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Clinical features and laboratory data were recorded. The systemic score was assessed to determine the disease severity. The maximal standardized uptake value (SUV<jats:sub>max<\/jats:sub>), metabolic lesion volume (MLV), and total lesion glycolysis (TLG) were used to evaluate the involved organs and tissues that abnormally accumulated <jats:sup>18<\/jats:sup>F-FDG. Multivariate analysis was performed to identify the PET\/CT-derived risk factors contributing to the AOSD-related MAS, and their diagnostic efficiency was evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>High <jats:sup>18<\/jats:sup>F-FDG accumulation was observed in the bone marrow (SUV<jats:sub>max<\/jats:sub> median, 5.10), spleen (SUV<jats:sub>max<\/jats:sub> median, 3.70), and lymph nodes (LNs, SUV<jats:sub>max<\/jats:sub> median, 5.55). The SUV<jats:sub>max<\/jats:sub> of the bone marrow (rho\u2009=\u20090.376, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), SUV<jats:sub>max<\/jats:sub> of the spleen (rho\u2009=\u20090.450, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), TLG<jats:sub>total<\/jats:sub> of LNs (rho\u2009=\u20090.386, <jats:italic>p<\/jats:italic>\u2009=\u20090.017), and MLV<jats:sub>total<\/jats:sub> of LNs (rho\u2009=\u20090.391, <jats:italic>p<\/jats:italic>\u2009=\u20090.015) were correlated with the systemic score. The SUV<jats:sub>max<\/jats:sub> of the spleen (<jats:italic>p<\/jats:italic>\u00a0=\u20090.017), TLG<jats:sub>total<\/jats:sub> of LNs (<jats:italic>p<\/jats:italic>\u2009=\u20090.045), and MLV<jats:sub>total<\/jats:sub> of LNs (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) were higher in patients with MAS than in those without MAS. A MLV<jats:sub>total<\/jats:sub> of LNs\u2009&gt;\u200962.2 (OR 27.375, <jats:italic>p<\/jats:italic>\u2009=\u20090.042) was an independent predictive factor for MAS with a sensitivity of 80.0% and a specificity of 93.9%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The glucose metabolic level of the spleen could be an effective and easy-to-use imaging indicator of disease severity, and MLV<jats:sub>total<\/jats:sub> of LNs\u2009&gt;\u200962.2 was a strong predictor of MAS occurrence in patients with AOSD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-021-02482-2","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T05:02:40Z","timestamp":1617080560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Total metabolic lesion volume of lymph nodes measured by 18F-FDG PET\/CT: a new predictor of macrophage activation syndrome in adult-onset Still\u2019s disease"],"prefix":"10.1186","volume":"23","author":[{"given":"Liyan","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junna","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengde","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-9518","authenticated-orcid":false,"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"2482_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jaut.2018.07.018","volume":"93","author":"R Giacomelli","year":"2018","unstructured":"Giacomelli R, Ruscitti P, Shoenfeld Y. 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