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To date, there are no adequate data regarding the diagnostic value of OST in the evaluation of inflammatory activity changes, during arthritis follow-up.<\/jats:p>\n                <jats:p>Objectives of this study were therefore to examine the performance of OST in assessing response to anti-inflammatory therapy in patients with active arthritis and to explore OST associations with clinical, laboratory, and ultrasonographic (US) activity markers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p><jats:italic>1173<\/jats:italic> joints of <jats:italic>54<\/jats:italic> patients with arthritides of the wrist and finger joints were examined by OST before and after oral administration of glucocorticoids (GC), during a disease flare. For the same time-points patients underwent clinical, laboratory, and joint US [grayscale (GSUS), power-Doppler (PDUS)] examinations. The distribution of \u0394OST-values between the two time-points was compared with the respective distributions of \u0394PDUS and \u0394GSUS by Bayesian statistical analyses. Moreover, the diagnostic performance of OST compared to a control group (<jats:italic>2508<\/jats:italic> joints of <jats:italic>114<\/jats:italic> subjects) was examined by receiver operating characteristics and associations of OST values with clinical, laboratory, and arthrosonographic parameters were evaluated by correlation analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>OST and US performed similarly in the assessment of inflammatory changes caused by GC (same value-change tendency in <jats:italic>83.2%<\/jats:italic> of the cases). Bayesian statistics revealed no significant differences between \u0394OST and \u0394PDUS for all 3 examined joint categories (accuracy: metacarpophalangeal (MCP): <jats:italic>68.1%<\/jats:italic>; proximal interphalangeal (PIP): <jats:italic>60.4%<\/jats:italic>; wrists: <jats:italic>50.4%<\/jats:italic>) and between \u0394OST and \u0394GSUS for MCP and PIP joints (accuracy: <jats:italic>51.1%<\/jats:italic> and <jats:italic>78.7%<\/jats:italic>, respectively). OST diagnostic performance (patients vs. controls) was excellent in both time-points [area under the curve (AUC) before GC=<jats:italic>0.883(95%CI=0.83\u20130.94)<\/jats:italic> and after GC=<jats:italic>0.811(95%CI=0.74\u20130.881); p&lt;0.001<\/jats:italic>]. Furthermore, OST correlated significantly with all examined sonographic activity scores (all; <jats:italic>p&lt;0.001<\/jats:italic>) and with swollen joint counts (<jats:italic>p&lt;0.01<\/jats:italic>).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>OST was able to assess response to therapy in a similar way to joint US and correlated significantly with arthritis activity markers. Therefore, OST has proved to be a valuable tool to assist disease activity monitoring in the examined cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>German Registry of Clinical Trials, DRKS00016752<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13075-023-03023-9","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T02:02:33Z","timestamp":1679709753000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Optical spectral transmission to assess glucocorticoid therapy response in patients with arthritis: a longitudinal follow-up comparison with joint ultrasound"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8764-2636","authenticated-orcid":false,"given":"Konstantinos","family":"Triantafyllias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Marinoska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"de Blasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthuraman","family":"Muthuraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schwarting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"issue":"7","key":"3023_CR1","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.3899\/jrheum.090980","volume":"37","author":"W Katchamart","year":"2010","unstructured":"Katchamart W, Bombardier C. 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Arthritis Res Ther. 2012;14(3):R112.","journal-title":"Arthritis Res Ther."}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-023-03023-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13075-023-03023-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13075-023-03023-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T03:08:38Z","timestamp":1679713718000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-023-03023-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,25]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3023"],"URL":"https:\/\/doi.org\/10.1186\/s13075-023-03023-9","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,25]]},"assertion":[{"value":"29 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The assessment was reviewed and approved by the Standing Committee for Clinical Studies of Rhineland-Palatinate, Germany, in adherence to the Declaration of Helsinki (Nr.: 13042). All patients gave their informed consent to the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"47"}}