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Animal studies were either conducted in accordance with Bolder BioPATH IACUC approved policies and procedures in accordance with <i>The Guide for the Care & Use of Laboratory Animals (8th Edition)<\/i> or were approved by the Purdue Animal Care and Use Committee in accordance with guidelines from the National Institutes of Health.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"143"}}