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The median follow-up time was 7 (3\u201310) years [median (25th\u201375th percentile)]. Clinical manifestations at admission were used to subdivide patients with AOSD as follows: systemic inflammation (cluster 1), pure (cluster 2), and intermediate (cluster 3). Each subtype had distinct clinical manifestations and prognoses: cluster 1 (34.6%)\u2014multiple organ manifestations, highest infection rate and mortality, and more than half of the patients with at least one relapse during follow-up; cluster 2 (21.3%)\u2014exclusively female, rash and joint involvement, no internal organ involvement, no mortality, and most of the patients with a monocyclic course; and cluster 3 (44.1%)\u2014less infection rate, no serious complications, and lower mortality rate. The 5- and 10-year survival rates after diagnosis were 92.4% and 86.9%, respectively. Independent risk factors for mortality were age at onset \u226550 (hazard ratio (HR): 6.78, 95% CI: 2.10\u201321.89), hepatomegaly (HR: 5.05, 95% CI: 1.44\u201317.70), infection (HR: 15.56, 95% CI: 5.88\u201341.20), and MAS (HR: 26.82, 95% CI: 7.52\u201395.60).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Three subtypes of AOSD were identified with distinct clinical manifestations and prognoses. Age at onset \u226550, hepatomegaly, infection, and MAS were prognostic factors for AOSD mortality.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-021-02688-4","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T06:03:20Z","timestamp":1638943400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical phenotypes and prognostic factors of adult-onset Still\u2019s disease: data from a large inpatient cohort"],"prefix":"10.1186","volume":"23","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-6038","authenticated-orcid":false,"given":"Liangjing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"issue":"5","key":"2688_CR1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/ard.2005.042143","volume":"65","author":"P Efthimiou","year":"2006","unstructured":"Efthimiou P, Paik PK, Bielory L. 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