{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:31:56Z","timestamp":1783405916656,"version":"3.54.6"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000991","name":"Faculty of Medicine, Nursing and Health Sciences, Monash University","doi-asserted-by":"publisher","award":["Strategic Grant Scheme ECD049"],"award-info":[{"award-number":["Strategic Grant Scheme ECD049"]}],"id":[{"id":"10.13039\/501100000991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13075-019-1953-4","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T12:02:49Z","timestamp":1562328169000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["High baseline fat mass, but not lean tissue mass, is associated with high intensity low back pain and disability in community-based adults"],"prefix":"10.1186","volume":"21","author":[{"given":"Sharmayne R. E.","family":"Brady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Urquhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultana Monira","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Teichtahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita E.","family":"Wluka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Cicuttini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"issue":"6","key":"1953_CR1","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1136\/annrheumdis-2013-204428","volume":"73","author":"D Hoy","year":"2014","unstructured":"Hoy D, March L, Brooks P, et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73(6):968\u201374.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"1953_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jmpt.2004.02.002","volume":"27","author":"BF Walker","year":"2004","unstructured":"Walker BF, Muller R, Grant WD. Low back pain in Australian adults: prevalence and associated disability. J Manip Physiol Ther. 2004;27(4):238\u201344.","journal-title":"J Manip Physiol Ther"},{"issue":"Suppl 2","key":"1953_CR3","first-page":"21","volume":"88","author":"JN Katz","year":"2006","unstructured":"Katz JN. Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. J Bone Joint Surg Am. 2006;88(Suppl 2):21\u20134.","journal-title":"J Bone Joint Surg Am"},{"issue":"2\u20133","key":"1953_CR4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0304-3959(95)00164-6","volume":"65","author":"CC Engel","year":"1996","unstructured":"Engel CC, von Korff M, Katon WJ. Back pain in primary care: predictors of high health-care costs. Pain. 1996;65(2\u20133):197\u2013204.","journal-title":"Pain."},{"key":"1953_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/sj.ijo.0803715","volume":"32","author":"A Anandacoomarasamy","year":"2007","unstructured":"Anandacoomarasamy A, Caterson I, Sambrook P, Fransen M, March L. The impact of obesity on the musculoskeletal system. Int J Obes. 2007;32:211.","journal-title":"Int J Obes"},{"issue":"2","key":"1953_CR6","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1097\/00007632-200001150-00015","volume":"25","author":"C Leboeuf-Yde","year":"2000","unstructured":"Leboeuf-Yde C. Body weight and low back pain. A systematic literature review of 56 journal articles reporting on 65 epidemiologic studies. Spine. 2000;25(2):226\u201337.","journal-title":"Spine."},{"issue":"2","key":"1953_CR7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/aje\/kwp356","volume":"171","author":"R Shiri","year":"2010","unstructured":"Shiri R, Karppinen J, Leino-Arjas P, Solovieva S, Viikari-Juntura E. The association between obesity and low back pain: a meta-analysis. Am J Epidemiol. 2010;171(2):135\u201354.","journal-title":"Am J Epidemiol"},{"issue":"10","key":"1953_CR8","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1002\/art.24862","volume":"60","author":"LJ Sandell","year":"2009","unstructured":"Sandell LJ. Obesity and osteoarthritis: is leptin the link? Arthritis Rheum. 2009;60(10):2858\u201360.","journal-title":"Arthritis Rheum"},{"key":"1953_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12891-016-0934-x","volume":"17","author":"AJ Teichtahl","year":"2016","unstructured":"Teichtahl AJ, Urquhart DM, Wang Y, et al. Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height - a 3.0 T-MRI study. BMC Musculoskelet Disord. 2016;17:92.","journal-title":"BMC Musculoskelet Disord"},{"issue":"16","key":"1953_CR10","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1097\/BRS.0b013e3181f9fb66","volume":"36","author":"DM Urquhart","year":"2011","unstructured":"Urquhart DM, Berry P, Wluka AE, et al. 2011 Young Investigator Award winner: increased fat mass is associated with high levels of low back pain intensity and disability. Spine. 2011;36(16):1320\u20135.","journal-title":"Spine."},{"issue":"15","key":"1953_CR11","doi-asserted-by":"publisher","first-page":"e3367","DOI":"10.1097\/MD.0000000000003367","volume":"95","author":"L Chou","year":"2016","unstructured":"Chou L, Brady SR, Urquhart DM, et al. The association between obesity and low back pain and disability is affected by mood disorders: a population-based, cross-sectional study of men. Medicine. 2016;95(15):e3367.","journal-title":"Medicine."},{"key":"1953_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.bone.2017.06.010","volume":"104","author":"JA Shepherd","year":"2017","unstructured":"Shepherd JA, Ng BK, Sommer MJ, Heymsfield SB. Body composition by DXA. Bone. 2017;104:101\u20135.","journal-title":"Bone."},{"key":"1953_CR13","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1097\/01.JSC.0000395638.55606.50","volume":"25","author":"JM Oliver","year":"2011","unstructured":"Oliver JM, Lambert BS, Martin SE, et al. Predicting body fat to the accuracy of DEXA using standard anthropometric measures. J Strength Cond Res. 2011;25:S38\u20139.","journal-title":"J Strength Cond Res"},{"issue":"2","key":"1953_CR14","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1152\/japplphysiol.01234.2003","volume":"97","author":"SG Glickman","year":"2004","unstructured":"Glickman SG, Marn CS, Supiano MA, Dengel DR. Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity. J Appl Physiol (1985). 2004;97(2):509\u201314.","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"1953_CR15","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/00005768-199704000-00020","volume":"29","author":"JL Clasey","year":"1997","unstructured":"Clasey JL, Hartman ML, Kanaley J, et al. Body composition by DEXA in older adults: accuracy and influence of scan mode. Med Sci Sports Exerc. 1997;29(4):560\u20137.","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"1953_CR16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/MED.0000000000000360","volume":"24","author":"T Lemos","year":"2017","unstructured":"Lemos T, Gallagher D. Current body composition measurement techniques. Curr Opin Endocrinol Diabetes Obes. 2017;24(5):310\u20134.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"1","key":"1953_CR17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13075-017-1242-z","volume":"19","author":"SM Hussain","year":"2017","unstructured":"Hussain SM, Urquhart DM, Wang Y, et al. Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study. Arthritis Res Ther. 2017;19(1):26.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"1953_CR18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.4085\/1062-6050-46.1.50","volume":"46","author":"NM Selkow","year":"2011","unstructured":"Selkow NM, Pietrosimone BG, Saliba SA. Subcutaneous thigh fat assessment: a comparison of skinfold calipers and ultrasound imaging. J Athl Train. 2011;46(1):50\u20134.","journal-title":"J Athl Train"},{"issue":"4","key":"1953_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jcm.2010.07.002","volume":"9","author":"MP McRae","year":"2010","unstructured":"McRae MP. Male and female differences in variability with estimating body fat composition using skinfold calipers. J Chiropr Med. 2010;9(4):157\u201361.","journal-title":"J Chiropr Med"},{"issue":"1","key":"1953_CR20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s12891-018-2137-0","volume":"19","author":"TP Walsh","year":"2018","unstructured":"Walsh TP, Arnold JB, Evans AM, Yaxley A, Damarell RA, Shanahan EM. The association between body fat and musculoskeletal pain: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2018;19(1):233.","journal-title":"BMC Musculoskelet Disord"},{"issue":"4","key":"1953_CR21","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/acr.22963","volume":"69","author":"F Pan","year":"2017","unstructured":"Pan F, Laslett L, Blizzard L, et al. Associations between fat mass and multisite pain: a five-year longitudinal study. Arthritis Care Res. 2017;69(4):509\u201316.","journal-title":"Arthritis Care Res."},{"issue":"2","key":"1953_CR22","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.spinee.2016.10.006","volume":"17","author":"AB Dario","year":"2017","unstructured":"Dario AB, Loureiro Ferreira M, Refshauge K, Luque-Suarez A, Ordonana JR, Ferreira PH. Obesity does not increase the risk of chronic low back pain when genetics are considered. A prospective study of Spanish adult twins. Spine J. 2017;17(2):282\u201390.","journal-title":"Spine J"},{"issue":"6","key":"1953_CR23","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1589\/jpts.29.978","volume":"29","author":"Y Hashimoto","year":"2017","unstructured":"Hashimoto Y, Matsudaira K, Sawada SS, et al. Obesity and low back pain: a retrospective cohort study of Japanese males. J Phys Ther Sci. 2017;29(6):978\u201383.","journal-title":"J Phys Ther Sci"},{"issue":"2","key":"1953_CR24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/HPC.0b013e318057d4c9","volume":"6","author":"JP Despres","year":"2007","unstructured":"Despres JP. Cardiovascular disease under the influence of excess visceral fat. Crit Pathw Cardiol. 2007;6(2):51\u20139.","journal-title":"Crit Pathw Cardiol"},{"issue":"12","key":"1953_CR25","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1093\/rheumatology\/keq255","volume":"49","author":"PA Berry","year":"2010","unstructured":"Berry PA, Wluka AE, Davies-Tuck ML, et al. The relationship between body composition and structural changes at the knee. Rheumatology. 2010;49(12):2362\u20139.","journal-title":"Rheumatology."},{"issue":"6","key":"1953_CR26","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JE Ware Jr","year":"1992","unstructured":"Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473\u201383.","journal-title":"Med Care"},{"issue":"2","key":"1953_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0304-3959(92)90154-4","volume":"50","author":"M Von Korff","year":"1992","unstructured":"Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain. Pain. 1992;50(2):133\u201349.","journal-title":"Pain."},{"issue":"2","key":"1953_CR28","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/BRS.0b013e3182647af2","volume":"38","author":"I Heuch","year":"2013","unstructured":"Heuch I, Heuch I, Hagen K, Zwart JA. Body mass index as a risk factor for developing chronic low back pain: a follow-up in the Nord-Trondelag Health Study. Spine. 2013;38(2):133\u20139.","journal-title":"Spine."},{"issue":"3","key":"1953_CR29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0895-4356(99)00155-9","volume":"53","author":"JK Lake","year":"2000","unstructured":"Lake JK, Power C, Cole TJ. Back pain and obesity in the 1958 British birth cohort: cause or effect? J Clin Epidemiol. 2000;53(3):245\u201350.","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"1953_CR30","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/aje\/kwr087","volume":"174","author":"TI Nilsen","year":"2011","unstructured":"Nilsen TI, Holtermann A, Mork PJ. Physical exercise, body mass index, and risk of chronic pain in the low back and neck\/shoulders: longitudinal data from the Nord-Trondelag Health Study. Am J Epidemiol. 2011;174(3):267\u201373.","journal-title":"Am J Epidemiol"},{"issue":"10","key":"1953_CR31","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.2105\/AJPH.91.10.1671","volume":"91","author":"C Power","year":"2001","unstructured":"Power C, Frank J, Hertzman C, Schierhout G, Li L. Predictors of low back pain onset in a prospective British study. Am J Public Health. 2001;91(10):1671\u20138.","journal-title":"Am J Public Health"},{"issue":"6","key":"1953_CR32","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.semarthrit.2012.09.002","volume":"42","author":"R Shiri","year":"2013","unstructured":"Shiri R, Solovieva S, Husgafvel-Pursiainen K, et al. The role of obesity and physical activity in non-specific and radiating low back pain: the Young Finns study. Semin Arthritis Rheum. 2013;42(6):640\u201350.","journal-title":"Semin Arthritis Rheum"},{"key":"1953_CR33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2474-7-27","volume":"7","author":"L Hestbaek","year":"2006","unstructured":"Hestbaek L, Leboeuf-Yde C, Kyvik KO. Are lifestyle-factors in adolescence predictors for adult low back pain? A cross-sectional and prospective study of young twins. BMC Musculoskelet Disord. 2006;7:27.","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"1953_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5271\/sjweh.971","volume":"32","author":"P Leino-Arjas","year":"2006","unstructured":"Leino-Arjas P, Solovieva S, Kirjonen J, Reunanen A, Riihimaki H. Cardiovascular risk factors and low-back pain in a long-term follow-up of industrial employees. Scand J Work Environ Health. 2006;32(1):12\u20139.","journal-title":"Scand J Work Environ Health"},{"issue":"4","key":"1953_CR35","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1002\/art.22513","volume":"56","author":"JH Andersen","year":"2007","unstructured":"Andersen JH, Haahr JP, Frost P. Risk factors for more severe regional musculoskeletal symptoms: a two-year prospective study of a general working population. Arthritis Rheum. 2007;56(4):1355\u201364.","journal-title":"Arthritis Rheum"},{"issue":"6","key":"1953_CR36","doi-asserted-by":"publisher","first-page":"411","DOI":"10.5271\/sjweh.1290","volume":"34","author":"H Miranda","year":"2008","unstructured":"Miranda H, Viikari-Juntura E, Punnett L, Riihimaki H. Occupational loading, health behavior and sleep disturbance as predictors of low-back pain. Scand J Work Environ Health. 2008;34(6):411\u20139.","journal-title":"Scand J Work Environ Health"},{"issue":"6","key":"1953_CR37","doi-asserted-by":"publisher","first-page":"E101","DOI":"10.1097\/01.BRS.0000115125.60331.72","volume":"29","author":"LA Elders","year":"2004","unstructured":"Elders LA, Burdorf A. Prevalence, incidence, and recurrence of low back pain in scaffolders during a 3-year follow-up study. Spine. 2004;29(6):E101\u20136.","journal-title":"Spine."},{"key":"1953_CR38","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2474-10-2","volume":"10","author":"A Van Nieuwenhuyse","year":"2009","unstructured":"Van Nieuwenhuyse A, Crombez G, Burdorf A, et al. Physical characteristics of the back are not predictive of low back pain in healthy workers: a prospective study. BMC Musculoskelet Disord. 2009;10:2\u20132.","journal-title":"BMC Musculoskelet Disord"},{"issue":"10","key":"1953_CR39","doi-asserted-by":"publisher","first-page":"e0141268","DOI":"10.1371\/journal.pone.0141268","volume":"10","author":"I Heuch","year":"2015","unstructured":"Heuch I, Heuch I, Hagen K, Zwart JA. A comparison of anthropometric measures for assessing the association between body size and risk of chronic low back pain: the HUNT study. PLoS One. 2015;10(10):e0141268.","journal-title":"PLoS One"},{"issue":"7121","key":"1953_CR40","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/nature05488","volume":"444","author":"JP Despres","year":"2006","unstructured":"Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881\u20137.","journal-title":"Nature."},{"issue":"6","key":"1953_CR41","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1080\/07315724.1989.10720320","volume":"8","author":"LF Van Gaal","year":"1989","unstructured":"Van Gaal LF, Vansant GA, De Leeuw IH. Upper body adiposity and the risk for atherosclerosis. J Am Coll Nutr. 1989;8(6):504\u201314.","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"1953_CR42","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0899-9007(02)01003-1","volume":"19","author":"A Misra","year":"2003","unstructured":"Misra A, Vikram NK. Clinical and pathophysiological consequences of abdominal adiposity and abdominal adipose tissue depots. Nutrition. 2003;19(5):457\u201366.","journal-title":"Nutrition"},{"issue":"2","key":"1953_CR43","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/acr.20663","volume":"64","author":"SK Tanamas","year":"2012","unstructured":"Tanamas SK, Wluka AE, Berry P, et al. Relationship between obesity and foot pain and its association with fat mass, fat distribution, and muscle mass. Arthritis Care Res. 2012;64(2):262\u20138.","journal-title":"Arthritis Care Res"},{"issue":"2","key":"1953_CR44","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/0956462414531404","volume":"26","author":"S Fillipas","year":"2015","unstructured":"Fillipas S, Tanamas SK, Davies-Tuck ML, et al. The relationship between body composition and knee structure in patients with human immunodeficiency virus. Int J STD AIDS. 2015;26(2):133\u20138.","journal-title":"Int J STD AIDS"},{"issue":"1","key":"1953_CR45","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1148\/radiology.166.1.3336678","volume":"166","author":"MT Modic","year":"1988","unstructured":"Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166(1 Pt 1):193\u20139.","journal-title":"Radiology."},{"issue":"10","key":"1953_CR46","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1097\/01.brs.0000261561.12944.ff","volume":"32","author":"M Kuisma","year":"2007","unstructured":"Kuisma M, Karppinen J, Niinimaki J, et al. Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers. Spine. 2007;32(10):1116\u201322.","journal-title":"Spine."},{"issue":"8","key":"1953_CR47","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.jpain.2015.04.006","volume":"16","author":"SR Brady","year":"2015","unstructured":"Brady SR, Mamuaya BB, Cicuttini F, et al. Body composition is associated with multisite lower body musculoskeletal pain in a community-based study. J Pain. 2015;16(8):700\u20136.","journal-title":"J Pain"},{"issue":"2","key":"1953_CR48","doi-asserted-by":"publisher","first-page":"T47","DOI":"10.1530\/JOE-13-0339","volume":"220","author":"H Cao","year":"2014","unstructured":"Cao H. Adipocytokines in obesity and metabolic disease. J Endocrinol. 2014;220(2):T47\u201359.","journal-title":"J Endocrinol"},{"issue":"1","key":"1953_CR49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/bcpt.12160","volume":"114","author":"K Vuolteenaho","year":"2014","unstructured":"Vuolteenaho K, Koskinen A, Moilanen E. Leptin - a link between obesity and osteoarthritis. Applications for prevention and treatment. Basic Clin Pharmacol Toxicol. 2014;114(1):103\u20138.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"4","key":"1953_CR50","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1093\/rheumatology\/kev408","volume":"55","author":"J Martel-Pelletier","year":"2016","unstructured":"Martel-Pelletier J, Raynauld JP, Dorais M, Abram F, Pelletier JP. The levels of the adipokines adipsin and leptin are associated with knee osteoarthritis progression as assessed by MRI and incidence of total knee replacement in symptomatic osteoarthritis patients: a post hoc analysis. Rheumatology (Oxford). 2016;55(4):680\u20138.","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"1953_CR51","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1002\/art.11303","volume":"48","author":"H Dumond","year":"2003","unstructured":"Dumond H, Presle N, Terlain B, et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 2003;48(11):3118\u201329.","journal-title":"Arthritis Rheum"},{"issue":"10","key":"1953_CR52","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1007\/s00264-013-1982-6","volume":"37","author":"A Lubbeke","year":"2013","unstructured":"Lubbeke A, Finckh A, Puskas GJ, et al. Do synovial leptin levels correlate with pain in end stage arthritis? Int Orthop. 2013;37(10):2071\u20139.","journal-title":"Int Orthop"},{"issue":"9","key":"1953_CR53","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1093\/aje\/kwn007","volume":"167","author":"R Shiri","year":"2008","unstructured":"Shiri R, Solovieva S, Husgafvel-Pursiainen K, et al. The association between obesity and the prevalence of low back pain in young adults: the Cardiovascular Risk in Young Finns Study. Am J Epidemiol. 2008;167(9):1110\u20139.","journal-title":"Am J Epidemiol"},{"key":"1953_CR54","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fphys.2018.00093","volume":"9","author":"SRE Brady","year":"2018","unstructured":"Brady SRE, Mousa A, Naderpoor N, de Courten MPJ, Cicuttini F, de Courten B. Adipsin concentrations are associated with back pain independently of adiposity in overweight or obese adults. Front Physiol. 2018;9:93.","journal-title":"Front Physiol"},{"issue":"3","key":"1953_CR55","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.spinee.2005.11.004","volume":"6","author":"TL Walsh","year":"2006","unstructured":"Walsh TL, Homa K, Hanscom B, Lurie J, Sepulveda MG, Abdu W. Screening for depressive symptoms in patients with chronic spinal pain using the SF-36 Health Survey. Spine J. 2006;6(3):316\u201320.","journal-title":"Spine J"},{"key":"1953_CR56","doi-asserted-by":"crossref","unstructured":"Deyo RA, Dworkin SF, Amtmann D, et al. Report of the NIH Task Force on research standards for chronic low back pain. J Pain. 2014;15(6):569\u201385.","DOI":"10.1016\/j.jpain.2014.03.005"},{"issue":"10070","key":"1953_CR57","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0140-6736(16)30970-9","volume":"389","author":"Chris Maher","year":"2017","unstructured":"Maher C, Underwood M, Buchbinder R. Non-specific low back pain. The Lancet. 2017;389(10070):736\u201347.","journal-title":"The Lancet"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-019-1953-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13075-019-1953-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-019-1953-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T23:14:52Z","timestamp":1593818092000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-019-1953-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,5]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1953"],"URL":"https:\/\/doi.org\/10.1186\/s13075-019-1953-4","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,5]]},"assertion":[{"value":"7 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Alfred Health Human Research and Ethics Committee (HREC), the Monash University HREC, the Austin Health HREC, and the University of Melbourne HREC approved this study. Written informed consent was obtained from all participants involved in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"165"}}