{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:48:47Z","timestamp":1790182127130,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Peking University Peking University People\u2019s Hospital Research and Development Funds","award":["RDH 2020-03"],"award-info":[{"award-number":["RDH 2020-03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The growing utilization of needle biopsy has challenged the current pathology consensus of IgG4-related disease (IgG4-RD). The aims of this study were to identify the histological characteristics of needle biopsy and surgical specimens and evaluate the ability of needle biopsy in histological diagnosis of IgG4-RD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Biopsies from patients who were referred to as IgG4-RD by the 2019 ACR\/EULAR IgG4-RD classification criteria in Peking University People\u2019s Hospital from 2012 to 2019 were re-evaluated. Typical histological features and diagnostic categories were compared between needle biopsy and surgical biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 69 patients met the 2019 ACR\/EULAR classification criteria and 72 biopsies of them were re-evaluated. All cases showed lymphoplasmacytic infiltrate, while storiform fibrosis and obliterative phlebitis were only present in 35 (48.6%) and 23 (31.9%) specimens, respectively. Storiform fibrosis was more likely to be seen in retroperitoneum lesion (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033). Surgical biopsy showed significantly higher IgG4+ plasma cells\/high-power field (IgG4\/HPF) count (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and higher proportion of IgG4\/HPF\u2009&gt;\u200910 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). No significant difference was observed with regard to the ratio of IgG4+ plasma cells\/IgG+ plasma cells (IgG4\/IgG) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.399), storiform fibrosis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.739), and obliterative phletibis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.153). According to the 2011 comprehensive diagnostic criteria, patients who performed a needle biopsy were less likely to be probable IgG4-RD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.045). Based on the 2011 pathology consensus, needle biopsy was less likely to be diagnosed as IgG4-RD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), especially to be highly suggestive IgG4-RD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Only 1\/18 (5.6%) needle salivary specimens fulfilled the cutoff of IgG4\/HPF\u2009&gt;\u2009100, which was significantly less than 15\/23 (65.2%) of surgical ones (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Needle biopsy shows an inferiority in detecting IgG4\/HPF count but not in IgG4\/IgG ratio, storiform fibrosis, and obliterative phlebitis. Compared with surgical samples, needle biopsy is less likely to obtain a histological diagnosis of IgG4-RD. A different IgG4\/HPF threshold for needle biopsy of the salivary glands may be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-021-02432-y","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T03:38:34Z","timestamp":1612928314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Needle biopsy compared with surgical biopsy: pitfalls of small biopsy in histologial diagnosis of IgG4-related disease"],"prefix":"10.1186","volume":"23","author":[{"given":"Yanying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangnan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhua","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"issue":"6","key":"2432_CR1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1056\/NEJMra1104650","volume":"366","author":"JH Stone","year":"2012","unstructured":"Stone JH, Zen Y, Deshpande V. 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