{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:08:27Z","timestamp":1782389307357,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009232","name":"University of Debrecen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009232","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Cardiac involvement in patients with idiopathic inflammatory myopathies (IIM) is associated with increased morbidity and mortality risk; however, little is known about the progression of cardiac dysfunction and long-term data are scarce. In the present work, we intended to prospectively study echocardiographic parameters in patients with IIM for 2 years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty-eight IIM patients (41.9\u00b11.6 years) without cardiovascular symptoms were enrolled. Patients with monophasic\/polyphasic disease patterns were studied separately and compared to age-matched healthy individuals. Conventional echocardiographic and tissue Doppler imaging (TDI) parameters of systolic [LV: ejection fraction (EF), mitral annulus systolic movement (MAPSE), lateral s\u2032) and diastolic left (mitral inflow velocities, lateral anulus velocities: e\u2032, a\u2032, E\/e\u2032) and right ventricular function (fractional area change: FAC, tricuspid annulus plane systolic excursion: TAPSE) were measured at the time of the diagnosis and 2 years later.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Subclinical LV systolic dysfunction is characterized by reduced lateral s\u2032 (10.4 vs. 6.4 cm\/s, <jats:italic>p<\/jats:italic>&lt;0.05), EF (62.6\u00b10.6%, vs. 51.7\u00b10.7%) and MAPSE (18.5\u00b10.6 vs. 14.5\u00b10.6 mm) could be observed in IIM patients with polyphasic disease course 2 years after diagnosis compared to controls. Furthermore, diastolic LV function showed a marked deterioration to grade I diastolic dysfunction at 2 years in the polyphasic group (lateral e\u2032: 12.9 \u00b10.6, vs. 7.4\u00b10.3 cm\/s; lateral a\u2032: 10.7\u00b10.3, vs. 17.3\u00b10.8 cm\/s; <jats:italic>p<\/jats:italic>&lt;0.05) supported by larger left atrium (32.1\u00b10.6 vs. 37.8\u00b10.6 mm; <jats:italic>p<\/jats:italic>&lt;0.05]. TDI measurements confirmed subclinical RV systolic dysfunction in polyphasic patients 2 years after diagnosis (FAC: 45.6\u00b11.8%, vs. 32.7\u00b11.4%; TAPSE: 22.7\u00b10.5, vs. 18.1\u00b10.3 mm; <jats:italic>p<\/jats:italic>&lt;0.05). Similar, but not significant tendencies could be detected in patients with monophasic disease patterns. Polyphasic patients showed significantly (<jats:italic>p<\/jats:italic>&lt;0.05) worse results compared to monophasic patients regarding EF (51.7\u00b10.7% vs. 58.1\u00b10.6%), lateral s\u2032 (6.4\u00b10.4 cm\/sec vs. 8.6\u00b10.4 cm\/s,), left atrium (37.8\u00b10.6 mm vs. 33.3\u00b10.8 mm), FAC (32.7\u00b11.4% vs. 41.0\u00b11.6%) and TAPSE (18.1\u00b10.3 mm vs. 21.3\u00b10.7 mm).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Significant subclinical cardiac dysfunction could be detected in IIM patients with polyphasic disease course 2 years after diagnosis, which identifies them as a high-risk population. TDI is a useful method to detect echocardiographic abnormalities in IIM complementing conventional echocardiography and can recognize the high cardiac risk.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-022-02906-7","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T07:02:48Z","timestamp":1662793368000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Subclinical systolic and diastolic myocardial dysfunction in polyphasic polymyositis\/dermatomyositis: a 2-year longitudinal study"],"prefix":"10.1186","volume":"24","author":[{"given":"Andrea","family":"P\u00e9ter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Csan\u00e1di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Dank\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Griger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"issue":"12","key":"2906_CR1","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1136\/annrheumdis-2017-211468","volume":"76","author":"IE Lundberg","year":"2017","unstructured":"Lundberg IE, Tj\u00e4rnlund A, Bottai M, et al. 2017 European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups [published correction appears in Ann Rheum Dis. 2018 Sep;77(9):e64]. 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