagnocco A, Naredo E, et al. Assessment of Omeract global power Doppler ultrasonography 44-joint scoring system and reduced joint scoring systems in rheumatoid arthritis patients treated with abatacept plus background methotrexate. Arthritis Rheum-Us. 2012;64(10):S352\u20133.","journal-title":"Arthritis Rheum-Us"},{"issue":"4","key":"1767_CR24","first-page":"848","volume":"34","author":"RJ Wakefield","year":"2007","unstructured":"Wakefield RJ, D'Agostino MA, Iagnocco A, Filippucci E, Backhaus M, Scheel AK, Joshua F, Naredo E, Schmidt WA, Grassi W, et al. The OMERACT ultrasound group: status of current activities and research directions. J Rheumatol. 2007;34(4):848\u201351.","journal-title":"J Rheumatol"},{"issue":"4","key":"1767_CR25","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/art.23529","volume":"59","author":"E Naredo","year":"2008","unstructured":"Naredo E, Rodriguez M, Campos C, Rodriguez-Heredia JM, Medina JA, Giner E, Martinez O, Toyos FJ, Ruiz T, Ros I, et al. Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis. Arthritis Rheum. 2008;59(4):515\u201322.","journal-title":"Arthritis Rheum"},{"key":"1767_CR26","unstructured":"Nederlandse Vereniging voor Reumatologie (NVR): Richtlijn Diagnostiek van Reumato\u00efde Artritis. Wat is de waarde van echografie voor de diagnose Reumato\u00efde Artritis. 2016;38\u201347. \n                    https:\/\/www.nvr.nl\/wp-content\/uploads\/2018\/09\/Richtlijndiagnostiekreumatoafdeartritis_FINAL-def.pdf\n                    \n                  . Accessed 25 Dec 2018."},{"issue":"3","key":"1767_CR27","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/art.20939","volume":"52","author":"AK Scheel","year":"2005","unstructured":"Scheel AK, Hermann KG, Kahler E, Pasewaldt D, Fritz J, Hamm B, Brunner E, Muller GA, Burmester GR, Backhaus M. A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis. Arthritis Rheum. 2005;52(3):733\u201343.","journal-title":"Arthritis Rheum"},{"key":"1767_CR28","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139342834","volume-title":"Applied longitudinal data analysis for epidemiology: a practical guide","author":"JWR Twisk","year":"2013","unstructured":"Twisk JWR. Applied longitudinal data analysis for epidemiology: a practical guide. Cambridge: Cambridge University Press; 2013."},{"key":"1767_CR29","doi-asserted-by":"publisher","first-page":"629","DOI":"10.12659\/PJR.899317","volume":"81","author":"S Vyas","year":"2016","unstructured":"Vyas S, Bhalla AS, Ranjan P, Kumar S, Kumar U, Gupta AK. Rheumatoid arthritis revisited - advanced imaging review. Pol J Radiol. 2016;81:629\u201335.","journal-title":"Pol J Radiol"},{"issue":"3","key":"1767_CR30","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3109\/14397595.2013.843763","volume":"24","author":"K Ikeda","year":"2014","unstructured":"Ikeda K, Seto Y, Ohno S, Sakamoto F, Henmi M, Fukae J, Narita A, Nakagomi D, Nakajima H, Tanimura K, et al. Analysis of the factors which influence the measurement of synovial power Doppler signals with semi-quantitative and quantitative measures - a pilot multicenter exercise in Japan. Mod Rheumatol. 2014;24(3):419\u201325.","journal-title":"Mod Rheumatol"},{"issue":"1","key":"1767_CR31","doi-asserted-by":"publisher","first-page":"e000428","DOI":"10.1136\/rmdopen-2016-000428","volume":"3","author":"MA D'Agostino","year":"2017","unstructured":"D'Agostino MA, Terslev L, Aegerter P, Backhaus M, Balint P, Bruyn GA, Filippucci E, Grassi W, Iagnocco A, Jousse-Joulin S, et al. Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 1: definition and development of a standardised, consensus-based scoring system. RMD open. 2017;3(1):e000428.","journal-title":"RMD open"},{"issue":"1","key":"1767_CR32","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s13075-017-1405-y","volume":"19","author":"M van der Ven","year":"2017","unstructured":"van der Ven M, van der Veer-Meerkerk M, Ten Cate DF, Rasappu N, Kok MR, Csakvari D, JMW H, Gerards AH, Luime JJ. Absence of ultrasound inflammation in patients presenting with arthralgia rules out the development of arthritis. Arthritis Res Ther. 2017;19(1):202.","journal-title":"Arthritis Res Ther"},{"key":"1767_CR33","doi-asserted-by":"publisher","unstructured":"Sahbudin I, Pickup L, Nightingale P, Allen G, Cader Z, Singh R, de Pablo P, Buckley CD, Raza K, Filer A. The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development. Rheumatology (Oxford). 2018. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/key025\n                    \n                  . [Epub ahead of print].","DOI":"10.1093\/rheumatology\/key025"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1767-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-018-1767-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-018-1767-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:09:36Z","timestamp":1576714176000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-018-1767-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1767"],"URL":"https:\/\/doi.org\/10.1186\/s13075-018-1767-9","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"20 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Slotervaart ethics committee. Signed informed consent was obtained from all patients prior to inclusion.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors gave their consent for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"279"}}