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Because we have limited knowledge whether RPF is associated with malignancy, we aimed to investigate the relationship between RPF and malignancy and to compare the characteristics and prognosis of cancers among patients with RPF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Medical records of 111 patients diagnosed as having RPF were reviewed and 38 cases of cancer, confirmed by biopsy, were identified. Standardized incidence ratios (\n                      <jats:italic>SIR<\/jats:italic>\n                      s) were calculated for cancers and stratified according to cancer type and RPF-cancer diagnosis interval. Cancer characteristics and outcomes were compared between RPF-cancer diagnosis intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average age at RPF diagnosis was 59.2 \u00b1 15.0 years, and 69.4% of the patients were male. The cancer\n                      <jats:italic>SIR<\/jats:italic>\n                      s in patients with RPF relative to age- and sex-matched individuals in the general population was 2.2 (1.6\u20133.1).\n                      <jats:italic>SIR<\/jats:italic>\n                      s of renal pelvis cancer and multiple myeloma were significantly higher than in the general population. When stratified by RPF-cancer intervals, the\n                      <jats:italic>SIR<\/jats:italic>\n                      for cancer was 9.9 within 1 year of RPF diagnosis, while no significant increase in the\n                      <jats:italic>SIR<\/jats:italic>\n                      was found after 1 year from RPF diagnosis. Cancer stage was more advanced at the time of diagnosis in patients within a 1-year interval for RPF than those with cancer within a &gt;5-year interval, with a correspondingly increased mortality in the former patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RPF was significantly associated with malignancy, particularly those diagnosed within 1 year of RPF diagnosis. Cancer stages at diagnosis were more advanced and the mortality rate was higher in patients within a 1-year interval between RPF and cancer diagnosis than in those with a &gt;5-year interval between diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13075-021-02627-3","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T12:06:20Z","timestamp":1632657980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of retroperitoneal fibrosis with malignancy and its outcomes"],"prefix":"10.1186","volume":"23","author":[{"given":"Sang Jin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Su","family":"Eun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Wook","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-0729","authenticated-orcid":false,"given":"Young Mo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"issue":"9506","key":"2627_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0140-6736(06)68035-5","volume":"367","author":"A Vaglio","year":"2006","unstructured":"Vaglio A, Salvarani C, Buzio C. 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