{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:39:08Z","timestamp":1781303948513,"version":"3.54.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Personalized Medicines\u2014\u2014Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDA12020107"],"award-info":[{"award-number":["XDA12020107"]}]},{"name":"Personalized Medicines\u2014\u2014Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDA12020215"],"award-info":[{"award-number":["XDA12020215"]}]},{"name":"The National Basic Research Program of China","award":["2014CB541906"],"award-info":[{"award-number":["2014CB541906"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402939"],"award-info":[{"award-number":["81402939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13075-019-1820-3","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T13:04:43Z","timestamp":1548767083000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal \u03b1-actinin-4 expression and stabilizing integrin-cytoskeleton linkage"],"prefix":"10.1186","volume":"21","author":[{"given":"Shijun","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"issue":"1","key":"1820_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1254\/jphs.FP0071337","volume":"106","author":"K Teramoto","year":"2008","unstructured":"Teramoto K, Negoro N, Kitamoto K, Iwai T, Iwao H, Okamura M, et al. Microarray analysis of glomerular gene expression in murine lupus nephritis. J Pharmacol Sci. 2008;106(1):56\u201367.","journal-title":"J Pharmacol Sci"},{"key":"1820_CR2","doi-asserted-by":"crossref","unstructured":"Devarapu S. Update on immune mechanisms in systemic lupus and lupus nephritis 2016. 116.","DOI":"10.35248\/2684-1630.16.1.116"},{"issue":"4","key":"1820_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/ki.2010.137","volume":"78","author":"YS Kang","year":"2010","unstructured":"Kang YS, Li Y, Dai C, Kiss LP, Wu C, Liu Y. Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria. Kidney Int. 2010;78(4):363\u201373.","journal-title":"Kidney Int"},{"issue":"1","key":"1820_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.mnh.0000199012.79670.0b","volume":"15","author":"RV Durvasula","year":"2006","unstructured":"Durvasula RV, Shankland SJ. Podocyte injury and targeting therapy: an update. Curr Opin Nephrol Hypertens. 2006;15(1):1\u20137.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"11","key":"1820_CR5","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1172\/JCI200114629","volume":"108","author":"D Kerjaschki","year":"2001","unstructured":"Kerjaschki D. Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Investig. 2001;108(11):1583\u20137.","journal-title":"J Clin Investig"},{"issue":"1 Pt 2","key":"1820_CR6","first-page":"F150","volume":"273","author":"WE Smoyer","year":"1997","unstructured":"Smoyer WE, Mundel P, Gupta A, Welsh MJ. Podocyte alpha-actinin induction precedes foot process effacement in experimental nephrotic syndrome. Am J Physiol. 1997;273(1 Pt 2):F150.","journal-title":"Am J Physiol"},{"issue":"5","key":"1820_CR7","first-page":"547","volume":"25","author":"B Alberts","year":"2002","unstructured":"Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. The cytoskeleton. In: molecular biology of the cell. Genetics. 2002;25(5):547\u201354.","journal-title":"Genetics"},{"issue":"4","key":"1820_CR8","first-page":"1283","volume":"148","author":"I Shirato","year":"1996","unstructured":"Shirato I, Sakai T, Kimura K, Tomino Y, Kriz W. Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis. Am J Pathol. 1996;148(4):1283\u201396.","journal-title":"Am J Pathol"},{"issue":"4","key":"1820_CR9","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/ndt\/gfg620","volume":"19","author":"NP Goode","year":"2004","unstructured":"Goode NP, Shires M, Khan TN, Mooney AF. Expression of \u03b1-actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study. Nephrol Dial Transplant. 2004;19(4):844\u201351.","journal-title":"Nephrol Dial Transplant"},{"issue":"41","key":"1820_CR10","doi-asserted-by":"publisher","first-page":"16080","DOI":"10.1073\/pnas.0702451104","volume":"104","author":"A Weins","year":"2007","unstructured":"Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, et al. Disease-associated mutant \u03b1-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007;104(41):16080\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1820_CR11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/73456","volume":"24","author":"JM Kaplan","year":"2000","unstructured":"Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, Tong HQ, et al. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet. 2000;24(3):251\u20136.","journal-title":"Nat Genet"},{"issue":"2","key":"1820_CR12","doi-asserted-by":"publisher","first-page":"F233","DOI":"10.1152\/ajprenal.2000.279.2.F233","volume":"279","author":"JA Kreidberg","year":"2000","unstructured":"Kreidberg JA, Symons JM. Integrins in kidney development, function, and disease. Am J Physiol Renal Physiol. 2000;279(2):F233.","journal-title":"Am J Physiol Renal Physiol"},{"issue":"13","key":"1820_CR13","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/jcs.114.13.2525","volume":"114","author":"JP Mulrooney","year":"2001","unstructured":"Mulrooney JP, Hong T, Grabel LB. Serine 785 phosphorylation of the beta1 cytoplasmic domain modulates beta1A-integrin-dependent functions. J Cell Sci. 2001;114(13):2525\u201333.","journal-title":"J Cell Sci"},{"issue":"2","key":"1820_CR14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/emboj.2009.376","volume":"29","author":"SA Wickstr\u00f6m","year":"2014","unstructured":"Wickstr\u00f6m SA, Lange A, Montanez E, F\u00e4ssler R. The ILK\/PINCH\/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J. 2014;29(2):281\u201391.","journal-title":"EMBO J"},{"issue":"10","key":"1820_CR15","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1096\/fj.00-0832fje","volume":"15","author":"M Kretzler","year":"2001","unstructured":"Kretzler M, Teixeira VPC, Unschuld PG, Cohen CD, Wanke R, Edenhofer I, et al. Integrin linked kinase as a candidate downstream effector in proteinuria. FASEB J. 2001;15(10):1843\u20135.","journal-title":"FASEB J"},{"issue":"4","key":"1820_CR16","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1096\/fasebj.10.4.8647346","volume":"10","author":"PK Chiang","year":"1996","unstructured":"Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, et al. S-Adenosylmethionine and methylation. FASEB J. 1996;10(4):471\u201380.","journal-title":"FASEB J"},{"issue":"2","key":"1820_CR17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.clim.2013.02.018","volume":"147","author":"V Tardif","year":"2013","unstructured":"Tardif V, Manenkova Y, Berger M, Hoebe K, Zuo JP, Yuan C, et al. Critical role of transmethylation in TLR signaling and systemic lupus erythematosus. Clin Immunol. 2013;147(2):133\u201343.","journal-title":"Clin Immunol"},{"issue":"2","key":"1820_CR18","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/aps.2013.167","volume":"35","author":"SJ He","year":"2014","unstructured":"He SJ, Lin ZM, Wu YW, Bai BX, Yang XQ, He PL, et al. Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZBxNZW F1 mice via interference with TLR-mediated APC response. Acta Pharmacol Sin. 2014;35(2):219\u201329.","journal-title":"Acta Pharmacol Sin"},{"key":"1820_CR19","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.phrs.2017.11.012","volume":"129","author":"ZM Lin","year":"2018","unstructured":"Lin ZM, Ma M, Li H, Qi Q, Liu YT, Yan YX, et al. Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-\u03b1\/IFN-\u03b3-induced inflammatory response in keratinocytes and T cell-derived IL-17. Pharmacol Res. 2018;129:443\u201352.","journal-title":"Pharmacol Res"},{"issue":"2","key":"1820_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/sj.tpj.6500164","volume":"3","author":"FA Witzmann","year":"2003","unstructured":"Witzmann FA, Grant RA. Pharmacoproteomics in drug development. Pharmacogenomics J. 2003;3(2):69\u201376.","journal-title":"Pharmacogenomics J"},{"key":"1820_CR21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/PGPM.S4708","volume":"2","author":"W Hueber","year":"2009","unstructured":"Hueber W, Robinson WH. Genomics and proteomics: applications in autoimmune diseases. Pharmacogenomics Personalized Med. 2009;2:39\u201348.","journal-title":"Pharmacogenomics Personalized Med"},{"key":"1820_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jim.2017.03.019","volume":"446","author":"S Pinna","year":"2017","unstructured":"Pinna S, Pasella S, Deiana M, Baralla A, Mannu A, Masala AGE, et al. Proteomic analysis of human plasma and peripheral blood mononuclear cells in systemic lupus erythematosus patients. J Immunol Methods. 2017;446:37\u201346.","journal-title":"J Immunol Methods"},{"issue":"4","key":"1820_CR23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/08916934.2017.1344975","volume":"50","author":"TAR Ferreira","year":"2017","unstructured":"Ferreira TAR, de Andrade HM, de Padua PM, Carvalho MDG, Pires SDF, Oliveira IHR, et al. Identification of potential biomarkers for systemic lupus erythematosus diagnosis using two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry. Autoimmunity. 2017;50(4):247\u201356.","journal-title":"Autoimmunity"},{"issue":"5","key":"1820_CR24","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/jcmm.13031","volume":"21","author":"O Nicolaou","year":"2017","unstructured":"Nicolaou O, Kousios A, Hadjisavvas A, Lauwerys B, Sokratous K, Kyriacou K. Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics: a systematic review. J Cell Mol Med. 2017;21(5):993\u20131012.","journal-title":"J Cell Mol Med"},{"issue":"2","key":"1820_CR25","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/cei.12930","volume":"188","author":"A Aggarwal","year":"2017","unstructured":"Aggarwal A, Gupta R, Negi VS, Rajasekhar L, Misra R, Singh P, et al. Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding protein identified by proteomics as potential biomarkers for lupus nephritis. Clin Exp Immunol. 2017;188(2):254\u201362.","journal-title":"Clin Exp Immunol"},{"key":"1820_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.mehy.2016.02.010","volume":"89","author":"AL Abrao","year":"2016","unstructured":"Abrao AL, Falcao DP, de Amorim RF, Bezerra AC, Pombeiro GA, Guimaraes LJ, et al. Salivary proteomics: a new adjuvant approach to the early diagnosis of familial juvenile systemic lupus erythematosus. Med Hypotheses. 2016;89:97\u2013100.","journal-title":"Med Hypotheses"},{"issue":"1","key":"1820_CR27","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/ndt\/gfu215","volume":"30","author":"A Alaiya","year":"2015","unstructured":"Alaiya A, Assad L, Alkhafaji D, Shinwari Z, Almana H, Shoukri M, et al. Proteomic analysis of class IV lupus nephritis. Nephrol Dial Transplant. 2015;30(1):62\u201370.","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"1820_CR28","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1002\/art.23428","volume":"58","author":"FR Bahjat","year":"2008","unstructured":"Bahjat FR, Pine PR, Reitsma A, Cassafer G, Baluom M, Grillo S, et al. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum. 2008;58(5):1433\u201344.","journal-title":"Arthritis Rheum"},{"issue":"8","key":"1820_CR29","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1002\/art.30392","volume":"63","author":"LF Hou","year":"2011","unstructured":"Hou LF, He SJ, Li X, Yang Y, He PL, Zhou Y, et al. Oral administration of artemisinin analog SM934 ameliorates lupus syndromes in MRL\/lpr mice by inhibiting Th1 and Th17 cell responses. Arthritis Rheum. 2011;63(8):2445\u201355.","journal-title":"Arthritis Rheum"},{"key":"1820_CR30","unstructured":"Monahan E, Yamazaki K. An Improved Urine Collection Technique for Laboratory Mice: The Bladder Massage Method. Lab Animal. 1993;22(6):38-39."},{"key":"1820_CR31","doi-asserted-by":"crossref","unstructured":"Wisniewski JR. Proteomic sample preparation from formalin fixed and paraffin embedded tissue. Journal of visualized experiments: JoVE. 2013;(79):50589.","DOI":"10.3791\/50589"},{"issue":"5","key":"1820_CR32","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nmeth.1322","volume":"6","author":"JR Wisniewski","year":"2009","unstructured":"Wisniewski JR, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome analysis. Nat Methods. 2009;6(5):359\u201362.","journal-title":"Nat Methods"},{"issue":"4","key":"1820_CR33","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.bbrc.2016.05.114","volume":"476","author":"X Liu","year":"2016","unstructured":"Liu X, Xu Y, Meng Q, Zheng Q, Wu J, Wang C, et al. Proteomic analysis of minute amount of colonic biopsies by enteroscopy sampling. Biochem Biophys Res Commun. 2016;476(4):286\u201392.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"1820_CR34","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1111\/adb.12435","volume":"22","author":"ZG Chen","year":"2017","unstructured":"Chen ZG, Liu X, Wang W, Geng F, Gao J, Gan CL, et al. Dissociative role for dorsal hippocampus in mediating heroin self-administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis. Addict Biol. 2017;22(6):1731\u201342.","journal-title":"Addict Biol"},{"issue":"12","key":"1820_CR35","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","volume":"26","author":"J Cox","year":"2008","unstructured":"Cox J, Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol. 2008;26(12):1367\u201372.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"1820_CR36","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1021\/pr101065j","volume":"10","author":"J Cox","year":"2011","unstructured":"Cox J, Neuhauser N, Michalski A, Scheltema RA, Olsen JV, Mann M. Andromeda: a peptide search engine integrated into the MaxQuant environment. J Proteome Res. 2011;10(4):1794\u2013805.","journal-title":"J Proteome Res"},{"issue":"9","key":"1820_CR37","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","volume":"13","author":"J Cox","year":"2014","unstructured":"Cox J, Hein MY, Luber CA, Paron I, Nagaraj N, Mann M. Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ. Mol Cell Proteomics. 2014;13(9):2513\u201326.","journal-title":"Mol Cell Proteomics"},{"issue":"D1","key":"1820_CR38","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","volume":"44","author":"JA Vizcaino","year":"2016","unstructured":"Vizcaino JA, Csordas A, del-Toro N, Dianes JA, Griss J, Lavidas I, et al. 2016 update of the PRIDE database and its related tools. Nucleic Acids Res. 2016;44(D1):D447\u201356.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"1820_CR39","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ceb.2012.06.003","volume":"24","author":"J Qin","year":"2012","unstructured":"Qin J, Wu C. ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling. Curr Opin Cell Biol. 2012;24(5):607\u201313.","journal-title":"Curr Opin Cell Biol"},{"issue":"7","key":"1820_CR40","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1681\/ASN.2004121112","volume":"16","author":"Y Yang","year":"2005","unstructured":"Yang Y, Guo L, Blattner SM, Mundel P, Kretzler M, Wu C. Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival. J Am Soc Nephrol. 2005;16(7):1966\u201376.","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"1820_CR41","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1681\/ASN.2006010033","volume":"17","author":"C Dai","year":"2006","unstructured":"Dai C, Stolz DB, Bastacky SI, St-Arnaud R, Wu C, Dedhar S, et al. Essential role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol. 2006;17(8):2164\u201375.","journal-title":"J Am Soc Nephrol"},{"key":"1820_CR42","volume-title":"Clinical features and treatment of systemic lupus erythematosus","author":"IO Tassiulas","year":"2008","unstructured":"Tassiulas IO, Boumpas DT. Clinical features and treatment of systemic lupus erythematosus; 2008."},{"issue":"16","key":"1820_CR43","doi-asserted-by":"publisher","first-page":"8563","DOI":"10.1073\/pnas.93.16.8563","volume":"93","author":"Y Wang","year":"1996","unstructured":"Wang Y, Hu Q, Madri JA, Rollins SA, Chodera A, Matis LA. Amelioration of lupus-like autoimmune disease in NZB\/W F1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci U S A. 1996;93(16):8563\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1820_CR44","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/BOR.0b013e32832efff1","volume":"21","author":"H Bagavant","year":"2009","unstructured":"Bagavant H, Fu SM. Pathogenesis of kidney disease in systemic lupus erythematosus. Curr Opin Rheumatol. 2009;21(5):489\u201394.","journal-title":"Curr Opin Rheumatol"},{"issue":"11","key":"1820_CR45","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/nrneph.2016.127","volume":"12","author":"L Perico","year":"2016","unstructured":"Perico L, Conti S, Benigni A, Remuzzi G. Podocyte-actin dynamics in health and disease. Nat Rev Nephrol. 2016;12(11):692\u2013710.","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"1820_CR46","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/ncb1400","volume":"8","author":"K Asanuma","year":"2006","unstructured":"Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol. 2006;8(5):485\u201391.","journal-title":"Nat Cell Biol"},{"issue":"9","key":"1820_CR47","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nm.1857","volume":"14","author":"C Faul","year":"2008","unstructured":"Faul C, Donnelly M, Merschergomez S, Chang YH, Franz S, Delfgaauw J, et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med. 2008;14(9):931\u20138.","journal-title":"Nat Med"},{"issue":"6","key":"1820_CR48","doi-asserted-by":"publisher","first-page":"e167","DOI":"10.1371\/journal.pbio.0020167","volume":"2","author":"J Yao","year":"2004","unstructured":"Yao J, Le TC, Kos CH, Henderson JM, Allen PG, Denker BM, et al. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol. 2004;2(6):e167.","journal-title":"PLoS Biol"},{"key":"1820_CR49","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fendo.2014.00160","volume":"5","author":"R Lennon","year":"2014","unstructured":"Lennon R, Randles MJ, Humphries MJ. The importance of podocyte adhesion for a healthy glomerulus. Front Endocrinol (Lausanne). 2014;5:160.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"1820_CR50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.gmit.2014.06.002","volume":"3","author":"CF Yen","year":"2014","unstructured":"Yen CF, Wang HS, Lee CL, Liao SK. Roles of integrin-linked kinase in cell signaling and its perspectives as a therapeutic target. Gynecol Minim Invasive Ther. 2014;3(3):67\u201372.","journal-title":"Gynecol Minim Invasive Ther"},{"issue":"4","key":"1820_CR51","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1042\/BST20130062","volume":"41","author":"S Ghatak","year":"2013","unstructured":"Ghatak S, Morgner J, Wickstr\u00f6m SA. ILK: a pseudokinase with a unique function in the integrin-actin linkage. Biochem Soc Trans. 2013;41(4):995\u20131001.","journal-title":"Biochem Soc Trans"},{"issue":"5","key":"1820_CR52","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.molcel.2009.11.028","volume":"36","author":"K Fukuda","year":"2009","unstructured":"Fukuda K, Gupta S, Chen K, Wu C, Qin J. The pseudo-active site of ILK is essential for its binding to \u03b1-parvin and localization to focal adhesions. Mol Cell. 2009;36(5):819.","journal-title":"Mol Cell"},{"key":"1820_CR53","doi-asserted-by":"crossref","unstructured":"Brunton VG, MacPherson IRJ, Frame MC. Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2004;1692(2-3):121-144.","DOI":"10.1016\/j.bbamcr.2004.04.010"},{"issue":"1","key":"1820_CR54","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1159\/000066647","volume":"93","author":"H Goto","year":"2003","unstructured":"Goto H, Wakui H, Komatsuda A, Ohtani H, Imai H, Sawada K, et al. Renal alpha-actinin-4: purification and puromycin aminonucleoside-binding property. Nephron Exp Nephrol. 2003;93(1):e27\u201335.","journal-title":"Nephron Exp Nephrol"},{"issue":"9","key":"1820_CR55","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1440-1827.2004.01683.x","volume":"54","author":"N Guan","year":"2004","unstructured":"Guan N, Ding J, Deng J, Zhang J, Yang J. Key molecular events in puromycin aminonucleoside nephrosis rats. Pathol Int. 2004;54(9):703\u201311.","journal-title":"Pathol Int"},{"issue":"6","key":"1820_CR56","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.4049\/jimmunol.168.6.3072","volume":"168","author":"B Deocharan","year":"2002","unstructured":"Deocharan B, Qing X, Lichauco J, Putterman C. \u03b1-Actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J Immunol. 2002;168(6):3072\u20138.","journal-title":"J Immunol"},{"issue":"4","key":"1820_CR57","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1002\/1521-4141(200104)31:4<1221::AID-IMMU1221>3.0.CO;2-P","volume":"31","author":"G Mostoslavsky","year":"2001","unstructured":"Mostoslavsky G, Fischel R, Yachimovich N, Yarkoni Y, Rosenmann E, Monestier M, et al. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur J Immunol. 2001;31(4):1221\u20137.","journal-title":"Eur J Immunol"},{"issue":"1","key":"1820_CR58","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ceb.2012.10.009","volume":"25","author":"JR Terman","year":"2013","unstructured":"Terman JR, Kashina A. Post-translational modification and regulation of actin. Curr Opin Cell Biol. 2013;25(1):30\u20138.","journal-title":"Curr Opin Cell Biol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-019-1820-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-019-1820-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-019-1820-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T02:45:14Z","timestamp":1662864314000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-019-1820-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,29]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1820"],"URL":"https:\/\/doi.org\/10.1186\/s13075-019-1820-3","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,29]]},"assertion":[{"value":"2 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"40"}}