{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:22:51Z","timestamp":1787818971696,"version":"build-2784847793"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) is a promising tool for diagnosing relapsing polychondritis (RP). However, its usefulness in assessing RP with airway involvement is unknown.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>This study aimed to further evaluate and confirm the potency of <jats:sup>18<\/jats:sup>F-FDG PET\/CT in diagnosing RP with airway involvement and monitoring response to steroid-based therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 30 patients from a dedicated respiratory centre, diagnosed with RP in accordance with McAdam, Damiani or Levine criteria, were included in this study. All patients underwent baseline <jats:sup>18<\/jats:sup>F-FDG PET\/CT, and 10 patients underwent second scans after 2.5\u201315\u2009months of steroid-based therapy. Visual scores (VS) and maximal standard uptake values (SUV<jats:sub>max<\/jats:sub>) were analysed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the initial scan, 83.3% (25\/30) of patients were found to have FDG uptake in more than one cartilage. The median VS and SUV<jats:sub>max<\/jats:sub> in the cartilages were 3 (range, 1\u20133) and 3.8 (range, 1.9\u201317.9), respectively. Positive rates for PET\/CT-guided biopsy in nasal, auricular, and tracheal\/bronchial cartilages were 100% (5\/5), 88.9% (8\/9), and 10.5% (2\/19), respectively, but the positive biopsy rate in the auricular cartilage was 92.3% (12\/13) even without PET\/CT assessment. Based on biopsy-proven sites, the sensitivity of PET\/CT was 55.6%, and the specificity was 5.3%. Compared with the baseline scan, the second scan showed much lower median VS (2 vs 3, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and SUV<jats:sub>max<\/jats:sub> (2.9 vs 3.8, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Of 10 patients who underwent second PET\/CT, 8 had complete therapeutic response, while 2 had partial response.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:sup>18<\/jats:sup>F-FDG PET\/CT assists in identifying multiple cartilage involvement in RP, but it seems neither a sensitive nor specific modality in diagnosing RP with airway involvement. Moreover, PET\/CT has limited utility in locating biopsy sites and monitoring therapeutic response to corticosteroids.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-019-2083-8","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T17:05:02Z","timestamp":1576170302000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Is 18F-FDG PET\/CT useful for diagnosing relapsing polychondritis with airway involvement and monitoring response to steroid-based therapy?"],"prefix":"10.1186","volume":"21","author":[{"given":"Yunxiang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"2083_CR1","first-page":"93","volume":"6","author":"R Jaksch-Wartenhorst","year":"1923","unstructured":"Jaksch-Wartenhorst R. 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