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Uni- and multivariable analyses were performed to identify prognostic parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Out of 280 SSc patients screened for PH, 225 were included in the analysis (81.3% female, mean age 58.1\u00b113.0 years, 68% limited cutaneous SSc, WHO-FC II\u2013III 74%, 24 manifest PH). During the observation period of 3.2\u00b12.7 (median 2.6) years 35 patients died. Tricuspid annular plane systolic excursion (TAPSE) at rest &lt;18 mm (<jats:italic>p<\/jats:italic>=0.001), RV output reserve as increase of cardiac index (CI) during exercise &lt;2 l\/min (<jats:italic>p<\/jats:italic>&lt;0.0001), RV pulmonary vascular reserve (\u0394 mean pulmonary artery pressure\/\u0394 cardiac output) \u22653 mmHg\/l\/min (<jats:italic>p<\/jats:italic>&lt;0.0001), peak CI &lt;5.5 l\/min\/m<jats:sup>2<\/jats:sup> (<jats:italic>p<\/jats:italic>=0.001), pulmonary arterial compliance &lt;2 ml\/mmHg (<jats:italic>p<\/jats:italic>=0.002), TAPSE\/systolic pulmonary arterial pressure (sPAP) ratio \u22640.6 ml\/mmHg (<jats:italic>p<\/jats:italic>&lt;0.0001) and echocardiographic qualitative RV function at rest (<jats:italic>p<\/jats:italic>&lt;0.0001) significantly predicted worse survival. In the multivariable analysis TAPSE\/sPAP ratio and diffusion capacity for carbon monoxide \u226465% were identified as independent prognostic predictors and had 75% sensitivity and 69% specificity to predict future development of pulmonary vascular disease (PVD) during follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and\/or PVD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-022-02863-1","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T12:03:48Z","timestamp":1658405028000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis"],"prefix":"10.1186","volume":"24","author":[{"given":"Panagiota","family":"Xanthouli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Miazgowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ojan","family":"Gordjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Egenlauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satenik","family":"Harutyunova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekka","family":"Seeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto M.","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns-Martin","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Gr\u00fcnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Eichstaedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"issue":"10103","key":"2863_CR1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","volume":"390","author":"CP Denton","year":"2017","unstructured":"Denton CP, Khanna D. 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The study complies with the Declaration of Helsinki in its current version.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"PX: has received personal fees from MSD and OMT outside the submitted work.JM, OJ, RS, CAE, NBe: nothing to declare.BE: received travel fees, consulting fees, speaking fees, and\/or honoraria from Actelion, MSD, Bayer and OMT, outside the submitted work.SH: received honoraria for lectures, consultancy, or both from Actelion, AOP, Bayer\/MSD, GSK, Novartis, OMT, Pfizer, and United Therapeutics out-side the submitted work.AMM: AMM has received personal fees from Bayer, outside the submitted work.NBl: has received consulting fees, speaking fees and\/or honoraria and unallocated funds from Roche out-side the submitted work.HML: has received consulting fees, speaking fees and\/or honoraria and unallocated funds for scientific talks and consultations from Abbvie, Astra-Zeneca, Actelion, Alexion, Amgen, Bayer Vital, Baxter, Biogen, Boehringer Ingelheim, BMS, Celgene, Fresenius, Genzyme, GSK, Gilead\/Galapagos, Hexal, Janssen-Cilag, Lilly, Medac, MSD, Mundipharm, Mylan, Novartis, octapharm, Pfizer, Roche\/Chugai, Sandoz, Sanofi, Shire, SOBI, Thermo Fisher, UCB.EG: has received grants and personal fees from Actelion, Bayer AG, and MSD; grants from GSK, Novartis, and United Therapeutics and personal fees from SCOPE, OrPha Swiss GmbH, and Zurich Heart House, outside the submitted work. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"173"}}