{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:36:30Z","timestamp":1790649390894,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","award":["2015-02228"],"award-info":[{"award-number":["2015-02228"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007949","name":"The Swedish Rheumatism Association","doi-asserted-by":"crossref","award":["R-664091"],"award-info":[{"award-number":["R-664091"]}],"id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"crossref","award":["ALFSKANE-446501"],"award-info":[{"award-number":["ALFSKANE-446501"]}],"id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Pain is a major symptom in patients with rheumatoid arthritis (RA). In early RA, pain is usually due to synovitis, but can also persist despite effective anti-inflammatory treatment. The objective of this study was to investigate the pain course over time and predictors of unacceptable pain and unacceptable pain with low inflammation, in patients with early RA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>An inception cohort of 232 patients with early RA, recruited in 1995\u20132005, was followed in a structured programme for 5\u2009years. Pain was assessed using a visual analogue scale (VAS; 0\u2013100). Unacceptable pain was defined as VAS pain &gt;\u200940 based on the patient acceptable symptom state (PASS) and low inflammation as CRP &lt;\u200910\u2009mg\/l. Baseline predictors of unacceptable pain were evaluated using logistic regression analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Pain improved significantly during the first 6\u2009months, but then remained basically unchanged. Thirty-four per cent of the patients had unacceptable pain 5\u2009years after inclusion. Baseline predictors of unacceptable pain after 5\u2009years were lower swollen joint counts [odds ratio (OR) 0.71 per standard deviation (95% confidence interval (CI) 0.51\u20130.99)] and higher VAS for pain and global assessment of disease activity. Unacceptable pain with low inflammation after 5\u2009years was negatively associated with anti-CCP antibodies [OR 0.50 (95% CI 0.22\u20130.98)].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Over one third of the patients had unacceptable pain 5\u2009years after inclusion. Lower swollen joint count was associated with unacceptable pain at 5\u2009years. The results may be explained by the positive effects of treatment on pain related to inflammation. Non-inflammatory long-lasting pain appears to be a greater problem in anti-CCP-negative patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-021-02550-7","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T10:03:03Z","timestamp":1623664983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Predictors of unacceptable pain with and without low inflammation over 5\u2009years in early rheumatoid arthritis\u2014an inception cohort study"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-4150","authenticated-orcid":false,"given":"Anna","family":"Eberhard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Olofsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rydholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Jacobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Turesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"issue":"1","key":"2550_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1471-2474-15-44","volume":"15","author":"K Hekmat","year":"2014","unstructured":"Hekmat K, Jacobsson LT, Nilsson J, Lindroth Y, Turesson C. Changes and sex differences in patient reported outcomes in rheumatoid factor positive RA-results from a community based study. BMC Musculoskelet Disord. 2014;15(1):44. https:\/\/doi.org\/10.1186\/1471-2474-15-44.","journal-title":"BMC Musculoskelet Disord"},{"issue":"4","key":"2550_CR2","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/art.20941","volume":"52","author":"T Pincus","year":"2005","unstructured":"Pincus T, Sokka T, Kautiainen H. Patients seen for standard rheumatoid arthritis care have significantly better articular, radiographic, laboratory, and functional status in 2000 than in 1985. Arthritis Rheumatism. 2005;52(4):1009\u201319. https:\/\/doi.org\/10.1002\/art.20941.","journal-title":"Arthritis Rheumatism"},{"issue":"3","key":"2550_CR3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3109\/09638288.2016.1140835","volume":"39","author":"I Thyberg","year":"2017","unstructured":"Thyberg I, Dahlstrom O, Bjork M, Stenstrom B, Adams J. Hand pains in women and men in early rheumatoid arthritis, a one year follow-up after diagnosis. The Swedish TIRA project. Disabil Rehabil. 2017;39(3):291\u2013300. https:\/\/doi.org\/10.3109\/09638288.2016.1140835.","journal-title":"Disabil Rehabil"},{"issue":"4","key":"2550_CR4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3109\/03009742.2014.997285","volume":"44","author":"I Ahlstrand","year":"2015","unstructured":"Ahlstrand I, Thyberg I, Falkmer T, Dahlstrom O, Bjork M. Pain and activity limitations in women and men with contemporary treated early RA compared to 10\u2009years ago: the Swedish TIRA project. Scand J Rheumatol. 2015;44(4):259\u201364. https:\/\/doi.org\/10.3109\/03009742.2014.997285.","journal-title":"Scand J Rheumatol"},{"issue":"4","key":"2550_CR5","first-page":"291","volume":"43","author":"T Martins Rocha","year":"2018","unstructured":"Martins Rocha T, Pimenta S, Bernardo A, Bernardes M, Barbosa M, Lucas R, et al. Determinants of non-nociceptive pain in rheumatoid arthritis. Acta Reumatol Portuguesa. 2018;43(4):291\u2013303.","journal-title":"Acta Reumatol Portuguesa"},{"key":"2550_CR6","doi-asserted-by":"publisher","unstructured":"Olofsson T, Wallman JK, J\u00f6ud A, Schelin ME, Ernestam S, van Vollenhoven R, et al. Pain over 2\u2009years after start of biological versus conventional combination treatment in early rheumatoid arthritis: results from the randomised controlled SWEFOT trial. Arthritis Care Res. 2020. https:\/\/doi.org\/10.1002\/acr.24264.","DOI":"10.1002\/acr.24264"},{"issue":"8","key":"2550_CR7","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/acr.22790","volume":"68","author":"R Altawil","year":"2016","unstructured":"Altawil R, Saevarsdottir S, Wedr\u00e9n S, Alfredsson L, Klareskog L, Lampa J. Remaining pain in early rheumatoid arthritis patients treated with methotrexate. Arthritis Care Res. 2016;68(8):1061\u20138. https:\/\/doi.org\/10.1002\/acr.22790.","journal-title":"Arthritis Care Res."},{"issue":"6","key":"2550_CR8","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.jpain.2019.01.001","volume":"20","author":"DF McWilliams","year":"2019","unstructured":"McWilliams DF, Dawson O, Young A, Kiely PDW, Ferguson E, Walsh DA. Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts. J Pain. 2019;20(6):716\u201327. https:\/\/doi.org\/10.1016\/j.jpain.2019.01.001.","journal-title":"J Pain"},{"issue":"5","key":"2550_CR9","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s11914-018-0473-5","volume":"16","author":"A Zhang","year":"2018","unstructured":"Zhang A, Lee YC. Mechanisms for joint pain in rheumatoid arthritis (RA): from cytokines to central sensitization. Curr Osteoporos Reports. 2018;16(5):603\u201310. https:\/\/doi.org\/10.1007\/s11914-018-0473-5.","journal-title":"Curr Osteoporos Reports"},{"issue":"2","key":"2550_CR10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/ar3306","volume":"13","author":"YC Lee","year":"2011","unstructured":"Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther. 2011;13(2):211. https:\/\/doi.org\/10.1186\/ar3306.","journal-title":"Arthritis Res Ther."},{"issue":"16","key":"2550_CR11","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.3109\/09638288.2012.731469","volume":"35","author":"C Friden","year":"2013","unstructured":"Friden C, Thoors U, Glenmark B, Kosek E, Nordmark B, Lundberg IE, et al. Higher pain sensitivity and lower muscle strength in postmenonpausal women with early rheumatoid arthritis compared with age-matched healthy women--a pilot study. Disabil Rehabil. 2013;35(16):1350\u20136. https:\/\/doi.org\/10.3109\/09638288.2012.731469.","journal-title":"Disabil Rehabil"},{"issue":"21-22","key":"2550_CR12","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1111\/j.1365-2702.2010.03335.x","volume":"19","author":"HC Lee","year":"2010","unstructured":"Lee HC, Tsai YF, Luo SF, Tsay PK. Predictors of disability in Taiwanese patients with rheumatoid arthritis. J Clin Nurs. 2010;19(21-22):2989\u201396. https:\/\/doi.org\/10.1111\/j.1365-2702.2010.03335.x.","journal-title":"J Clin Nurs"},{"issue":"4","key":"2550_CR13","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00296-014-3134-8","volume":"35","author":"P Goulia","year":"2015","unstructured":"Goulia P, Voulgari PV, Tsifetaki N, Andreoulakis E, Drosos AA, Carvalho AF, et al. Sense of coherence and self-sacrificing defense style as predictors of psychological distress and quality of life in rheumatoid arthritis: a 5-year prospective study. Rheumatol Int. 2015;35(4):691\u2013700. https:\/\/doi.org\/10.1007\/s00296-014-3134-8.","journal-title":"Rheumatol Int"},{"issue":"4","key":"2550_CR14","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s10067-014-2759-z","volume":"34","author":"AM Rathbun","year":"2015","unstructured":"Rathbun AM, Harrold LR, Reed GW. Temporal associations between the different domains of rheumatoid arthritis disease activity and the onset of patient-reported depressive symptoms. Clin Rheumatol. 2015;34(4):653\u201363. https:\/\/doi.org\/10.1007\/s10067-014-2759-z.","journal-title":"Clin Rheumatol"},{"issue":"12","key":"2550_CR15","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s10067-013-2337-9","volume":"32","author":"L Heimans","year":"2013","unstructured":"Heimans L, Wevers-de Boer KV, Visser K, Ronday HK, Steup-Beekman GM, van Oosterhout M, et al. The relationship between disease activity and depressive symptoms severity and optimism--results from the IMPROVED study. Clin Rheumatol. 2013;32(12):1751\u20137. https:\/\/doi.org\/10.1007\/s10067-013-2337-9.","journal-title":"Clin Rheumatol"},{"issue":"12","key":"2550_CR16","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1136\/oemed-2018-105171","volume":"75","author":"G Wynne-Jones","year":"2018","unstructured":"Wynne-Jones G, Chen Y, Croft P, Peat G, Wilkie R, Jordan K, et al. Secular trends in work disability and its relationship to musculoskeletal pain and mental health: a time-trend analysis using five cross-sectional surveys (2002-2010) in the general population. Occup Environ Med. 2018;75(12):877\u201383. https:\/\/doi.org\/10.1136\/oemed-2018-105171.","journal-title":"Occup Environ Med"},{"issue":"5","key":"2550_CR17","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1136\/annrheumdis-2012-202911","volume":"73","author":"T Olofsson","year":"2014","unstructured":"Olofsson T, Petersson IF, Eriksson JK, Englund M, Simard JF, Nilsson J, et al. Predictors of work disability during the first 3\u2009years after diagnosis in a national rheumatoid arthritis inception cohort. Ann Rheum Dis. 2014;73(5):845\u201353. https:\/\/doi.org\/10.1136\/annrheumdis-2012-202911.","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"2550_CR18","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s00296-012-2619-6","volume":"33","author":"AJ Steiman","year":"2013","unstructured":"Steiman AJ, Pope JE, Thiessen-Philbrook H, Li L, Barnabe C, Kalache F, et al. Non-biologic disease-modifying antirheumatic drugs (DMARDs) improve pain in inflammatory arthritis (IA): a systematic literature review of randomized controlled trials. Rheumatol Int. 2013;33(5):1105\u201320. https:\/\/doi.org\/10.1007\/s00296-012-2619-6.","journal-title":"Rheumatol Int"},{"issue":"7","key":"2550_CR19","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1002\/acr.22787","volume":"68","author":"CL Olsen","year":"2016","unstructured":"Olsen CL, Lie E, Kvien TK, Zangi HA. Predictors of fatigue in rheumatoid arthritis patients in remission or in a low disease activity state. Arthritis Care Res (Hoboken). 2016;68(7):1043\u20138. https:\/\/doi.org\/10.1002\/acr.22787.","journal-title":"Arthritis Care Res (Hoboken)."},{"issue":"5","key":"2550_CR20","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/art.40789","volume":"71","author":"YC Lee","year":"2019","unstructured":"Lee YC, Kremer J, Guan H, Greenberg J, Solomon DH. Chronic opioid use in rheumatoid arthritis: prevalence and predictors. Arthritis Rheumatol (Hoboken, NJ). 2019;71(5):670\u20137.","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"issue":"11","key":"2550_CR21","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1002\/acr.23619","volume":"70","author":"TSJ Olofsson","year":"2018","unstructured":"Olofsson TSJ, Gulfe A, Kristensen LE, Wallman JK. Patient reported outcomes more important than objective inflammatory markers for sick leave in biologics-treated rheumatoid arthritis patients. Arthritis Care Research. 2018;70(11):1712\u20136. https:\/\/doi.org\/10.1002\/acr.23619.","journal-title":"Arthritis Care Research."},{"issue":"1","key":"2550_CR22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13075-018-1575-2","volume":"20","author":"E Rydell","year":"2018","unstructured":"Rydell E, Forslind K, Nilsson J, Jacobsson LTH, Turesson C. Smoking, body mass index, disease activity, and the risk of rapid radiographic progression in patients with early rheumatoid arthritis. Arthritis Res Therapy. 2018;20(1):82. https:\/\/doi.org\/10.1186\/s13075-018-1575-2.","journal-title":"Arthritis Res Therapy"},{"issue":"8","key":"2550_CR23","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/acr2.11062","volume":"1","author":"M Rydholm","year":"2019","unstructured":"Rydholm M, Wikstr\u00f6m I, Hagel S, Jacobsson LTH, Turesson C. The relation between disease activity, patient-reported outcomes, and grip force over time in early rheumatoid arthritis. ACR Open Rheumatology. 2019;1(8):507\u201315. https:\/\/doi.org\/10.1002\/acr2.11062.","journal-title":"ACR Open Rheumatology"},{"issue":"3","key":"2550_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31(3):315\u201324. https:\/\/doi.org\/10.1002\/art.1780310302.","journal-title":"Arthritis Rheum"},{"issue":"4","key":"2550_CR25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3109\/03009748809098795","volume":"17","author":"C Ekdahl","year":"1988","unstructured":"Ekdahl C, Eberhardt K, Andersson SI, Svensson B. Assessing disability in patients with rheumatoid arthritis. Use of a Swedish version of the Stanford health assessment questionnaire. Scand J Rheumatol. 1988;17(4):263\u201371. https:\/\/doi.org\/10.3109\/03009748809098795.","journal-title":"Scand J Rheumatol"},{"issue":"3","key":"2550_CR26","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3109\/11038128.2011.553687","volume":"19","author":"T Nilsen","year":"2012","unstructured":"Nilsen T, Hermann M, Eriksen CS, Dagfinrud H, Mowinckel P, Kjeken I. Grip force and pinch grip in an adult population: reference values and factors associated with grip force. Scand J Occup Ther. 2012;19(3):288\u201396. https:\/\/doi.org\/10.3109\/11038128.2011.553687.","journal-title":"Scand J Occup Ther"},{"issue":"11","key":"2550_CR27","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1002\/acr.21747","volume":"64","author":"F Tubach","year":"2012","unstructured":"Tubach F, Ravaud P, Martin-Mola E, Awada H, Bellamy N, Bombardier C, et al. Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: results from a prospective multinational study. Arthritis Care Res. 2012;64(11):1699\u2013707.","journal-title":"Arthritis Care Res."},{"issue":"2","key":"2550_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/acr.23245","volume":"70","author":"C Lourdudoss","year":"2018","unstructured":"Lourdudoss C, Di Giuseppe D, Wolk A, Westerlind H, Klareskog L, Alfredsson L, et al. Dietary intake of polyunsaturated fatty acids and pain in spite of inflammatory control among methotrexate-treated early rheumatoid arthritis patients. Arthritis Care Res. 2018;70(2):205\u201312. https:\/\/doi.org\/10.1002\/acr.23245.","journal-title":"Arthritis Care Res"},{"issue":"7","key":"2550_CR29","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/acr.20146","volume":"62","author":"A Baillet","year":"2010","unstructured":"Baillet A, Zeboulon N, Gossec L, Combescure C, Bodin LA, Juvin R, et al. Efficacy of cardiorespiratory aerobic exercise in rheumatoid arthritis: meta-analysis of randomized controlled trials. Arthritis Care Res (Hoboken). 2010;62(7):984\u201392. https:\/\/doi.org\/10.1002\/acr.20146.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2550_CR30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ijnurstu.2018.03.008","volume":"82","author":"L Prothero","year":"2018","unstructured":"Prothero L, Barley E, Galloway J, Georgopoulou S, Sturt J. The evidence base for psychological interventions for rheumatoid arthritis: a systematic review of reviews. Int J Nurs Stud. 2018;82:20\u20139. https:\/\/doi.org\/10.1016\/j.ijnurstu.2018.03.008.","journal-title":"Int J Nurs Stud"},{"issue":"1","key":"2550_CR31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00296-016-3481-8","volume":"37","author":"N Hylands-White","year":"2017","unstructured":"Hylands-White N, Duarte RV, Raphael JH. An overview of treatment approaches for chronic pain management. Rheumatol Int. 2017;37(1):29\u201342. https:\/\/doi.org\/10.1007\/s00296-016-3481-8.","journal-title":"Rheumatol Int"},{"issue":"12","key":"2550_CR32","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.jpain.2013.08.007","volume":"14","author":"PH Finan","year":"2013","unstructured":"Finan PH, Goodin BR, Smith MT. The association of sleep and pain: an update and a path forward. J Pain. 2013;14(12):1539\u201352. https:\/\/doi.org\/10.1016\/j.jpain.2013.08.007.","journal-title":"J Pain"},{"issue":"2","key":"2550_CR33","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3899\/jrheum.080147","volume":"36","author":"O Schieir","year":"2009","unstructured":"Schieir O, Thombs BD, Hudson M, Taillefer S, Steele R, Berkson L, et al. Symptoms of depression predict the trajectory of pain among patients with early inflammatory arthritis: a path analysis approach to assessing change. J Rheumatol. 2009;36(2):231\u20139. https:\/\/doi.org\/10.3899\/jrheum.080147.","journal-title":"J Rheumatol"},{"issue":"12","key":"2550_CR34","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.3899\/jrheum.130493","volume":"40","author":"ML Andersson","year":"2013","unstructured":"Andersson ML, Svensson B, Bergman S. Chronic widespread pain in patients with rheumatoid arthritis and the relation between pain and disease activity measures over the first 5\u2009years. J Rheumatol. 2013;40(12):1977\u201385. https:\/\/doi.org\/10.3899\/jrheum.130493.","journal-title":"J Rheumatol"},{"issue":"1","key":"2550_CR35","doi-asserted-by":"publisher","first-page":"R7","DOI":"10.1186\/ar2591","volume":"11","author":"T Sokka","year":"2009","unstructured":"Sokka T, Toloza S, Cutolo M, Kautiainen H, Makinen H, Gogus F, et al. Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study. Arthritis Res Ther. 2009;11(1):R7. https:\/\/doi.org\/10.1186\/ar2591.","journal-title":"Arthritis Res Ther."},{"issue":"1","key":"2550_CR36","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12891-016-1192-7","volume":"17","author":"DF McWilliams","year":"2016","unstructured":"McWilliams DF, Walsh DA. Factors predicting pain and early discontinuation of tumour necrosis factor-\u03b1-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskelet Disord. 2016;17(1):337. https:\/\/doi.org\/10.1186\/s12891-016-1192-7.","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"2550_CR37","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s13075-016-1186-8","volume":"18","author":"DF McWilliams","year":"2016","unstructured":"McWilliams DF, Ferguson E, Young A, Kiely PD, Walsh DA. Discordant inflammation and pain in early and established rheumatoid arthritis: latent class analysis of early rheumatoid arthritis network and British Society for Rheumatology biologics register data. Arthritis Res Ther. 2016;18(1):295. https:\/\/doi.org\/10.1186\/s13075-016-1186-8.","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"2550_CR38","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1093\/rheumatology\/keu449","volume":"54","author":"PM Ten Klooster","year":"2015","unstructured":"Ten Klooster PM, Vonkeman HE, Oude Voshaar MA, Siemons L, van Riel PL, van de Laar MA. Predictors of satisfactory improvements in pain for patients with early rheumatoid arthritis in a treat-to-target study. Rheumatology (Oxford). 2015;54(6):1080\u20136. https:\/\/doi.org\/10.1093\/rheumatology\/keu449.","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"2550_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.berh.2010.01.011","volume":"25","author":"F Atzeni","year":"2011","unstructured":"Atzeni F, Cazzola M, Benucci M, Di Franco M, Salaffi F, Sarzi-Puttini P. Chronic widespread pain in the spectrum of rheumatological diseases. Best Pract Res Clin Rheumatol. 2011;25(2):165\u201371. https:\/\/doi.org\/10.1016\/j.berh.2010.01.011.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"9","key":"2550_CR40","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s00296-017-3725-2","volume":"37","author":"F Heidari","year":"2017","unstructured":"Heidari F, Afshari M, Moosazadeh M. Prevalence of fibromyalgia in general population and patients, a systematic review and meta-analysis. Rheumatol Int. 2017;37(9):1527\u201339. https:\/\/doi.org\/10.1007\/s00296-017-3725-2.","journal-title":"Rheumatol Int"},{"issue":"6","key":"2550_CR41","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3109\/03009742.2016.1139174","volume":"45","author":"AW Christensen","year":"2016","unstructured":"Christensen AW, Rifbjerg-Madsen S, Christensen R, Dreyer L, Tillings\u00f8e H, Seven S, et al. Non-nociceptive pain in rheumatoid arthritis is frequent and affects disease activity estimation: cross-sectional data from the FRAME study. Scand J Rheumatol. 2016;45(6):461\u20139. https:\/\/doi.org\/10.3109\/03009742.2016.1139174.","journal-title":"Scand J Rheumatol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-021-02550-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-021-02550-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-021-02550-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T10:05:36Z","timestamp":1623665136000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-021-02550-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,14]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2550"],"URL":"https:\/\/doi.org\/10.1186\/s13075-021-02550-7","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,14]]},"assertion":[{"value":"16 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Regional Ethical Review Board for southern Sweden (Lund, Sweden: LU 410-94), and was conducted in accordance with the declaration of Helsinki. All participants gave their written informed consent to participate in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"C.T. has received consulting fees from Roche, speaking fees from Abbvie, Bristol Myers-Squibb, Pfizer and Roche, and an unrestricted grant from Bristol Myers-Squibb. T.M. is an employee of the pharmaceutical company Novartis, working as medical advisor in rheumatology. Jacobsson L.T.H. has received lecture and consulting fees from Pfizer, Abbvie, Novartis, Eli-Lily, and Janssen. T.O. has performed consulting tasks for Eli Lilly, and Merck Sharp & Dohme unrelated to the present work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"169"}}