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Perioral fibrosis produces a characteristic microstomia together with microcheilia, both of which cause severe difficulties and affects patients\u2019 daily life, such as eating and oral hygiene. Since there are no effective and specific therapies, we have aimed at evaluating the response to filler injections of hyaluronic acid together with platelet-rich plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten female patients aged between 18 and 70 were included in this study. Each patient was treated with three filler injections of hyaluronic acid and platelet-rich plasma at an interval of 15 to 20\u2009days. Follow-up check-ups were recorded 1, 3, and 24\u2009months after the end of the treatment. During the therapy and the subsequent follow-up, we evaluated the mouth\u2019s opening, freedom of movement of the lips, and skin elasticity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the treatment, patients had achieved good results already after the first injection and the improvement was maintained in the following months, up to 2\u00a0years. In particular, 8 (80%) patients showed a greater mouth\u2019s opening and increased upper lip\u2019s thickness during 1-month follow-up and maintained these results after 2\u00a0years (maximum mouth\u2019s opening T0 47.61; T3 49.23; T4 48.60<jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.0001. Upper lip\u2019s thickness T0 4.20; T3 4.75; T4 4.45<jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.0001). Moreover, distance between upper and lower incisors (T0 27.05; T3 29.03; T4 28.14<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), inter-commissural distance (T0 49.12; T3 51.44; T4 50.31:<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and lower lip\u2019s thickness (T0 3.80; T3 4.85, 5.10; T4 4.25;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) were increased in all of patients in 1-month follow-up, keeping these benefits after 24\u00a0months and having a significant increase of skin elasticity 1\u00a0month after the end of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that filler injections of hyaluronic acid and platelet-rich plasma represent an efficient local therapeutic alternative for patients affected by scleroderma. The treatment has significantly improved patients\u2019 quality of living.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13075-019-2062-0","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T17:03:48Z","timestamp":1576256628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hyaluronic acid and platelet-rich plasma, a new therapeutic alternative for scleroderma patients: a prospective open-label study"],"prefix":"10.1186","volume":"21","author":[{"given":"Roberto","family":"Pirrello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Verro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Ruscitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Cordova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giacomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ciccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2479-6958","authenticated-orcid":false,"given":"Giuliana","family":"Guggino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"2062_CR1","doi-asserted-by":"crossref","unstructured":"Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP, Varga J. 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No names will be utilized in publications in order to maintain confidentiality. Consent was obtained from all participants by either the principal investigator or other authorized research staff. Documentation for the informed consent process as well as the signed consent forms is maintained in study binders in the Dipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche, Sezione di Chirurgia Plastica e Ricostruttiva, Universit\u00e0 di Palermo.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"286"}}