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In this study, we investigated the mechanisms whereby miR-155 regulates cytokine production by DCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The formation of autophagosomes in DCs was detected by transmission electron microscopy. Western blotting was used to detect the protein levels of LC3, Beclin-1, P62, p-mTOR, and p-Akt in DCs. TNF-\u03b1, IL-6, and IL-1\u03b2 expression were investigated by ELISA. MiR-155 mimics were transfected to DCs to evaluate its effects on autophagy and cytokine production. RNA interference was used to downregulate the expression of TAB2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The formation of autophagosomes was found in DCs of active BD patients. The expressions of LC3-II, Beclin-1, and P62 were significantly increased in DCs of active BD patients compared to that of inactive BD patients and healthy controls. The expressions of IL-6, IL-1\u03b2, and TNF-\u03b1 were significantly increased in DCs of active BD patients compared to that of healthy controls. The autophagy promoter (3-MA) and inhibitor (rapamycin) significantly decreased or increased the expression of TNF-\u03b1, IL-6, and IL-1\u03b2 by DCs. The expression of LC3-II and Beclin-1 was significantly increased, but the expression of P62 proteins was decreased in DCs transfected with miR-155 mimics or after TAB2 was downregulated. The expression of TNF-\u03b1, IL-6, and IL-1\u03b2 was decreased in DCs after miR-155 was upregulated or TAB2 was downregulated. The ratios of p-Akt\/Akt and p-mTOR\/mTOR were decreased in DCs after miR-155 was upregulated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that miR-155 affects the production of TNF-\u03b1, IL-6, and IL-1\u03b2 by DCs through activation of the Akt\/mTOR signaling pathway and by affecting the process of autophagy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-021-02517-8","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T04:03:36Z","timestamp":1620273816000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Decreased microRNA-155 in Behcet\u2019s disease leads to defective control of autophagy thereby stimulating excessive proinflammatory cytokine production"],"prefix":"10.1186","volume":"23","author":[{"given":"Liang","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"issue":"1","key":"2517_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10238-004-0033-4","volume":"4","author":"M Suzuki Kurokawa","year":"2004","unstructured":"Suzuki Kurokawa M, Suzuki N. 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