{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:36:21Z","timestamp":1793036181538,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803179"],"award-info":[{"award-number":["81803179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803178"],"award-info":[{"award-number":["81803178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fecal samples collected from OA and KBD patients were used to characterize the gut microbiota using 16S rDNA gene sequencing. To identify whether gut microbial changes at the species level are associated with the genes or functions of the gut bacteria between OA and KBD groups, metagenomic sequencing of fecal samples from OA and KBD subjects was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The OA group was characterized by elevated <jats:italic>Epsilonbacteraeota<\/jats:italic> and <jats:italic>Firmicutes<\/jats:italic> levels. A total of 52 genera were identified to be significantly differentially abundant between the two groups. The genera <jats:italic>Raoultella<\/jats:italic>, <jats:italic>Citrobacter<\/jats:italic>, <jats:italic>Flavonifractor<\/jats:italic>, <jats:italic>g__Lachnospiraceae_UCG-004<\/jats:italic>, and <jats:italic>Burkholderia-Caballeronia-Paraburkholderia<\/jats:italic> were more abundant in the OA group. The KBD group was characterized by higher <jats:italic>Prevotella_9<\/jats:italic>, <jats:italic>Lactobacillus<\/jats:italic>, <jats:italic>Coprococcus_2<\/jats:italic>, <jats:italic>Senegalimassilia<\/jats:italic>, and <jats:italic>Holdemanella<\/jats:italic>. The metagenomic sequencing showed that the <jats:italic>Subdoligranulum_sp._APC924\/74<\/jats:italic>, <jats:italic>Streptococcus_parasanguinis<\/jats:italic>, and <jats:italic>Streptococcus_salivarius<\/jats:italic> were significantly increased in abundance in the OA group compared to those in the KBD group, and the species <jats:italic>Prevotella_copri<\/jats:italic>, <jats:italic>Prevotella_sp._CAG:386<\/jats:italic>, and <jats:italic>Prevotella_stercorea<\/jats:italic> were significantly decreased in abundance in the OA group compared to those in the KBD group by using metagenomic sequencing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study provides a comprehensive landscape of the gut microbiota between OA and KBD patients and provides clues for better understanding the mechanisms underlying the pathogenesis of OA and KBD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-022-02819-5","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T09:03:04Z","timestamp":1653901384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China"],"prefix":"10.1186","volume":"24","author":[{"given":"Yujie","family":"Ning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruitian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko J.","family":"Lammi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"issue":"9","key":"2819_CR1","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.joca.2019.05.009","volume":"27","author":"Y Liu","year":"2019","unstructured":"Liu Y, Ding W, Wang HL, Dai LL, Zong WH, Wang YZ, et al. Gut microbiota and obesity-associated osteoarthritis. Osteoarthr Cartilage. 2019;27(9):1257\u201365.","journal-title":"Osteoarthr Cartilage."},{"key":"2819_CR2","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jtemb.2018.01.012","volume":"50","author":"YJ Ning","year":"2018","unstructured":"Ning YJ, Wang X, Zhang P, Anatoly SV, Prakash NT, Li C, et al. Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. J Trace Elem Med Bio. 2018;50:441\u201360.","journal-title":"J Trace Elem Med Bio."},{"issue":"6","key":"2819_CR3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/s41419-021-03832-3","volume":"12","author":"X Wang","year":"2021","unstructured":"Wang X, Ning YJ, Zhang P, Poulet B, Huang RT, Gong Y, et al. Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis. Cell Death Dis. 2021;12(6):551.","journal-title":"Cell Death Dis."},{"key":"2819_CR4","doi-asserted-by":"crossref","unstructured":"Cheng BL, Liang CJ, Yang XN, Li P, Liu L, Cheng SQ, et al. Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease. Bone. 2021;150:115997.","DOI":"10.1016\/j.bone.2021.115997"},{"issue":"3","key":"2819_CR5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10067-012-2115-0","volume":"32","author":"Y Li","year":"2013","unstructured":"Li Y, Zhou ZK, Shen B, Yang J, Kang PD, Yang XB, et al. Clinical features of Kashin-Beck disease in adults younger than 50 years of age during a low incidence period: severe elbow and knee lesions. Clin Rheumatol. 2013;32(3):317\u201324.","journal-title":"Clin Rheumatol."},{"issue":"4","key":"2819_CR6","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrmicro2974","volume":"11","author":"F Sommer","year":"2013","unstructured":"Sommer F, Backhed F. The gut microbiota - masters of host development and physiology. Nat Rev Microbiol. 2013;11(4):227\u201338.","journal-title":"Nat Rev Microbiol."},{"issue":"2","key":"2819_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2019-001037","volume":"5","author":"JM Berthelot","year":"2019","unstructured":"Berthelot JM, Sellam J, Maugars Y, Berenbaum F. Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis. Rmd Open. 2019;5(2):e001037.","journal-title":"Rmd Open."},{"issue":"1","key":"2819_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01134","volume":"5","author":"MA Szychlinska","year":"2019","unstructured":"Szychlinska MA, Di Rosa M, Castorina A, Mobasheri A, Musumeci G. A correlation between intestinal microbiota dysbiosis and osteoarthritis. Heliyon. 2019;5(1):e01134.","journal-title":"Heliyon."},{"issue":"1","key":"2819_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/BOR.0000000000000681","volume":"32","author":"LJ Favazzo","year":"2020","unstructured":"Favazzo LJ, Hendesi H, Villani DA, Soniwala S, Dar QA, Schott EM, et al. The gut microbiome-joint connection: implications in osteoarthritis. Curr Opin Rheumatol. 2020;32(1):92\u2013101.","journal-title":"Curr Opin Rheumatol."},{"issue":"11","key":"2819_CR10","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","volume":"22","author":"X Guo","year":"2014","unstructured":"Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthr Cartilage. 2014;22(11):1774\u201383.","journal-title":"Osteoarthr Cartilage."},{"issue":"44","key":"2819_CR11","doi-asserted-by":"publisher","first-page":"18933","DOI":"10.1073\/pnas.1007028107","volume":"107","author":"AK Benson","year":"2010","unstructured":"Benson AK, Kelly SA, Legge R, Ma FR, Low SJ, Kim J, et al. Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. P Natl Acad Sci USA. 2010;107(44):18933\u20138.","journal-title":"P Natl Acad Sci USA."},{"issue":"11","key":"2819_CR12","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/s41419-021-04322-2","volume":"12","author":"X Wang","year":"2021","unstructured":"Wang X, Ning YJ, Li C, Gong Y, Huang RT, Hu MH, et al. Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China. Cell Death Dis. 2021;12(11):1015.","journal-title":"Cell Death Dis."},{"issue":"7","key":"2819_CR13","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1002\/art.41210","volume":"70","author":"C Dunn","year":"2018","unstructured":"Dunn C, Velasco C, Rivas A, Andrews M, Jacob P, Jeffries MA. Identification of a human cartilage microbial DNA signature and characterization of distinct microbiome profiles associated with osteoarthritis. Arthritis Rheumatol. 2018;70(7):1111\u201322.","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"2819_CR14","doi-asserted-by":"publisher","first-page":"14305","DOI":"10.1038\/s41598-018-32675-w","volume":"8","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Chen B, Li SF, Yang LX, Zhu DQ, Wang Y, et al. Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients. Sci Rep-Uk. 2018;8(1):14305.","journal-title":"Sci Rep-Uk."},{"issue":"6","key":"2819_CR15","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1002\/art.39555","volume":"68","author":"MA Jeffries","year":"2016","unstructured":"Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Humphrey MB, et al. Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage. Arthritis Rheumatol. 2016;68(6):1403\u201314.","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"2819_CR16","first-page":"320","volume":"10","author":"AK Behera","year":"2008","unstructured":"Behera AK, Durand E, Cugini C, Antonara S, Bourassa L, Hildebrand E, et al. Borrelia burgdorferi BBB07 interaction with integrin alpha(3)beta(1) stimulates production of pro-inflammatory mediators in primary human chondrocytes. Cell Microbiol. 2008;10(2):320\u201331.","journal-title":"Cell Microbiol."},{"key":"2819_CR17","first-page":"3495173","volume":"2016","author":"YS Li","year":"2016","unstructured":"Li YS, Luo W, Deng ZH, Lei GH. Diet-intestinal microbiota axis in osteoarthritis: a possible role. Mediat Inflamm. 2016;2016:3495173.","journal-title":"Mediat Inflamm."},{"issue":"2","key":"2819_CR18","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3390\/nu12020574","volume":"12","author":"A de Sire","year":"2020","unstructured":"de Sire A, de Sire R, Petito V, Masi L, Cisari C, Gasbarrini A, et al. Gut-joint axis: the role of physical exercise on gut microbiota modulation in older people with osteoarthritis. Nutrients. 2020;12(2):574.","journal-title":"Nutrients."},{"issue":"1","key":"2819_CR19","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.1038\/s41467-019-12873-4","volume":"10","author":"CG Boer","year":"2019","unstructured":"Boer CG, Radjabzadeh D, Medina-Gomez C, Garmaeva S, Schiphof D, Arp P, et al. Intestinal microbiome composition and its relation to joint pain and inflammation. Nat Commun. 2019;10(1):4881.","journal-title":"Nat Commun."},{"issue":"19","key":"2819_CR20","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1001\/jama.1977.03280200066025","volume":"238","author":"T Mcguire","year":"1977","unstructured":"Mcguire T, Gerjarusak P, Hinthorn DR, Liu C. Osteomyelitis caused by beta-hemolytic Streptococcus group-B. JAMA. 1977;238(19):2054\u20135.","journal-title":"JAMA"},{"issue":"1","key":"2819_CR21","doi-asserted-by":"publisher","first-page":"O33","DOI":"10.1111\/1469-0691.12302","volume":"20","author":"O Murillo","year":"2014","unstructured":"Murillo O, Roset A, Sobrino B, Lora-Tamayo J, Verdaguer R, Jimenez-Mejias E, et al. Streptococcal vertebral osteomyelitis: multiple faces of the same disease. Clin Microbiol Infec. 2014;20(1):O33\u2013O8.","journal-title":"Clin Microbiol Infec."},{"issue":"4","key":"2819_CR22","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3109\/08830185.2014.917411","volume":"33","author":"MW Cunningham","year":"2014","unstructured":"Cunningham MW. Rheumatic fever, autoimmunity, and molecular mimicry: the streptococcal connection. Int Rev Immunol. 2014;33(4):314\u201329.","journal-title":"Int Rev Immunol."},{"issue":"3","key":"2819_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nrcardio.2012.197","volume":"10","author":"R Tandon","year":"2013","unstructured":"Tandon R, Sharma M, Chandrashekhar Y, Kotb M, Yacoub MH, Narula J. Revisiting the pathogenesis of rheumatic fever and carditis. Nat Rev Cardiol. 2013;10(3):171\u20137.","journal-title":"Nat Rev Cardiol."},{"issue":"8","key":"2819_CR24","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1093\/rheumatology\/keh225","volume":"43","author":"SL Mackie","year":"2004","unstructured":"Mackie SL, Keat A. Poststreptococcal reactive arthritis: what is it and how do we know? Rheumatology. 2004;43(8):949\u201354.","journal-title":"Rheumatology."},{"issue":"3","key":"2819_CR25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s11908-013-0335-3","volume":"15","author":"J Barash","year":"2013","unstructured":"Barash J. Rheumatic fever and post-group A streptococcal arthritis in children. Curr Infect Dis Rep. 2013;15(3):263\u20138.","journal-title":"Curr Infect Dis Rep."},{"issue":"10","key":"2819_CR26","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nrmicro3480","volume":"13","author":"L Brown","year":"2015","unstructured":"Brown L, Wolf JM, Prados-Rosales R, Casadevall A. Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi. Nat Rev Microbiol. 2015;13(10):620\u201330.","journal-title":"Nat Rev Microbiol."},{"issue":"8","key":"2819_CR27","first-page":"1612","volume":"1843","author":"KE Bonnington","year":"2014","unstructured":"Bonnington KE, Kuehn MJ. Protein selection and export via outer membrane vesicles. Bba-Mol Cell Res. 2014;1843(8):1612\u20139.","journal-title":"Bba-Mol Cell Res."},{"issue":"11-12","key":"2819_CR28","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1042\/CS20120073","volume":"123","author":"D Metcalfe","year":"2012","unstructured":"Metcalfe D, Harte AL, Aletrari MO, Al Daghri NM, Al Disi D, Tripathi G, et al. Does endotoxaemia contribute to osteoarthritis in obese patients? Clin Sci. 2012;123(11-12):627\u201334.","journal-title":"Clin Sci."},{"issue":"19","key":"2819_CR29","doi-asserted-by":"publisher","first-page":"7421","DOI":"10.1073\/pnas.1201193109","volume":"109","author":"U Ohto","year":"2012","unstructured":"Ohto U, Fukase K, Miyake K, Shimizu T. Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4\/MD-2. P Natl Acad Sci USA. 2012;109(19):7421\u20136.","journal-title":"P Natl Acad Sci USA."},{"issue":"7","key":"2819_CR30","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1136\/ard.2005.045724","volume":"66","author":"S Dahaghin","year":"2007","unstructured":"Dahaghin S, Bierma-Zeinstra SMA, Koes BW, Hazes JMW, Pols HAP. Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study. Ann Rheum Dis. 2007;66(7):916\u201320.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"2819_CR31","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1128\/JCM.00845-13","volume":"51","author":"VC Antharam","year":"2013","unstructured":"Antharam VC, Li EC, Ishmael A, Sharma A, Mai V, Rand KH, et al. Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea. J Clin Microbiol. 2013;51(9):2884\u201392.","journal-title":"J Clin Microbiol."},{"key":"2819_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116299","volume":"155","author":"Q Li","year":"2022","unstructured":"Li Q, Chen H, Li Z, Zhang F, Chen L. Glucocorticoid caused lactic acid accumulation and damage in human chondrocytes via ROS-mediated inhibition of monocarboxylate transporter 4. Bone. 2022;155:116299.","journal-title":"Bone."},{"issue":"10","key":"2819_CR33","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3390\/genes10100748","volume":"10","author":"JY Lee","year":"2019","unstructured":"Lee JY, Mannaa M, Kim Y, Kim J, Kim GT, Seo YS. Comparative analysis of fecal microbiota composition between rheumatoid arthritis and osteoarthritis patients. Genes-Basel. 2019;10(10):748.","journal-title":"Genes-Basel."},{"issue":"2","key":"2819_CR34","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1574-6968.2007.00962.x","volume":"277","author":"TR Licht","year":"2007","unstructured":"Licht TR, Madsen B, Wilcks A. Selection of bacteria originating from a human intestinal microbiota in the gut of previously germ-free rats. Fems Microbiol Lett. 2007;277(2):205\u20139.","journal-title":"Fems Microbiol Lett."},{"issue":"6","key":"2819_CR35","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.cmet.2015.10.001","volume":"22","author":"P Kovatcheva-Datchary","year":"2015","unstructured":"Kovatcheva-Datchary P, Nilsson A, Akrami R, Lee YS, De Vadder F, Arora T, et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab. 2015;22(6):971\u201382.","journal-title":"Cell Metab."},{"issue":"11","key":"2819_CR36","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/ni.1657","volume":"9","author":"T Rubic","year":"2008","unstructured":"Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, et al. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol. 2008;9(11):1261\u20139.","journal-title":"Nat Immunol."},{"issue":"10","key":"2819_CR37","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.humimm.2011.05.021","volume":"72","author":"LF Tian","year":"2011","unstructured":"Tian LF, Wang W, Hou WK, Tian J, Zhong NN, Sun J, et al. Autoimmune and inflammatory responses in Kashin-Beck disease compared with rheumatoid arthritis and osteoarthritis. Hum Immunol. 2011;72(10):812\u20136.","journal-title":"Hum Immunol."},{"issue":"6","key":"2819_CR38","doi-asserted-by":"publisher","first-page":"BSR20190188","DOI":"10.1042\/BSR20190188","volume":"39","author":"ZQ Gao","year":"2019","unstructured":"Gao ZQ, Duan C, Yu FF, Guo X. Differential gene expression in articular cartilage between rheumatoid arthritis and endemic Kashin-Beck disease. Bioscience Rep. 2019;39(6):BSR20190188.","journal-title":"Bioscience Rep."},{"issue":"1","key":"2819_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028439","volume":"7","author":"S Wang","year":"2012","unstructured":"Wang S, Guo X, Wu XM, Lammi MJ. Genome-wide gene expression analysis suggests an important role of suppressed immunity in pathogenesis of Kashin-Beck disease. Plos One. 2012;7(1):e28439.","journal-title":"Plos One."},{"key":"2819_CR40","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3389\/fimmu.2020.00730","volume":"11","author":"HS Na","year":"2020","unstructured":"Na HS, Park JS, Cho KH, Kwon JY, Choi J, Jhun J, et al. Interleukin-1-interleukin-17 signaling axis induces cartilage destruction and promotes experimental osteoarthritis. Front Immunol. 2020;11:730.","journal-title":"Front Immunol."},{"issue":"1","key":"2819_CR41","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00018-017-2674-y","volume":"75","author":"A Santoro","year":"2018","unstructured":"Santoro A, Ostan R, Candela M, Biagi E, Brigidi P, Capri M, et al. Gut microbiota changes in the extreme decades of human life: a focus on centenarians. Cell Mol Life Sci. 2018;75(1):129\u201348.","journal-title":"Cell Mol Life Sci."},{"issue":"11","key":"2819_CR42","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.joca.2015.03.014","volume":"23","author":"KH Collins","year":"2015","unstructured":"Collins KH, Paul HA, Reimer RA, Seerattan RA, Hart DA, Herzog W. Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model. Osteoarthr Cartilage. 2015;23(11):1989\u201398.","journal-title":"Osteoarthr Cartilage."},{"issue":"10","key":"2819_CR43","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/j.joca.2016.05.008","volume":"24","author":"ZY Huang","year":"2016","unstructured":"Huang ZY, Stabler T, Pei FX, Kraus VB. Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation. Osteoarthr Cartilage. 2016;24(10):1769\u201375.","journal-title":"Osteoarthr Cartilage."}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-022-02819-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-022-02819-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-022-02819-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T09:04:54Z","timestamp":1653901494000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-022-02819-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,30]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2819"],"URL":"https:\/\/doi.org\/10.1186\/s13075-022-02819-5","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,30]]},"assertion":[{"value":"7 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All samples were collected under approval from the human ethics committee of Xi\u2019an Jiaotong University, and all subjects properly consented before samples were collected.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}