{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:22:00Z","timestamp":1790709720949,"version":"4.1.0"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010782","name":"exzellenzclusters entz\u00fcndungsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Max Planck Institute for Evolutionary Biology"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone disease for which a lack of bacterial involvement is a key diagnostic feature to distinguish it from other symptomatically related diseases. However, the growing evidence suggesting an involvement of the host-associated microbiota in rheumatic disorders together with the now wide accessibility of modern culture-independent methods warrant a closer examination of CRMO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we show through bacterial 16S rRNA gene profiling that numerous features of the oral- and fecal microbial communities differentiate children with and without CRMO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Notably, communities in diseased children are characterized by a lack of potential probiotic bacteria in the fecal community and an overabundance of known pathobionts in the oral microbial communities. Of special interest is the HACEK group, a set of commonly known oral pathogens that are implicated in the development of several acute and chronic diseases such as osteitis and rheumatoid arthritis. Furthermore, we observe that gut bacterial communities in the diseased children\u00a0appear to reflect an altered host physiology more strongly than the oral community, which could suggest an oral disease\u00a0origin followed by propagation and\/or responses beyond the oral cavity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bacterial communities, in particular the oral microbiota, may serve as an indicator of underlying susceptibility to CRMO, or play a yet undefined role in its development.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13075-021-02711-8","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T10:03:08Z","timestamp":1645524188000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis"],"prefix":"10.1186","volume":"24","author":[{"given":"Philipp","family":"Rausch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Baines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"von Bismarck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"issue":"3","key":"2711_CR1","first-page":"329","volume":"15","author":"A Giedion","year":"1972","unstructured":"Giedion A, Holthusen W, Masel LF, Vischer D. Subacute and chronic \u201csymmetrical\u201d osteomyelitis. Annales de Radiologie (Paris). 1972;15(3):329\u201342.","journal-title":"Annales de Radiologie (Paris)"},{"issue":"6","key":"2711_CR2","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.jbspin.2011.02.010","volume":"78","author":"J Wipff","year":"2011","unstructured":"Wipff J, Adamsbaum C, Kahan A, Job-Deslandre C. Chronic recurrent multifocal osteomyelitis. Joint Bone Spine. 2011;78(6):555\u201360.","journal-title":"Joint Bone Spine"},{"issue":"5","key":"2711_CR3","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/BOR.0b013e32825f5492","volume":"19","author":"PJ Ferguson","year":"2007","unstructured":"Ferguson PJ, El-Shanti HI. Autoinflammatory bone disorders. Curr Opin Rheumatol. 2007;19(5):492\u20138.","journal-title":"Curr Opin Rheumatol"},{"issue":"7","key":"2711_CR4","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1002\/art.10539","volume":"46","author":"AD Wagner","year":"2002","unstructured":"Wagner AD, Andresen J, Jendro MC, H\u00fclsemann JL, Zeidler H. Sustained response to tumor necrosis factor \u03b1\u2013blocking agents in two patients with SAPHO syndrome. Arthritis Rheum. 2002;46(7):1965\u20138.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2711_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/rheumatology\/kel190","volume":"46","author":"A Jansson","year":"2007","unstructured":"Jansson A, Renner ED, Ramser J, Mayer A, Haban M, Meindl A, et al. Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford, England). 2007;46(1):154\u201360.","journal-title":"Rheumatology (Oxford, England)"},{"issue":"6","key":"2711_CR6","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/s11914-017-0405-9","volume":"15","author":"SR Hofmann","year":"2017","unstructured":"Hofmann SR, Kapplusch F, Girschick HJ, Morbach H, Pablik J, Ferguson PJ, et al. Chronic recurrent multifocal osteomyelitis (CRMO): presentation, pathogenesis, and treatment. Curr Osteopor Rep. 2017;15(6):542\u201354.","journal-title":"Curr Osteopor Rep"},{"issue":"9","key":"2711_CR7","doi-asserted-by":"publisher","first-page":"737.e733","DOI":"10.1016\/j.crad.2019.02.021","volume":"74","author":"S Andronikou","year":"2019","unstructured":"Andronikou S, Mendes da Costa T, Hussien M, Ramanan AV. Radiological diagnosis of chronic recurrent multifocal osteomyelitis using whole-body MRI-based lesion distribution patterns. Clin Radiol. 2019;74(9):737.e733\u201315.","journal-title":"Clin Radiol"},{"issue":"1","key":"2711_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/1529-0131(200001)43:1<109::AID-ANR14>3.0.CO;2-3","volume":"43","author":"O Vittecoq","year":"2000","unstructured":"Vittecoq O, Ait Said L, Michot C, Mejjad O, Thomine J-M, Mitrofanoff P, et al. Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term. Arthritis Rheum. 2000;43(1):109\u201319.","journal-title":"Arthritis Rheum"},{"issue":"8","key":"2711_CR9","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1007\/s004310000500","volume":"159","author":"BC Beretta-Piccoli","year":"2000","unstructured":"Beretta-Piccoli BC, Sauvain MJ, Gal I, Schibler A, Saurenmann T, Kressebuch H, et al. Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: a report of ten cases and review of the literature. Eur J Pediatr. 2000;159(8):594\u2013601.","journal-title":"Eur J Pediatr"},{"issue":"11","key":"2711_CR10","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1097\/00000478-199611000-00008","volume":"20","author":"JD Reith","year":"1996","unstructured":"Reith JD, Bauer TW, Schils JP. Osseous manifestations of SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome. Am J Surg Pathol. 1996;20(11):1368\u201377.","journal-title":"Am J Surg Pathol"},{"key":"2711_CR11","unstructured":"Voit A. Bakterielle osteomyelitis und Nichtbakterielle Osteitis(NBO): Eine vergleichende Datenerhebung zur Inzidenz und klinischen manifestation der beiden Erkrankungen im Kindesalter und zus\u00e4tzliche Betrachtung des Langzeitverlaufs der NBO. Dissertation. Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen. 2013."},{"key":"2711_CR12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1546-0096-11-47","volume":"11","author":"CM Hedrich","year":"2013","unstructured":"Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ. Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 2013;11:47.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"3","key":"2711_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/sj.ejhg.5200789","volume":"10","author":"A Golla","year":"2002","unstructured":"Golla A, Jansson A, Ramser J, Hellebrand H, Zahn R, Meitinger T, et al. Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a susceptibility gene located on chromosome 18q21.3-18q22. Eur J Hum Genet. 2002;10(3):217.","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"2711_CR14","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.clim.2011.08.012","volume":"141","author":"SR Hofmann","year":"2011","unstructured":"Hofmann SR, Schwarz T, M\u00f6ller JC, Morbach H, Schnabel A, R\u00f6sen-Wolff A, et al. Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression. Clin Immunol. 2011;141(3):317\u201327.","journal-title":"Clin Immunol"},{"issue":"2","key":"2711_CR15","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00296-010-1768-8","volume":"32","author":"J Hamel","year":"2012","unstructured":"Hamel J, Paul D, Gahr M, Hedrich CM. Pilot study: possible association of IL10 promoter polymorphisms with CRMO. Rheumatol Int. 2012;32(2):555\u20136.","journal-title":"Rheumatol Int"},{"issue":"4","key":"2711_CR16","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nri2062","volume":"7","author":"H Takayanagi","year":"2007","unstructured":"Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 2007;7(4):292\u2013304.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2711_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bone.2005.07.009","volume":"38","author":"PJ Ferguson","year":"2006","unstructured":"Ferguson PJ, Bing XY, Vasef MA, Ochoa LA, Mahgoub A, Waldschmidt TJ, et al. A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis. Bone. 2006;38(1):41\u20137.","journal-title":"Bone"},{"issue":"8","key":"2711_CR18","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1093\/hmg\/11.8.961","volume":"11","author":"CA Wise","year":"2002","unstructured":"Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, et al. Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. Hum Mol Genet. 2002;11(8):961\u20139.","journal-title":"Hum Mol Genet"},{"issue":"7","key":"2711_CR19","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2174\/138920210793175921","volume":"11","author":"EJ Smith","year":"2010","unstructured":"Smith EJ, Allantaz F, Bennett L, Zhang D, Gao X, Wood G, et al. Clinical, molecular, and genetic characteristics of PAPA syndrome: a review. Curr Genom. 2010;11(7):519\u201327.","journal-title":"Curr Genom"},{"issue":"7530","key":"2711_CR20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/nature13788","volume":"516","author":"JR Lukens","year":"2014","unstructured":"Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, et al. Dietary modulation of the microbiome affects autoinflammatory disease. Nature. 2014;516(7530):246\u20139.","journal-title":"Nature"},{"issue":"12","key":"2711_CR21","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s004310100799","volume":"160","author":"HA Majeed","year":"2001","unstructured":"Majeed HA, Al-Tarawna M, El-Shanti H, Kamel B, Al-Khalaileh F. The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review. Eur J Pediatr. 2001;160(12):705\u201310.","journal-title":"Eur J Pediatr"},{"issue":"3","key":"2711_CR22","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1136\/annrheumdis-2012-201818","volume":"72","author":"T Herlin","year":"2013","unstructured":"Herlin T, Fiirgaard B, Bjerre M, Kerndrup G, Hasle H, Bing X, et al. Efficacy of anti-IL-1 treatment in Majeed syndrome. Ann Rheum Dis. 2013;72(3):410\u20133.","journal-title":"Ann Rheum Dis"},{"issue":"23","key":"2711_CR23","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1056\/NEJMoa0807865","volume":"360","author":"I Aksentijevich","year":"2009","unstructured":"Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, et al. An autoinflammatory disease with deficiency of the interleukin-1\u2013receptor antagonist. N Engl J Med. 2009;360(23):2426\u201337.","journal-title":"N Engl J Med"},{"issue":"8","key":"2711_CR24","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1093\/rheumatology\/keq122","volume":"49","author":"D Eleftheriou","year":"2010","unstructured":"Eleftheriou D, Gerschman T, Sebire N, Woo P, Pilkington CA, Brogan PA. Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood. Rheumatology. 2010;49(8):1505\u201312.","journal-title":"Rheumatology"},{"issue":"7","key":"2711_CR25","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1093\/rheumatology\/keq074","volume":"49","author":"M Colina","year":"2010","unstructured":"Colina M, Pizzirani C, Khodeir M, Falzoni S, Bruschi M, Trotta F, et al. Dysregulation of P2X7 receptor-inflammasome axis in SAPHO syndrome: successful treatment with anakinra. Rheumatology. 2010;49(7):1416\u20138.","journal-title":"Rheumatology"},{"issue":"6","key":"2711_CR26","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1007\/s00296-011-2020-x","volume":"32","author":"J Rech","year":"2012","unstructured":"Rech J, Manger B, Lang B, Schett G, Wilhelm M, Birkmann J. Adult-onset Still\u2019s disease and chronic recurrent multifocal osteomyelitis: a hitherto undescribed manifestation of autoinflammation. Rheumatol Int. 2012;32(6):1827\u20139.","journal-title":"Rheumatol Int"},{"issue":"5","key":"2711_CR27","doi-asserted-by":"publisher","first-page":"e1190","DOI":"10.1542\/peds.2011-3788","volume":"130","author":"A Borzutzky","year":"2012","unstructured":"Borzutzky A, Stern S, Reiff A, Zurakowski D, Steinberg EA, Dedeoglu F, et al. Pediatric chronic nonbacterial osteomyelitis. Pediatrics. 2012;130(5):e1190\u20137.","journal-title":"Pediatrics"},{"issue":"1","key":"2711_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.clim.2012.07.012","volume":"145","author":"SR Hofmann","year":"2012","unstructured":"Hofmann SR, Morbach H, Schwarz T, R\u00f6sen-Wolff A, Girschick HJ, Hedrich CM. Attenuated TLR4\/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression. Clin Immunol. 2012;145(1):69\u201376.","journal-title":"Clin Immunol"},{"issue":"Suppl 1","key":"2711_CR29","doi-asserted-by":"publisher","first-page":"O28","DOI":"10.1186\/1546-0096-13-S1-O28","volume":"13","author":"S Hofmann","year":"2015","unstructured":"Hofmann S, Kubasch A, R\u00f6sen-Wolff A, Girschick H, Morbach H, Hedrich C. Altered expression of IL-10 family cytokines in CRMO result in enhanced inflammasome activation. Pediatr Rheumatol Online J. 2015;13(Suppl 1):O28.","journal-title":"Pediatr Rheumatol Online J"},{"key":"2711_CR30","doi-asserted-by":"crossref","unstructured":"Young S, Sharma N, Lee JH, Chitu V, Neumeister V, Sohr E, Stanley ER, Hedrich CM, Craig AWB. Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis. Dis Model Mech. 2019;12(8):1\u20139.","DOI":"10.1242\/dmm.040097"},{"issue":"12","key":"2711_CR31","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1002\/eji.201847504","volume":"48","author":"M De Zuani","year":"2018","unstructured":"De Zuani M, Dal Secco C, Frossi B. Mast cells at the crossroads of microbiota and IBD. Eur J Immunol. 2018;48(12):1929\u201337.","journal-title":"Eur J Immunol"},{"issue":"03","key":"2711_CR32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1055\/s-2004-835364","volume":"8","author":"AG Jurik","year":"2004","unstructured":"Jurik AG. Chronic recurrent multifocal osteomyelitis. Semin Musculoskelet Radiol. 2004;8(03):243\u201353.","journal-title":"Semin Musculoskelet Radiol"},{"issue":"5","key":"2711_CR33","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1136\/gutjnl-2016-313235","volume":"66","author":"V Pascal","year":"2017","unstructured":"Pascal V, Pozuelo M, Borruel N, Casellas F, Campos D, Santiago A, et al. A microbial signature for Crohn's disease. Gut. 2017;66(5):813\u201322.","journal-title":"Gut"},{"key":"2711_CR34","first-page":"1","volume-title":"P\u00e4diatrie: Grundlagen und praxis","author":"O Oster","year":"2015","unstructured":"Oster O. P\u00e4diatrisch relevante Referenzwerte: klinische Chemie. In: Hoffmann GF, Lentze MJ, Spranger J, Zepp F, editors. P\u00e4diatrie: Grundlagen und praxis. Berlin, Heidelberg: Springer Berlin Heidelberg; 2015. p. 1\u201367."},{"issue":"19","key":"2711_CR35","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","volume":"26","author":"RC Edgar","year":"2010","unstructured":"Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010;26(19):2460\u20131.","journal-title":"Bioinformatics"},{"key":"2711_CR36","unstructured":"Hannon G: FASTX-Toolkit. In. http:\/\/hannonlab.cshl.edu\/fastx_toolkit; 2010."},{"issue":"16","key":"2711_CR37","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","volume":"27","author":"RC Edgar","year":"2011","unstructured":"Edgar RC, Haas BJ, Clemente JC, Quince C, Knight R. UCHIME improves sensitivity and speed of chimera detection. Bioinformatics. 2011;27(16):2194\u2013200.","journal-title":"Bioinformatics"},{"issue":"16","key":"2711_CR38","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","volume":"73","author":"Q Wang","year":"2007","unstructured":"Wang Q, Garrity GM, Tiedje JM, Cole JR. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol. 2007;73(16):5261\u20137.","journal-title":"Appl Environ Microbiol"},{"issue":"23","key":"2711_CR39","doi-asserted-by":"publisher","first-page":"7537","DOI":"10.1128\/AEM.01541-09","volume":"75","author":"PD Schloss","year":"2009","unstructured":"Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, et al. Introducing mothur: open source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol. 2009;75(23):7537\u201341.","journal-title":"Appl Environ Microbiol"},{"key":"2711_CR40","doi-asserted-by":"crossref","unstructured":"Westcott SL, Schloss PD. OptiClust, an improved method for assigning amplicon-based sequence data to operational taxonomic units. mSphere 2017;2(2):1\u201311.","DOI":"10.1128\/mSphereDirect.00073-17"},{"key":"2711_CR41","volume-title":"R Foundation for Statistical Computing. 3.3.2","author":"Team RC","year":"2016","unstructured":"Team RC. R: a language and environment for statistical computing. In: R Foundation for Statistical Computing. 3.3.2; 2016."},{"key":"2711_CR42","volume-title":"Vegan: community ecology package","author":"J Oksanen","year":"2011","unstructured":"Oksanen J, Blanchet FG, Kindt R, Legendre P, O'Hara RB, Simpson GL, et al. Vegan: community ecology package1.17-6 edn: http:\/\/CRAN.R-project.org; 2011."},{"issue":"4","key":"2711_CR43","doi-asserted-by":"publisher","first-page":"783","DOI":"10.2307\/2531532","volume":"43","author":"A Chao","year":"1987","unstructured":"Chao A. Estimating the population size for capture-recapture data with unequal catchability. Biometrics. 1987;43(4):783\u201391.","journal-title":"Biometrics"},{"issue":"2","key":"2711_CR44","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/j.2006.0030-1299.14714.x","volume":"113","author":"L Jost","year":"2006","unstructured":"Jost L. Entropy and diversity. Oikos. 2006;113(2):363\u201375.","journal-title":"Oikos"},{"key":"2711_CR45","first-page":"1","volume":"20:i-xv","author":"P Legendre","year":"1998","unstructured":"Legendre P, Legendre L. Numerical ecology. Second English edition. Dev Environ Model. 1998;20:i-xv:1\u2013853.","journal-title":"Dev Environ Model"},{"issue":"1","key":"2711_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1890\/0012-9615(1999)069[0001:DBRATM]2.0.CO;2","volume":"69","author":"P Legendre","year":"1999","unstructured":"Legendre P, Anderson MJ. Distance-based redundancy analysis: testing multispecies responses in multifactorial ecological experiments. Ecol Monogr. 1999;69(1):1\u201324.","journal-title":"Ecol Monogr"},{"key":"2711_CR47","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/978-0-387-21706-2_7","volume-title":"Modern applied statistics with S","author":"WN Venables","year":"2002","unstructured":"Venables WN, Ripley BD. Generalized linear models. In: Modern applied statistics with S. New York: Springer New York; 2002. p. 183\u2013210."},{"issue":"3","key":"2711_CR48","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1198\/000313006X118430","volume":"60","author":"T Hothorn","year":"2006","unstructured":"Hothorn T, Hornik K, Van de Wiel MA, Zeileis A. A Lego system for conditional inference. Am Stat. 2006;60(3):257\u201363.","journal-title":"Am Stat"},{"issue":"10","key":"2711_CR49","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1111\/j.1600-0706.2010.18334.x","volume":"119","author":"M De C\u00e1ceres","year":"2010","unstructured":"De C\u00e1ceres M, Legendre P, Moretti M. Improving indicator species analysis by combining groups of sites. Oikos. 2010;119(10):1674\u201384.","journal-title":"Oikos"},{"issue":"1","key":"2711_CR50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B Met. 1995;57(1):289\u2013300.","journal-title":"J Roy Stat Soc B Met"},{"issue":"1","key":"2711_CR51","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1010933404324","volume":"45","author":"L Breiman","year":"2001","unstructured":"Breiman L. Random forests. Mach Learn. 2001;45(1):5\u201332.","journal-title":"Mach Learn"},{"issue":"5","key":"2711_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v028.i05","volume":"28","author":"M Kuhn","year":"2008","unstructured":"Kuhn M. Building predictive models in R using the caret package. J Stat Softw. 2008;28(5):1\u201326.","journal-title":"J Stat Softw"},{"issue":"6","key":"2711_CR53","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1214\/009053607000000505","volume":"35","author":"GJ Sz\u00e9kely","year":"2007","unstructured":"Sz\u00e9kely GJ, Rizzo ML, Bakirov NK. Measuring and testing dependence by correlation of distances. Ann Stat. 2007;35(6):2769\u201394.","journal-title":"Ann Stat"},{"issue":"9","key":"2711_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002687","volume":"8","author":"J Friedman","year":"2012","unstructured":"Friedman J, Alm EJ. Inferring correlation networks from genomic survey data. PLoS Comput Biol. 2012;8(9):e1002687.","journal-title":"PLoS Comput Biol"},{"key":"2711_CR55","volume-title":"InterJournal 2006, complex systems","author":"G Csardi","year":"1695","unstructured":"Csardi G, Nepusz T. The igraph software package for complex network research. In: InterJournal 2006, complex systems; 1695."},{"issue":"1-7","key":"2711_CR56","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0169-7552(98)00110-X","volume":"30","author":"S Brin","year":"1998","unstructured":"Brin S, Page L. The anatomy of a large-scale hypertextual web search engine. Comput Netw Isdn Syst. 1998;30(1-7):107\u201317.","journal-title":"Comput Netw Isdn Syst"},{"issue":"3","key":"2711_CR57","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0378-8733(78)90021-7","volume":"1","author":"LC Freeman","year":"1979","unstructured":"Freeman LC. Centrality in social networks conceptual clarification. Soc Networks. 1979;1(3):215\u201339.","journal-title":"Soc Networks"},{"issue":"4","key":"2711_CR58","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.cell.2014.09.053","volume":"159","author":"JK Goodrich","year":"2014","unstructured":"Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, et al. Human genetics shape the gut microbiome. Cell. 2014;159(4):789\u201399.","journal-title":"Cell"},{"issue":"43","key":"2711_CR59","doi-asserted-by":"publisher","first-page":"16731","DOI":"10.1073\/pnas.0804812105","volume":"105","author":"H Sokol","year":"2008","unstructured":"Sokol H, Pigneur B, Watterlot L, Lakhdari O, Berm\u00fadez-Humar\u00e1n LG, Gratadoux J-J, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci. 2008;105(43):16731\u20136.","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"2711_CR60","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1099\/00207713-50-1-365","volume":"50","author":"MD Collins","year":"2000","unstructured":"Collins MD, Lawson PA. The genus Abiotrophia (Kawamura et al.) is not monophyletic: proposal of Granulicatella gen. Nov., Granulicatella adiacens comb. nov., Granulicatella elegans comb. nov. and Granulicatella balaenopterae comb. nov. Int J Syst Evol Microbiol. 2000;50(1):365\u20139.","journal-title":"Int J Syst Evol Microbiol"},{"issue":"3","key":"2711_CR61","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1086\/314046","volume":"31","author":"MA Bhatti","year":"2000","unstructured":"Bhatti MA, Frank MO. Veillonella parvula meningitis: case report and review of Veillonella infections. Clin Infect Dis. 2000;31(3):839\u201340.","journal-title":"Clin Infect Dis"},{"key":"2711_CR62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.anaerobe.2014.05.003","volume":"28","author":"I Mashima","year":"2014","unstructured":"Mashima I, Nakazawa F. The influence of oral Veillonella species on biofilms formed by streptococcus species. Anaerobe. 2014;28:54\u201361.","journal-title":"Anaerobe"},{"issue":"3","key":"2711_CR63","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1128\/jb.105.3.999-1005.1971","volume":"105","author":"SK Ng","year":"1971","unstructured":"Ng SK, Hamilton IR. Lactate metabolism by Veillonella parvula. J Bacteriol. 1971;105(3):999\u20131005.","journal-title":"J Bacteriol"},{"issue":"3","key":"2711_CR64","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0735-6757(94)90156-2","volume":"12","author":"LA Swisher","year":"1994","unstructured":"Swisher LA, Roberts JR, Glynn MJ. Needle lickers osteomyelitis. Am J Emerg Med. 1994;12(3):343\u20136.","journal-title":"Am J Emerg Med"},{"issue":"12","key":"2711_CR65","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1902\/jop.1992.63.12.941","volume":"63","author":"CK Chen","year":"1992","unstructured":"Chen CK, Wilson ME. Eikenella corrodens in human oral and non-oral infections: a review. J Periodontol. 1992;63(12):941\u201353.","journal-title":"J Periodontol"},{"issue":"4","key":"2711_CR66","first-page":"139","volume":"1","author":"WD Patrick","year":"1990","unstructured":"Patrick WD, Brown WD, Ian Bowmer M, Sinave CP. Infective endocarditis due to Eikenella corrodens: case report and review of the literature. Can J Infect Dis. 1990;1(4):139\u201342.","journal-title":"Can J Infect Dis"},{"issue":"1","key":"2711_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-015-0986-9","volume":"15","author":"N Principi","year":"2015","unstructured":"Principi N, Esposito S. Kingella kingae infections in children. BMC Infect Dis. 2015;15(1):1\u20137.","journal-title":"BMC Infect Dis"},{"issue":"2","key":"2711_CR68","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/00005792-197903000-00003","volume":"58","author":"JJ Ellner","year":"1979","unstructured":"Ellner JJ, Rosenthal MS, Lerner PI, McHenry MC. Infective endocarditis caused by slow-growing, fastidious. Gram-negative bacteria. Medicine. 1979;58(2):145\u201358.","journal-title":"Medicine"},{"issue":"Pt 6","key":"2711_CR69","first-page":"892","volume":"63","author":"HS Yew","year":"2014","unstructured":"Yew HS, Chambers ST, Roberts SA, Holland DJ, Julian KA, Raymond NJ, et al. Association between HACEK bacteraemia and endocarditis. J Med Microbiol. 2014;63(Pt 6):892\u20135.","journal-title":"J Med Microbiol"},{"issue":"5","key":"2711_CR70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063181","volume":"8","author":"ST Chambers","year":"2013","unstructured":"Chambers ST, Murdoch D, Morris A, Holland D, Pappas P, Almela M, et al. HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort. PLoS One. 2013;8(5):e63181.","journal-title":"PLoS One"},{"key":"2711_CR71","doi-asserted-by":"publisher","first-page":"198560","DOI":"10.1155\/2015\/198560","volume":"2015","author":"S Naushad","year":"2015","unstructured":"Naushad S, Adeolu M, Goel N, Khadka B, Al-Dahwi A, Gupta RS. Phylogenomic and molecular demarcation of the core members of the polyphyletic pasteurellaceae genera actinobacillus, haemophilus, and pasteurella. Int J Genomics. 2015;2015:198560.","journal-title":"Int J Genomics"},{"issue":"11","key":"2711_CR72","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.archoralbio.2012.07.012","volume":"57","author":"T Sato","year":"2012","unstructured":"Sato T, Watanabe K, Kumada H, Toyama T, Tani-Ishii N, Hamada N. Peptidoglycan of Actinomyces naeslundii induces inflammatory cytokine production and stimulates osteoclastogenesis in alveolar bone resorption. Arch Oral Biol. 2012;57(11):1522\u20138.","journal-title":"Arch Oral Biol"},{"issue":"1","key":"2711_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anaerobe.2007.12.001","volume":"14","author":"V Hall","year":"2008","unstructured":"Hall V. Actinomyces\u2014gathering evidence of human colonization and infection. Anaerobe. 2008;14(1):1\u20137.","journal-title":"Anaerobe"},{"issue":"3","key":"2711_CR74","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.anaerobe.2008.04.004","volume":"14","author":"ERK Eribe","year":"2008","unstructured":"Eribe ERK, Olsen I. Leptotrichia species in human infections. Anaerobe. 2008;14(3):131\u20137.","journal-title":"Anaerobe"},{"key":"2711_CR75","doi-asserted-by":"crossref","unstructured":"Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW, et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature. 2019;569(7758):655\u201362.","DOI":"10.1038\/s41586-019-1237-9"},{"issue":"3","key":"2711_CR76","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/biom.12200","volume":"70","author":"C-H Chiu","year":"2014","unstructured":"Chiu C-H, Wang Y-T, Walther BA, Chao A. An improved nonparametric lower bound of species richness via a modified good\u2013turing frequency formula. Biometrics. 2014;70(3):671\u201382.","journal-title":"Biometrics"},{"key":"2711_CR77","doi-asserted-by":"crossref","unstructured":"Zeus M, Janssen S, Laws H-J, Fischer U, Borkhardt A, Oommen PT. Results from a pilot study on the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis. Z Rheumatol. 2021:1\u201310.","DOI":"10.1007\/s00393-021-01035-x"},{"issue":"8","key":"2711_CR78","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nm.3914","volume":"21","author":"X Zhang","year":"2015","unstructured":"Zhang X, Zhang D, Jia H, Feng Q, Wang D, Liang D, et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med. 2015;21(8):895\u2013905.","journal-title":"Nat Med"},{"issue":"1","key":"2711_CR79","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1471-230X-13-20","volume":"13","author":"J Kabeerdoss","year":"2013","unstructured":"Kabeerdoss J, Sankaran V, Pugazhendhi S, Ramakrishna B. Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case-control study in India. BMC Gastroenterol. 2013;13(1):20.","journal-title":"BMC Gastroenterol"},{"issue":"6015","key":"2711_CR80","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1126\/science.1198469","volume":"331","author":"K Atarashi","year":"2011","unstructured":"Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of colonic regulatory T cells by indigenous clostridium species. Science. 2011;331(6015):337\u201341.","journal-title":"Science"},{"issue":"3","key":"2711_CR81","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.jaci.2015.08.021","volume":"137","author":"H Song","year":"2016","unstructured":"Song H, Yoo Y, Hwang J, Na Y-C, Kim HS. Faecalibacterium prausnitzii subspecies\u2013level dysbiosis in the human gut microbiome underlying atopic dermatitis. J Allergy Clin Immunol. 2016;137(3):852\u201360.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"2711_CR82","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1002\/art.40827","volume":"71","author":"EHP van Dijkhuizen","year":"2019","unstructured":"van Dijkhuizen EHP, Del Chierico F, Malattia C, Russo A, Pires Marafon D, ter Haar NM, et al. Microbiome analytics of the gut microbiota in patients with juvenile idiopathic arthritis: a longitudinal observational cohort study. Arthritis Rheum. 2019;71(6):1000\u201310.","journal-title":"Arthritis Rheum"},{"issue":"12","key":"2711_CR83","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1586\/eri.11.137","volume":"9","author":"A Perry","year":"2011","unstructured":"Perry A, Lambert P. Propionibacterium acnes: infection beyond the skin. Expert Rev Anti-Infect Ther. 2011;9(12):1149\u201356.","journal-title":"Expert Rev Anti-Infect Ther"},{"issue":"2","key":"2711_CR84","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1902\/jop.1994.65.2.139","volume":"65","author":"L Shapira","year":"1994","unstructured":"Shapira L, Soskolne WA, Sela MN, Offenbacher S, Barak V. The secretion of PGE2, IL-1\u03b2, IL-6, and TNF\u03b1 by adherent mononuclear cells from early onset periodontitis patients. J Periodontol. 1994;65(2):139\u201346.","journal-title":"J Periodontol"},{"issue":"1","key":"2711_CR85","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0046-8177(99)90301-5","volume":"30","author":"HJ Girschick","year":"1999","unstructured":"Girschick HJ, Huppertz H-I, Harmsen D, Krauspe R, M\u00fcller-Hermelink HK, Papadopoulos T. Chronic recurrent multifocal osteomyelitis in children: diagnostic value of histopathology and microbial testing. Hum Pathol. 1999;30(1):59\u201365.","journal-title":"Hum Pathol"},{"issue":"11","key":"2711_CR86","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.clinmicnews.2013.05.001","volume":"35","author":"WM Janda","year":"2013","unstructured":"Janda WM. Update on the HACEK group of fastidious gram-negative bacilli. Part I. Clin Microbiol Newsl. 2013;35(11):87\u201392.","journal-title":"Clin Microbiol Newsl"},{"issue":"12","key":"2711_CR87","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.clinmicnews.2013.05.004","volume":"35","author":"WM Janda","year":"2013","unstructured":"Janda WM. Update on the HACEK group of fastidious gram-negative bacilli. Part II. Clin Microbiol Newslet. 2013;35(12):95\u2013101.","journal-title":"Clin Microbiol Newslet"},{"issue":"3","key":"2711_CR88","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1073\/pnas.1318685111","volume":"111","author":"SL Cassel","year":"2014","unstructured":"Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, et al. Inflammasome-independent IL-1\u03b2 mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci. 2014;111(3):1072\u20137.","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"2711_CR89","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/cmi.12560","volume":"18","author":"FQ Bui","year":"2016","unstructured":"Bui FQ, Johnson L, Roberts J, Hung SC, Lee J, Atanasova KR, et al. Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1\u03b2 and the danger signals ASC and HMGB1. Cell Microbiol. 2016;18(7):970\u201381.","journal-title":"Cell Microbiol"},{"issue":"3","key":"2711_CR90","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4161\/21505594.2014.982428","volume":"6","author":"CH \u00c5berg","year":"2015","unstructured":"\u00c5berg CH, Kelk P, Johansson A. Aggregatibacter actinomycetemcomitans: virulence of its leukotoxin and association with aggressive periodontitis. Virulence. 2015;6(3):188\u201395.","journal-title":"Virulence"},{"issue":"1","key":"2711_CR91","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/prd.12084","volume":"69","author":"\u00d6 Yilmaz","year":"2015","unstructured":"Yilmaz \u00d6, Lee KL. The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. Periodontol. 2015;69(1):83\u201395.","journal-title":"Periodontol"},{"issue":"1","key":"2711_CR92","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40364-017-0097-4","volume":"5","author":"T-R Kuo","year":"2017","unstructured":"Kuo T-R, Chen C-H. Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives. Biomark Res. 2017;5(1):18.","journal-title":"Biomark Res"},{"issue":"7","key":"2711_CR93","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.syapm.2015.07.007","volume":"38","author":"T Accetto","year":"2015","unstructured":"Accetto T, Avgustin G. Polysaccharide utilization locus and CAZYme genome repertoires reveal diverse ecological adaptation of Prevotella species. Syst Appl Microbiol. 2015;38(7):453\u201361.","journal-title":"Syst Appl Microbiol"},{"key":"2711_CR94","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12864-015-1350-6","volume":"16","author":"VK Gupta","year":"2015","unstructured":"Gupta VK, Chaudhari NM, Iskepalli S, Dutta C. Divergences in gene repertoire among the reference Prevotella genomes derived from distinct body sites of human. BMC Genomics. 2015;16:153.","journal-title":"BMC Genomics"},{"key":"2711_CR95","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01202","volume":"2","author":"JU Scher","year":"2013","unstructured":"Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife. 2013;2:e01202.","journal-title":"eLife"},{"issue":"369","key":"2711_CR96","doi-asserted-by":"publisher","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","volume":"8","author":"MF Konig","year":"2016","unstructured":"Konig MF, Abusleme L, Reinholdt J, Palmer RJ, Teles RP, Sampson K, et al. Aggregatibacter actinomycetemcomitans\u2013induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med. 2016;8(369):369ra176.","journal-title":"Sci Transl Med"},{"issue":"7","key":"2711_CR97","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/odi.12676","volume":"23","author":"A Acharya","year":"2017","unstructured":"Acharya A, Chan Y, Kheur S, Kheur M, Gopalakrishnan D, Watt RM, et al. Salivary microbiome of an urban Indian cohort and patterns linked to subclinical inflammation. Oral Dis. 2017;23(7):926\u201340.","journal-title":"Oral Dis"},{"issue":"4","key":"2711_CR98","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1399-302X.1988.tb00004.x","volume":"3","author":"Y Ohmori","year":"1988","unstructured":"Ohmori Y, Honda K, Kikuchu H, Hanazawa S, Amano S, Hirose K, et al. Inducing effect of periodontopathic bacteria on interleukin-1 production by mouse peritoneal macrophages. Oral Microbiol Immunol. 1988;3(4):169\u201372.","journal-title":"Oral Microbiol Immunol"},{"issue":"3","key":"2711_CR99","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/jid.2013.438","volume":"134","author":"M Kistowska","year":"2014","unstructured":"Kistowska M, Gehrke S, Jankovic D, Kerl K, Fettelschoss A, Feldmeyer L, et al. IL-1beta drives inflammatory responses to propionibacterium acnes in vitro and in vivo. J Invest Dermatol. 2014;134(3):677\u201385.","journal-title":"J Invest Dermatol"},{"issue":"3","key":"2711_CR100","first-page":"457","volume":"25","author":"M Colina","year":"2007","unstructured":"Colina M, Lo Monaco A, Khodeir M, Trotta F. Propionibacterium acnes and SAPHO syndrome: a case report and literature review. Clin Exp Rheumatol. 2007;25(3):457\u201360.","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"2711_CR101","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1128\/JCM.00818-09","volume":"48","author":"JSJ Wong","year":"2010","unstructured":"Wong JSJ, Seaward LM, Ho CP, Anderson TP, Lau EOC, Amodeo MR, et al. Corynebacterium accolens-associated pelvic osteomyelitis. J Clin Microbiol. 2010;48(2):654\u20135.","journal-title":"J Clin Microbiol"},{"issue":"5","key":"2711_CR102","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/clinids\/13.5.819","volume":"13","author":"I Brook","year":"1991","unstructured":"Brook I, Frazier EH. Infections caused by Propionibacterium species. Rev Infect Dis. 1991;13(5):819\u201322.","journal-title":"Rev Infect Dis"},{"issue":"9","key":"2711_CR103","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3390\/genes11091041","volume":"11","author":"A Di Ciaula","year":"2020","unstructured":"Di Ciaula A, Stella A, Bonfrate L, Wang DQH, Portincasa P. Gut microbiota between environment and genetic background in familial Mediterranean fever (FMF). Genes. 2020;11(9):1041.","journal-title":"Genes"},{"issue":"10","key":"2711_CR104","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1136\/annrheumdis-2019-215258","volume":"78","author":"S Deshayes","year":"2019","unstructured":"Deshayes S, Fellahi S, Bastard JP, Launay JM, Callebert J, Fraisse T, et al. Specific changes in faecal microbiota are associated with familial Mediterranean fever. Ann Rheum Dis. 2019;78(10):1398\u2013404.","journal-title":"Ann Rheum Dis"},{"issue":"18","key":"2711_CR105","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.12998\/wjcc.v7.i18.2734","volume":"7","author":"YQ Dong","year":"2019","unstructured":"Dong YQ, Wang W, Li J, Ma MS, Zhong LQ, Wei QJ, et al. Characterization of microbiota in systemic-onset juvenile idiopathic arthritis with different disease severities. World J Clin Cases. 2019;7(18):2734\u201345.","journal-title":"World J Clin Cases"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-021-02711-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-021-02711-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-021-02711-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:28:57Z","timestamp":1726705737000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-021-02711-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2711"],"URL":"https:\/\/doi.org\/10.1186\/s13075-021-02711-8","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]},"assertion":[{"value":"18 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The samples were taken with consent over the course of regular clinical control examinations in the pediatric rheumatology outpatient clinic at the \u201cKlinik f\u00fcr Kinder- und Jugendmedizin I\u201d, Universit\u00e4ts klinikum Schleswig Holstein, Campus Kiel (UKSH, Kiel campus, Germany, ethical permit: D 438\/13). All procedures related to patients and healthy subjects followed the guidelines of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}