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Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients with AS, ulcerative colitis (UC), and healthy controls (HC) and to determine relationships between fecal microbiota, fecal calprotectin, and disease-related variables in AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fecal microbiota composition was assessed with GA-map\u2122 Dysbiosis Test (Genetic Analysis, Oslo, Norway), which also reports the degree of deviation of the microbiota composition compared with a healthy control population, a Dysbiosis Index (DI) score 1\u20135. The AS patients were assessed with questionnaires, back mobility tests, fecal calprotectin, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totally, 150 patients with AS (55% men, median age 55.5\u2009years, median BASDAI 3.2), 18 patients with UC (56% men, median age 30.5\u2009years), and 17 HC (65% men, median age 22\u2009years) were included. Principal component analysis showed highly separate clustering of fecal microbiota from the patients with AS, UC, and HC. Compared with HC, fecal microbiota in AS was characterized by a higher abundance of\n                      <jats:italic>Proteobacteria<\/jats:italic>\n                      ,\n                      <jats:italic>Enterobacteriaceae<\/jats:italic>\n                      ,\n                      <jats:italic>Bacilli<\/jats:italic>\n                      ,\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      species, and\n                      <jats:italic>Actinobacteria<\/jats:italic>\n                      , but lower abundance of\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      and\n                      <jats:italic>Lachnospiraceae<\/jats:italic>\n                      .\n                    <\/jats:p>\n                    <jats:p>\n                      Further, fecal microbiota composition differed between patients with normal (\u2264\u200950\u2009mg\/kg,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200957) and increased (\u2265\u2009200\u2009mg\/kg,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) fecal calprotectin. Patients with increased fecal calprotectin had lower abundance of bacteria with anti-inflammatory properties such as\n                      <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>\n                      and\n                      <jats:italic>Clostridium<\/jats:italic>\n                      and higher abundance of the genus\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      . No association was found between the fecal microbiota composition and HLAB27 status, disease activity, function, or medication. Dysbiosis (defined as DI\u2009\u2265\u20093) was found in 87% of AS patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with AS have a distinct fecal microbiota signature, which is linked to fecal calprotectin levels, a marker of intestinal inflammation, but not to other clinical parameters. These findings suggest a local interplay between intestinal microbiota and gut inflammation in AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00858819\">NCT00858819<\/jats:ext-link>\n                      . Registered March 9, 2009.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-019-2018-4","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T21:02:32Z","timestamp":1574802152000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-6413","authenticated-orcid":false,"given":"Eva","family":"Klingberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria K.","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Strid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Deminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"St\u00e5hl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Sundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Carlsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"\u00d6hman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Forsblad-d\u2019Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"issue":"Suppl 2","key":"2018_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/rheumatology\/XXVII.suppl_2.95","volume":"27","author":"H Mielants","year":"1988","unstructured":"Mielants H, Veys EM, Cuvelier C, de Vos M. 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