{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:58:09Z","timestamp":1781848689622,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by specific vascular and obstetric manifestations and by antiphospholipid antibodies (aPL) positivity. Microvascular damage in the course of APS and \u201caPL carrier\u201d patients without symptoms is poorly investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study aims to compare nailfold videocapillaroscopy (NVC) microvascular parameters in APS patients and non-symptomatic \"aPL carriers\" and to investigate their possible correlations with different aPL subtypes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>NVC was performed during standard evaluations in 18 APS patients (mean age 50 \u00b1 13.8\u2009years), 24 \"aPL carriers\" without symptoms (mean age 46.4 \u00b1 16.4\u2009years), and 18 control patients (CTR) (mean age 74 \u00b1 12.5\u2009years) taking oral anticoagulants for non-immunological indications (i.e., cardiovascular accidents). All patients were investigated for the presence of dilated capillaries, giant capillaries, microhemorrhages, capillary loss, and further non-specific\/specific abnormalities (i.e., branched \u201cbushy\u201d capillaries, sign of neoangiogenesis) by NVC. Every alteration was also classified according to a semi-quantitative score. Lupus anticoagulant, anticardiolipin antibodies, and antibeta2 glycoprotein I antibodies were tested in each patient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>APS patients showed at NVC increased frequency of microhemorrhages (<jats:italic>p<\/jats:italic> = 0.039)\u2014particularly a \u201ccomb-like\u201d pattern (parallel hemorrhages) (<jats:italic>p<\/jats:italic> = 0.002)\u2014than \"aPL carriers\". Of note, there were no significant differences concerning the isolated number of microhemorrhages between APS and the CTR group (<jats:italic>p<\/jats:italic> = 0.314), but \u201ccomb-like\u201d hemorrhages were significantly more frequent in the APS group (<jats:italic>p<\/jats:italic> = 0.034). Not any significant correlation was found between the aPL subtypes and NVC parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>APS patients showed significantly a greater number of non-specific NVC abnormalities than \"aPL carriers\", particularly the \u201ccomb-like\u201d NVC pattern. Oral anticoagulants may represent a confounding factor for isolated microhemorrhages. Not any correlation was found between aPL subtypes and NVC parameters. Further investigations are needed to better characterize the microvascular endothelium damage induced by aPL.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-021-02551-6","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T16:02:22Z","timestamp":1624809742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antiphospholipid antibodies and anticoagulant therapy: capillaroscopic findings"],"prefix":"10.1186","volume":"23","author":[{"given":"Giorgia","family":"Ferrari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Gotelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Paolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaola","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Nanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Maria","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Schenone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Pizzorni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Sulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-0932","authenticated-orcid":false,"given":"Maurizio","family":"Cutolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"issue":"9751","key":"2551_CR1","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/S0140-6736(10)60709-X","volume":"376","author":"G Ruiz-Irastorza","year":"2010","unstructured":"Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA. Antiphospholipid syndrome. Lancet. 2010;376(9751):1498\u2013509. https:\/\/doi.org\/10.1016\/S0140-6736(10)60709-X.","journal-title":"Lancet"},{"issue":"2","key":"2551_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295\u2013306. https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01753.x.","journal-title":"J Thromb Haemost"},{"issue":"4","key":"2551_CR3","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1055\/s-0032-1304719","volume":"38","author":"V Pengo","year":"2012","unstructured":"Pengo V, Banzato A, Bison E, Bracco A, Denas G, Ruffatti A. What have we learned about antiphospholipid syndrome from patients and antiphospholipid carrier cohorts? Semin Thromb Hemost. 2012;38(4):322\u20137. https:\/\/doi.org\/10.1055\/s-0032-1304719.","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"2551_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2019-000924","volume":"5","author":"MG Tektonidou","year":"2019","unstructured":"Tektonidou MG, Andreoli L, Limper M, Tincani A, Ward MM. Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the EULAR recommendations for the management of antiphospholipid syndrome in adults. RMD Open. 2019;5(1):e000924. https:\/\/doi.org\/10.1136\/rmdopen-2019-000924.","journal-title":"RMD Open."},{"issue":"9","key":"2551_CR5","first-page":"444","volume":"89","author":"M Candela","year":"1998","unstructured":"Candela M, Pansoni A, De Carolis ST, et al. Nailfold capillary microscopy in patients with antiphospholipid syndrome. Recenti Prog Med. 1998;89(9):444\u20139.","journal-title":"Recenti Prog Med"},{"key":"2551_CR6","first-page":"141","volume-title":"Atlas of capillaroscopy in rheumatic diseases","author":"M Cutolo","year":"2010","unstructured":"Cutolo M. The most important capillaroscopic parameters in normal and pathological conditions. In: Cutolo M, editor. Atlas of capillaroscopy in rheumatic diseases. Milano: Elsevier; 2010. p. 141\u20133."},{"issue":"6","key":"2551_CR7","first-page":"1574","volume":"27","author":"A Sulli","year":"2000","unstructured":"Sulli A, Pizzorni C, Cutolo M. Nailfold videocapillaroscopy abnormalities in patients with antiphospholipid antibodies. J Rheumatol. 2000;27(6):1574\u20136.","journal-title":"J Rheumatol"},{"issue":"6","key":"2551_CR8","doi-asserted-by":"publisher","first-page":"e158","DOI":"10.1016\/j.ejim.2011.07.007","volume":"22","author":"A Pyrpasopoulou","year":"2011","unstructured":"Pyrpasopoulou A, Triantafyllou A, Anyfanti P, Douma S, Aslanidis S. Capillaroscopy as a screening test for clinical antiphospholipid syndrome. Eur J Intern Med. 2011;22(6):e158\u20139. https:\/\/doi.org\/10.1016\/j.ejim.2011.07.007.","journal-title":"Eur J Intern Med"},{"issue":"9","key":"2551_CR9","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/art.40930","volume":"71","author":"M Aringer","year":"2019","unstructured":"Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. European League Against Rheumatism\/American College of Rheumatology classification criteria for systemic lupus erythematosus. Arthritis Rheumatol. 2019;71(9):1400\u201312. https:\/\/doi.org\/10.1002\/art.40930.","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"2551_CR10","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","volume":"65","author":"F Van den Hoogen","year":"2013","unstructured":"Van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative. Arthritis Rheum. 2013;65(11):2737\u201347. https:\/\/doi.org\/10.1002\/art.38098.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2551_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","volume":"69","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, et al. 2016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol. 2017;69(1):35\u201345. https:\/\/doi.org\/10.1002\/art.39859.","journal-title":"Arthritis Rheumatol"},{"key":"2551_CR12","first-page":"41","volume-title":"Mixed connective tissue disease and antinuclear antibodies","author":"R Kasukawa","year":"1987","unstructured":"Kasukawa R, Tojo T, Miyawaki S. Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: Kasukawa R, Sharp G, editors. Mixed connective tissue disease and antinuclear antibodies. Amsterdam: Elsevier; 1987. p. 41\u20137."},{"issue":"12","key":"2551_CR13","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1136\/annrheumdis-2017-211468","volume":"76","author":"IE Lundberg","year":"2017","unstructured":"Lundberg IE, Tj\u00e4rnlund A, Bottai M, Werth VP, Pilkington C, Visser M, et al. 2017 European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017;76(12):1955\u201364. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211468.","journal-title":"Ann Rheum Dis"},{"key":"2551_CR14","doi-asserted-by":"publisher","first-page":"102458","DOI":"10.1016\/j.autrev.2020.102458","volume":"19","author":"V Smith","year":"2020","unstructured":"Smith V, Herrick AL, Ingegnoli F, EULAR Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium Group on Capillaroscopy, et al. Standardization of nailfold capillaroscopy for the assessment of patients with Raynaud\u2019s phenomenon and systemic sclerosis. Autoimmun Rev. 2020;19:102458.","journal-title":"Autoimmun Rev"},{"issue":"6","key":"2551_CR15","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.berh.2008.09.001","volume":"22","author":"M Cutolo","year":"2008","unstructured":"Cutolo M, Pizzorni C, Secchi ME, Sulli A. Capillaroscopy. Best Pract Res Clin Rheumatol. 2008;22(6):1093\u2013108. https:\/\/doi.org\/10.1016\/j.berh.2008.09.001.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"6","key":"2551_CR16","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1136\/ard.2007.079756","volume":"67","author":"A Sulli","year":"2008","unstructured":"Sulli A, Secchi ME, Pizzorni C, Cutolo M. Scoring the nailfold microvascular changes during the capillaroscopic analysis in systemic sclerosis patients. Ann Rheum Dis. 2008;67(6):885\u20137. https:\/\/doi.org\/10.1136\/ard.2007.079756.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"2551_CR17","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1093\/rheumatology\/kex460","volume":"57","author":"M Cutolo","year":"2018","unstructured":"Cutolo M, Melsens K, Herrick AL, Foeldvari I, Deschepper E, de Keyser F, et al. EULAR Study Group on Microcirculation in Rheumatic Diseases. Reliability of simple capillaroscopic definitions in describing capillary morphology in rheumatic diseases. Rheumatology. 2018;57(4):757\u20139. https:\/\/doi.org\/10.1093\/rheumatology\/kex460.","journal-title":"Rheumatology"},{"issue":"9","key":"2551_CR18","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1007\/s10067-019-04716-w","volume":"38","author":"M Cutolo","year":"2019","unstructured":"Cutolo M, Paolino S, Smith V. Nailfold capillaroscopy in rheumatology: ready for the daily use but with care in terminology. Clin Rheumatol. 2019;38(9):2293\u20137. https:\/\/doi.org\/10.1007\/s10067-019-04716-w.","journal-title":"Clin Rheumatol"},{"issue":"5","key":"2551_CR19","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1093\/rheumatology\/kez374","volume":"59","author":"A Sulli","year":"2020","unstructured":"Sulli A, Paolino S, Pizzorni C, Ferrari G, Pacini G, Pesce G, et al. Progression of nailfold capillaroscopic patterns and correlation with organ involvement in systemic sclerosis: a 12-year study. Rheumatology. 2020;59(5):1051\u20138. https:\/\/doi.org\/10.1093\/rheumatology\/kez374.","journal-title":"Rheumatology"},{"key":"2551_CR20","doi-asserted-by":"publisher","unstructured":"Pizzorni C, Cutolo M, Sulli Aet al. Long-term follow-up of nailfold videocapillaroscopic changes in dermatomyositis versus systemic sclerosis patients. Clin Rheumatol 2018; 37:2723-2729, 10, DOI: https:\/\/doi.org\/10.1007\/s10067-018-4211-2.","DOI":"10.1007\/s10067-018-4211-2"},{"issue":"12","key":"2551_CR21","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1007\/s10067-019-04710-2","volume":"38","author":"C Soubrier","year":"2019","unstructured":"Soubrier C, Seguier J, Di Costanzo MP, et al. Nailfold videocapillaroscopy alterations in dermatomyositis, antisynthetase syndrome, overlap myositis, and immune-mediated necrotizing myopathy. Clin Rheumatol. 2019;38(12):3451\u20138. https:\/\/doi.org\/10.1007\/s10067-019-04710-2.","journal-title":"Clin Rheumatol"},{"issue":"Suppl 119","key":"2551_CR22","first-page":"102","volume":"37","author":"S Paolino","year":"2019","unstructured":"Paolino S, Ferrari G, Pizzorni C, et al. Long-term follow-up of nailfold videocapillaroscopic microvascular parameters in mixed connective tissue disease versus systemic sclerosis patients: a retrospective cohort study. Clin Exp Rheumatol. 2019;37(Suppl 119):102\u20137.","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"2551_CR23","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.autrev.2017.11.025","volume":"17","author":"M Cutolo","year":"2018","unstructured":"Cutolo M, Melsens K, Wijnant S, Ingegnoli F, Thevissen K, de Keyser F, et al. Nailfold capillaroscopy in systemic lupus erythematosus: a systematic review and critical appraisal. Autoimmun Rev. 2018;17(4):344\u201352. https:\/\/doi.org\/10.1016\/j.autrev.2017.11.025.","journal-title":"Autoimmun Rev"},{"issue":"Suppl 126","key":"2551_CR24","first-page":"150","volume":"38","author":"K Melsens","year":"2020","unstructured":"Melsens K, Leone MC, Paolino S, et al. Nailfold capillaroscopy in Sj\u00f6gren\u2019s syndrome: a systematic literature review and standardised interpretation. Clin Exp Rheumatol. 2020;38(Suppl 126):150\u20137.","journal-title":"Clin Exp Rheumatol"},{"issue":"8","key":"2551_CR25","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/rheumatology\/keh233","volume":"43","author":"JL Vaz","year":"2004","unstructured":"Vaz JL, Dancour MA, Bottino DA, Bouskela E. Nailfold videocapillaroscopy in primary antiphospholipid syndrome (PAPS). Rheumatology. 2004;43(8):1025\u20137. https:\/\/doi.org\/10.1093\/rheumatology\/keh233.","journal-title":"Rheumatology"},{"issue":"2","key":"2551_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00296-019-04427-0","volume":"40","author":"V Bernardino","year":"2020","unstructured":"Bernardino V, Rodrigues A, Llad\u00f3 A, Panarra A. Nailfold capillaroscopy and autoimmune connective tissue diseases in patients from a Portuguese nailfold capillaroscopy clinic. Rheumatol Int. 2020;40(2):295\u2013301. https:\/\/doi.org\/10.1007\/s00296-019-04427-0.","journal-title":"Rheumatol Int"},{"issue":"1","key":"2551_CR27","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s13075-019-2032-6","volume":"21","author":"F Pignataro","year":"2019","unstructured":"Pignataro F, Maglione W, Minniti A, Sambataro D, Sambataro G, Campanaro F, et al. NEMO score in nailfold videocapillaroscopy is a good tool to assess both steady state levels and overtime changes of disease activity in patients with systemic sclerosis: a comparison with the proposed composite indices for this disease status entity. Arthritis Res Ther. 2019;21(1):258. https:\/\/doi.org\/10.1186\/s13075-019-2032-6.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2551_CR28","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s13075-017-1354-5","volume":"19","author":"R Andracco","year":"2017","unstructured":"Andracco R, Irace R, Zaccara E, Vettori S, Maglione W, Riccardi A, et al. The cumulative number of micro-haemorrhages and micro-thromboses in nailfold videocapillaroscopy is a good indicator of disease activity in systemic sclerosis: a validation study of the NEMO score. Arthritis Res Ther. 2017;19(1):133. https:\/\/doi.org\/10.1186\/s13075-017-1354-5.","journal-title":"Arthritis Res Ther"},{"issue":"5-6","key":"2551_CR29","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.thromres.2004.06.045","volume":"114","author":"PL Meroni","year":"2004","unstructured":"Meroni PL, Borghi MO, Raschi E, Ventura D, Sarzi Puttini PC, Atzeni F, et al. Inflammatory response and the endothelium. Thromb Res. 2004;114(5-6):329\u201334. https:\/\/doi.org\/10.1016\/j.thromres.2004.06.045.","journal-title":"Thromb Res"},{"issue":"2","key":"2551_CR30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/ar4549","volume":"16","author":"PL Meroni","year":"2014","unstructured":"Meroni PL, Chighizola CB, Rovelli F, Gerosa M. Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers. Arthritis Res Ther. 2014;16(2):209. https:\/\/doi.org\/10.1186\/ar4549.","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"2551_CR31","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1177\/096120339500400211","volume":"4","author":"O Bongard","year":"1995","unstructured":"Bongard O, Bounameaux H, Miescher PA, De Moerloose P. Association of anticardiolipin antibodies and abnormal nailfold capillaroscopy in patients with systemic lupus erythematosus. Lupus. 1995;4(2):142\u20134. https:\/\/doi.org\/10.1177\/096120339500400211.","journal-title":"Lupus"},{"issue":"2","key":"2551_CR32","first-page":"307","volume":"29","author":"S Aslanidis","year":"2011","unstructured":"Aslanidis S, Pyrpasopoulou A, Doumas M, Triantafyllou A, Chatzimichailidou S, Zamboulis C. Association of capillaroscopic microhaemorrhages with clinical and immunological antiphospholipid syndrome. Clin Exp Rheumatol. 2011;29(2):307\u20139.","journal-title":"Clin Exp Rheumatol"},{"issue":"8","key":"2551_CR33","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","volume":"129","author":"SS Chugh","year":"2014","unstructured":"Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129(8):837\u201347. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.005119.","journal-title":"Circulation"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-021-02551-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-021-02551-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-021-02551-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T16:03:44Z","timestamp":1624809824000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-021-02551-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,27]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2551"],"URL":"https:\/\/doi.org\/10.1186\/s13075-021-02551-6","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,27]]},"assertion":[{"value":"22 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice. All the patients signed the written informed consent to manage their clinical data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"175"}}